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纳武利尤单抗和伊匹木单抗联合治疗错配修复缺陷的转移性结直肠癌的疗效和安全性的Meta分析

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中国医药生物技术 2024年第2期19卷 174-179页

作者：贾平平武笑笑沈方琪赵倩倩首都医科大学附属北京世纪坛医院临床营养科/国家市场监管重点实验室(肿瘤特医食品) 北京100038

结直肠癌为全球第三大常见肿瘤,其发病率和死亡率呈逐年上升趋势[1]。2018年,结直肠癌占世界当年确诊肿瘤的10.2%,当年80万人死于该疾病[2]。2020年,一年内发生190多万结直肠癌新病例和93.5万例死亡,约占癌症病例和死亡人数的十分之一[3]。

关键词：新病例 Meta分析结直肠癌疗效和安全性死亡人数单抗

Preparation of maximally-entangled states with multiple cat-state qutrits in circuit QED

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Frontiers of physics 2024年第3期19卷 239-251页

作者： Chui-ping Yang jia-Heng Ni Liang Bin Yu Zhang Yang Yu Qi-ping Su Department of Physics Hangzhou Normal UniversityHangzhou 311121China School of Physics Nanjing UniversityNanjing 210093China Institute for Quantum Science and Technology University of CalgaryAlberta T2N 1N4Canada

In recent years,cat-state encoding and high-dimensional entanglement have attracted much ***,previous works are limited to generation of entangled states of cat-state qubits(two-dimensional entanglement with cat-state encoding),while how to prepare entangled states of cat-state qutrits or qudits(high-dimensional entanglement with cat-state encoding)has not been *** here propose to generate a maximally-entangled state of multiple cat-state qutrits(three-dimensional entanglement by cat-state encoding)in circuit *** entangled state is prepared with multiple microwave cavities coupled to a superconducting flux ququart(a four-level quantum system).This proposal operates essentially by the cavity-qutrit dispersive *** circuit hardware resource is minimized because only a coupler ququart is *** higher intermediate level of the ququart is occupied only for a short time,thereby decoherence from this level is greatly suppressed during the state ***,the state preparation time does not depend on the number of the qutrits,thus it does not increase with the number of the *** an example,our numerical simulations demonstrate that,with the present circuit QED technology,the high-fidelity preparation is feasible for a maximally-entangled state of two cat-state ***,we numerically analyze the effect of the inter-cavity crosstalk on the scalability of this *** proposal is universal and can be extended to accomplish the same task with multiple microwave or optical cavities coupled to a natural or artificial four-level atom.

关键词： maximally-entangled states cat state qutrit circuit QED

Effects of diamond particle size on microstructure and properties of diamond/Al-12Si composites prepared by vacuum-assisted pressure infiltration

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China Foundry 2024年第4期21卷 360-368页

作者： jia-ping Fu Can-xu Zhou Guo-fa Mi Yuan Liu School of Materials Science and Engineering Henan Polytechnic UniversityJiaozuo 454100HenanChina School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China Key Laboratory for Advanced Materials Processing Technology Ministry of EducationBeijing 100084China

Diamond/aluminium composites have attracted attention in the field of thermal management of electronic packaging for their excellent *** order to solve the interfacial problem between diamond and aluminium,a novel process combining pressure infiltration with vacuum-assisted technology was proposed to prepare diamond/aluminum *** effect of diamond particle size on the microstructure and properties of the diamond/Al-12Si composites was *** results show that the diamond/Al-12Si composites exhibit high relative density and a uniform *** thermal conductivity and coefficient of thermal expansion increase with increasing particle size,while the bending strength exhibits the opposite *** the average diamond particle size increases from 45μm to 425μm,the thermal conductivity of the composites increases from 455 W·m^(-1)·K^(-1)to 713 W·m^(-1)·K^(-1)and the coefficient of thermal expansion increases from 4.97×10^(-6)K^(-1)to 6.72×10^(-6)K^(-1),while the bending strength decreases from 353 MPa to 246 *** research demonstrates that high-quality composites can be prepared by the vacuum-assisted pressure infiltration process and the thermal conductivity of the composites can be effectively improved by increasing the diamond particle size.

关键词： diamond/aluminum composites thermal conductivity electronic packaging vacuum-assisted pressure infiltration

Influence of pressure disturbance wave on dynamic response characteristics of liquid film seal for multiphase pump

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Petroleum Science 2024年第3期21卷 2048-2065页

作者： Qing-ping Li Jin-Ya Zhang jia-Xiang Zhang Yong-Xue Zhang CNOOC Research Institute Company Limited Beijing100028China State Key Laboratory of Natural Gas Hydrate Beijing100028China College of Mechanical and Transportation Engineering China University of PetroleumBeijing2249China

Slug flow or high GVF(Gas Volume Fraction)conditions can cause pressure disturbance waves and alternating loads at the boundary of mechanical seals for multiphase pumps,endangering the safety of multiphase pump *** mechanical seal model is simplified by using periodic boundary conditions and numerical calculations are carried out based on the Zwart-Gerber-Belamri cavitation ***(User Define Function)programs such as structural dynamics equations,alternating load equations,and pressure disturbance equations are embedded in numerical calculations,and the dynamic response characteristics of mechanical seal are studied using layered dynamic mesh *** results show that when the pressure disturbance occurs at the inlet,as the amplitude and period of the disturbance increase,the film thickness gradually *** the fundamental reason for the hysteresis of the film thickness change is that the pressure in the high-pressure area cannot be restored in a timely *** maximum value of leakage and the minimum value of axial velocity are independent of the disturbance period and determined by the disturbance *** mutual interference between enhanced waves does not have a significant impact on the film thickness,while the front wave in the attenuated wave has a promoting effect on the subsequent film thickness changes,and the fluctuation of the liquid film cavitation rate and axial velocity under the attenuated wave condition deviates from the initial *** with pressure disturbance conditions,alternating load conditions have a more significant impact on film thickness and *** actual operation,it is necessary to avoid alternating load conditions in multiphase pump mechanical seals.

关键词： Multiphase pump Liquid film seal Pressure disturbance wave Dynamic response characteristics

Rheological Behaviors of Polymers with Nanoparticles Tethered at Each End

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Chinese Journal of Polymer Science 2024年第3期42卷 400-406,I0009页

作者： Song-Qi Zhang Wen-Qing Wang jia-ping Lin Li-Quan Wang Shanghai Key Laboratory of Advanced Polymeric Materials Key Laboratory for Ultrafine Materials of Ministry of EducationSchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghai 200237China

The polymer with nanoparticles tethered at each end is a unique model for unraveling the effect of chain ends on the polymer dynamics. We investigated the rheological behavior of this kind of polymer by using nonequilibrium molecular dynamics simulation. The effect of polymer lengths and nanoparticle radii on the complex moduli and viscosity was examined. The dependence of complex moduli on the frequency becomes less pronounced as the polymer is short or the nanoparticle is large. The shear thinning behavior was revealed for these systems, and the scaling exponent of complex viscosity with respect to the frequency was found to change from-1/2 to-3/4 as the polymer shortens or the nanoparticle enlarges. The rheological behavior was further explained by analyzing the mean square distance of nanoparticles. The simulation results were compared with the existing experimental finding, showing an agreement. The work provides information for understanding the chain end effect on polymer rheology.

关键词： Polymer rheology Modulus Viscosity Molecular dynamics

Furan-derived Schiff base covalent adaptable thermosets with recyclability and anti-flammability

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Green Chemical Engineering 2024年第3期5卷 364-373页

作者： ping Zhang Shuyu jia Ruishi Xie Lin Chen Ying Xiong State Key Laboratory of Environment-friendly Energy Materials School of Materials Science and Engineering Southwest University of Science and Technology

Conventional thermosetting polymers, mostly derived from nonrenewable petroleum resources, are not reprocessable and recyclable due to their highly cross-linked three-dimensional networks and face the disadvantage of high flammability. To solve these issues, in this study, we synthesized a novel Schiff base covalent adaptable thermoset from a furan-derived tri-aldehyde monomer(TMFP) and a furan-derived di-amine monomer(DFDA).The as-prepared TMFP-DFDA-Vitrimer exhibited superior anti-flammability with a high limiting oxygen index(LOI) of 35.0% and a UL-94 V-0 rating, which was attributed to the excellent charring ability. Additionally, TMFPDFDA-Vitrimer could also be conveniently recycled by chemical decomposition under a mixed hydrochloric acid/tetrahydrofuran(HCl/THF) solution. After recycling for 5 times, the thermal, mechanical, and flame retardant properties of the recycled TMFP-DFDA-Vitrimer retained almost unchanged compared to the original one. This work provides a prime instance to develop advanced thermosetting polymers from abundant furan-based compounds.

关键词： Furan-based compounds Vitrimer Recyclability Flame retardancy

Estimating the optimal vegetation coverage for the dominant tree and shrub species over China's northwest drylands

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Science China Earth Sciences 2024年第5期67卷 1500-1517页

作者： Zhongdian ZHANG Xiaoxu jia ping ZHU Mingbin HUANG Lidong REN Ming’an SHAO School of Geographic Sciences Xinyang Normal UniversityXinyang 464000China Key Laboratory of Ecosystem Network Observation and Modeling Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100190China Yellow River Delta Modern Agricultural Engineering Laboratory Chinese Academy of SciencesBeijing 100101China State Key Laboratory of Soil Erosion and Dryland Farming on the Loess Plateau Institute of Soil and Water ConservationNorthwest A&F UniversityYangling 712100China

Anthropogenic revegetation is an effective way to control soil erosion and restore degraded ecosystems in China's northwest drylands(NWD).However,excessive vegetation cover expansion has long been known to increase evapotranspiration,leading to reduced local water availability,which can in turn threaten the health and services of restored *** the optimal vegetation coverage(OVC)is critical for balancing the trade-off between plant growth and water consumption in water-stressed areas,yet quantitative assessments over the entire NWD are still *** this study,a modified Biome BioGeochemical Cycles(Biome-BGC)model was used to simulate the long-term(1961–2020)dynamics of actual evapotranspiration(ET_(a)),net primary productivity(NPP),and leaf area index(LAI)for the dominant non-native tree(*** and ***)and shrub(*** and ***)species at 246 meteorological sites over *** modified model incorporated the Richards equation to simulate transient unsaturated water flow in a multilayer soil module,and both soil and eco-physiological parameters required by the model were validated using field-observed ETadata for each *** distributions of OVC(given by the mean maximum LAI,LAI_(max))for the dominant species were determined within three hydrogeomorphic sub-areas(i.e.,the loess hilly-gully sub-area,the windy and sandy sub-area,and the desert sub-area).The modified Biome-BGC model performed well in terms of simulating ET_(a) dynamics for the four plant *** distributions of mean ET_a,NPP,and LAI_(max)generally exhibited patterns similar to mean annual precipitation(MAP).In the loess hilly-gully sub-area(MAP:210 to 710 mm),the OVC respectively ranged from 1.7 to 2.9 and 0.8 to 2.9 for *** and *** the windy and sandy sub-area(MAP:135 to 500 mm),the OVC ranged from 0.3 to 3.3,0.5 to 2.6 and 0.6 to 2.1for ***,*** and ***,*** the desert sub-

关键词： Optimal vegetation coverage Water balance Leaf area index Biome-BGC model Dryland

Anti-OX40 Antibody Combined with HBc VLPs Delays Tumor Growth in a Mouse Colon Cancer Model

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Biomedical and Environmental Sciences 2024年第2期37卷 187-195页

作者： LIU jia jia SU Qiu Dong YI Yao SHEN Li ping BI Sheng Li National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206China

Objective Combination immunotherapy strategies targeting OX40,a co-stimulatory molecule that can enhance antitumor immunity by modulating the proliferation,differentiation,and effector function of tumor-infiltrating T cells,have attracted much attention for their excellent therapeutic *** this study,we aimed to evaluate the antitumor efficacy of combined anti-OX40 and hepatitis B core viruslike particles(HBc VLPs)therapy using a mouse colon cancer *** Humanized B-h OX40 mice were injected subcutaneously with MC38 colon tumor cells and treated with HBc VLPs+anti-h OX40 *** growth was *** cytometric analysis was performed to evaluate the populations of T cell subsets in the *** The combination of anti-OX40 with HBc VLPs resulted in a significant delay in tumor growth,suggesting that a potent antitumor immunity was induced by the combination *** studies revealed that HBc VLPs+anti-OX40 treatment induced a significant increase in effector T cells(Teffs)and a significant decrease in regulatory T cells(Tregs)in the tumor microenvironment(TME),which accounted for the synergistic antitumor effect of anti-OX40 in combination with HBc *** Combination therapy of anti-h OX40 and HBc VLPs provides synergistic antitumor activity in colon cancer-bearing mice,which may represent a potential design strategy for cancer immunotherapy.

关键词： Anti-OX40 antibody Hepatitis B core virus-like particles Tumor Combination therapy

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TiAl-Nb基合金高温抗氧化研究进展

表面技术 2018年第3期47卷 224-230页

作者：贾平平渭南师范学院数理学院陕西渭南714000

TiAl-Nb基合金具有优异的综合性能,在先进飞行器及武器等耐高温部件中有巨大的应用潜力,但其高温抗氧化性能无法满足实际使用需求。综述了TiAl-Nb基合金高温抗氧化防护方面的研究进展,包括TiAl-Nb基合金的多元合金化、表面合金化、抗氧... 详细信息

TiAl-Nb基合金具有优异的综合性能,在先进飞行器及武器等耐高温部件中有巨大的应用潜力,但其高温抗氧化性能无法满足实际使用需求。综述了TiAl-Nb基合金高温抗氧化防护方面的研究进展,包括TiAl-Nb基合金的多元合金化、表面合金化、抗氧化涂层及其抗氧化机理,通过分析不同氧化防护措施的特性,展望了TiAl-Nb基合金高温抗氧化防护的发展趋势。国内外研究结果显示,通过多元合金化方法改善合金组织,并在氧化过程中促进形成保护性Al_2O_3而抑制形成TiO_2,是提高TiAl-Nb基合金高温抗氧化性能的有效手段。利用表面合金化对合金表面的显微组织和成分进行改善,氧化时促进抗氧化性能优良的Al_2O_3或SiO_2保护膜形成,显著提高了TiAl-Nb基合金的抗氧化性能。但高温下合金化层与基体之间的Al、Si、Ti等元素的互扩散会加剧合金化层的退化,进行表面多元合金化,特别是添加微量活性元素,对促进保护性氧化膜的形成及抑制互扩散有良好效果。通过制备表面抗氧化涂层,在氧化时生成保护性氧化膜,阻碍O的内扩散,能够起到良好的高温抗氧化作用,但需要解决涂层/基体合金的结合力较差和反应扩散等问题,制备复合涂层或扩散阻挡层是解决上述问题的有效途径。

关键词： TiAl-Nb基合金合金化表面合金化高温抗氧化涂层抗氧化机理