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Transarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma(CHANCE001)

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Signal Transduction and Targeted Therapy 2023年第3期8卷 1198-1207页

作者： hai-Dong Zhu hai-liang li Ming-Sheng Huang wei-Zhu Yang Guo-Wen Yin bin-Yan zhong Jun-Hui Sun Zhi-Cheng Jin jian-jian Chen Nai-jian Ge Wen-bin Ding Wen-Hui li Jin-Hua Huang wei Mu Shan-Zhi Gu jia-ping li Hui Zhao Shu-wei Wen Yan-Ming Lei yu-Sheng Song Chun-wang yuan wei-Dong wang Ming Huang wei Zhao jian-bing Wu Song wang Xu Zhu jian-Jun Han wei-Xin Ren Zai-Ming Lu Wen-Ge Xing Yong Fan hai-Lan lin Zi-Shu zhang Guo-Hui Xu Wen-Hao Hu Qiang Tu Hong-ying Su Chuan-Sheng Zheng Yong Chen Xu-Ya Zhao Zhu-Ting Fang Qi wang Jin-wei Zhao Ai-bing Xu jian Xu Qing-Hua Wu Huan-zhang Niu jian wang Feng Dai Dui-ping Feng Qing-Dong li Rong-Shu Shi jia-Rui li Guang Yang hai-bin Shi jian-Song Ji yu-E liu Zheng Cai Po Yang Yang Zhao Xiao-li Zhu li-Gong Lu Gao-Jun Teng Center of Interventional Radiology&Vascular Surgery Department of RadiologyZhongda HospitalMedical SchoolSoutheast UniversityNanjing 210009China Department of Minimally invasive Intervention The Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhou 450008China Department of Interventional Radiology the Third Affiliated HospitalSun Yat-Sen UniversityGuangzhou 510630China Department of Interventional Radiology Union Hospital of Fujian Medical UniversityFuzhou 350001China Department of Interventional Radiology Jiangsu Cancer Hospital&Jiangsu Institute of Cancer Research&The Affiliated Cancer Hospital of Nanjing Medical UniversityNanjing 210009China Department of Interventional Radiology The First Affiliated Hospital of Soochow UniversitySoochow UniversitySuzhou 215006China Hepatobiliary and Pancreatic Interventional Treatment Center Division of Hepatobiliary and Pancreatic SurgeryThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Interventional Radiology Eastern Hospital of Hepatobiliary SurgeryNavy Medical University(Second Military Medical University)Shanghai 200438China Department of Interventional Radiology Nantong First People’s HospitalNantong 226001China Department of Interventional Radiology Yancheng Third People’s HospitalYancheng 224008China Department of Minimally Invasive Interventional Therapy Sun YatSen University Cancer CenterGuangzhou 510060China Department of Vascular Surgery Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China. Department of Interventional Radiology Hunan Cancer HospitalChangsha 410031China Department of Interventional Oncology The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080China Department of Interventional Radiology The Hospital of Nantong UniversityNantong 226001China Department of Interventional Therapy Shanxi Tumor HospitalTaiyuan 030001China Department of Interventional Radiology Tibet Autonomous Region People’s

There is considerable potential for integrating transarterial chemoembolization(TACE),programmed death-(ligand)1(PD-[L]1)inhibitors,and molecular targeted treatments(MTT)in hepatocellular carcinoma(HCC).It is necessary to investigate the therapeutic efficacy and safety of TACE combined with PD-(L)1 inhibitors and MTT in real-world *** this nationwide,retrospective,cohort study,826 HCC patients receiving either TACE plus PD-(L)1 blockades and MTT(combination group,n=376)or TACE monotherapy(monotherapy group,n=450)were included from January 2018 to May *** primary endpoint was progression-free survival(PFS)according to modified *** secondary outcomes included overall survival(OS),objective response rate(ORR),and *** performed propensity score matching approaches to reduce bias between two *** matching,228 pairs were included with a predominantly advanced disease *** PFS in combination group was 9.5 months(95%confidence interval[CI],8.4-11.0)versus 8.0 months(95%CI,6.6-9.5)(adjusted hazard ratio[HR],0.70,P=0.002).OS and ORR were also significantly higher in combination group(median OS,19.2[16.1-27.3]vs.15.7 months[13.0-20.2];adjusted HR,0.63,P=0.001;ORR,60.1%vs.32.0%;Pbination and monotherapy groups,*** results suggest that TACE plus PD-(L)1 blockades and MTT could significantly improve PFS,OS,and ORR versus TACE monotherapy for Chinese patients with predominantly advanced HCC in real-world practice,with an acceptable safety profile.

关键词： hepatocellular targeted matching

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Significant loss of soil inorganic carbon at the continental scale

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National Science Review 2022年第2期9卷 13-20页

作者： Xiao-Dong Song Fei Yang Hua-Yong Wu Jing zhang De-Cheng li Feng liu yu-Guo Zhao Jin-ling Yang bing Ju Chong-Fa Cai Biao Huang Huai-yu Long ying Lu yue-yu Sui Qiu-bing wang Ke-Ning Wu Feng-Rong zhang Ming-Kui zhang Zhou Shi Wan-Zhu Ma Gang Xin Zhi-ping Qi Qing-Rui Chang En Ci Da-Gang yuan Yang-Zhu zhang Jun-ping Bai jia-ying Chen jie Chen Yin-Jun Chen yun-zhong Dong Chun-Lan Han ling li li-Ming liu jian-Jun Pan Fu-Peng Song Fu-Jun Sun Deng-Feng wang Tian-wei wang Xiang-Hua wei Hong-Qi Wu Xia Zhao Qing Zhou Gan-lin zhang State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil Science Chinese Academy of Sciences College of Advanced Agricultural Sciences University of Chinese Academy of Sciences College of Resources and Environment Huazhong Agricultural University Institute of Agricultural Resources and Regional Planning Chinese Academy of Agricultural Sciences College of Natural Resources and Environment South China Agricultural University Northeast Institute of Geography and Agroecology Chinese Academy of Sciences College of Land and Environment Shenyang Agricultural University School of Land Science and Technology China University of Geosciences College of Land Science and Technology China Agricultural University College of Environmental and Resource Sciences Zhejiang University Institute of Digital Agriculture Zhejiang Academy of Agricultural Sciences College of Agriculture Heilongjiang Bayi Agricultural University Tropical Crops Genetic Resources Institute Chinese Academy of Tropical Agricultural Sciences College of Natural Resources and Environment Northwest A & F University College of Resources and Environment Southwest University College of Resources Sichuan Agricultural University College of Resources and Environment Hunan Agricultural University Institute of Agricultural Product Quality Standard and Testing Research Tibet Academy of Agricultural and Animal Husbandry Sciences School of Agricultural Sciences Zhengzhou University Institute of Agriculture Environment and Resources Research Shanxi Academy of Agricultural Sciences College of Resources and Environment Henan Agricultural University College of Resources and Environment China Agricultural University College of Resources and Environmental Sciences Nanjing Agricultural University College of Resources and Environment Shandong Agricultural University Agricultural College Guangxi University College of Grassland and Environment Science Xinjiang Agricultural University College of Geographical Science Qinghai Normal University

Widespread soil acidification due to atmospheric acid deposition and agricultural fertilization may greatly accelerate soil carbonate dissolution and ***,to date,few studies have addressed these ***,we use meta-analysis and nationwide-survey datasets to investigate changes in soil inorganic carbon(SIC) stocks in *** observe an overall decrease in SIC stocks in topsoil(0-30 cm)(11.33 g C m-2yr-1) from the 1980 s to the 2010 *** SIC stocks have decreased by～8.99±2.24%(1.37±0.37 Pg C).The average SIC losses across China(0.046 Pg C yr-1) and in cropland(0.016 Pg C yr-1) account for～17.6%-24.0% of the terrestrial C sink and 57.1% of the soil organic carbon sink in cropland,*** deposition and climate change have profound influences on SIC *** estimate that～19.12%-19.47% of SIC stocks will be further lost by *** consumption of SIC may offset a large portion of global efforts aimed at ecosystem carbon sequestration,which emphasizes the importance of achieving a better understanding of the indirect coupling mechanisms of nitrogen and carbon cycling and of effective countermeasures to minimize SIC loss.

关键词： China soil inorganic carbon stocks global change carbonate soil acidification

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lijiang 2.4-meter Telescope and its instruments

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Research in Astronomy and Astrophysics 2019年第10期19卷 95-108页

作者： Chuan-Jun wang Jin-Ming Bai yu-Feng Fan Ji-Rong Mao liang Chang yu-Xin Xin Ju-jia zhang Bao-li Lun jian-Guo wang Xi-liang zhang Mei ying kai-Xing Lu Xiao-li wang kai-Fan Ji Ding-Rong Xiong Xiao-Guang yu Xu Ding kai Ye li-Feng Xing wei-Min Yi liang Xu Xiang-Ming Zheng yuan-jie Feng Shou-Sheng He Xue-li wang zhong liu Dong Chen Jun Xu Song-Nian Qin Rui-Long zhang Hui-Song Tan Zhi li Ke Lou jian li wei-wei liu yunnan Observatories Chinese Academy of SciencesKunming 650216China Key Laboratory for the Structure and Evolution of Celestial Objects Chinese Academy of Sciences Kunming 650216 China Center for Astronomical Mega-Science Chinese Academy of Sciences Beijing 100101 China University of Chinese Academy of Sciences Beijing 100049 China Astrophysics Center of Guangzhou University Guangzhou 510006China

The lijiang 2.4-meter Telescope(LJT), the largest common-purpose optical telescope in China,has been available to the worldwide astronomical community since 2008. It is located at the Gaomeigu site,lijiang Observatory(LJO), in the southwest of China. The site has very good observational *** its 10-year operation, several instruments have been equipped on the LJT. Astronomers can perform both photometric and spectral observations. The main scientific goals of LJT include recording photometric and spectral evolution of supernovae, reverberation mapping of active galactic nuclei, investigating the physical properties of binary stars and near-earth objects(comets and asteroids), and identification of exoplanets and all kinds of transients. Until now, the masses of 41 high accretion rate black holes have been measured, and more than 168 supernovae have been identified by the LJT. More than 190 papers related to the LJT have been published. In this paper, the general observation conditions of the Gaomeigu site is introduced at first. Then, the structure of the LJT is described in detail, including the optical, mechanical, motion and control system. The specification of all the instruments and some detailed parameters of the YFOSC is also presented. Finally, some important scientific results and future expectations are summarized.

关键词： telescopes lijiang 2.4-m Telescope-instrumentation photometers-instrumentation spectrographs

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Paired quasi-periodic pulsations of hard X-ray emission in a solar flare

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Science China(Physics,Mechanics & Astronomy) 2023年第5期66卷 195-206页

作者： hai-Sheng Zhao Dong li Shao-lin Xiong Yan-Qiu zhang Yang Su wei Chen Yi Zhao Xiao-Bo li jia-cong liu Wen-Xi Peng Rui Qiao Xin-Qiao li Xiang-Yang Wen li-Ming Song Shi-jie Zheng Xin-ying Song Xiao-yun Zhao yue Huang Shuang-Nan zhang Shuo Xiao Ce Cai Zheng-Hua An Can Chen Gang Chen wei Chen Yan-Qi Du Min Gao Ke Gong Dong-Ya Guo Zhi-wei Guo jian-jian He bin li Chao li Chao-Yang li Gang li jian-Hui li Lu li Qing-Xin li Yan-Guo li Jing liang Xiao-Hua liang Jin-yuan liao Xiao-Jing liu Ya-Qing liu Qi Luo Xiang Ma bin Meng Ge Ou Dong-li Shi Jing-Yan Shi Gong-Xing Sun Xi-Lei Sun You-li Tuo Chen-wei wang Hui wang Jin wang Jin-Zhou wang ping wang Wen-Shuai wang Hong Wu Sheng-Lun Xie Yan-bing Xu yu-Peng Xu wang-Chen Xue Sheng Yang Min Yao jian-ying Ye Qi-bin Yi Chao-yue zhang Da-li zhang Fan zhang Fei zhang Hong-Mei zhang kai zhang Peng zhang Xiao-Lu zhang Zhen zhang Guo-ying Zhao Shi-Yi Zhao Chao Zheng Xing Zhou yue Zhu Key Laboratory for Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Purple Mountain Observatory Chinese Academy of SciencesNanjing 210023China University of Chinese Academy of Sciences Beijing 100049China Department of Astronomy Beijing Normal UniversityBeijing 100875China School of Computing and Artificial Intelligence Southwest Jiaotong UniversityChengdu 611756China Physics and Space Science College China West Normal UniversityNanchong 637002China Key Laboratory of Stellar and Interstellar Physics and Department of Physics Xiangtan UniversityXiangtan 411105China Institute of Astrophysics Central China Normal UniversityWuhan 430079China School of Physics Changchun University of Science and TechnologyChangchun 130022China College of Physics and Engineering Qufu Normal UniversityQufu 273165China College of Physics Sciences&Technology Hebei UniversityBaoding 071002China

We investigate high time resolution data obtained by the Gravitational wave high-energy Electromagnetic Counterpart All-sky Monitor(GECAM)during the flare event on 2022 April 21 at 01:52 *** subpeaks with durations of 4-6 s have been detected in the hard X-ray precursor phase,and the key feature is that they appear in pairs and seem like double-peak *** subpeaks are rarely observed in hard X-ray band and confirmed by the microwave obtained by Nobeyama Radio Polarimeters(NoRP)and Radio Solar Telescope Network(RSTN).While an exponential function can describe the continuum component of the time profile from the precursor to part of the impulsive *** periods of quasi-periodic pulsations(QPPs)are detected to be about 7.3 and 12.8 s for the precursor and impulsive phase,respectively,with at least 95%confidence *** paired QPPs are assumed to be double-peak QPPs and then the scenario of current loop coalescence model is found to be in good agreement with our *** precursor phase can be interpreted as the oscillating coalescence of two islands,while the impulsive phase can be interpreted as more islands to coalesce one by one to form larger islands.

关键词： solar flare QPPs loop coalescence circular-ribbon flare

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Expert Consensus on Clinical Diagnostic Criteria for Fatal Familial Insomnia

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Chinese Medical Journal 2018年第13期131卷 1613-1617页

作者： li-Yong Wu Shu-Qin Zhan Zhao-Yang Huang bin zhang Tao wang Chun-Feng liu Hui Lu Xiao-ping Dong Zhi-ying Wu jie-Wen zhang Ji-Hui zhang zhong-Xin Zhao Fang Han Yah Huang Jun Lu Serge Gauthier jian-ping jia yu-ping wang Department of Neurology Xuan Wu Hospital Capital Medical University Belling 100053 China Department of Psychiatry Nanfang Hospital Southern Medical University Guangzhou Guangdong 510515 China Department of Neurology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei 430022 China Department of Neurorogy Second Affiliated Hospital of Soochow University Suzhou Jiangsu 215004 China State Key Laboratory for Infectious Disease Prevention and Control National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing 100050 China Department of Neurology and Research Center of Neurology Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou Zhejiang 310009 China Department of Neurology Henan Provincial People's Hospital Zhengzhou Henan 450003 China Department of Psychiatry Faculty of Medicine The Chinese University of Hong Kong Shatin NT Hong Kong SAR 000000 China Department of Neurology Changzheng Hospital The Second Military Medical University Shanghai 200003 China Department of Respiratory Medicine Peking University People's Hospital Beijing 100044 China Department of Neurology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China Department of Neurology Program in Neuroscience and Division of Sleep Medicine Harvard Medical School and Beth Israel Deaconess Medical Center Boston 02215 MA USA McGill Centre for Studies in Aging Alzheimer's Disease Research Unit Montreal H4H 1R3 Canada

INTRODUCTION Fatal familial insomnia （FFI） is a serious and rare prion disease, which was first reported by Lugaresi et al. in *** diagnosis of FFI might be important for early and sufficient counseling of patients and their relatives, also concerning the risk of inheritance, and potentially also for treatment studies. However, the diagnosis of FFI might be difficult because of the heterogeneity of clinical features, low sensitivity of diagnostic tests, and absence of family history. The aim of the present study was to develop a clinical scheme and diagnostic criteria for FFI based on our research and expert consensus.

关键词： HUMAN PRION DISEASES CREUTZFELDT-JAKOB-DISEASE PROTEIN NEUROPATHOLOGY DEGENERATION FEATURES DISORDERS THALAMUS MUTATION ONSET

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水下航行体通气超空泡减阻特性实验研究

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船舶工程 2006年第3期28卷 14-17页

作者：王海斌张嘉钟魏英杰王聪于开平贾力平哈尔滨工业大学航天学院哈尔滨150001

为了研究超空泡的减阻效果,保证在较低流速下生成超空泡,在水洞中开展了水下航行体通气超空泡的实验研究.采用通气的方法在较低水速下生成人工通气超空泡,通过改变通气率和弗劳德数,获得了不同条件下通气空泡的长度,以及不同空泡长度下... 详细信息

为了研究超空泡的减阻效果,保证在较低流速下生成超空泡,在水洞中开展了水下航行体通气超空泡的实验研究.采用通气的方法在较低水速下生成人工通气超空泡,通过改变通气率和弗劳德数,获得了不同条件下通气空泡的长度,以及不同空泡长度下的模型阻力系数.研究表明,来流速度不变时,空泡长度随通气率的增加而增加,阻力系数随空泡长度的增加先递增后递减;空化器直径对阻力系数的影响较大,在大弗劳德数条件下,阻力系数会因空化器直径过大而出现随通气量的增加而变大的趋势.利用商用软件对超空泡形态及阻力系数作了数值仿真,并与实验结果作了对比,两者符合较好.

关键词：水动力学水下航行体通气超空泡弗劳德数阻力系数水洞实验

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Safety and efficacy of meplazumab in healthy volunteers and COVID-19 patients: a randomized phase 1 and an exploratory phase 2 trial

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Signal Transduction and Targeted Therapy 2021年第6期6卷 1845-1855页

作者： Huijie Bian Zhao-Hui Zheng Ding wei Aidong Wen Zheng zhang jian-Qi lian Wen-Zhen Kang Chun-Qiu Hao Jing wang Rong-Hua Xie Ke Dong jie-Lai Xia Jin-lin Miao Wen Kang Guoquan li Di zhang Mingru zhang Xiu-Xuan Sun likun Ding Kui zhang Junfeng jia Jin Ding Zhiqin li Yanyan jia lin-Na liu Zhe zhang Zhao-wei Gao Hong Du Na Yao Qing wang Ke wang jie-jie Geng bin wang Ting Guo Ruo Chen yu-Meng Zhu li-Juan wang Qian He Rui-Rui Yao ying Shi Xiang-Min Yang jian-Sheng Zhou Yi-Nan Ma Ya-Tao wang Xue liang Fei Huo Zhe wang Yang zhang Xu Yang Ye zhang Lu-Hua Gao ling wang Xiao-Chun Chen Hao Tang Shuang-Shuang liu Qing-Yi wang Zhi-Nan Chen ping Zhu National Translational Science Center for Molecular Medicine and Department of Cell Biology Fourth Military Medical UniversityXi'anChina Department of Clinical Immunology Xijing HospitalFourth Military Medical UniversityXi'anChina Department of Pharmacy Xijing HospitalFourth Military Medical UniversityXi'anChina Center for Infectious Diseases Tangdu HospitalFourth Military Medical UniversityXi'anChina Department of Nuclear Medicine Xijing HospitalFourth Military Medical UniversityXi'anChina department of Clinical Diagnosis Tangdu HospitalFourth Military Medical UniversityXKanChina College of Military Preventive Medicine Fourth Military Medical UniversityXi'anChina Department of Pharmaceutics Tangdu HospitalFourth Military Medical UniversityXi'anChina Department of Pathology Fourth Military Medical UniversityXi'anChina jiangsu Pacific Meinuoke Biopharmaceutical Co.Ltd ChangzhouChina Department of Foreign Languages Fourth Military Medical UniversityXi'anChina

Recent evidence suggests that CD147 serves as a novel receptor for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)*** CD147 via anti-CD147 antibody could suppress the in vitro SARS-CoV-2 *** is a humanized anti-CD147 IgG_(2) monoclonal antibody,which may effectively prevent SARS-CoV-2 infection in coronavirus disease 2019(COVID-19)***,we conducted a randomized,double-blinded,placebo-controlled phase 1 trial to evaluate the safety,tolerability,and pharmacokinetics of meplazumab in healthy subjects,and an open-labeled,concurrent controlled add-on exploratory phase 2 study to determine the efficacy in COVID-19 *** phase 1 study,59 subjects were enrolled and assigned to eight cohorts,and no serious treatment-emergent adverse event(TEAE)or TEAE grade≥3 was *** serum and peripheral blood Cmax and area under the curve showed non-linear pharmacokinetic *** obvious relation between the incidence or titer of positive anti-drug antibody and dosage was observed in each *** biodistribution study indicated that meplazumab reached lung tissue and maintained>14 days stable with the lung tissue/cardiac blood-pool ratio ranging from 0.41 to *** the exploratory phase 2 study,17 COVID-19 patients were enrolled,and 11 hospitalized patients were involved as concurrent *** meplazumab treatment significantly improved the discharged(P=0.005)and case severity(P=0.021),and reduced the time to virus negative(P=0.045)in comparison to the control *** results show a sound safety and tolerance of meplazumab in healthy volunteers and suggest that meplazumab could accelerate the recovery of patients from COVID-19 pneumonia with a favorable safety profile.

关键词： patients dosage phase

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空泡形态与典型空化器参数关系的研究——小空泡数下的发展空泡形态

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水动力学研究与进展（A辑） 2005年第2期20卷 251-257页

作者：王海斌张嘉钟魏英杰于开平贾力平哈尔滨工业大学航天学院黑龙江哈尔滨150001

空化器在自然空泡的形成过程中起着很重要的作用,空泡的尺寸与它的头部形状密切相关,因此,研究空化器对于解决空泡问题具有极其重要的意义。为了掌握空泡形态,为工程实际应用提供设计参考依据,本文利用 FLUENT软件对典型空化器引起的自... 详细信息

空化器在自然空泡的形成过程中起着很重要的作用,空泡的尺寸与它的头部形状密切相关,因此,研究空化器对于解决空泡问题具有极其重要的意义。为了掌握空泡形态,为工程实际应用提供设计参考依据,本文利用 FLUENT软件对典型空化器引起的自然空化现象进行了深入的数值仿真研究,得到了零攻角小空泡数下空化器几何形状与空泡形态参数之间的经验公式,并将仿真结果与实验进行了对比,二者符合较好。

关键词：空化器数值模拟空泡形态

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Diagnosis and Treatment of Cholangiocarcinoma: A Consensus from Surgical Specialists of China

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2014年第4期34卷 469-475页

作者： jian-qiang Cai Shou-wang Cai Wen-ming cong Min-shan Chen ping Chen Xiao-ping Chen Yan-ling Chen Yi-fa Chen Chao-liu Dai Qiang Huang Zhi-yong Huang Bo jiang bin jiang Ke-wei jiang Bo li Zong-fangli li-jian liang bin liu Hui-chun liu lian-xin liu Qing-guang liu Rong liu ying-bin liu jian-guo Lu Shi-chun Lu Yi Lu Yi-lei Mao bin Mei Jun Niu Bao-gang Peng Xiao Qin yu-dong Qiu Guang-yi wang Yao-don wangg Zhi-ming wang Ren-hua Wan Ya-fu Wu Bao-cai Xing Feng Xia Ge-liang Xu jia-mei Yang Xiao-fang yu Yong Zeng Yong-yi Zeng Bi-xiang zhang bin-hao zhang Qi-yu zhang Shui-jun zhang Wan-guang zhang Yong-jie zhang Zhi-wei zhang Dong Zhou wei-ping Zhou Cancer Institute and Hospital Chinese Academy of Medical Sciences Chinese PLA General Hospital Eastern Hepatobiliary Surgery Hospital of Second Military Medical University Sun Yat-sen University Cancer Center Daping Hospital of Third Military Medical University Tongji Hospital Tongji Medical CollegeHuazhong University of Science and Technology Fujian Medical University Union Hospital Shengjing Hospital of China Medical University Anhui Provincial Hospital Hunan Provincial People’s Hospital Taihe Hospital Affiliated to Hubei University of Medicine Peking University People’s Hospital West China Hospital Sichuan University The Second Affiliated Hospital of Xi’an jiao Tong University The First Affiliated Hospital Sun Yat-sen University First Affiliated Hospital of Kunming Medical University The First Affiliated Hospital of Bengbu Medical College The First Affiliated Hospital of Harbin Medical University The First Affiliated Hospital of Xi’an jiao Tong University Xinhua Hospital Affiliated to Shanghai jiao Tong University School of Medicine Tangdu Hospital of Fourth Military Medical University Peking Union Medical College Hospital Qilu Hospital of Shandong University The First Affiliated Hospital of Guangxi Medical University Nanjing Drum Tower Hospital The First Affiliated Hospital of Jilin University Fujian Provincial Hospital Xiangya Hospital of Central South University The First Affiliated Hospital of Nanchang University Beijing Cancer Hospital Southwest Hospital of Third Military Medical University Shenzhen People’s Hospital The First Affiliated Hospital of Fujian Medical University The First Affiliated Hospital of Wenzhou Medical University The First Affiliated Hospital of Zhengzhou University Fujian Provincial Cancer Hospital

Cholangiocarcinoma refers to malignant tumors that develop in epithelial lining of biliary system, and it is divided into two categories according to tumor location, intrahepatic cholangiocarcinoma （ICC） and extrahepatic cholangiocarcinoma （ECC）. ICC occurs from the epithelial cells of the intrahepatic bile duct, its branches and interlobular biliary tree; and ECC is divided into hilar cholangiocarcinoma and distal cholangiocarcinoma by the circumscription at the confluence of cystic duct and the common hepatic duct.

关键词： A Consensus from Surgical Specialists of China Diagnosis and Treatment of Cholangiocarcinoma

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The first data release(DR1) of the LAMOST regular survey

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Research in Astronomy and Astrophysics 2015年第8期15卷 1095-1124页

作者： A-li Luo Yong-Heng Zhao Gang Zhao li-Cai Deng Xiao-wei liu Yi-Peng Jing Gang wang Hao-Tong zhang jian-Rong Shi Xiang-Qun Cui Yao-Quan Chu Guo-ping li zhong-Rui Bai yue Wu Yan Cai Shu-yun Cao Zi-Huang Cao Jeffrey L.Carlin hai-yuan Chen jian-Jun Chen Kun-Xin Chen li Chen Xue-Lei Chen Xiao-Yan Chen ying Chen Norbert Christlieb jia-Ru Chu Chen-Zhou Cui Yi-Qiao Dong bing Du Dong-wei Fan Lei Feng jian-Ning Fu Peng Gao Xue-Fei Gong Bo-zhong Gu Yan-Xin Guo Zhan-Wen Han Bo-liang He Jin-liang Hou Yong-Hui Hou Wen Hou Hong-Zhuan Hu Ning-Sheng Hu zhong-Wen Hu Zhi-ying Huo Lei jia Fang-Hua jiang Xiang jiang Zhi-Bo jiang Ge Jin Xiao Kong Xu Kong Ya-Juan Lei Ai-Hua li Chang-Hua li Guang-wei li hai-Ning li jian li Qi li Shuang li Sha-Sha li Xin-Nan li Yan li Yin-Bi li Ye-ping li yuan liang Chien-Cheng lin Chao liu Gen-Rong liu Guan-Qun liu Zhi-Gang liu Wen-Zhi Lu yu Luo Yin-Dun Mao Heidi Newberg Ji-Jun Ni Zhao-Xiang Qi Yong-Jun Qi Shi-Yin Shen Huo-Ming Shi Jing Song Yi-Han Song Ding-Qiang Su Hong-Jun Su Zheng-Hong Tang Qing-Sheng Tao yuan Tian Dan wang Da-Qi wang Feng-Fei wang Guo-Min wang hai wang Hong-Chi wang jian wang jia-Ning wang jian-ling wang jian-ping wang Jun-Xian wang Lei wang Meng-Xin wang Shou-Guan wang Shu-Qing wang Xia wang Ya-Nan wang You wang yue-Fei wang You-Fen wang Peng wei Ming-Zhi wei Hong Wu Ke-Fei Wu Xue-bing Wu yu-zhong Wu Xiao-Zheng Xing ling-Zhe Xu Xin-Qi Xu Yan Xu Tai-Sheng Yan De-Hua Yang hai-Feng Yang Hui-Qin Yang Ming Yang Zheng-Qiu Yao Yong yu Hui yuan hai-Bo yuan hai-Long yuan wei-Min yuan Chao Zhai En-Peng zhang Hua-wei zhang jian-Nan zhang li-Pin zhang wei zhang Yong zhang Yan-Xia zhang Zheng-Chao zhang Ming Zhao Fang Zhou Xu Zhou jie Zhu Yong-Tian Zhu Si-Cheng Zou Fang Zuo National Astronomical Observatories Chinese Academy of Sciences Department of Astronomy Peking University Shanghai Astronomical Observatory Chinese Academy of Sciences Nanjing Institute of Astronomical Optics & Technology National Astronomical ObservatoriesChinese Academy of Sciences University of Science and Technology of China Department of Physics Applied Physics and AstronomyRensselaer Polytechnic InstituteTroyNY 12180USA Department of Physics and Astronomy Earlham CollegeRichmondIN 47374USA Universitt Heidelberg Zentrum für AstronomieLandessternwarteKnigstuhl 1269117 HeidelbergGermany Department of Astronomy Beijing Normal University yunnan Observatories Chinese Academy of Sciences Purple Mountain Observatory Chinese Academy of Sciences

The Large sky Area Multi-Object Fiber Spectroscopic Telescope（LAMOST） general survey is a spectroscopic survey that will eventually cover approximately half of the celestial sphere and collect 10 million spectra of stars, galaxies and QSOs. Objects in both the pilot survey and the first year regular survey are included in the LAMOST DR1. The pilot survey started in October 2011 and ended in June 2012, and the data have been released to the public as the LAMOST Pilot Data Release in August 2012. The regular survey started in September 2012, and completed its first year of operation in June 2013. The LAMOST DR1 includes a total of 1202 plates containing 2 955 336 spectra, of which 1 790 879 spectra have observed signalto-noise ratio（SNR） ≥ 10. All data with SNR ≥ 2 are formally released as LAMOST DR1 under the LAMOST data policy. This data release contains a total of 2 204 696 spectra, of which 1 944 329 are stellar spectra, 12 082 are galaxy spectra and 5017 are quasars. The DR1 not only includes spectra, but also three stellar catalogs with measured parameters： late A,FGK-type stars with high quality spectra（1 061 918 entries）, A-type stars（100 073 entries）, and M-type stars（121 522 entries）. This paper introduces the survey design, the observational and instrumental limitations, data reduction and analysis, and some caveats. A description of the FITS structure of spectral files and parameter catalogs is also provided.

关键词： techniques: spectroscopic survey—data release—catalog

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