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Monotropein Induced Apoptosis and Suppressed Cell Cycle Progression in Colorectal Cancer Cells

Chinese Journal of Integrative Medicine 2024年第1期30卷 25-33页

作者： GAO Quan li lin ZHANG Qi-man SHENG Qin-song ZHANG Ji-liang jin li-jun SHANG Rui-yan School of Pharmacy and Department of Medical Oncology the Affiliated Hospital of Hangzhou Normal UniversityHangzhou Normal UniversityHangzhou(311121)China Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines Engineering Laboratory of Development and Application of Traditional Chinese MedicinesCollaborative Innovation Center of Traditional Chinese Medicines of Zhejiang ProvinceHangzhou Normal UniversityHangzhou(311121)China Department of Colorectal Surgery the First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouChina Beijing Tong Ren Tang Chinese Medicine Co. Ltd.Beijing(100000)China Department of Traditional Chinese Medicine Hangzhou Shangcheng District People's HospitalHangzhou(310006)China Department of Gynecology Hangzhou Women's HospitalHangzhou(310008)China

Objective: To determine whether monotropein has an anticancer effect and explore its potential mechanisms against colorectal cancer(CRC) through network pharmacology and molecular docking combined with experimental verification. Methods: Network pharmacology and molecular docking were used to predict potential targets of monotropein against CRC. Cell counting kit assay, plate monoclonal assay and microscopic observation were used to investigate the antiproliferative effects of monotropein on CRC cells HCT116, HT29 and LoVo. Flow cytometry and scratch assay were used to analyze apoptosis and cell cycle, as well as cell migration, respectively in HCT116, HT29, and LoVo cells. Western blotting was used to detect the expression of proteins related to apoptosis, cell cycle, and cell migration, and the expression of proteins key to the Akt pathway. Results: The Gene Ontology and Reactome enrichment analyses indicated that the anticancer potential of monotropein against CRC might be involved in multiple cancer-related signaling pathways. Among these pathways, RAC-beta serine/threonine-protein kinase(Akt1, Akt2), cyclin-dependent kinase 6(CDK6), matrix metalloproteinase-9(MMP9), epidermal growth factor receptor(EGFR), cell division control protein 42 homolog(CDC42) were shown as the potential anticancer targets of monotropein against CRC. Molecular docking suggested that monotropein may interact with the 6 targets(Akt1, Akt2, CDK6, MMP9, EGFR, CDC42). Subsequently, cell activity of HCT116, HT29 and LoVo cell lines were significantly suppressed by monotropein(PlinD1, CDK4 and CDK6, inhibited cell migration by suppressing the expressions of CDC42 and MMP9(Pling pathway. Conclusions: Monotropein exerts its antitumor

关键词： monotropein Chinese medicine anticancer activity colorectal cancer cells network pharmacology

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清末古文选本辑考与叙录

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玉林师范学院学报 2024年第1期45卷 18-27页

作者：李矜君华东师范大学中国语言文学系上海200241

清末民初,是古文选本史上一个重要的转型时期。八股取士制度解体、新学制建立动摇了此前古文选本赖以生存的制度基础。西学思想涌入,文字、书面语体改革等则使与古文选本关系密切之传统文化环境发生了变革。在此基础上,古文选本具备了... 详细信息

清末民初,是古文选本史上一个重要的转型时期。八股取士制度解体、新学制建立动摇了此前古文选本赖以生存的制度基础。西学思想涌入,文字、书面语体改革等则使与古文选本关系密切之传统文化环境发生了变革。在此基础上,古文选本具备了观察此一时期文学、社会史的重要功能。然而,此前学界主要将目光集中于“新选本”,即“国文”教科书的探讨,对传统古文选本关注则相对不足。为此,本文汇辑历年来所见清末古文选本十五种,依次对其考辨、叙录,以期对该领域研究的深入有所裨益。

关键词：清末古文选本文学批评辑考叙录

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地质构造分析在矿山安全生产中的应用

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世界有色金属 2024年第3期 193-195页

作者：李进军张磊神华地质勘查有限责任公司北京102209 中国地质学会资源勘查钻探技术与装备创新基地北京102488

地质构造分析对矿山安全生产具有重要影响。综合研究分析地质构造特征可揭示矿山地质构造与其矿石分布,围岩稳定性及临水破坏的关系,为矿山开采设计,围岩稳定性评价,临水防治及资源评价提供科学依据与技术支持。文章将对矿山安全生产过... 详细信息

地质构造分析对矿山安全生产具有重要影响。综合研究分析地质构造特征可揭示矿山地质构造与其矿石分布,围岩稳定性及临水破坏的关系,为矿山开采设计,围岩稳定性评价,临水防治及资源评价提供科学依据与技术支持。文章将对矿山安全生产过程中地质构造分析的运用进行论述,探究其重要意义及展望。

关键词：地质构造矿山安全生产地质灾害

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新时代硕士研究生培养质量提升路径探析

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黑龙江教师发展学院学报 2024年第7期43卷 44-49页

作者：靳利军孙永军罗艳梅黑龙江大学经济与工商管理学院哈尔滨150080

硕士研究生人才培养是我国研究生教育的重要组成部分。近年来,我国硕士研究生教育快速发展,招生人数不断增加,专业学位研究生占比不断提高。目前,硕士研究生教育在培养模式、师资队伍、经费投入、过程管理、学位点建设等方面存在的问题... 详细信息

硕士研究生人才培养是我国研究生教育的重要组成部分。近年来,我国硕士研究生教育快速发展,招生人数不断增加,专业学位研究生占比不断提高。目前,硕士研究生教育在培养模式、师资队伍、经费投入、过程管理、学位点建设等方面存在的问题,影响了硕士研究生培养质量的进一步提高。鉴于此,针对存在的问题并结合新时代党和政府对研究生教育提出的要求,提出培养模式创新、导师指导能力提升、经费投入改善、培养过程强化质量控制、充分发挥学位点作用等新时代硕士研究生培养质量提升路径。

关键词：新时代硕士研究生人才培养质量提升路径

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GLP-1-RA类药物市场现状分析

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国外医药（抗生素分册） 2024年第3期45卷 210-216页

作者：李进军赵晨王辂李端华成都大学抗生素研究与再评价四川省重点实验室成都610052

胰高血糖素样肽-1受体激动剂(GLP-1-RA)类药物凭借降糖平稳,适应证广泛,用药依从性强的优点,在最近十几年里,发展迅速,一跃成为糖尿病药物中销售额最大的品类,但因价格高,上市时间短,普及率不足10%,故市场前景有待挖掘。GLP-1-RA类药物... 详细信息

胰高血糖素样肽-1受体激动剂(GLP-1-RA)类药物凭借降糖平稳,适应证广泛,用药依从性强的优点,在最近十几年里,发展迅速,一跃成为糖尿病药物中销售额最大的品类,但因价格高,上市时间短,普及率不足10%,故市场前景有待挖掘。GLP-1-RA类药物市场竞争激烈,有多款重磅炸弹药物问世,甚至有年销售额超百亿美元的产品。本文从作用机理、分类、市场演变史、专利状态,国内仿制药现状及国内医疗政策方面描述了GLP-1-RA类药物特点和市场现状。

关键词：胰高血糖素样肽-1受体激动剂(GLP-1-RA) 糖尿病作用机理市场专利仿制药医疗政策

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流体明胶在单侧双通道脊柱内镜治疗腰椎退变性疾病中的应用

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临床和实验医学杂志 2024年第9期23卷 960-963页

作者：金凤刘平平李锦军费琦孟海首都医科大学附属北京友谊医院骨科北京100050

目的探讨流体明胶应用于单侧双通道内镜治疗腰椎退行性疾病中的有效性及安全性。方法选取2020年1月至2022年6月在首都医科大学附属北京友谊医院骨科行单侧双通道内镜的腰椎椎间盘退变性疾病患者共89例进行回顾性分析。根据术中是否应用... 详细信息

目的探讨流体明胶应用于单侧双通道内镜治疗腰椎退行性疾病中的有效性及安全性。方法选取2020年1月至2022年6月在首都医科大学附属北京友谊医院骨科行单侧双通道内镜的腰椎椎间盘退变性疾病患者共89例进行回顾性分析。根据术中是否应用流体明胶分为试验组(使用流体明胶,n=40)和对照组(n=49)。所有患者均接受至少3个月随访,比较手术前和手术后3 d、1个月、3个月的腰腿部疼痛[视觉模拟评分法(VAS)]评分和Oswestry功能障碍指数(ODI)。手术后3个月,比较两组临床疗效、术后引流量、凝血功能以及术后并发症发生情况等。结果所有患者均顺利完成手术并进行随访。手术后3 d、1个月、3个月,两组腰腿部VAS评分和ODI均较手术前明显改善,差异均有统计学意义(P0.05)。手术后3个月,Fischgrund标准评价结果显示,试验组优良率为90.0%,对照组优良率为85.7%,两组比较差异无统计学意义(P>0.05)。试验组术后引流量为(15.23±13.46)mL,明显少于对照组[(28.69±29.68)mL],差异有统计学意义(P0.05)。试验组发生并发症2例(5.0%),对照组发生并发症2例(4.1%),两组并发症发生率比较,差异无统计学意义(P>0.05)。结论流体明胶应用于单侧双通道内镜治疗腰椎退行性疾病中,临床疗效确切,可以显著降低术后引流量,且不影响凝血功能,不增加并发症发生率,安全性高。

关键词：腰椎单侧双通道内镜技术退行性疾病流体明胶术后引流量

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Investigation on the influence of vortex generator on particle resuspension

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Particuology 2024年第3期86卷 126-136页

作者： Dongchi Yu jun-li lin jin-Han Xie ASML 80W Tasman DrSan Jose95134CaliforniaUSA Department of Mechanics and Engineering Science at College of Engineering and State Key Laboratory for Turbulence and Complex Systems Peking UniversityBeijing100081China

The vortex generator(VG)and its well-known effect in flow optimization are widely studied and employed across different engineering ***,while the same working principles of VG may be well suited for the applications on surface-cleaning technologies,such promising potential is hardly,if any,explored in the published ***,in the present study,the influence on flow-induced particle resuspension brought by a rectangular vG in a channel flow is investigated with the help of highfidelity computational fluid dynamics *** increases of particle removal forces and resuspension rates are discovered in long,strip-like regions with reduced boundary-layer thickness resulted from the vG-induced vortices,and the enhancement effect is especially significant for configurations with the VG installed at a greater angle of *** is also shown that while the resuspension enhancements on the lower and the upper surfaces of the channel exhibit distinct statistical characteristics,having a VG in the channel improves the overall particle-removing capability of the channel flow by introducing higher surface-averaged removal forces and particle resuspension *** but not least,the increase of resuspension rate is especially significant for the smaller,micron-scale particles which are otherwise hardly disturbed by a VG-less channel flow,and such resuspension-enhancement effectgenerally subsides with increasing particle size.

关键词： Particle resuspension Vortexgenerator CFD Surface cleaning

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Pion-photon and kaon-photon transition distribution amplitudes in the Nambu–Jona-Lasinio model

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Chinese Physics C 2024年第8期48卷 94-103页

作者： jin-li Zhang jun Wu Department of Mathematics and Physics Nanjing Institute of TechnologyNanjing 211167China National Laboratory of Solid State Microstructures Department of PhysicsNanjing UniversityNanjing 210093China

The Nambu–Jona-Lasinio model is utilized to investigate the pion-and kaon-photon leading-twist transition distribution amplitudes using proper time ***,the properties of the vector and axial vector pion-photon transition distribution amplitudes are examined,and the results meet the desired *** study involves sum rule and polynomiality *** vector and axial vector pion-photon transition form factors that are present in theπ^(+)→γe^(+)νprocess are the first Mellin moments of the pion-photon transition distribution *** vector transition form factor originates from the internal structure of hadrons,the axial current can be coupled to a pion,this pion is virtual,and its contribution will be present independently of the external *** kaon transition form factors are *** vector form factor's value at zero momentum transfer is determined by the axial anomaly,while this is not the case for the axial *** vector and axial form factors,as well as the neutral pion vector form factor F_(πγγ)(t),are *** to our findings,the pion axial transition form factor is harder than the vector transition form factor and harder than the electromagnetic form *** also discuss the link betweenπ−γandγ−πtransitions distribution amplitudes.

关键词： transition form factors NJL model transition distribution amplitudes

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Hausdorff dimensions of some irregular sets associated with β-expansions

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Science China Mathematics 2016年第3期59卷 445-458页

作者： li jin jun li Bing School of Mathematics and Statistics Minnan Normal University School of Mathematics South China University of Technology

The Hausdorff dimensions of some refined irregular sets associated with β-expansions are determined for any β > 1. More precisely, Hausdorff dimensions of the sets {x ∈ [0, 1) :lim inf(n→∞) S_n(x, β)/n= α_1, lim sup (n→∞) S_n(x, β)/n= α_2}, α_1, α_2≥0 are obtained completely, where S_n(x, β) =sum ε_k(x, β) from k=1 to n denotes the sum of the first n digits of the β-expansion of x. As an application, we present another concise proof of that the set of points x ∈ [0, 1) satisfying lim_(n→∞) S_n(x,β)/n does not exist is of full Hausdorff dimension.

关键词： Hausdorff维数规则集关联 lim

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Effect of multiple coulomb scattering on the beam tests of silicon pixel detectors

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Nuclear Science and Techniques 2024年第4期35卷 200-207页

作者： Lan-Kun li Ming-Yi Dong Ze Gao liang-Cheng-Long jin Shu-jun Zhao School of Physics and Microelectronics Zhengzhou UniversityZhengzhou 450001China State Key Laboratory of Particle Detection and Electronics(Institute of High Energy Physics CAS)Beijing 100049China University of Chinese Academy of Science Beijing 100049China University of South China Hengyang 421001China

In the research and development of new silicon pixel detectors,a collimated monoenergetic charged-particle test beam equipped with a high-resolution pixel-beam telescope is crucial for prototype verification and performance *** the beam energy is low,the effect of multiple Coulomb scattering on the measured resolution of the Device Under Test(DUT)must be considered to accurately evaluate the performance of the pixel chips and *** study aimed to investigate the effect of multiple Coulomb scattering on the measured resolution,particularly at low beam *** were conducted using Allpix^(2) to study the effects of multiple Coulomb scattering under different beam energies,material budgets,and telescope *** simulations also provided the minimum energy at which the effect of multiple Coulomb scattering could be *** with the results of a five-layer detector system tested with an electron beam at DESY,the simulation results were consistent with the beam test results,confirming the reliability of the simulations.

关键词： Silicon Pixel Detectors Beam Telescope Multiple Coulomb Scattering Spatial Resolution

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