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Analysis of the impact of immunotherapy efficacy and safety in patients with gastric cancer and liver metastasis

World Journal of Gastrointestinal Surgery 2024年第3期16卷 700-709页

作者： Kai Liu Chun-Xiao Wu Hui Liang Tao Wang ji-yuan zhang Xiao-Tao Wang Department of Radiation and Oncology Traditional Chinese Hospital of Lu’an affiliated to Anhui University of Traditional Chinese MedicineLu’an 237000Anhui ProvinceChina Department of Gastroenterology Ehu branch of Xishan People’s Hospital of Wuxi CityWuxi 214116Jiangsu ProvinceChina Department of Gastrointestinal Surgery The First Affiliated Hospital of Guangzhou University of Traditional Chinese MedicineGuangzhou 510400Guangdong ProvinceChina Department of Gastrointestinal Surgery Hunan Provincial People’s HospitalChangsha 410002Hunan ProvinceChina Department of Traditional Chinese medicine Ehu branch of Xishan People’s Hospital of Wuxi CityWuxi 214116Jiangsu ProvinceChina

BACKGROUND Gastric cancer(GC)is the fifth most common type of cancer and has the fourth highest death rate among all *** is a lack of studies examining the impact of liver metastases on the effectiveness of immunotherapy in individuals diagnosed with *** To investigate the influence of liver metastases on the effectiveness and safety of immunotherapy in patients with advanced *** This retrospective investigation collected clinical data of patients with advanced stomach cancer who had immunotherapy at our hospital from February 2021 to January *** baseline attributes were compared using either the Chi-square test or the Fisher exact probability *** chi-square test and Kaplan-Meier survival analysis were employed to assess the therapeutic efficacy and survival duration in GC patients with and without liver *** The analysis comprised 48 patients diagnosed with advanced GC,who were categorized into two groups:A liver metastasis cohort(n=20)and a non-liver metastatic cohort(n=28).Patients with liver metastasis exhibited a more deteriorated physical condition compared to those without liver *** objective response rates in the cohort with metastasis and the cohort without metastasis were 15.0%and 35.7%(P>0.05),***,the disease control rates in these two cohorts were 65.0%and 82.1%(P>0.05),*** median progression-free survival was 5.0 months in one group and 11.2 months in the other group,with a hazard ratio of 0.40 and a significance level(P)less than *** median overall survival was 12.0 months in one group and 19.0 months in the other group,with a significance level(P)greater than *** Immunotherapy is less effective in GC patients with liver metastases compared to those without liver metastasis.

关键词： Gastric cancer Spread of cancer to the liver Treatment with immunotherapy Effectiveness of treatment

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Monkeypox outbreak: a novel threat after COVID-19?

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Military Medical Research 2023年第1期10卷 137-138页

作者： Yang zhang ji-yuan zhang Fu-Sheng Wang Senior Department of Infectious Diseases the Fifth Medical Center of Chinese PLA General HospitalNational Clinical Research Center for Infectious DiseasesBeijing 100039China

Dear Editor,Monkeypox is a zoonosis caused by monkeypox virus (MPXV)infection first reported in Central and West Africa[1]. The first outbreak of monkeypox outside of Africa was reported in2003[2].Afterthat,Israel,theUnitedKingdom(UK),Singapore, and other countries have reported monkeypox cases among travelers back from Nigeria since 2018[3].

关键词： Monkeypox Outbreak Zoonosis Human-to-human transmission

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Pediatric Acute Severe Hepatitis of Unknown Origin: What is New?

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Journal of Clinical and Translational Hepatology 2022年第3期10卷 509-514页

作者： jing Li Wei Hu ji-yuan zhang Fu-Sheng Wang Peking University 302 Clinical Medical School BeijingChina Senior Department of Infectious Diseases The Fifth Medical Center of Chinese PLA General HospitalBeijingChina

Globally,there are emerging cases of acute severe hepatitis of unknown origin in *** cases have gathered increasing attention,owing to the development of acute liver failure in some cases that resulted in liver *** review briefly summarizes the outbreak and diagnostic criteria of the *** further discuss the possible causes and related mechanisms underlying its occurrence and progression,and analyze the challenges in ***,this review emphasizes patient management in clinical settings and a combination of efforts to unmask the disease.

关键词： Hepatitis Children Diagnostic Mechanism Management

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Advances and Challenges of Epidemic Outbreaks in the Post-COVID-19 Era in China

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Infectious Diseases & Immunity 2023年第2期3卷 49-51页

作者： Chao zhang ji-yuan zhang Fu-Sheng Wang Department of Infectious Diseases Fifth Medical Center of Chinese PLA General HospitalNational Clinical Research Center for Infectious DiseasesBeijing 100039China.

The coronavirus disease 2019(COVID-19)outbreak,caused by severe acute respiratory syndrome coronavirus(SARS-CoV-2),[1]has spread globally,having profound impacts on peoples'lives,social and economic activities,and national *** the pandemic,China has adopted a policy of putting“the people and their lives first”and provided comprehensive free medical care for all infected patients.[2]The first wave of Wuhan outbreak was successfully controlled within 3 months in early *** then,China has effectively curbed more than 100 clusters of SARS-CoV-2 infections and subsequent outbreaks,and 5 waves of global epidemics from 2020 to ***,the proportion of confirmed cases in China is 0.27%of the global average,and the case fatal rate is 0.43%of the global average.[3]These achievements emphasize the important role that professional medical care and holistic nonpharmaceutical intervention played from 2020 to the end of 2021,in protecting the population from SARS-CoV-2 infection and death associated with COVID-19 in China[Figure 1].

关键词： Figure globally subsequent

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Human Atypical Monkeypox:Early Warning for Global Outbreak?

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Infectious Diseases & Immunity 2022年第4期2卷 239-241页

作者： Hui-Fang Wang Yang zhang ji-yuan zhang Fu-Sheng Wang Senior Department of Infectious Diseases and Hepatology the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Senior Department of Infectious Diseases the Fifth Medical Center of Chinese PLA General HospitalNational Clinical Research Center for Infectious DiseasesBeijing 100039China

Monkeypox is usually considered as a zoonosis caused bymonkeypox viruswith potential threat to public health in the post-smallpox *** recent outbreak ofmonkeypox began inMay 7,2022,and has been found in many countries out of *** Organization declared that this endemic is an“atypical”phenomenon with definite human-to-human *** understand the situation more clearly,this review briefly summarizes the epidemiologic and clinical characteristics of the disease and highlights the clinical management and preventive strategies.

关键词： Monkeypox Atypical Human-to-human transmission Zoonosis

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Structural features in the mid-southern section of the Kyushu–Palau Ridge based on satellite altimetry gravity anomaly

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Acta Oceanologica Sinica 2024年第4期43卷 50-60页

作者： Feifei zhang Dingding Wang Xiaolin ji Fanghui Hou yuan Yang Wanyin Wang School of Geological Engineering and Geomatics Chang’an UniversityXi’an 710054China Qingdao Institute of Marine Geology China Geological SurveyQingdao 266071China Information and Navigation College Air Force Engineering UniversityXi’an 710077China National Engineering Research Center of Offshore Oil and Gas Exploration Beijing 100028China Key Laboratory of Marine Geology and Environment Institute of OceanologyChinese Academy of SciencesQingdao 266071China

The Kyushu–Palau Ridge(KPR),an anti-S-shaped submarine highland at the center of the Philippine Sea Plate(PSP),is considered the residual arc of the Izu–Bonin–Mariana Island Arc,which retains key information about the cessation of the Western Philippine Basin(WPB)expansion and the Parece Vela Basin(PVB)***,using the new generation of satellite altimetry gravity data,high-precision seafloor topography data,and newly acquired ship-borne gravity data,the topographic and gravity characteristics of the KPR mid-southern section and adjacent region are *** distribution characteristics of the faults were delineated using the normalized vertical derivative–total horizontal derivative method(NVDR-THDR)and the minimum curvature potential field separation *** Moho depth and crustal thickness were inverted using the rapid inversion method for a double-interface model with depth *** on these results,the crust structure features in the KPR mid-southern section,and the“triangular”structure geological significance where the KPR and Central Basin Rift(CBR)of the WPB intersect are *** KPR crustal thickness is approximately 6–16 km,with a distinct discontinuity that is slightly thicker than the normal oceanic *** KPR mid-southern section crust structure was divided into four segments(S1–S4)from north to south,formed by the CBR eastward extension joint action and clockwise rotation of the PVB expansion axis and the Mindanao fault zone blocking effect.

关键词： structural features satellite altimetry gravity data Kyushu-Palau Ridge Central Basin Rift faults Moho depth

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Pyrolysis Empirical Modeling of Polyester Glass Fiber Reinforced Plastics Using Sestak-Berggren Model Method

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Journal of Thermal Science 2024年第2期33卷 725-738页

作者： NAN Wei ji Wenhui yuan Yanping yuan Zhongyuan SUN Yong School of Mechanical Engineering Southwest Jiaotong UniversityChengdu610031China CRRC Changchun Railway Vehicles Co. LtdChangchun130062China

Polyester Glass Fiber Reinforced Plastic(Polyester GFRP),a thermosetting plastic comprised of glass fiber and polyester polymer compounds,is extensively utilized in high-speed *** its pyrolysis mechanism is crucial as it significantly influences the combustion characteristics and fire safety ***,kinetic research on polyester GFRP primarily focuses on employing the Coats-Redfern method to derive a theoretical kinetic ***,the pyrolysis process of polyester GFRP is complex and the aforementioned theoretical model fails to accurately describe the pyrolysis ***,this study seeks to utilize the Sestak and Berggren(SB) model as a methodological approach to reveal the complex reaction mechanism during the pyrolysis *** on thermogravimetric analysis,the entire pyrolysis process of polyester GFRP is divided into two primary ***,model-free methods are employed to ascertain the activation energy and pre-exponential *** results show that the fitted empirical models of the two main pyrolysis stages are f(α)=(1-α)^(1.47)[-ln(1-α)]^(1.50) and f(α)=(1-α)^(1.77)[-ln(1-α)]^(1.72),*** predicted results are in good agreement with experimental data under different heating rates,which indicates that the empirical model can sufficiently describe the pyrolysis process of polyester GFRP.

关键词： polyester GFRP model-fitting methods empirical models pyrolysis

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Understanding the Thermal Impedance of Silicone Rubber/Hexagonal Boron Nitride Composites as Thermal Interface Materials

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Chinese Journal of Polymer Science 2024年第3期42卷 352-363,I0008页

作者： yuan ji Shi-Da Han Hong Wu Shao-Yun Guo Feng-Shun zhang jian-Hui Qiu The State Key Laboratory of Polymer Materials Engineering Sichuan Provincial Engineering Laboratory of Plastic/Rubber Complex Processing TechnologyPolymer Research InstituteSichuan UniversityChengdu 610065China Institute of Chemical Materials China Academy of Engineering PhysicsMianyang 621900China Department of Mechanical Engineering Faculty of Systems Science and TechnologyAkita Prefectural UniversityAkita 015-0055Japan

Silicone rubber(SR) composites are most widely used as thermal interface materials(TIMs) for electronics heat dissipation. Thermal impedance as the main bottleneck limiting the performance of TIMs is usually neglected. Herein, the thermal impedance of SR composites loaded with different levels of hexagonal boron nitride(h-BN) as TIMs was elaborated for the first time by the ASTM D 5470 standard test and finite element analysis. It was found that elastic modulus and surface roughness of SR composites increased with the increase of h-BN content, indicating that the conformity was reduced. When the assembly pressure was 0.69 MPa, there existed an optimal h-BN content at which the contact resistance was minimum(0.39 K·cm^(2)·W^(-1)). Although the decreased bond line thickness(BLT) by increasing the assembly pressure was beneficial to reduce the thermal impedance, the proper assembly pressure should be selected to prevent the warpage of the contact surfaces and the increase in contact resistance, according to the compression properties of the SR composites. This study provides valuable insights into fabrication of high-performance TIMs for modern electronic device applications.

关键词： Thermal interface materials Hexagonal boron nitride Thermal impedance Surfaces

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Index-free triangle-based graph local clustering

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Frontiers of Computer Science 2024年第3期18卷 143-153页

作者： Zhe yuan Zhewei WEI Fangrui LV ji-Rong WEN The Country and Area Studies Academy Beijing Foreign Studies UniversityBeijing 100089China Gaoling School of Artificial Intelligence Renmin University of ChinaBeijing 100872China

Motif-based graph local clustering(MGLC)is a popular method for graph mining tasks due to its various ***,the traditional two-phase approach of precomputing motif weights before performing local clustering loses locality and is impractical for large *** some attempts have been made to address the efficiency bottleneck,there is still no applicable algorithm for large scale graphs with billions of *** this paper,we propose a purely local and index-free method called Index-free Triangle-based Graph Local Clustering(TGLC^(*))to solve the MGLC problem w.r.t.a ***^(*)directly estimates the Personalized PageRank(PPR)vector using random walks with the desired triangleweighted distribution and proposes the clustering result using a standard sweep *** demonstrate TGLC^(*)’s scalability through theoretical analysis and its practical benefits through a novel visualization ***^(*)is the first algorithm to solve the MGLC problem without precomputing the motif *** experiments on seven real-world large-scale datasets show that TGLC^(*)is applicable and scalable for large graphs.

关键词： graph local clustering triangle motif index-free sampling method visualization

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Five quinolizidine alkaloids with anti-tobacco mosaic virus activities from two species of Sophora

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Chinese Chemical Letters 2024年第6期35卷 380-384页

作者： ji zhang Tong zhang Qiao An Peng zhang Cai-Yan Tian Chun-Mao yuan Ping Yi Zhan-Xing Hu Xiao-jiang Hao State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical UniversityGuiyang 550014China Natural Products Research Center of Guizhou Province Guiyang 550014China School of Pharmaceutical Sciences Guizhou Medical UniversityGuiyang 550025China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of ScienceKunming 650201China Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical SciencesKunming 650201China

Three novel matrine-type alkaloids(1-3)and two unprecedented aloperine-type alkaloids(4 and 5)were isolated from the root of Sophora tonkinensis and the seeds of Sophora alopecuroides ***,compound 1 possessed an unprecedented 6/5/6 tricyclic skeleton,while compounds 2 and 3 characterized by rare 6/6/5/6 tetracyclic system and 6/6/6/6/6 pentacyclic system ***,compound 4 possessed an unprecedented 6/7/6/6 tetracyclic core,and compound 5 characterized by rare 6/6/6/6tetracyclic *** structures were elucidated by comprehensive spectroscopic data analysis and electronic circular dichroism(ECD)*** tests indicated that compound 5 displayed significant anti-tobacco mosaic virus(TMV)activity compared with the positive control ningnanmycin.

关键词： Matrine-type alkaloids Aloperine-type alkaloids Sophora tonkinensis Sophora alopecuroides Anti-tobacco mosaic virus

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