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A survey on the real-world clinical utilization of a traditional acupuncture in Republic of Korea:Sa-am acupuncture

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Journal of Integrative Medicine 2024年第5期22卷 570-578页

作者： ji-Yeun Park Ye-Seul lee Hi-Joon Park Seungmin Kathy lee ji-won lee Song-Yi Kim College of Korean Medicine Daejeon UniversityDaejeon 34520Republic of Korea Jaseng Spine and Joint Research Institute Jaseng Medical FoundationSeoul 06110Republic of Korea Acupuncture and Meridian Science Research Center Kyung Hee UniversitySeoul 02447Republic of Korea Department of Korean Medicine Korean Medical CenterLusail 201184Qatar Virginia University of Integrative Medicine ViennaVA 22182USA Department of Anatomy and Acupoint College of Korean MedicineGachon UniversitySeongnamGyeonggi 13120Republic of Korea Department of Ophthalmology Otolaryngologyand DermatologyCollege of Korean MedicineDongguk UniversityGoyangGyeonggi 10326Republic of Korea

Objective This study investigated the clinical details and usage of Sa-am acupuncture in Korean medicine clinics and explored how practicing Korean medicine doctors(KMDs)think about Sa-am *** We conducted a questionnaire-based survey of KMDs who utilize Sa-am acupuncture in their *** study comprehensively investigated issues related to clinical application of Sa-am acupuncture,needling techniques used during treatment,training methods,and directions for its future *** We analyzed 572 *** average of 50%of the patients visiting Korean medicine clinics were receiving Sa-am *** most prevalent indication for Sa-am acupuncture use was digestive *** patients’appetite level and digestive function were most frequently used indicators for selecting acupuncture *** prescription compositions,Jung-Gyuk formulas were more frequently used than Seung-Gyuk *** the needle along the flow of the channel or against the flow of the channel was most *** acupuncture style most frequently used in combination with Sa-am acupuncture was Ashi point *** of Sa-am acupuncture included its versatility,easy application,and good *** included the lack of rigorous education and training programs,difficulty in applying the principles for beginners,and insufficient clinical research *** In clinics where Sa-am acupuncture is available,KMDs were providing Sa-am acupuncture to about half of their *** were not using all of the tonification and sedation techniques which may be due to time constraints or simply a lack of ***-am acupuncture demonstrated high utility in clinical practice and high satisfaction based on the efficacy and *** training programs and high-quality research are needed to help expand the use of Sa-am acupuncture.

关键词： Sa-am acupuncture Traditional East Asian medicine Acupuncture education Acupoint selection

Administration frequency as well as dosage of PTH are associated with development of cortical porosity in ovariectomized rats

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Bone Research 2017年第2期5卷 109-122页

作者： Aya Takakura ji-won lee Kyoko Hirano Yukihiro Isogai Toshinori Ishizuya Ryoko Takao-Kawabata Tadahiro Iimura Pharmaceuticals Research Center Asahi Kasei Pharma Corporation Shizuoka Japan Graduate School of Medicine Division of Analytical BioMedicine Ehime University Ehime Japan Division of Bio-Imaging Proteo-Science Center (PROS) Ehime University Ehime Japan Division of Analytical Bio-Medicine Advanced Research Support Center (ADRES) Ehime University Ehime Japan and Artificial Joint Integrated Center Ehime University Hospital Ehime Japan

To investigate whether the administration frequency of parathyroid hormone(PTH) is associated with the development of cortical porosity, this study established 15 dosage regimens of teriparatide [human PTH(1–34), TPTD] with four distinct concentrations and four distinct administration frequencies of TPTD to 16-week-old ovariectomized rats. Our analyses demonstrated that the bone mineral density, mechanical properties, and bone turnover were associated with the total amount of TPTD administered. Our observations further revealed that the cortical porosity was markedly developed as a result of an increased administration frequency with a lower concentration of total TPTD administration in our setting, although the highest concentration also induced cortical porosity. Deconvolution fluorescence tiling imaging on calcein-labeled undecalcified bone sections also demonstrated the development of cortical porosity to be closely associated with the bone site where periosteal bone formation took place. This site-specific cortical porosity involved intracortical bone resorption and an increased number and proximity of osteocytic lacunae,occasionally causing fused lacunae. Taken together, these findings suggested the involvement of local distinctions in the rate of bone growth that may be related to the site-specific mechanical properties in the development of cortical porosity induced by frequent and/or high doses of TPTD.

关键词： frequency Administration PTH

Nonalcoholic fatty liver disease is associated with coronary artery disease in Koreans

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World Journal of Gastroenterology 2013年第38期19卷 6453-6457页

作者： Dae Hee Choi Sung Joon lee Chang Don Kang Myoung Ok Park Dong Wook Choi Tae Suk Kim wonho lee Byung Ryul Cho Yong Hoon Kim Bong-ki lee Dong Ryeol Ryu ji won lee Department of Internal Medicine Kangwon National University School of Medicine Department of Radiology Kangwon National University School of Medicine

AIM:To investigate whether nonalcoholic fatty liver disease(NAFLD)affects coronary artery disease(CAD)and identify candidate ***:Patients who underwent coronary angiography were consecutively *** patients were classified into four groups by coronary artery stenosis:A,insignificant;B,one-vessel disease;C,two-vessel disease;and D,three-vessel *** ultrasonography was performed to determine the presence of a fatty liver and categorize by grade:0,no evidence;1,mild;2,moderate;and 3,*** measured not only known CAD risk factors,but also serum insulin,HOMA-index,adiponectin,interleukin-6,tumor necrosis factor-αand high-sensitivity C-reactive protein ***:Of the 134 patients who met the inclusion criteria,82(61.2%)had ultrasonographically diagnosed *** the 46 patients with CAD,37(80.4%)had evidence of a fatty *** two groups(A vs B-D)were significantly different in terms of age,total cholesterol,triglycerides,low-density lipoprotein levels and fatty *** artery stenosis was strongly associated with fatty liver in a grade-dependent manner(P=0.025).In binary logistic regression,NAFLD was a significant independent predictor of CAD(P=0.03,OR=1.685;95%CI:1.051-2.702).Among the candidate mediators,the serum adiponectin level showed a trend toward lowering based on CAD progression(P=0.071).CONCLUSION:NAFLD is an independent risk factor for CAD in a grade-dependent ***,adiponectin might be related to the pathogenesis of NAFLD.

关键词： Nonalcoholic fatty liver disease Coronary artery disease Coronary angiography Adiponectin Insulin resistance

Gradient Estimation for Demosaicking in a Color Filter Array Image

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通讯和计算机（中英文版） 2013年第1期10卷 59-71页

作者： Hye-Rin Choi Rae-Hong Park ji won lee Department of Electronic Engineering Sogang University Seou1121-7 4 2 Korea

Hybridization of different types of exceptional points

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Photonics Research 2019年第12期7卷 1473-1478页

作者： jiNHYEOK RYU SUNJAE GWAK JAEwon KIM HYEON-HYE YU ji-HWAN KIM ji-won lee CHANG-HWAN YI CHIL-MIN KIM Department of Emerging Materials Science DGISTDaegu 42988South Korea Institut fur Physik Technische Universitat IlmenauD-98693 IlmenauGermany Samsung Electro-Mechanics Suwon 16674South Korea

A large number of different types of second-order non-Hermitian degeneracies called exceptional points(EPs)were found in various physical systems depending on the mechanism of coupling between *** show that these EPs can be hybridized to form higher-order EPs,which preserve the original properties of the initial EPs before *** a demonstration,we hybridize chiral and supermode second-order EPs,where the former and the latter are the results of intra-disk and inter-disk mode coupling in an optical system comprised of two Mie-scale microdisks and one Rayleigh-scale *** high sensitivity of the resulting third-order EP against external perturbations in our feasible system is emphasized.

关键词： exceptional coupling system

Treatment of pediatric average-risk medulloblastoma using craniospinal irradiation less than 2500 cGy and chemotherapy: single center experience in Korea

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World Journal of Pediatrics 2017年第4期13卷 367-373页

作者： Jong Hyung Yoon Kyung Duk Park Hyoung jin Kang Hyery Kim ji won lee Seung-Ki Kim Kyu-Chang Wang Sung-Hye Park Il Han Kim Hee Young Shin Department of Pediatrics Cancer Research InstituteSeoul National University College of MedicineSeoul Department of Pediatrics Hallym University College of medicineChuncheon Sacred Heart HospitalChuncheonKorea Departments of Neurosurgery Seoul National University College of MedicineSeoul Pathology Seoul National University College of MedicineSeoul Radiation Oncology Seoul National University College of MedicineSeoul

Background:Although craniospinal irradiation (CSI) of 2340 cGy plus tumor booster with chemotherapy have been established as a standard treatment of childhood average-risk (AvR) medulloblastoma (MBL) in Western counties,there are a few recent reports in outcomes ofAvR MBL using this strategy in Korean and other Asian *** investigated the outcome of the Korean children with AvR MBL who were treated with CSI <2500 cGy and ***:Between January 2001 and December 2010,clinical characteristics and outcomes of 42 patients who were diagnosed with AvR MBL postoperatively and treated with radiation including CSI <2500 cGy and chemotherapy in Seoul National University Children's Hospital were ***:Their median age was 9 years (range:3-18.8),and 29 were *** subtypes were classic type in 28 patients,nodular/desmoplastic in 7,and large cell/anaplastic (LCA) in *** the patients received adjuvant radiotherapy (CSI with median 2340 cGy and booster) and multiagent chemotherapy as the first-fine *** a median follow-up of 54 months,12 patients experienced relapse or progression of the *** 3-and 5-year disease-free survival (DFS) rates were 78.0%±6.5% and 75.0%±6.9%,respectively,and overall survival (OS) rates were 85.3%±5.6% and 76.8%±6.9%,*** LCA subtype was associated with poorer DFS (P=0.023) and OS (P=0.008),compared with non-LCA ***:The outcomes of children and adolescents with AvR MBL treated with radiation including CSI <2500 cGy and chemotherapy,are compatible to those in Western countries;however,the LCA subtype has a poor outcome with this strategy.

关键词： average-risk craniospinal irradiation medulloblastoma

Investigation on the insecticidal limonoid content of commercial biopesticides and neem extract using solid phase extraction

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Journal of Agricultural Chemistry and Environment 2013年第4期2卷 81-85页

作者： ji-won lee Cho-Long jin Ki Chang Jang Geun-Hyoung Choi Hee-Dong lee jin Hyo Kim Chemical Safety Division National Academy of Agricultural Science RDA Suwon Republic of Korea Research Policy Planning Division Research Policy Bureau RDA Suwon Republic of Korea

Neem extract is an alternative insecticide for organic farming and is an allowed component for commercial biopesticide in Korea. However, crop protection properties are not consistent in commercial products. In this report, quantitative analysis of commercial biopesticides for the four insecticidal limonoids of neem extract-azadirachtin A, azadirachtin B, deacetylsalannin and salannin, was conducted through solid phase extraction method with lipophilic-hydrophilic balanced material. The recoveries of the four limonoids ranged from 80.5% to 105%, and their limit of quantitation ranged from 0.028 mg/L to 0.356 mg/L. On the five imported neem extracts, the total contents of the four bioactive limonoids extracted were from 321 mg/L to 5810 mg/L, but there were big variations in the relative composition of the limonoids. The total limonoidal concentrations in 23 commercial bio-pesticides made from neem showed from below LOQ to 7190 mg/L with significant differences in the relative composition. These differences determine the biopesticide’s efficacy on pests, therefore, tracking the active ingredients is necessary for the quality control of commercial bio-pesticides.

关键词： Solid Phase Extraction Azadirachitn Salannin Quantitative Analysis Biopesticide

Aligned Ion Conduction Pathway of Polyrotaxane‑Based Electrolyte with Dispersed Hydrophobic Chains for Solid‑State Lithium–Oxygen Batteries

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Nano-Micro Letters 2025年第2期17卷 169-186页

作者： Bitgaram Kim Myeong‑Chang Sung Gwang‑Hee lee Byoungjoon Hwang Sojung Seo ji‑Hun Seo Dong‑Wan Kim Department of Materials Science and Engineering Korea University145 Anam‑RoSeongbuk‑GuSeoul 02841Republic of Korea School of Civil Environmental and Architectural EngineeringKorea University145 Anam‑RoSeongbuk‑GuSeoul 02841Republic of Korea Materials Science and Chemical Engineering Center Institute for Advanced Engineering(IAE)Yongin 17180Republic of Korea

A critical challenge hindering the practical application of lithium–oxygen batteries(LOBs)is the inevitable problems associated with liquid electrolytes,such as evaporation and safety *** study addresses these problems by proposing a modified polyrotaxane(mPR)-based solid polymer electrolyte(SPE)design that simultaneously mitigates solvent-related problems and improves ***-SPE exhibits high ion conductivity(2.8×10^(−3)S cm^(−1)at 25℃)through aligned ion conduction pathways and provides electrode protection ability through hydrophobic chain *** this mPR-SPE into solid-state LOBs resulted in stable potentials over 300 *** situ Raman spectroscopy reveals the presence of an LiO_(2)intermediate alongside Li_(2)O_(2)during oxygen *** situ X-ray diffraction confirm the ability of the SPE to hinder the permeation of oxygen and moisture,as demonstrated by the air permeability *** present study suggests that maintaining a low residual solvent while achieving high ionic conductivity is crucial for restricting the sub-reactions of solid-state LOBs.

关键词： Solid polymer electrolyte Lithium-oxygen batteries Polyrotaxane ion conductivity Hydrophobic chain

Significance of adverse outcome pathways in biomarker-based environmental risk assessment in aquatic organisms

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Journal of Environmental Sciences 2015年第9期27卷 115-127页

作者： jin Wuk lee Eun-ji won Sheikh Raisuddin Jae-Seong lee Department of Biological Science College of Science Sungkyunkwan University Department of Medical Elementology and Toxicology Hamdard University

In environmental risk assessments（ERA）, biomarkers have been widely used as an early warning signal of environmental contamination. However, biomarker responses have limitation due to its low relevance to adverse outcomes（e.g., fluctuations in community structure, decreases in population size, and other similar ecobiologically relevant indicators of community structure and function）. To mitigate these limitations, the concept of adverse outcome pathways（AOPs） was developed. An AOP is an analytical, sequentially progressive pathway that links a molecular initiating event（MIE） to an adverse outcome. Recently, AOPs have been recognized as a potential informational tool by which the implications of molecular biomarkers in ERA can be better understood. To demonstrate the utility of AOPs in biomarker-based ERA, here we discuss a series of three different biological repercussions caused by exposure to benzo（a）pyrene（Ba P）, silver nanoparticles（Ag NPs）, and selenium（Se）. Using mainly aquatic invertebrates and selected vertebrates as model species, we focus on the development of the AOP concept. Aquatic organisms are suitable bioindicator species whose entire lifespans can be observed over a short period; moreover, these species can be studied on the molecular and population ***, interspecific differences between aquatic organisms are important to consider in an AOP framework, since these differences are an integral part of the natural *** development of an environmental pollutant-mediated AOP may enable a better understanding of the effects of environmental pollutants in different scenarios in the diverse community of an ecosystem.

关键词： Adverse outcome pathway Biomarker Omics Environmental risk assessment Aquatic organisms Interspecific difference