Two macrophages, osteoclasts and microglia: from development to pleiotropy
Two macrophages, osteoclasts and microglia: from development to pleiotropy作者机构：Department of NephrologyTransplant Research ProgramBoston Children’s HospitalBostonMA 02115USA Department of PharmacologyGraduate School of Dental MedicineHokkaido UniversitySapporo 060-8586Japan Computational Health Informatics ProgramBoston Children’s HospitalBostonMA 02115USA Department of PediatricsHarvard Medical SchoolBostonMA 02115USA
出 版 物：《Bone Research》 (骨研究（英文版）)
年 卷 期：2021年第9卷第2期
页 面：143-152页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 100203[医学-老年医学] 10[医学]
基 金：supported by the grants from the National Institution of Health(R01MH107205,R24OD024622,and U01TR002623) supported by Grantin-Aids for Scientific Research from the Japan Society for the Promotion of Science(19K10044)
主 题：diagnosis osteoporosis osteoclast
摘 要：Tissue-resident macrophages are highly specialized to their tissue-specific microenvironments,activated by various inflammatory signals and modulated by genetic and environmental *** and microglia are distinct tissue-resident cells of the macrophage lineage in bone and brain that are responsible for pathological changes in osteoporosis and Alzheimer’s disease(AD),*** is more frequently observed in individuals with AD compared to the prevalence in general *** of AD is often delayed until underlying pathophysiological changes progress and cause irreversible damages in structure and function of *** such earlier diagnosis and intervention of individuals at higher risk would be indispensable to modify clinical *** is the phenomenon that a genetic variant affects multiple traits and the genetic correlation between two traits could suggest a shared molecular *** this review,we discuss that the Pyk2-mediated actin polymerization pathway in osteoclasts and microglia in bone and brain,respectively,is the horizontal pleiotropic mediator of shared risk factors for osteoporosis and AD.
维普期刊数据库
同方期刊数据库