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无机阴离子对低温拜耳法中脱硅产物析出的影响

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Transactions of Nonferrous Metals Society of China 2024年第4期34卷 1300-1310页

作者：刘吉龙潘晓林吴鸿飞侯宪林于海燕东北大学多金属共生矿生态化冶金教育部重点实验室沈阳110819 东北大学冶金学院沈阳110819 沈阳市有色金属资源循环利用重点实验室沈阳110819

利用XRD、FT-IR、SEM和PSD等手段系统研究无机阴离子对低温拜耳法过程中脱硅产物(DSPs)的组成、结构以及微观形貌的影响。当溶液中存在氯化物、硫酸盐和碳酸盐时,形成氯化物型方钠石、碳酸盐型方钠石和黝方石,部分铝酸盐离子被阴离子杂... 详细信息

利用XRD、FT-IR、SEM和PSD等手段系统研究无机阴离子对低温拜耳法过程中脱硅产物(DSPs)的组成、结构以及微观形貌的影响。当溶液中存在氯化物、硫酸盐和碳酸盐时,形成氯化物型方钠石、碳酸盐型方钠石和黝方石,部分铝酸盐离子被阴离子杂质取代。硫酸盐与DSPs的结合能力强于铝酸盐、氯化物和碳酸盐。随着阴离子浓度的增加,DSPs的粒径增大,且DSPs的团聚程度和圆形片层结构的厚度均有所增加。此外,阴离子杂质会促进沸石骨架的溶解和方钠石中四元环的形成,从而促进沸石向方钠石转化。

关键词：拜耳法水合铝硅酸钠无机阴离子脱硅晶体结构

Temperature-sensitive cytoophidium assembly in Schizosaccharomyces pombe

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Journal of Genetics and Genomics 2019年第9期46卷 423-432页

作者： jing Zhang ji-long liu MRC Functional Genomics Unit Department of PhysiologyAnatomy and GeneticsUniversity of OxfordOxford0X13PTUnited Kingdom School of Life Science and Technology ShanghaiTech UniversityShanghai201210China

The metabolic enzyme CTP synthase(CTPS) is able to compartmentalize into filaments,termed cytoophidia,in a variety of organisms including bacteria,budding yeast,fission yeast,fruit flies and mammals.A previous study in budding yeast shows that the filament-forming process of CTPS is not sensitive to temperature *** we study CTPS filamentation in the fission yeast Schizosaccharomyces *** our surprise,we find that both the length and the occurrence of cytoophidia in *** decrease upon cold shock or heat *** temperature-dependent changes of cytoophidia are fast and *** advantage of yeast genetics,we demonstrate that heat-shock proteins are required for cytoophidium assembly in *** sensitivity of cytoophidia makes *** an attractive model system for future investigations of this novel membraneless organelle.

关键词： CTP synthase Cytoophidium Schizosaccharomyces pombe Heat-shock protein Nucleoside/nucleotide metabolism Cell biology Yeast genetics Cell compartmentalization

mTOR-S6K1 pathway mediates cytoophidium assembly

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Journal of Genetics and Genomics 2019年第2期46卷 65-74页

作者： Zhe Sun ji-long liu School of Life Science and Technology ShanghaiTech University MRC Functional Genomics Unit Department of Physiology Anatomy and Genetics University of Oxford

CTP synthase(CTPS), the rate-limiting enzyme in de novo CTP biosynthesis, has been demonstrated to assemble into evolutionarily conserved filamentous structures, termed cytoophidia, in Drosophila, bacteria, yeast and mammalian cells. However, the regulation and function of the cytoophidium remain elusive. Here, we provide evidence that the mechanistic target of rapamycin(mTOR) pathway controls cytoophidium assembly in mammalian and Drosophila cells. In mammalian cells, we find that inhibition of mTOR pathway attenuates cytoophidium formation. Moreover, CTPS cytoophidium assembly appears to be dependent on the mTOR complex 1(mTORC1) mainly. In addition, knockdown of the mTORC1 downstream target S6 K1 can inhibit cytoophidium formation, while overexpression of the constitutively active S6 K1 reverses mTOR knockdown-induced cytoophidium disassembly. Finally, reducing m TOR protein expression results in a decrease of the length of cytoophidium in Drosophila follicle ***, our study connects CTPS cytoophidium formation with the mTOR signaling pathway.

关键词： mTOR Cytoophidium CTP synthase Colorectal cancer cell Drosophila

The atlas of cytoophidia in Drosophila larvae

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Journal of Genetics and Genomics 2020年第6期47卷 321-331页

作者： Yuanbing Zhang jingnan liu ji-long liu School of Life Science and Technology Shanghai Tech UniversityShanghai201210China University of Chinese Academy of Sciences Beijing100049China Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai200031China

In 2010,cytidine 50-triphosphate synthase(CTPS)was reported to form the filamentous or serpentine structure in Drosophila,which we termed the *** the last decade,CTPS filaments/cytoophidia have been found in bacteria,budding yeast,human cells,mice,fission yeast,plants,and archaea,indicating that this mechanism is highly conserved in *** addition to CTPS,other metabolic enzymes have been identified to have the characteristics of forming cytoophidia or similar advanced structures,demonstrating that this is a basic strategy of ***,our understanding of the physiological function of the cytoophidium remains incomplete and ***,we took the larva of Drosophila melanogaster as a model to systematically describe the localization and distribution of cytoophidia in different tissues during larval *** found that the distribution pattern of CTPS cytoophidia is dynamic and heterogenic in larval *** study provides a road map for further understanding of the function and regulatory mechanism of cytoophidia.

关键词： CTP synthase Cytoophidium Drosophila Larva Metabolic enzyme

Sparks of the CRISPR explosion:Applications in medicine and agriculture

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Journal of Genetics and Genomics 2017年第9期44卷 413-414页

作者： ji-long liu School of Life Science and Technology ShanghaiTech University Department of Physiology Anatomy and Genetics University of Oxford

Exactly 30 years ago,Nakata and coworkers published a paper analyzing the 1664-nucleotide sequence of a chromosomal DNA segment that contained the iap gene and its flanking regions in Escherichia coli（Ishino et al.,1... 详细信息

关键词： Sparks of the CRISPR explosion:Applications in medicine and agriculture

May the Force Be with You: Metabolism of Arginine and Pyrimidines

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Journal of Genetics and Genomics 2015年第5期42卷 179-180页

作者： ji-long liu Medical Research Council Functional Genomics Unit Department of Physiology Anatomy and Genetics University of Oxford

＂Why do arginine and pyrimidines have to be considered together？＂ This was the question I asked when I was invited by Barbara Zimmermann to attend the 23rd Intemational Conference on Arginine and Pyrimidines （ICAP） three years ago. The meeting was held in the summer of 2012 at Bogota, Columbia, known as the ＂the Athens of South America＂. I am not alone in wanting to know more about the relationship between arginine and pyrimidines. Last summer, when ! was organising the next ICAP meeting at Oxford （Aughey et al., 2014）, one of my colleagues asked me, ＂Why such a weird name for a conference？＂ I am not sure if I had given her a satisfying answer and I was enthused to find out what the reasons may be.

关键词： ICAP Metabolism of Arginine and Pyrimidines May the Force Be with You CPS

CTP synthase forms cytoophidia in archaea

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Journal of Genetics and Genomics 2020年第4期47卷 213-223页

作者： Shuang Zhou Hua Xiang ji-long liu School of Life Science and Technology ShanghaiTech UniversityShanghai201210China University of Chinese Academy of Sciences Beijing100049China Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai200031China State Key Laboratory of Microbial Resources Institute of MicrobiologyChinese Academy of SciencesBeijing100101China

CTP synthase(CTPS)is an important metabolic enzyme that catalyzes the rate-Iimiting reaction of nucleotide CrP de novo *** 2010,a series of studies have demonstrated that CTPS can form filamentous structures in bacteria and eukaryotes,which are termed ***,it is unknown whether cytoophidia exist in the third domain of life,*** Haloarcula hispanica as a model system,here we demonstrate that CTPS forms distinct intracellular compartments in *** stimulated emission depletion microscopy,we find that the structures of *** CTPS are elongated,similar to cytoophidia in bacteria and *** Haloarcula cells are cultured in lowsalt medium,the occurrence of cytoophidia increases *** addition,treatment of *** with a glutamine analog or overexpression of CTPS can promote cytoophidium *** study reveals that CTPS can fo rm cytoophidia in all three domains of life,suggesting that forming cytoophidia is an ancient property of CTPS.

关键词： Archaea CTP synthase Cytoophidium Haloarcula hispanica

CRISPR/Cas9 and Genome Editing in Drosophila

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Journal of Genetics and Genomics 2014年第1期41卷 7-19页

作者： Andrew R.Bassett ji-long liu MRC Functional Genomics Unit University of Oxford Department of Physiology Anatomy and Genetics

Recent advances in our ability to design DNA binding factors with specificity for desired sequences have resulted in a revolution in genetic engineering, enabling directed changes to the genome to be made relatively easily. Traditional techniques for generating genetic mutations in most organisms have relied on selection from large pools of randomly induced mutations for those of particular interest, or time-consuming gene targeting by homologous recombination. Drosophila melanogaster has always been at the forefront of genetic analysis, and application of these new genome editing techniques to this organism will revolutionise our approach to performing analysis of gene function in the future. We discuss the recent techniques that apply the CRISPR/Cas9 system to Drosophila, highlight potential uses for this technology and speculate upon the future of genome engineering in this model organism.

关键词： Drosophila melanogaster CRISPR Cas9 Genome engineering Targeted mutagenesis

Neurodevelopmental defects as a primer of neurodegeneration:lessons from spinal muscular atrophy and Huntington's disease

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Neural Regeneration Research 2023年第9期18卷 1952-1953页

作者： Stuart J.Grice ji-long liu Medical Research Council Functional Genomics Unit Department of PhysiologyAnatomy and GeneticsUniversity of OxfordOxfordUK School of Life Science and Technology ShanghaiTech UniversityShanghaiChina

Developmental motifs in neurodegeneration:Neurodegeneration,the prominent feature of neurodegenerative disease,is characterized by the progressive and selective loss of neuronal *** some of the pathologies caused by neurodegeneration may be irreversible,early intervention will be required for the treatments that aim to slow or halt the manifestation of these ***,neurodegeneration evokes the idea of a progressive decline of brain function.

关键词： neurodegeneration Huntington function