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Novel miR-490-3p/hnRNPA1-b/PKM2 axis mediates the Warburg effect and proliferation of colon cancer cells via the PI3K/AKT pathway

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 2038-2059页

作者： Xiang-hui Wan Guo-Bing jin Qun Yang ji-long hu Zhi-Liang Liu Jun Rao Can Wen Peng-Ling Li Xi-Mei Yang Bo huang Xiao-Zhong Wang jiangxi Medical College Nanchang UniversityNanchang 330029Jiangxi ProvinceChina Department of Clinical Laboratory Jiangxi Cancer HospitalNanchang 330029Jiangxi ProvinceChina jiangxi Key Laboratory of Translational Research for Cancer Jiangxi Cancer HospitalNanchang 330029Jiangxi ProvinceChina Department of Abdominal Surgery Jiangxi Cancer HospitalNanchang 330029Jiangxi ProvinceChina Department of Pathology Jiangxi Cancer HospitalNanchang 330029Jiangxi ProvinceChina Science and Education Section Jiangxi Cancer HospitalNanchang 330029Jiangxi ProvinceChina Department of Clinical Laboratory Jiangxi Children’s HospitalNanchang 330006Jiangxi ProvinceChina Department of Clinical Laboratory The Second Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina jiangxi Province Key Laboratory of Laboratory Medicine The Second Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina

BACKGROUND Heterogeneous ribonucleoprotein A1(hnRNPA1)has been reported to enhance the Warburg effect and promote colon cancer(CC)cell proliferation,but the role and mechanism of the miR-490-3p/hnRNPA1-b/PKM2 axis in CC have not yet been *** To investigate the role and mechanism of a novel miR-490-3p/hnRNPA1-b/PKM2 axis in enhancing the Warburg effect and promoting CC cell proliferation through the PI3K/AKT *** Paraffin-embedded pathological sections from 220 CC patients were collected and subjected to immunohistochemical analysis to determine the expression of *** relationship between the expression values and the clinicopathological features of the patients was *** in mRNA expression were analyzed using quantitative real-time polymerase chain reaction,while differences in protein expression were analyzed using western *** proliferation was evaluated using the cell counting kit-8 and 5-ethynyl-2’-deoxyuridine assays,and cell cycle and apoptosis were detected using flow cytometric *** targeted binding of miR-490-3p to hnRNPA1-b was validated using a dual luciferase reporter *** Warburg effect was evaluated by glucose uptake and lactic acid production *** The expression of hnRNPA1-b was significantly increased in CC tissues and cells compared to normal controls(P<0.05).Immunohistochemical results demonstrated significant variations in the expression of the hnRNPA1-b antigen in different stages of CC,including stage I,II-III,and ***,the clinicopathologic characterization revealed a significant correlation between hnRNPA1-b expression and clinical stage as well as T ***1-b was found to enhance the Warburg effect through the PI3K/AKT pathway,thereby promoting proliferation of HCT116 and SW620 ***,the proliferation of HCT116 and SW620 cells was inhibited when miR-490-3p targeted and bound to hnRNPA1-b,effectively blocking the Warburg ***

关键词： Heterogeneous ribonucleoprotein A1-b MiR-490-3p Colon cancer Alternative splicing Warburg effect

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CRD-CGAN:category-consistent and relativistic constraints for diverse text-to-image generation

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Frontiers of Computer Science 2024年第1期18卷 61-75页

作者： Tao hu Chengjiang long Chunxia XIAO College of Intelligent Systems Science and Engineering Hubei Minzu UniversityEnshi 445000China School of Computer Science Wuhan UniversityWuhan 430072China Key Laboratory of Performing Art Equipment&System Technology Ministry of Culture and TourismBeijing 100007China Meta Reality Labs BurlingameCA94010USA

Generating photo-realistic images from a text description is a challenging problem in computer *** works have shown promising performance to generate synthetic images conditional on text by Generative Adversarial Networks(GANs).In this paper,we focus on the category-consistent and relativistic diverse constraints to optimize the diversity of synthetic *** on those constraints,a category-consistent and relativistic diverse conditional GAN(CRD-CGAN)is proposed to synthesize K photo-realistic images *** use the attention loss and diversity loss to improve the sensitivity of the GAN to word attention and ***,we employ the relativistic conditional loss to estimate the probability of relatively real or fake for synthetic images,which can improve the performance of basic conditional ***,we introduce a category-consistent loss to alleviate the over-category issues between K synthetic *** evaluate our approach using the Caltech-UCSD Birds-200-2011,Oxford 102 flower and MS COCO 2014 datasets,and the extensive experiments demonstrate superiority of the proposed method in comparison with state-of-the-art methods in terms of photorealistic and diversity of the generated synthetic images.

关键词： text-to-image diverse conditional GAN relativi-stic category-consistent

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A viscoelastic metamaterial beam for integrated vibration isolation and energy harvesting

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Applied Mathematics and Mechanics(English Edition) 2024年第7期45卷 1243-1260页

作者： long ZHAO Zeqi LU hu DING Liqun CHEN Shanghai Institute of Applied Mathematics and Mechanics Shanghai Key Laboratory of Mechanics in Energy EngineeringShanghai Frontier Science Center of MechanoinformaticsSchool of Mechanics and Engineering ScienceShanghai UniversityShanghai200072China School of Microelectronics Shanghai UniversityShanghai201800China

Locally resonant metamaterials have low-frequency band gaps and the capability of converging vibratory energy in the band gaps at resonant *** has been demonstrated by several researchers that the dissipatioin of vibratory energy within the band gap can be improved by using viscoelastic *** paper designs an integrated viscoelastic metamaterial for energy harvesting and vibration *** viscoelastic metamaterial is achieved by a viscoelastic beam periodically arrayed with spatial ball-pendulum nonlinear energy *** nonlinear resonator with an energy harvesting function is achieved by placing a free-rolling magnetic ball in a spherical cavity with an additional induction *** dynamic equations of viscoelastic metamaterials under transverse excitation are established,and the energy harvesting and vibration isolation characteristics within the dispersion relation of viscoelastic metamaterials are *** results show that the vibrations of the main body of the viscoelastic metamaterial beam are significantly suppressed in the frequency range of the local resonance band *** the same time,the elastic waves are limited in the nonlinear resonator with an energy harvesting function,which improves the energy ***,an experimental platform of viscoelastic metamaterial vibration is established for validation purposes.

关键词： viscoelastic metamaterial nonlinear vibration vibration isolation energy harvesting

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Anisotropic magnetism and band evolution induced by ferromagnetic phase transition in titanium-based kagome ferromagnet SmTi_3Bi_4

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Science China(Physics,Mechanics & Astronomy) 2024年第6期67卷 137-145页

作者： Zhe Zheng long Chen Xuecong ji Ying Zhou Gexing Qu Mingzhe hu Yaobo huang Hongming Weng Tian Qian Gang Wang Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China School of Physics and Engineering Henan University of Science and TechnologyLuoyang 471023China Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201210China Songshan Lake Materials Laboratory Dongguan 523808China CAS Center for Excellence in Topological Quantum Computation Chinese Academy of SciencesBeijing 100190China

Kagome magnets with diverse topological quantum responses are crucial for next-generation topological *** anisotropic magnetism and band evolution induced by ferromagnetic phase transition(FMPT)is reported in a newly discovered titanium-based kagome ferromagnet Sm Ti3Bi4,which features a distorted Ti kagome lattice and Sm atomic zig-zag ***-dependent resistivity,heat capacity,and magnetic susceptibility reveal a ferromagnetic ordering temperature Tc of23.2 K.A large magnetic anisotropy,observed by applying the magnetic field along three crystallographic axes,identifies the b axis as the easy ***-resolved photoemission spectroscopy with first-principles calculations unveils the characteristic kagome motif,including the Dirac point at the Fermi level and multiple van Hove ***,a band splitting and gap closing attributed to FMPT is observed,originating from the exchange coupling between Sm 4 f local moments and itinerant electrons of the kagome Ti atoms,as well as the time-reversal symmetry breaking induced by the long-range ferromagnetic *** the large in-plane magnetization and the evolution of electronic structure under the influence of ferromagnetic ordering,such materials promise to be a new platform for exploring the intricate electronic properties and magnetic phases based on the kagome lattice.

关键词： kagome lattice anisotropic magnetism band splitting ferromagnetic phase transition ARPES

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The New Methods for Characterization of Molecular Weight of Supramolecular Polymers

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Chinese Journal of Polymer Science 2024年第10期42卷 1403-1413,I0006页

作者： hui Liu Rui hu Zi-Qing hu Xiao-Fan ji Key Laboratory of Materials Chemistry for Energy Conversion and Storage Ministry of EducationHubei Key Laboratory of Materials Chemistry and Service FailureHubei Engineering Research Center for Biomaterials and Medical Protective MaterialsSchool of Chemistry and Chemical EngineeringHuazhong University of Science and TechnologyWuhan430074China

Supramolecular polymers,as a type of dynamic polymers,are subordinate to the interdisciplinary field of polymer chemistry and supramolecular chemistry,whose development has greatly promoted the prosperity of new ***,molecular weight is one of the most important parameters of supramolecular polymers,which affects the physical/chemical properties and processing applications of *** new methods for characterizing the molecular weight of supramolecular polymers is crucial for advancing the development of supramolecular *** this review,we elaborate and summarize three strategies for characterizing the molecular weight of supramolecular polymers that recently reported by our research group according to the characteristics of supramolecular polymers,including(1)the molecular weight distinction corresponding to variable fluorescence colors,(2)matching different molecular weights with different fluorescence lifetime,(3)transforming supramolecular polymers into mechanically interlocked polymers or covalent ***,we also discuss the limitations of current methods for characterizing supramolecular *** hope that this review can promote the development of supramolecular polymers and significantly inspire to exploit new methods to characterizing molecular weight of supramolecular polymers.

关键词： Supramolecular polymers Molecular weight Self-assembly Mechanically interlocked polymers Dynamic polymers

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Classifying hepatitis B therapies with insights from covalently closed circular DNA dynamics

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Virologica Sinica 2024年第1期39卷 9-23页

作者： jie-Li hu Ai-long huang Key Laboratory of Molecular Biology on Infectious Diseases Ministry of EducationChongqing Medical UniversityChongqing400016China

The achievement of a functional cure for chronic hepatitis B(CHB)remains limited to a minority of patients treated with currently approved *** primary objective in developing new anti-HBV drugs is to enhance the functional cure rates for CHB.A critical prerequisite for the functional cure of CHB is a substantial reduction,or even eradication of covalently closed circular DNA(cccDNA).Within this context,the changes in cccDNA levels during treatment become as a pivotal *** have previously analyzed the factors influencing cccDNA dynamics and introduced a preliminary classification of hepatitis B treatment strategies based on these *** this review,we employ a systems thinking perspective to elucidate the fundamental aspects of the HBV replication cycle and to rationalize the classification of treatment strategies according to their impact on the dynamic equilibrium of *** upon this foundation,we categorize current anti-HBV strategies into two distinct groups and advocate for their combined use to significantly reduce cccDNA levels within a well-defined timeframe.

关键词： Hepatitis B cccDNA Functional cure Dynamics Treatment Strategy

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Ascending colon cancer and situs inversus totalis-altered surgeon position for successful laparoscopic hemicolectomy: A case report

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World Journal of Clinical Oncology 2022年第10期13卷 848-852页

作者： ji-long hu Qi-Yun Li Kun Wu Department of Abdominal Tumor Surgery Jiangxi Cancer HospitalNanchang 330000Jiangxi ProvinceChina

BACKGROUND Situs inversus totalis(SIT)is a rare congenital condition in which the structure of the abdominal and thoracic cavities is the mirror image of *** anatomic reversal makes laparoscopic surgery difficult when treating colorectal *** SUMMARY We describe the successful laparoscopic hemicolectomy of a 68-year-old Chinese woman with SIT and ascending colon *** on preoperative imaging and careful consideration of the patient’s anatomy,the position of the surgeon was modified such that the surgeon stood between her legs,while the surgical assistant and endoscopist stood to the surgeon’s *** position was also adjusted *** surgery lasted 178 min,during which the patient lost 50 mL of *** analysis of the resected tumor confirmed an adenocarcinoma in clinical stage pT3N0M0,without lymph node *** patient experienced no postoperative complications and was discharged 10 d after *** This case illustrates that careful positioning of the surgeon can facilitate laparoscopic surgery of SIT patients.

关键词： Colon cancer Situs inversus totalis Laparoscopic surgery Case report

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Research,application and development of inorganic binder for casting process

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China Foundry 2024年第5期21卷 461-475页

作者： Xiao-long Gong Sheng-li hu Zi-tian Fan State Key Laboratory of Materials Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China School of Materials Science and Engineering Wuhan University of TechnologyWuhan 430070China

Inorganic binder used in casting process has the advantages of low odor,labor-friendly conditions,and relatively low cost,which is one of the main development directions for casting molding materials in the ***,compared to organic binders(such as resin binders),inorganic binders exhibit lower bonding strength and are more sensitive to environmental *** sensitivity poses challenges,particularly in the reclamation of used sand,thus limiting their broader *** this paper,the research and application status of inorganic binders(mainly silicate inorganic binders)and their curing methods are *** addition,the research and application of phosphate inorganic binders and 3D printing inorganic binders that are being developed are ***,a detailed comparative analysis is conducted on the challenging issue of“reclamation for used sand”in the application of inorganic ***,the development direction of inorganic binders is clarified.

关键词： inorganic binder silicate system phosphate system 3D printing used sand reclamation development trend

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Identifying and localizing of seismogenic electromagnetic anomalies from data observed by permanent MT stations

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Science China Earth Sciences 2024年第5期67卷 1698-1713页

作者： Bing HAN Wenbao hu Guoze ZHAO ji TANG State Key Laboratory of Earthquake Dynamics Institute of GeologyBeijing 100029China Key Laboratory of Exploration Technologies for Oil and Gas Resources of Ministry of Education Yangtze UniversityWuhan 430100China

In this research, an arbitrarily oriented electric dipole at subsurface is used to simulate Seismogenic Electromagnetic(SEM) radiation emanating from a seismic zone during its gestation phase. Analytical synthesis of responses at the Lijiang magnetotelluric(MT) station has revealed that SEM radiation could induce identifiable anomalies in the electromagnetic(EM)spectrum, apparent resistivity and phase within specific frequency bands. Background variations were extracted from long-term observation data of Dali and Lijiang MT stations, enabling the identification of SEM anomalies related to the Yunlong and Yangbi earthquakes. Multiple parameters of dipole sources at subsurface were obtained by applying the Differential Ant Colony Optimization(DACO) algorithm to anomalous data of two stations with multi-frequencies and various response functions. The spatial distribution of these predicted dipoles is predominantly clustered in or around the seismogenic area, with their azimuthal orientation aligning towards the seismogenic fault in general. This study has demonstrated the potential of using subsurface electric dipole simulations for SEM radiation analysis, offering a feasible approach for the prediction and understanding of seismogenic zones.

关键词： MT responses Identifying SEM anomaly Vector electric dipole responses Localizing SEM sources by inversion

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The neuroscience of pain,addiction,and anesthesia

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Zoological Research 2024年第3期45卷 709-710页

作者： ji hu Ping Zheng School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China State Key Laboratory of Medical Neurobiology Institutes of Brain ScienceMOE Frontier Center for Brain ScienceDepartment of Neurology of Zhongshan HospitalFudan UniversityShanghai 200032China

Researchers and clinicians have long been interested in the mechanisms of pain,anesthesia,and *** International Association for the Study of Pain(IASP)defines pain as an unpleasant sensory and emotional experience associated with,or resembling that associated with,actual or potential tissue damage(Raja et al.,2020).Drug addiction refers to a condition of reliance that develops from regular drug consumption,which may lead to withdrawal symptoms when use is *** involves the complete loss of consciousness induced by an inhaled or intravenous anesthetic(Tosello et al.,2022).In this special collection,Zoological Research presents research findings focused on pain,addiction,and anesthesia.

关键词： anesthesia damage

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