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Cellular & Molecular Immunology 2011年第4期8卷 341-347页

作者： Thanh-Nhan Nguyen-Pham Mi-Seon Lim Truc Anh Thi Nguyen youn-Kyung Lee Chun-ji jin hyun Ju Lee Cheol Yi Hong Jae-Sook Ahn Deok-Hwan Yang Yeo-Kyeoung Kim Ik-Joo Chung Byoung Chul Park Hyeoung-Joon Kim Je-Jung Lee Research Center for Cancer Immunotherapy Chonnam National University Hwasun HospitalJeollanamdoKorea Department of Hematology-Oncology Chonnam National UniversityGwangjuKorea The Brain Korea 21 Project Center for Biomedical Human Resources at Chonnam National UniversityGwangjuKorea Vaxcell-Bio Therapeutics JeollanamdoKorea Korea Research Institute of Bioscience and Biotechnology(KRIBB) DaejeonKorea

The major limitation for the maturation of dendritic cells(DCs)using Toll-like receptor(TLR)agonists is their decreased ability to migrate into lymph nodes compared with conventional ***38 can be used as a multifunctional marker to modulate migration,survival and Th1 responses of ***74 has been shown to negatively regulate DC *** goal of this study was to investigate the combinations of TLR agonists and interferons(IFNs)that most effectively regulate CD38 and CD74 expression on *** TLR agonist stimulation in combination with IFN-a and IFN-c was the best method for regulating CD38 and CD74 expression and inducing the highest secretion of *** in vitro migration assay showed that DCs treated with this combination had significantly enhanced migratory ability,similar to that observed in cells expressing CD38,CD74 and *** results of this study suggest that an alternative maturation protocol in which two TLR ligands are combined with type I and II IFNs generates potent DCs that have both a high migratory capacity and high IL-12p70 production.

关键词： CD38 CD74 dendritic cells interferon Toll-like receptor

Decomposition kinetics of dimethyl methylphospate(chemical agent simulant) by supercritical water oxidation

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Journal of Environmental Sciences 2006年第1期18卷 13-16页

作者： Bambang VERIANSYAH Jae-Duck KIM youn-Woo LEE Supercritical Fluid Research Laboratory Korea Institute of Science and Technology(KIST) 39-1 Hawolgok-dong Seoungbuk-gu Seoul 136-791 Korea. School of Chemical and Biological Engineering Seoul National University(SNU) San 56-1 Sillim-dong Gwanak-gu Seoul 151-744 Korea

Supercritical water oxidation （SCWO） has been drawing much attention due to effectively destroy a large variety of high-risk wastes resulting from munitions demilitarization and complex industrial chemical. An important design consideration in the development of supercritical water oxidation is the information of decomposition rate. In this paper, the decomposition rate of dimethyl methylphosphonate（DMMP）, which is similar to the nerve agent VX and GB（Sarin） in its structure, was investigated under SCWO conditions. The experiments were performed in an isothermal tubular reactor with a H2O2 as an oxidant. The reaction temperatures were ranged from 398 to 633℃ at a fixed pressure of 24 MPa. The conversion of DMMP was monitored by analyzing total organic carbon （TOC） on the liquid effluent samples. It is found that the oxidative decomposition of DMMP proceeded rapidly and a high TOC decomposition up to 99.99% was obtained within 11 s at 555℃. On the basis of data derived from experiments, a global kinetic equation for the decomposition of DMMP was developed. The model predictions agreed well with the experimental data.

关键词： supercritical water oxidation kinetics chemical agent DMMP

Disease progression in chronic hepatitis C patients with normal alanine aminotransferase levels

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World Journal of Gastroenterology 2013年第14期19卷 2256-2261页

作者： Dong hyun Sinn Geum-youn Gwak Jae-uk Shin Moon Seok Choi Joon Hyeok Lee Kwang Cheol Koh Seung Woon Paik Byung Chul Yoo Department of Internal Medicine Sanggye Paik HospitalInje University School of Medicine Department of Medicine Samsung Medical CenterSungkyunkwan University School of Medicine

AIM:To investigate whether the disease progression of chronic hepatitis C patients with normal alanine aminotransferase(ALT) levels differs by ALT ***:A total of 232 chronic hepatitis C patients with normal ALT( 26 IU/L(highnormal),respectively(P = 0.043),and it was 1.4% and 4.8% for female patients with baseline ALT levels ≤ 22 IU/L(low-normal) and > 23 IU/L(high-normal),respectively(P = 0.023).ALT levels fluctuated during the follow-up *** the follow-up,more patients with "high-normal" ALT levels at baseline experienced ALT elevation(> 41 IU/L) than did patients with "lownormal" ALT levels at baseline(47.7% vs 27.9%,P = 0.002).The 5 year cumulative incidence of disease progression was significantly lower in patients with persistently "low-normal" ALT levels than "high-normal" ALT levels or those who exhibited an ALT elevation > 41 U/L during the follow-up period(0%,8.3% and 34.3%,P < 0.001).CONCLUSION:A "high normal" ALT level in chronic hepatitis C patients was associated with disease progression,suggesting that the currently accepted normal threshold of serum ALT should be lowered.

关键词： Alanine aminotransferase Upper limits of normal Disease progression Hepatitis C virus Hepatocellular carcinoma

Assessment of colon polyp morphology: Is education effective?

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World Journal of Gastroenterology 2017年第34期23卷 6281-6286页

作者： Jae hyun Kim Kyoung Sik Nam Hye Jung Kwon youn Jung Choi Kyoungwon Jung Sung Eun Kim Won Moon Moo In Park Seun Ja Park Division of Gastroenterology Department of Internal MedicineKosin University College of Medicine

AIM To determine the inter-observer variability for colon polyp morphology and to identify whether education can improve agreement among *** For purposes of the tests, we recorded colonoscopy video clips that included scenes visualizing the polyps. A total of 15 endoscopists and 15 nurses participated in the study. Participants watched 60 video clips of the polyp morphology scenes and then estimated polyp morphology(pre-test). After education for 20 min, participants performed a second test in which the order of 60 video clips was changed(post-test). To determine if the effectiveness of education was sustained, four months later, a third, follow-up test was performed with the same *** The overall Fleiss' kappa value of the inter-observer agreement was 0.510 in the pre-test, 0.618 in the post-test, and 0.580 in the follow-up test. The overall diagnostic accuracy of the estimation for polyp morphology in the pre-, post-, and follow-up tests was 0.662, 0.797, and 0.761, respectively. After education, the inter-observer agreement and diagnostic accuracy of all participants improved. However, after four months, the inter-observer agreement and diagnostic accuracy of expert groups were markedly decreased, and those of beginner and nurse groups remained similar to pre-test levels. CONCLUSION The education program used in this study can improve inter-observer agreement and diagnostic accuracy in assessing the morphology of colon polyps; it is especially effective when first learning endoscopy.

关键词： Colon polyp Morphology Education

Identification of novel HLA-A 0201-restricted epitopes from anterior gradient-2 as a tumor-associated antigen against colorectal cancer

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Cellular & Molecular Immunology 2012年第2期9卷 175-183页

作者： hyun Ju Lee Cheol Yi Hong Chun-ji jin Mi-hyun Kim youn-Kyung Lee Thanh-Nhan Nguyen-Pham hyunah Lee Byoung Chul Park Ik-Joo Chung Hyeoung-Joon Kim Je-Jung Lee Research Center for Cancer Immunotherapy Chonnam National University Hwasun Hospital Hwasun Jeollanamdo Korea Department of Hematology-Oncology Chonnam National University Gwangju Korea VaxcelI-Bio Therapeutics Hwasun Jeollanamdo Korea Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea Korea Research Institute of Bioscience and Biotechnology （KRIBB） Daejeon Korea The Brain Korea 21 Project Center for Biomedical Human Resources at Chonnam National University Gwangiu Korea

Anterior gradient-2 （AGR2） promotes tumor growth, cell migration and cellular transformation and its enhanced expression is almost completely restricted to malignant tissues, thus making AGR2 an interesting target for the development of immunotherapeutic strategies. We investigated whether the AGR2 molecule comprises human leukocyte antigen （HLA）-A 0201-binding epitopes recognized by human cytotoxic T lymphocytes （CTLs）, which could be targeted in dendritic cell （DC）-based cancer immunotherapy against colorectal cancer （CRC）. We reviewed the sequence of AGR2 for peptides that could potentially bind to HLA-A 0201 with the aid of a computer-based program. Five candidate peptides with different binding scores were synthesized and tested. These peptides were then assessed for their immunogenicity to elicit specific immune responses mediated by CTLs in vitro by means of enzyme-linked immunospot assays and CTL assays. AGR2 was highly expressed in several CRC cell lines, including DK01, DLD1, KM 12C, HCT-8 and HT-29. DCs pulsed with AGR2-P2 （aa 11-19; LLVALSYTL） or AGR2-P4 （aa 127-135; RIMFVDPSL） generated potent CTLs that could lyse T2 cells pulsed with AGR2-P2 or AGR2-P4 and HLA-A0201＋ AGR2-positive CRC cell lines in a strong dose-dependent and HLA-A 0201-restricted manner. In conclusion, these novel epitopes derived from AGR2 protein may be attractive candidates for DC-based immunotherapy for CRC.

关键词： AGR2 colorectal cancer dendritic cell tumor-associated antigen

Dendrite Spacing Selection during Directional Solidification of Pivalic Acid-Ethanol System

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Journal of Materials Science & Technology 2008年第3期24卷 340-342页

作者： Myung-jin Suk young-Min Park youn-Che Kim Department of Materials and-Metallurgical Engineering Kangwon National University

Unidirectional solidification of pivalic acid （PVA）-ethanol （Eth） mixture was performed to examine whether an allowable range of primary dendrite spacing definitely exists at a given growth velocity and how the range is history-dependent. PVA-0.59 wt pct Eth was unidirectionally solidified in the range of growth velocity 0.5-64 μm/s at the temperature gradient of 2.3 K/ram. Sequential change in growth velocity was imposed to determine the upper and lower limits for the allowable range of stable spacing. An allowable range of the steady state primary spacing was observed at a given growth velocity, and the extent of the range seems to be dependent on the degree to which step-increase or step-decrease in growth velocity is accomplished. As the degree of sequential change in growth velocity increases, the history-dependence of the selection for the primary dendrite spacing tends to disappear.

关键词： Dendrite spacing History-dependent Spacing selection Pivalic acid-ethanol

Numerical study on the heat dissipation characteristics of high-power LED module

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Science China(Technological Sciences) 2013年第9期56卷 2150-2155页

作者： LEE DaeWoo CHO Sung-Wook KIM youn-Jea Graduate School of Mechanical Engineering Sungkyunkwan University School of Mechanical Engineering Sungkyunkwan University

LED lighting has problems such as short life span, power reduction due to the LED chip's heat, and decreased luminance efficiency etc. Many studies on the optimization of the thermal performance of LEDs have been conducted actively to solve these problems. The present study changes the fin shape and intervals of various heat sink designs so that LED can effectively produce a thermal effect. The water-cooling heat release system and the heat pipe methods show higher thermal performance results than the existing systems; however, the system is of high cost and requires a large-scale apparatus. This study carried out a numerical analysis of the thermal control system by applying heat flux and heat sink properties as an active heat release system using the commercial code ANSYS ver. 13.0 and verified the validity of the new heat sink design for temperature distribution analysis.

关键词： LED lighting water-cooling heat release system heat loss

Multifaceted neuroprotective effects of(-)-epigallocatechin-3-gallate(EGCG)in Alzheimer's disease:an overview of pre-clinical studies focused onβ-amyloid peptide

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Food Science and Human Wellness 2022年第3期11卷 483-493页

作者： Kumju youn Chi-Tang Ho Mira Jun Department of Food Science and Nutrition Dong-A UniversityBusan 49315Korea Department of Food Science Rutgers UniversityNJ 08901USA Department of Health Sciences The graduate School of Dong-A UniversityBusan 49315Korea

Alzheimer’s disease(AD)is the most common neurodegenerative disease characterized by cognitive decline and memory *** lines of evidence indicate that excessiveβ-amyloid peptide(Aβ)generation and aggregation play pivotal roles in the initiation of AD,leading to various biochemical alteration including oxidative damage,mitochondrial dysfunction,neuroinflammation,signaling pathway and finally resulting in neuronal *** has a complex pathogenic mechanism,and a single-target approach for anti-AD strategy is thus full of *** overcome these limitations,the present study focused to review on one of multiple target-compounds,(-)-epigallocatechin-3-gallate(EGCG)for the prevention and treatment of *** is a main bioactive polyphenol in green tea and has been reported to exert potent neuroprotective properties in a wide array of both cellular and animal models in *** review demonstrated multiple neuroprotective efficacies of EGCG by focusing on the involvement of Aβ-evoked damage and its Aβ***,to understand its mechanism of action on the brain,the permeability of the blood-brain barrier was also discussed.

关键词： Alzheimer’s disease β-Amyloid peptide Green tea EGCG Neuroinflammation

Impact of guideline adherence on the prognosis of Barcelona clinic liver cancer stage B hepatocellular carcinoma

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World Journal of Gastroenterology 2023年第47期29卷 6122-6137页

作者： ji Eun Han Hyo Jung Cho Jae youn Cheong Sun Gyo Lim Min Jae Yang Choong-Kyun Noh Gil Ho Lee Soon Sun Kim Department of Gastroenterology Ajou University School of MedicineSuwon 16499Gyeonggi-doSouth Korea

BACKGROUND Patients with Barcelona clinic liver cancer(BCLC)stage B hepatocellular carcinoma(HCC)are considerably heterogeneous in terms of tumor burden,liver function,and performance *** improve the poor survival outcomes of these patients,treatment approaches other than transarterial chemoembolization(TACE),which is recommended by HCC guidelines,have been adopted in realworld clinical *** hypothesize that this non-adherence to treatment guidelines,particularly with respect to the use of liver resection,improves survival in patients with stage B *** To assess guideline adherence in South Korean patients with stage B HCC and study its impact on *** A retrospective analysis was conducted using data from 2008 to 2016 obtained from the Korea Central Cancer *** with stage B HCC were categorized into three treatment groups,guideline-adherent,upward,and downward,based on HCC guidelines recommended by the Asian Pacific Association for the Study of the Liver(APASL),the European Association for the Study of the Liver(EASL),and the American Association for the Study of Liver Diseases(AASLD).The primary outcome was HCC-related deaths;tumor recurrence served as the secondary *** among the groups was compared using the Kaplan-Meier method and the log-rank *** of survival outcomes were identified using multivariable Cox regression *** In South Korea, over the study period from 2008 to 2016, a notable trend was observed in adherence to HCCguidelines. Adherence to the EASL guidelines started relatively high, ranging from 77% to 80% between 2008 and2012, but it gradually declined to 58.8% to 71.6% from 2013 to 2016. Adherence to the AASLD guidelines began at71.7% to 75.9% from 2008 to 2010, and then it fluctuated between 49.2% and 73.8% from 2011 to 2016. In contrast,adherence to the APASL guidelines remained consistently high, staying within the range of 90.14% to 94.5%throughout the entire study per

关键词： Hepatocellular carcinoma Barcelona clinic liver cancer stage B Guideline adherence Liver neoplasms Transarterial chemoembolization Liver resection

Newly-modeled graphene-based ternary nanocomposite for the magnetophotocatalytic reduction of CO_(2) with electrochemical performance

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Frontiers of Chemical Science and Engineering 2022年第10期16卷 1438-1459页

作者： Zambaga Otgonbayar Kwang youn Cho Chong-Hun Jung Won-Chun Oh Department of Advanced Materials Science&Engineering Hanseo UniversitySeosan-Si 31962Korea Korea Institutes of Ceramic Engineering and Technology Jinju-Si 660031Korea Decommissioning Technology Research Division Korea Atomic Energy Research InstituteDaejeon 305-600Korea Anhui International Joint Research Center for Nano Carbon-based Materials and Environmental Health College of Materials Science and EngineeringAnhui University of Science&TechnologyHuainan 232001China

The development of CO_(2)into hydrocarbon fuels has emerged as a green method that could help mitigate global *** novel structured photocatalyst is a promising material for use in a photocatalytic and magneto-electrochemical method that fosters the reduction of CO_(2)by suppressing the recombination of electron−hole pairs and effectively transferring the electrons to the surface for the chemical reaction of CO_(2)*** our study,we have developed a novel-structured AgCuZnS_(2)–graphene–TiO_(2)to analyze its catalytic activity toward the selective evolution of CO_(2).The selectivity of each nanocomposite substantially enhanced the activity of the AgCuZnS_(2)–graphene–TiO_(2)ternary nanocomposite due to the successful interaction,and the selectivity of the final product was improved to a value 3 times higher than that of the pure AgCuZnS_(2)and 2 times higher than those of AgCuZnS_(2)–graphene and AgCuZnS_(2)–TiO_(2)under ultraviolet(UV)-light(λ=254 nm)irradiation in the photocatalytic *** electrochemical CO_(2)reduction test was also conducted to analyze the efficacy of the AgCuZnS_(2)–graphene–TiO_(2)when used as a working electrode in laboratory electrochemical *** electrochemical process was conducted under different experimental conditions,such as various scan rates(mV·s^(–1)),under UV-light and with a 0.07 T *** evolution of CO_(2)substantially improved under UV-light(λ=254 nm)and with 0.07 T magnetic-core treatment;these improvements were attributed to the facts that the UV-light activated the electron-transfer pathway and the magnetic core controlled the pathway of electrontransmission/prevention to protect it from chaotic electron *** all tested nanocomposites,AgCuZnS_(2)–graphene–TiO_(2)absorbed the CO_(2)most strongly and showed the best ability to transfer the electron to reduce the CO_(2)to *** believe that our newly-modeled ternary nanocomposite opens up new opportunities for the evolution of C

关键词： ternary nanocomposite photocatalytic electrochemical CO_(2) reduction UV-light magnetic core