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Neural Regeneration Research 2016年第8期11卷 1274-1277页

作者： Sung Ho jang Woo Hyuk jang Department of Physical Medicine and Rehabilitation College of MedicineYeungnam University

There have been no studies reported on the difference in cortical activation during use of volar and dorsal hand *** attempted to investigate the difference in cortical activation in the somatosensory cortical area during use of volar and dorsal hand splints by functional magnetic resonance imaging（f MRI）.We recruited eight healthy volunteers.f MRI was performed while subjects who were fitted with volar or dorsal hand splints performed grasp-release *** of interest were placed on the primary motor cortex（M1）,primary somatosensory cortex（S1）,posterior parietal cortex（PPC）,and secondary somatosensory cortex（S2）.Results of group analysis of f MRI data showed that the total numbers of activated voxels in all ROIs were significantly higher during use of volar hand splint（3,376） compared with that（1,416） during use of dorsal hand *** each ROI,use of volar hand splint induced greater activation in all ROIs（M1：1,748,S1 ：1,455,PPC：23,and S2：150） compared with use of dorsal hand splint（M1：783,S1：625,PPC：0,and S2：8）.The peak activated value was also higher during use of volar hand splint（t-value：17.29） compared with that during use of dorsal hand splint（t-value：13.11）.Taken together,use of volar hand splint induced greater cortical activation relevant to somatosensory function than use of dorsal hand *** result would be important for the physiatrist and therapist to apply appropriate somatosensory input in patients with brain injury.

关键词： nerve regeneration functional MRI hand splint somatosensory function dorsal hand splint volar hand splint neural regeneration

Recovery mechanisms of somatosensory function in stroke patients: implications of brain imaging studies

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Neuroscience Bulletin 2013年第3期29卷 366-372页

作者： Sung Ho jang Department of Physical Medicine and Rehabilitation College of Medicine Yeungnam University

Somatosensory dysfunction is associated with a high incidence of functional impairment and safety in patients with stroke. With developments in brain mapping techniques, many studies have addressed the recovery of various functions in such patients. However, relatively little is known about the mechanisms of recovery of somatosensory function. Based on the previous human studies, a review of 11 relevant studies on the mecha- nisms underlying the recovery of somatosensory function in stroke patients was conducted based on the fol- lowing topics：（1） recovery of an injured somatosensory pathway, （2） peri-lesional reorganization, （3） contribu- tion of the unaffected somatosensory cortex, （4） contribution of the secondary somatosensory cortex, and （5） mechanisms of recovery in patients with thalamic lesions. We believe that further studies in this field using combinations of diffusion tensor imaging, functional neuroimaging, and magnetoencephalography are needed. In addition, the clinical significance, critical period, and facilitatory strategies for each recovery mechanism should be clarified.

关键词： stroke somatosensory recovery brain mapping brain plasticity

Ternary layered double hydroxide oxygen evolution reaction electrocatalyst for anion exchange membrane alkaline seawater electrolysis

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Journal of Energy Chemistry 2022年第12期75卷 127-134,I0004页

作者： Yoo Sei Park Jae-Yeop Jeong Myeong Je jang Chae-Yeon Kwon Geul Han Kim Jaehoon Jeong ji-hoon Lee Jooyoung Lee Sung Mook Choi Department of Hydrogen Energy Materials Surface&Nano Materials DivisionKorea Institute of Materials Science(KIMS)Changwon 51508Republic of Korea Department of Advanced Material Engineering Chungbuk National University1 Chungdae-roSeowon-guCheongjuChungbuk 28644Republic of Korea Department of Chemical Engineering University of WaterlooWaterlooOntario N2L 3G1 Canada School of Materials Science and Engineering Gyeongsang National UniversityJinju 52828Republic of Korea Department of Materials Science and Engineering Pusan National UniversityBusan 46241Republic of Korea Energy Industry Support Center Daegu Mechatronics&Materials InstituteDaegu 42704Republic of Korea Advanced Materials Engineering University of Science and Technology(UST)Yuseong-guDaejeon 34113Republic of Korea

Anion exchange membrane(AEM)water electrolyzers are promising energy devices for the production of clean hydrogen from ***,the lack of active and robust electrocatalysts for the oxygen evolution reaction(OER)severely impedes the development of this *** this study,a ternary layered double hydroxide(LDH)OER electrocatalyst(NiFeCo-LDH)is developed for high-performance AEM alkaline seawater *** AEM alkaline seawater electrolyzer catalyzed by the NiFeCo LDH shows high seawater electrolysis performance(0.84 A/cm^(2)at 1.7 Vcell)and high hydrogen production efficiency(77.6%at 0.5 A/cm^(2)),thus outperforming an electrolyzer catalyzed by a benchmark IrO_(2)*** NiFeCo-LDH electrocatalyst greatly improves the kinetics of the AEM alkaline seawater electrolyzer,consequently reducing its activation loss and leading to high *** on the results,this NiFeCo-LDH-catalyzed AEM alkaline seawater electrolyzer can likely surpass the energy conversion targets of the US Department of Energy.

关键词： Anion exchange membranes water electrolysis Oxygen evolution reactions Alkaline seawater electrolysis Hydrogen production

Removal of primary iron rich phase from aluminum-silicon melt by centrifugal separation

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China Foundry 2013年第2期10卷 112-117页

作者： Seong Woo Kim Un Ho Im Hyeong Cheol Cha Se Hyeong Kim ji Eun jang Ki Young Kim School of Energy Materials and Chemical EngineeringKorea University of Technology and Education

Recycling is a major consideration in continued aluminum use due to the enormous demand for high quality products. Some impurity elements gradually accumulate through the repetitive reuse of aluminum alloy scrap. Of them, the iron content should be suppressed under the allowed limit. In the present research, a novel separation method was introduced to remove primary iron-rich intermetallic compounds by centrifugation during solidification of AI-Si-Fe alloys. This method does not use the density difference between two phases as in other centrifugal methods, but uses the order of solidification in AI-Si-Fe alloys, because iron promotes the formation of intermetallic compounds with other alloying elements as a primary phase. Two AI-Si-Fe alloys which have different iron contents were chosen as the starting materials. The iron-rich phase could be efficiently removed by centrifuging under a centrifugal force of 40 g. Coarse intermetallic compounds were found in the sample inside the crucible, while rather fine intermetallic compounds were found in the sample outside the crucible. Primary intermetallic compounds were linked to each other via aluminum-rich matrix, and formed like a network. The highest iron removal fraction is 67% and the lowest one is 7% for AI-12Si-1.7Fe alloy. And they are 82% and 18% for AI-12Si-3.4Fe alloy, respectively.

关键词： Al-Si alloys iron removal centrifugal separation

Real-Time Tunable Gas Sensing Platform Based on SnO_(2) Nanoparticles Activated by Blue Micro-Light-Emitting Diodes

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Nano-Micro Letters 2024年第12期16卷 103-119页

作者： Gi Baek Nam Jung-El Ryu Tae Hoon Eom Seung Ju Kim Jun Min Suh Seungmin Lee Sungkyun Choi Cheon Woo Moon Seon Ju Park Soo Min Lee Byungsoo Kim Sung Hyuk Park jin Wook Yang Sangjin Min Sohyeon Park Sung Hwan Cho Hyuk jin Kim Sang Eon Jun Tae Hyung Lee Yeong Jae Kim Jae Young Kim Young Joon Hong Jong-In Shim Hyung-Gi Byun Yongjo Park Inkyu Park Sang-Wan Ryu Ho Won jang Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Republic of Korea Research Laboratory of Electronics Department of Mechanical EngineeringMassachusetts Institute of TechnologyCambridgeMA 02139USA Ming Hsieh Department of Electrical and Computer Engineering University of Southern CaliforniaLos AngelesCA 90089USA Department of Display Materials Engineering Soonchunhyang UniversityAsan 31538Republic of Korea Department of Photonics and Nanoelectronics BK21 FOUR ERICA-ACE CenterHanyang University ERICAAnsan 15588Republic of Korea Department of Nanotechnology and Advanced Materials Engineering Sejong UniversitySeoul 05006Republic of Korea Department of Electronics Information and Communication EngineeringKangwon National UniversitySamcheok 25913Republic of Korea Advance Institute of Convergence Technology Seoul National UniversitySuwon 16229Republic of Korea Department of Mechanical Engineering Korea Advanced Institute of Science and TechnologyDaejeon 34141Republic of Korea Department of Physics Chonnam National UniversityGwangju 500-757Republic of Korea

Micro-light-emitting diodes(μLEDs)have gained significant interest as an activation source for gas sensors owing to their advantages,including room temperature operation and low power ***,despite these benefits,challenges still exist such as a limited range of detectable gases and slow *** this study,we present a blueμLED-integrated light-activated gas sensor array based on SnO_(2)nanoparticles(NPs)that exhibit excellent sensitivity,tunable selectivity,and rapid detection with micro-watt level power *** optimal power forμLED is observed at the highest gas response,supported by finite-difference time-domain ***,we first report the visible light-activated selective detection of reducing gases using noble metal-decorated SnO_(2)*** noble metals induce catalytic interaction with reducing gases,clearly distinguishing NH3,H2,and ***-time gas monitoring based on a fully hardwareimplemented light-activated sensing array was demonstrated,opening up new avenues for advancements in light-activated electronic nose technologies.

关键词： Micro-LED Gas sensor array Low power consumption Metal decoration Real-time detection

Mesenchymal stem cells for enhancing biological healing after meniscal injuries

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World Journal of Stem Cells 2021年第8期13卷 1005-1029页

作者： Hye Chang Rhim Ok Hee Jeon Seung-Beom Han ji Hoon Bae Dong Won Suh Ki-Mo jang T.H.Chan School of Public Health Harvard UniversityBostonMA 02115United States Department of Biomedical Sciences Korea University College of MedicineSeoul 02841SeoulSouth Korea Department of Orthopaedic Surgery Anam HospitalKorea University College of MedicineSeoul 02841SeoulSouth Korea Department of Orthopaedic Surgery Guro HospitalKorea University College of MedicineSeoul 08308SeoulSouth Korea Department of Orthopaedic Surgery Barunsesang HospitalSeongnam 13497South Korea

The meniscus is a semilunar fibrocartilage structure that plays important roles in maintaining normal knee biomechanics and *** roles of the meniscus,including load distribution,force transmission,shock absorption,joint stability,lubrication,and proprioception,have been well *** to the meniscus can disrupt overall joint stability and cause various symptoms including pain,swelling,giving-way,and *** treated properly,it can lead to early degeneration of the knee *** meniscal injuries remain a significant challenge due to its low intrinsic healing potential,most notably in avascular and aneural inner two-thirds of the area,more efficient repair methods are *** stem cells(MSCs)have been investigated for their therapeutic potential in vitro and in *** far,the application of MSCs,including bone marrow-derived,synovium-derived,and adipose-derived MSCs,has shown promising results in preclinical studies in different animal *** preclinical studies could be categorized into intra-articular injection and tissueengineered construct application according to delivery *** promising results in preclinical studies,there is still a lack of clinical *** review describes the basic knowledge,current treatment,and recent studies regarding the application of MSCs in treating meniscal *** directions for MSC-based approaches to enhance meniscal healing are suggested.

关键词： Meniscus Meniscus healing Cell-based treatment Mesenchymal stem cell Tissue engineering

功能性消化不良动物模型的中医证型及其评价指标研究进展

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药物评价研究 2024年第4期47卷 889-896页

作者：马玉朋袁亚茹邸志权姜溪胡金芳天津中医药大学天津301617 天津天诚新药评价有限公司天津300462 安徽医科大学安徽合肥230032 药物成药性评价与系统转化全国重点实验室天津300462 天津市药代动力学和药效动力学重点实验室天津300462 天津市新药非临床评价技术工程中心天津300462

功能性消化不良(FD)作为功能性胃肠病,中医临床通过病症结合的方式进行治疗,将其分为脾虚气滞证、肝胃不和证、脾胃湿热证、脾胃虚寒证、寒热错杂证、肝郁脾虚证、肝郁气滞证等证型。FD动物模型的构建依据证型特定的发病机制来模拟人体... 详细信息

功能性消化不良(FD)作为功能性胃肠病,中医临床通过病症结合的方式进行治疗,将其分为脾虚气滞证、肝胃不和证、脾胃湿热证、脾胃虚寒证、寒热错杂证、肝郁脾虚证、肝郁气滞证等证型。FD动物模型的构建依据证型特定的发病机制来模拟人体症状,检测指标常采用行为学、胃肠动力学及相关蛋白水平等评估模型与FD患者的相似度。符合病症的动物模型是开展药效研究和药效评价的前提和基础,对FD中医证型的造模方法及检测指标进行整理和分析,旨在完善和优化动物模型,为后续的药物研究提供支持。

关键词：功能性消化不良动物模型中医证型病证结合评价指标

Intranasal administration of induced pluripotent stem cell-derived cortical neural stem cell-secretome as a treatment option for Alzheimer’s disease

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Translational Neurodegeneration 2023年第1期12卷 170-188页

作者： Hyunkyung Mo Juryun Kim Jennifer Yejean Kim jang Woon Kim Heeju Han Si Hwa Choi Yeri Alice Rim ji Hyeon Ju Present Address:CiSTEM Laboratory Catholic iPSC Research CenterCollege of MedicineThe Catholic University of KoreaSeoul 06591Republic of Korea Department of Biomedicine and Health Science College of MedicineThe Catholic University of KoreaSeoul 06591Republic of Korea YiPSCELL IncOmnibus ParkBanpo-daero 222Seocho-guSeoul 06591Republic of Korea Department of Biology Georgetown University3700 O St NWWashingtonDC 20057USA Division of Rheumatology Department of Internal MedicineSeoul St.Mary’s HospitalInstitute of Medical ScienceCollege of MedicineThe Catholic University of KoreaSeoul 06591Republic of Korea

Background Alzheimer’s disease(AD)is the most common neurodegenerative disorder in the elderly,resulting in gradual destruction of cognitive *** on the development of various AD treatments is underway;however,no definitive treatment has been developed ***,we present induced pluripotent stem cell(iPSC)-derived cortical neural stem cell secretome(CNSC-SE)as a new treatment candidate for AD and explore its *** We first assessed the effects of CNSC-SE treatment on neural maturation and electromagnetic signal during cortical nerve cell *** to confirm the efficacy in vivo,CNSC-SE was administered to the 5×FAD mouse model through the nasal cavity(5μg/g,once a week,4 weeks).The cell-mediated effects on nerve recovery,amyloid beta(Aβ)plaque aggregation,microglial and astrocyte detection in the brain,and neuroinflammatory responses were *** analysis of iPSC-derived CNSC-SE revealed that it contained components that could exert neuro-protective effects or amplify cognitive restorative *** Human iPSC-derived CNSC-SE increased neuronal proliferation and dendritic structure formation in ***,CNSC-SE-treated iPSC-derived cortical neurons acquired electrical network activity and action potential *** 5×FAD mice treated with CNSC-SE showed memory restoration and reduced Aβplaque *** Our findings suggest that the iPSC-derived CNSC-SE may serve as a potential,non-invasive therapeutic option for AD in reducing amyloid infiltration and restoring memory.

关键词： Induced pluripotent stem cells Alzheimer’s disease Cortical neural stem cells Secretome Intranasal administration Memory disorders Neuroprotective agents

Identifying and Verifying Vulnerabilities through PLC Network Protocol and Memory Structure Analysis

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Computers, Materials & Continua 2020年第10期65卷 53-67页

作者： Joo-Chan Lee Hyun-Pyo Choi jang-Hoon Kim Jun-Won Kim Da-Un Jung ji-Ho Shin Jung-Taek Seo Department of Information Security Engineering Soonchunhyang UniversityAsan31538Korea

Cyberattacks on the Industrial Control System(ICS)have recently been increasing,made more intelligent by advancing *** such,cybersecurity for such systems is attracting *** a core element of control devices,the Programmable Logic Controller(PLC)in an ICS carries out on-site control over the ICS.A cyberattack on the PLC will cause damages on the overall ICS,with Stuxnet and Duqu as the most representative ***,cybersecurity for PLCs is considered essential,and many researchers carry out a variety of analyses on the vulnerabilities of PLCs as part of preemptive efforts against *** this study,a vulnerability analysis was conducted on the XGB *** vulnerabilities were identified by analyzing the network protocols and memory structure of PLCs and were utilized to launch replay attack,memory modulation attack,and FTP/Web service account theft for the verification of the *** on the results,the attacks were proven to be able to cause the PLC to malfunction and disable it,and the identified vulnerabilities were defined.

关键词： Industrial control system programmable logic controller cybersecurity network protocol vulnerability

A Structural Topic Model for Exploring User Satisfaction with Mobile Payments

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Computers, Materials & Continua 2022年第11期73卷 3815-3826页

作者： jang Hyun Kim jisung jang Yonghwan Kim Dongyan Nan Department of Human-Artificial Intelligence Interaction Sungkyunkwan UniversitySeoul03063Korea Department of Interaction Science Sungkyunkwan UniversitySeoul03063Korea Department of Applied Artificial Intelligence Sungkyunkwan UniversitySeoul03063Korea NAVER Green Factory Seongnam13561Korea

This study explored user satisfaction with mobile payments by applying a novel structural topic ***,we collected 17,927 online reviews of a specific mobile payment(i.e.,PayPal).Then,we employed a structural topic model to investigate the relationship between the attributes extracted from online reviews and user satisfaction with mobile ***,we discovered that“lack of reliability”and“poor customer service”tend to appear in negative ***,the terms“convenience,”“user-friendly interface,”“simple process,”and“secure system”tend to appear in positive *** the basis of information system success theory,we categorized the topics“convenience,”“user-friendly interface,”and“simple process,”as system *** addition,“poor customer service”was categorized as service ***,based on the previous studies of trust and security,“lack of reliability”and“secure system”were categorized as trust and security,*** outcomes indicate that users are satisfied when they perceive that system quality and security of specific mobile payments are *** the contrary,users are dissatisfied when they feel that service quality and reliability of specific mobile payments is ***,our research implies that a novel structural topic model is an effective method to explore mobile payment user experience.

关键词： Mobile payment user satisfaction online review structural topic model