Mesenchymal stem cells for enhancing biological healing after meniscal injuries
作者机构：T.H.Chan School of Public HealthHarvard UniversityBostonMA 02115United States Department of Biomedical SciencesKorea University College of MedicineSeoul 02841SeoulSouth Korea Department of Orthopaedic SurgeryAnam HospitalKorea University College of MedicineSeoul 02841SeoulSouth Korea Department of Orthopaedic SurgeryGuro HospitalKorea University College of MedicineSeoul 08308SeoulSouth Korea Department of Orthopaedic SurgeryBarunsesang HospitalSeongnam 13497South Korea
出 版 物：《World Journal of Stem Cells》 (世界干细胞杂志（英文版）（电子版）)
年 卷 期：2021年第13卷第8期
页 面：1005-1029页
核心收录：
学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学]
基 金：Supported by Technology Innovation Program(or Industrial Strategic Technology Development Program)funded by the Ministry of Trade Industry&Energy(MOTIE Korea) No.20003688
主 题：Meniscus Meniscus healing Cell-based treatment Mesenchymal stem cell Tissue engineering
摘 要：The meniscus is a semilunar fibrocartilage structure that plays important roles in maintaining normal knee biomechanics and *** roles of the meniscus,including load distribution,force transmission,shock absorption,joint stability,lubrication,and proprioception,have been well *** to the meniscus can disrupt overall joint stability and cause various symptoms including pain,swelling,giving-way,and *** treated properly,it can lead to early degeneration of the knee *** meniscal injuries remain a significant challenge due to its low intrinsic healing potential,most notably in avascular and aneural inner two-thirds of the area,more efficient repair methods are *** stem cells(MSCs)have been investigated for their therapeutic potential in vitro and in *** far,the application of MSCs,including bone marrow-derived,synovium-derived,and adipose-derived MSCs,has shown promising results in preclinical studies in different animal *** preclinical studies could be categorized into intra-articular injection and tissueengineered construct application according to delivery *** promising results in preclinical studies,there is still a lack of clinical *** review describes the basic knowledge,current treatment,and recent studies regarding the application of MSCs in treating meniscal *** directions for MSC-based approaches to enhance meniscal healing are suggested.
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