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Rare Metals 2024年第2期43卷 682-691页

作者： ji Zhou bin-bin liu Hu Zheng Wen-Qing Ma Qian Li Cai-Xia Xu Institute for Advanced Interdisciplinary Research(iAIR) Collaborative Innovation Center of Technology and Equipment for Biological Diagnosis and Therapy in Universities of ShandongSchool of Chemistry and Chemical EngineeringUniversity of JinanJinan250022China

Co_(3)V_(2)O_(8)/Co_(3)O_(4)/Ti_(3)C_(2)T_(x) composite was easily synthesized via one-step succinct-operated hydrothermal *** interconnected Co_(3)V_(2)O_(8)/Co_(3)O_(4) nanowires network can in-situ grow and anchor on the surface of Ti_(3)C_(2)T_(x) via the strong Co-F bonds and contribute tremendously to depress Ti_(3)C_(2)T_(x) *** from the synergistically interplayed effect among the multiple interfaces and high conductivity of Ti_(3)C_(2)T_(x) as well as outstanding stability of the as-designed nanostructure,the optimum Co_(3)V_(2)O_(8)/Co_(3)O_(4)/Ti_(3)C_(2)T_(x)electrode reaches a commendable specific capacitance(up to 3800 mF·cm^(−2)),great rate capability(80%capacitance retention after 20-times current increasing),and preeminent cycling stability(95.4%/85.5%retention at 7000th/20,000th cycle).Moreover,the all-solid-state asymmetric supercapacitor based on Co_(3)V_(2)O_(8)/Co_(3)O_(4)/Ti_(3)C_(2)T_(x) and active carbon can deliver a high energy density of 84.0μWh·cm^(−2) at the power energy of 3.2 mW·cm^(−2),and excellent cycling durability with 87.0%of initial capacitance retention upon 20,000 *** work provides a practicable pathway to tailor MXene-based composites for high-performance supercapacitor.

关键词： Ti_(3)C_(2)T_(x) Co_(3)V_(2)O_(8)/Co_(3)O_(4) Heterostructure Cathode Supercapacitor

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Ultrasound Assessraent of Intima-media Thickness and Diameter of Carotid Arteries in Patients Undergoing Hemodialysis or Renal Transplantation

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Current Medical Science 2018年第4期38卷 727-733页

作者： Zhao-jun Li Lian-fang DU Yan QIN ji-bin liu Xiang-hong LUO Department of Ultrasound Shanghai General Hospital Shanghai Jiao Tong University Shanghai 200080 China Department of Urology Shanghai General Hospital Shanghai Jiao Tong University Shanghai 200080 China Department of Radiology Thomas Jefferson University Philadelphia 19107 USA Department of Echocardiography Shanghai General Hospital Shanghai Jiao Tong University Shanghai 200080 China

Renal transplant （RT） recipients have a high risk of developing cardiovascular diseases. However, the effects of renal transplantation on the development of arteriosclerosis have been controversial. The carotid intima-media thickness （CIMT） and diameter （CD） are important indicators of vascular remodeling and arteriosclerosis. In this study, 31 patients with hemodialysis （HD）, 31 RT recipients and 84 age- and gender-matched control subjects were enrolled. Their CIMT and CD were measured by ultrasonic radiofrequency tracking, and the linear regression models and Z test were used to identify the progression of arteriosclerosis and the risk factors. Compared with HD group, RT group had significantly lower CIMT and CD. CIMT was found to be associated with age, body weight, resistance index and diastolic velocity, while CD was associated significantly with age, body weight, pulsatility index, end diastolic velocity and diastolic blood pressure （DBP）, respectively. The correlation curves between CIMT and age showed the slopes of curves were decreased successively in control, RT and HD groups, and the curves between CD and age showed the slopes were decreased in order of RT 〉 control 〉 HD groups. It was concluded that CIMT and CD were significantly correlated with age in RT and moderately with age in HD patients. RT could reduce the progress of arteriosclerosis in patients with end-stage renal disease.

关键词： ultrasonic radiofrequency tracking renal transplantation arteriosclerosis carotid intima-media thickness age

Insight into the selective separation of CO_(2)from biomass pyrolysis gas over metal-incorporated nitrogen-doped carbon materials:a first-principles study

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Frontiers of Chemical Science and Engineering 2024年第3期18卷 1-12页

作者： Li Zhao Xinru liu Zihao Ye bin Hu Haoyu Wang ji liu bing Zhang Qiang Lu National Engineering Research Center of New Energy Power Generation North China Electric Power UniversityBeijing102206China

The composition of biomass pyrolysis gas is complex,and the selective separation of its components is crucial for its further ***-incorporated nitrogen-doped materials exhibit enormous potential,whereas the relevant adsorption mechanism is still ***,16 metal-incorporated nitrogen-doped carbon materials were designed based on the density functional theory calculation,and the adsorption mechanism of pyrolysis gas components H2,CO,CO_(2),CH_(4),and C2H6 was *** results indicate that metal-incorporated nitrogen-doped carbon materials generally have better adsorption effects on CO and CO_(2)than on H_(2),CH_(4),and C_(2)H_(6).Transition metal Mo-and alkaline earth metal Mg-and Ca-incorporated nitrogen-doped carbon materials show the potential to separate CO and CO_(2).The mixed adsorption results of CO_(2)and CO further indicate that when the CO_(2)ratio is significantly higher than that of CO,the saturated adsorption of CO_(2)will precede that of ***,the three metal-incorporated nitrogen-doped carbon materials can selectively separate CO_(2),and the alkaline earth metal Mg-incorporated nitrogen-doped carbon material has the best *** study provides theoretical guidance for the design of carbon capture materials and lays the foundation for the efficient utilization of biomass pyrolysis gas.

关键词： CO_(2)capture biomass pyrolysis gas selective adsorption carbon materials first-principles

Span-based joint entity and relation extraction augmented with sequence tagging mechanism

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Science China(Information Sciences) 2024年第5期67卷 84-98页

作者： bin ji Shasha LI Hao XU jie YU Jun MA Huijun liu jing YANG College of Computer National University of Defense Technology

Span-based joint extraction simultaneously conducts named entity recognition(NER) and relation extraction(RE) in a text span form. However, since previous span-based models rely on span-level classifications, they cannot benefit from token-level label information, which has been proven advantageous for the task. In this paper, we propose a sequence tagging augmented span-based network(STSN), a spanbased joint model that can make use of token-level label information. In STSN, we construct a core neural architecture by deep stacking multiple attention layers, each of which consists of three basic attention *** the one hand, the core architecture enables our model to learn token-level label information via the sequence tagging mechanism and then uses the information in the span-based joint extraction; on the other hand, it establishes a bi-directional information interaction between NER and RE. Experimental results on three benchmark datasets show that STSN consistently outperforms the strongest baselines in terms of F1,creating new state-of-the-art results.

关键词： joint extraction named entity recognition relation extraction span sequence tagging mechanism

Quantitative Assessment of Hepatic Fibrosis by Contrast-enhanced Ultrasonography

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Chinese Medical Sciences Journal 2011年第4期26卷 208-215页

作者： Ming-bo Zhang En-ze Qux En-ze Qu ji-bin liu jin-rui Wang Department of Ultrasound Peking University Third Hospital Beijing 100191 China Inner Mongolia Institute of Ultrasound Erdos 017000 China

Objective To explore the contrast-enhanced ultrasonographic features for quantitative assessment of hepatic fibrosis. Methods 86 patients with chronic viral hepatitis B were enrolled in this study from March 2007 to August 2009. The patients were classified into 5 groups (S0-S4) according to fibrosis stage evaluated with ultrasound guided liver biopsy. New contrast-enhanced ultrasonography (CEUS) features including area under the time-intensity curve (TIC) of portal venous phase/hepatic arterial phase (Qp/Qa) and intensity of portal venous phase/hepatic arterial phase (Ip/Ia) were used to detect the blood supply ratio (portal vein/hepatic artery) in each group. Arrival time of portal vein trunk (Tp) and decreasing rate of TIC (β ) were also analyzed. Results Qp/Qa and Ip/Ia decreased from S0 to S4, while Tp and β increased. These 4 features were significantly correlated with the degree of fibrosis (P<0.001) and were significantly different among the five groups (P<0.001). Sensitivity and specificity of Ip/Ia were 80% and 86% for groups ≥S1, 75% and 86% for groups ≥ S2, 71% and 84% for groups ≥ S3, and 76% and 80% for group S4, respectively. Sensitivity and specificity of Qp/Qa were 70% and 88% for groups ≥ S1, 80% and 76% for groups ≥ S2, 74% and 70% for groups ≥ S3, and 81% and 95% for group S4, respectively. Conclusion Ip/Ia and Qp/Qa could be adopted as reliable, non-invasive features for quantitative assessment of hepatic fibrosis.

关键词： hepatic fibrosis contrast-enhanced ultrasonography quantitative non- invasive

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Effect of a poloxamer 407-based thermosensitive gel on minimization of thermal injury to diaphragm during microwave ablation of the liver

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World Journal of Gastroenterology 2017年第12期23卷 2141-2148页

作者： Li-Li Zhang Gui-Min Xia Yu-jiang liu Rui Dou John Eisenbrey ji-bin liu Xiao-Wei Wang Lin-Xue Qian Department of Ultrasound Beijing Friendship Hospital Capital Medical University Department of Pharmaceutics Institute of Medicinal Biotechnology Chinese Academy of Medical Science and Peking Union Medical College Department of Radiology Thomas Jefferson University

AIM To assess the insulating effect of a poloxamer 407(P407)-based gel during microwave ablation of liver adjacent to the *** We prepared serial dilutions of P407, and 22.5%(w/w) concentration was identified as suitable for ablation procedures. Subsequently, microwave ablations were performed on the livers of 24 rabbits(gel, saline, control groups, n = 8 in each). The P407 solution and 0.9% normal saline were injected into the potential space between the diaphragm and liver in experimental groups. No barriers were applied to the controls. After microwave ablations, the frequency, size and degree of thermal injury were compared histologically among the three groups. Subsequently, another 8 rabbits were injected with the P407 solution and microwave ablation was performed. The levels of alanine aminotransferase(ALT), aspartate aminotransferase(AST), blood urea nitrogen(BUN) and creatinine(Cr) in serum were tested at 1 d before microwave ablation and 3 and 7 d after operation. RESULTS In vivo ablation thermal injury to the adjacent diaphragm was evaluated in the control, saline and 22.5% P407 gel groups(P = 0.001-0.040). However, there was no significant difference in the volume of ablation zone among the three groups(P > 0.05). Moreover, there were no statistical differences among the preoperative and postoperative gel groups according to the levels of ALT, AST, BUN and Cr in serum(all P > 0.05).CONCLUSION Twenty-two point five percent P407 gel could be a more effective choice during microwave ablation of hepatic tumors adjacent to the diaphragm. Further studies for clinical translation are warranted.

关键词： Microwave ablation Injury Hepatocellular carcinoma Poloxamer Hydrodissection

Can contrast enhanced ultrasound differentiate intrahepatic cholangiocarcinoma from hepatocellular carcinoma?

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World Journal of Gastroenterology 2020年第27期26卷 3938-3951页

作者： jia-Yan Huang jia-Wu Li Wen-Wu Ling Tao Li Yan Luo ji-bin liu Qiang Lu Department of Medical Ultrasound West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Anesthesiology West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Radiology Thomas Jefferson UniversityPhiladelphiaPA 19107United States

BACKGROUND Hepatocellular carcinoma(HCC)and intrahepatic cholangiocarcinoma(ICC)differ in treatment and prognosis,warranting an effective differential diagnosis between *** LR-M category in the contrast-enhanced ultrasound(CEUS)liver imaging reporting and data system(LI-RADS)was set up for lesions that are malignant but not specific to ***,a substantial number of HCC cases in this category elevated the diagnostic *** To investigate the possibility and efficacy of differentiating ICC from HCC classified in the LR-M category according to the CEUS *** Patients with complete CEUS records together with pathologically confirmed ICC and LR-M HCC(HCC classified in the CEUS LI-RADS LR-M category)between January 2015 and October 2018 were included in this retrospective *** ICC was assigned a category as per the CEUS *** enhancement pattern,washout timing,and washout degree between the ICC and LR-M HCC were compared using theχ2 *** regression analysis was used for prediction of *** operating characteristic(ROC)curve analysis was used to investigate the possibility of LR-M criteria and serum tumor markers in differentiating ICC from LR-M *** A total of 228 nodules(99 ICCs and 129 LR-M HCCs)in 228 patients were *** mean sizes of ICC and LR-M HCC were 6.3±2.8 cm and 5.5±3.5 cm,respectively(P=0.03).Peripheral rim-like arterial phase hyperenhancement(APHE)was detected in 50.5%(50/99)of ICCs vs 16.3%(21/129)of LR-M HCCs(P0.05).Marked washout was observed in 23.2%(23/99)of ICCs and 7.8%(10/129)of LR-M HCCs(P=0.002),while this feature did not show up alone either in ICC or LR-M *** hyperenhancement was detected in 15.2%(15/99)of ICCs and 37.2%(48/129)of LR-M HCCs(P<0.001).The logistic regression showed that rim APHE,carbohydrate antigen 19-9(CA 19-9),and alpha fetoprotein(AFP)had significant correlation

关键词： Diagnosis Contrast enhanced ultrasound Hepatocellular carcinoma Intrahepatic cholangiocarcinoma Liver imaging reporting and data system

PREPARATION OF POLYELECTROLYTE MULTILAYER COATED MICROBUBBLES FOR USE AS ULTRASOUND CONTRAST AGENT

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Chinese Medical Sciences Journal 2008年第2期23卷 103-107页

作者： Zhan-wen Xing Heng-te Ke Shao-qin liu Zhi-fei Dai jin-rui Wang ji-bin liu Nanomedicine and Biosensor Laboratory Bio-X Center Harbin Institute of Technology Harbin 150080 Department of Ultrasonography Third Hospital Peking University Beijing 100083 Ultrasound Research and Education Institute Thomas Jefferson University Hospital Philadelphia 19107 USA

Objeelive To prepare and characterize polyelectrolyte multilayer film coated microbubbles for use as ultrasound contrast agent （UCA） and evaluate its effects in ultrasonic imaging on normal rabbit＇s fiver parenchyma. Methods Perfluorocarbon （PFC）-containing microbubbles （ST68-PFC） were prepared by sonication based on suffactant （ Span 60 and Tween 80）. Subsequently, the resulting ST68-PFC microbubbles were coated using oppositely charged polyelectrolytes by microbubble-templated layer-by-layer self-assembly technique via electrostatic interaction. The enhancement effects in ultrasonic imaging on normal rabbit＇s liver parenchyma were assessed. Results The obtained microbubbles exhibited a narrow size distribution. The polyelectrolytes were successfully assembled onto the surface of ST68-PFC microbubbles. In vivo experiment showed that polyelectrolyte multilayer film coated UCA effectively enhanced the imaging of rabbit＇s liver parenchyma. Conclusions The novel microbubbles UCA coated with polyelectrolyte multilayer, when enabled more function, has no obvious difference in enhancement effects compared with the pre-modified microbubbles. The polymers with chemically active groups （ such as amino group and carboxyl group） can be used as the outermost layer for attachment of targeting ligands onto microbubbles, allowing selective targeting of the microbubbles to combine with desired sites.

关键词： microbubbles ultrasound contrast agent layer-by-layer self-assembly technique polyelectrolyte

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Diagnostic value of two dimensional shear wave elastography combined with texture analysis in early liver fibrosis

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World Journal of Clinical Cases 2019年第10期7卷 1122-1132页

作者： Zhao-Cheng jian jin-Feng Long Yu-jiang liu Xiang-Dong Hu ji-bin liu Xian-Quan Shi Wei-Sheng Li Lin-Xue Qian Department of Ultrasound Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Medical Imaging Center Affiliated Hospital of Weifang Medical UniversityWeifang 261031Shandong ProvinceChina Institute of Ultrasound Thomas Jefferson University HospitalPhiladelphiaPA 19107United States

BACKGROUND Staging diagnosis of liver fibrosis is a prerequisite for timely diagnosis and therapy in patients with chronic hepatitis *** recent years,ultrasound elastography has become an important method for clinical noninvasive assessment of liver fibrosis stage,but its diagnostic value for early liver fibrosis still needs to be further *** this study,the texture analysis was carried out on the basis of two dimensional shear wave elastography(2D-SWE),and the feasibility of 2D-SWE plus texture analysis in the diagnosis of early liver fibrosis was *** To assess the diagnostic value of 2D-SWE combined with textural analysis in liver fibrosis *** This study recruited 46 patients with chronic hepatitis *** underwent 2DSWE and texture analysis;Young's modulus values and textural patterns were obtained,*** pattern was analyzed with regard to contrast,correlation,angular second moment(ASM),and *** results of biopsy specimens were the gold standard;comparison and assessment of the diagnosis efficiency were conducted for 2D-SWE,texture analysis and their *** 2D-SWE displayed diagnosis efficiency in early fibrosis,significant fibrosis,severe fibrosis,and early cirrhosis(AUC>0.7,P0.7,P0.05).Combined diagnosis(PRE)displayed diagnostic efficiency(AUC>0.7,P<0.01)for all fibrosis stages with respective AUC of 0.952(0.841-0.994),

关键词： Elastography Two-dimensional shear wave Texture analysis Liver fibrosis,Staging

Contrast-enhanced ultrasound in association with serum biomarkers for differentiating combined hepatocellular-cholangiocarcinoma from hepatocellular carcinoma and intrahepatic cholangiocarcinoma

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World Journal of Gastroenterology 2020年第46期26卷 7325-7337页

作者： jie Yang Ya-han Zhang jia-Wu Li Ying-Yu Shi jia-Yan Huang Yan Luo ji-bin liu Qiang Lu Department of Medical Ultrasound West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Pathology West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Radiology Thomas Jefferson UniversityPhiladelphiaPA 19107United States

BACKGROUND Combined hepatocellular-cholangiocarcinoma(CHC)is a rare type of primary liver *** to its complex histopathological characteristics,the imaging features of CHC can overlap with those of hepatocellular carcinoma(HCC)and intrahepatic cholangiocarcinoma(ICC).AIM To investigate the possibility and efficacy of differentiating CHC from HCC and ICC by using contrast-enhanced ultrasound(CEUS)Liver Imaging Reporting and Data System(LI-RADS)and tumor *** Between January 2016 and December 2019,patients with histologically confirmed CHC,ICC and HCC with chronic liver disease were *** diagnostic formula for CHC was as follows:(1)LR-5 or LR-M with elevated alphafetoprotein(AFP)and carbohydrate antigen 19-9(CA19-9);(2)LR-M with elevated AFP and normal CA19-9;or(3)LR-5 with elevated CA19-9 and normal *** sensitivity,specificity,accuracy and area under the receiver operating characteristic curve were calculated to determine the diagnostic value of the *** After propensity score matching,134 patients(mean age of 51.4±9.4 years,108 men)were enrolled,including 35 CHC,29 ICC and 70 HCC *** on CEUS LI-RADS classification,74.3%(26/35)and 25.7%(9/35)of CHC lesions were assessed as LR-M and LR-5,*** rates of elevated AFP and CA19-9 in CHC patients were 51.4%and 11.4%,respectively,and simultaneous elevations of AFP and CA19-9 were found in 8.6%(3/35)of CHC *** sensitivity,specificity,positive predictive value,negative predictive value,accuracy and area under the receiver operating characteristic curve of the aforementioned diagnostic criteria for discriminating CHC from HCC and ICC were 40.0%,89.9%,58.3%,80.9%,76.9%and 0.649,*** considering the reported prevalence of CHC(0.4%-14.2%),the positive predictive value and NPV were revised to 1.6%-39.6%and 90.1%-99.7%,*** CHCs are more likely to be classified as LR-M than LR-5 by CEUS *** combination of the CEUS LI-R

关键词： Combined hepatocellular-cholangiocarcinoma Contrast-enhanced ultrasound Liver imaging reporting and data system Sensitivity Diagnosis Liver neoplasms