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A Volumetric and Functional Connectivity MRI Study of Brain Arginine-Vasopressin Pathways in Autistic Children

Neuroscience Bulletin 2017年第2期33卷 130-142页

作者： Xiao-jing Shou Xin-jie Xu Xiang-Zhu Zeng Ying Liu Hui-Shu Yuan Yan Xing Mei-Xiang jia Qing-Yun Wei Song-Ping han Rong Zhang ji-Sheng han Neuroscience Research Institute Peking UniversityBeijing 100191China Department of Neurobiology School of Basic Medical SciencesPeking UniversityBeijing 100191China Key Laboratory for Neuroscience Ministry of Education/National Health and Family Planning CommissionPeking UniversityBeijing 100191China Radiology Department Peking University Third HospitalBeijing 100191China Department of Pediatrics Peking University Third HospitalBeijing 100191China Mental Health Institute Peking UniversityBeijing 100191China Key Laboratory of Ministry of National Health and Family Planning Commission Beijing 100191China Sunshine Friendship Rehabilitation Centre Beijing 100085China

Dysfunction of brain-derived arginine-vasopressin（AVP） systems may be involved in the etiology of autism spectrum disorder（ASD）. Certain regions such as the hypothalamus, amygdala, and hippocampus are known to contain either AVP neurons or terminals and may play an important role in regulating complex social *** present study was designed to investigate the concomitant changes in autistic behaviors, circulating AVP levels, and the structure and functional connectivity（FC） of speci？c brain regions in autistic children compared with typically developing children（TDC） aged from 3 to5 years. The results showed：（1） children with ASD had a signi？cantly increased volume in the left amygdala and left hippocampus, and a signi？cantly decreased volume in the bilateral hypothalamus compared to TDC, and these were positively correlated with plasma AVP level.（2） Autistic children had a negative FC between the left amygdala and the bilateral supramarginal gyri compared to TDC. The degree of the negative FC between amygdala and supramarginal gyrus was associated with a higher score on the clinical autism behavior checklist.（3） The degree of negative FC between left amygdala and left supramarginal gyrus was associated with a lowering of the circulating AVP concentration in boys with ASD.（4） Autistic children showed a higher FC between left hippocampus and right subcortical area compared to TDC.（5） The circulating AVP was negatively correlated with the visual and listening response score of the childhood autism rating *** results strongly suggest that changes in structure and FC in brain regions containing AVP may be involved in the etiology of autism.

关键词： Autism Children Arginine-vasopressin MRI Structure Connectivity Behavior

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Latest insights into the global epidemiological features,screening,early diagnosis and prognosis prediction of esophageal squamous cell carcinoma

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World Journal of Gastroenterology 2024年第20期30卷 2638-2656页

作者： Yi-Xin Zhao He-Ping Zhao Meng-Yao Zhao Yan Yu Xi Qi ji-han Wang jing Lv Department of Clinical Laboratory Honghui HospitalXi’an Jiaotong UniversityXi’an 710054Shaanxi ProvinceChina Institute of Medical Research Northwestern Polytechnical UniversityXi’an 710072Shaanxi ProvinceChina

As a highly invasive carcinoma,esophageal cancer(EC)was the eighth most prevalent malignancy and the sixth leading cause of cancer-related death worldwide in *** squamous cell carcinoma(ESCC)is the major histological subtype of EC,and its incidence and mortality rates are decreasing *** to the lack of specific early symptoms,ESCC patients are usually diagnosed with advanced-stage disease with a poor prognosis,and the incidence and mortality rates are still high in many countries,especially in ***,enormous challenges still exist in the management of ESCC,and novel strategies are urgently needed to further decrease the incidence and mortality rates of *** the key molecular mechanisms underlying ESCC pathogenesis have not been fully elucidated,certain promising biomarkers are being investigated to facilitate clinical *** the advent and advancement of highthroughput technologies,such as genomics,proteomics and metabolomics,valuable biomarkers with high sensitivity,specificity and stability could be identified for ***,we aimed to determine the epidemiological features of ESCC in different regions of the world,especially in China,and focused on novel molecular biomarkers associated with ESCC screening,early diagnosis and prognosis prediction.

关键词： Esophageal squamous cell carcinoma Epidemiology Diagnosis Genomics Proteomics Metabolomics

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Unraveling templated-regulated distribution of isolated SiO4 tetrahedra in silicoaluminophosphate zeolites with high-throughput computations

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National Science Review 2022年第9期9卷 19-27页

作者： Yan Li Chao Shi Lin Li Guoju Yang Junyan Li Jun Xu Qinfen Gu Xingxing Wang ji han Tianjun Zhang Yi Li jihong Yu State Key Laboratory of Inorganic Synthesis and Preparative Chemistry Jilin University School of Textile and Clothing Yancheng Institute of Technology State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics National Center for Magnetic Resonance in Wuhan Wuhan Institute of Physics and MathematicsInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of Sciences Australian Synchrotron International Center of Future Science Jilin University

Silicoaluminophosphate(SAPO) zeolites are well-known catalytic materials because of the mild acidity originating from the isolated SiO4tetrahedra in their frameworks. Regulating the distribution of isolated SiO4tetrahedra in SAPO zeolites is formidably challenging because SiO4tetrahedra tend to agglomerate to form Si islands and the isolated SiO4tetrahedra are difficult to determine using conventional characterization techniques. Here we synthesized Si-island-free SAPO-35 zeolites by using N-methylpiperidine as a new template, which exhibited excellent thermal stability compared to conventional SAPO-35 zeolites and a substantially improved methanol-to-olefins catalytic lifetime even comparable to that of commercial SAPO-34 zeolites. More strikingly, with the aid of high-throughput computations on 44 697 structure models combined with various state-of-the-art characterization techniques, for the first time, we reveal that the host–guest interactions between template molecules and SAPO frameworks determine the specific distributions of isolated SiO4tetrahedra, which are responsible for the improvement in the chemical properties of zeolites. Our work provides an insight into the template-based regulation of isolated SiO4tetrahedra in SAPO zeolites, which opens a new avenue in the discovery of promising zeolite catalysts with optimal Si O4distribution.

关键词： acidity computational chemistry heterogeneous catalysis structure–activity relationships zeolites

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APPROXIMATION ALGORITHM FOR MAX-BISECTION PROBLEM WITH THE POSITIVE SEMIDEFINITE RELAXATION

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Journal of Computational Mathematics 2003年第3期21卷 357-366页

作者： Da-chuan Xu ji-ye han(Institute of Applied Mathematics, Academy of Mathematics and System Sciences, Chinese Academyof Sciences, Beijing 100080, China) Institute of Applied Mathematics Academy of Mathematics and System Sciences Chinese Academy of Sciences 北京 100080

Using outward rotations, we obtain an approximation algorithm for Max-Bisection problem, i.e., partitioning the vertices of an undirected graph into two blocks of equal cardinality so as to maximize the weights of crossing edges. In many interesting cases, the algorithm performs better than the algorithms of Ye and of Halperin and Zwick. The main tool used to obtain this result is semidefinite programming.

关键词： Approximation algorithm Max-Bisection problem Semidefinite programming Approximation ratio.

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High gene flows promote close genetic relationship among finewool sheep populations(Ovis aries) in China

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Journal of Integrative Agriculture 2016年第4期15卷 862-871页

作者： han ji-long YANG Min GUO Ting-ting LIU jian-bin NIU Chun-e YUAN Chao YUE Yao-jing YANG Bo-hui Lanzhou Institute of Husbandry and Pharmaceutical Sciences Chinese Academy of Agricultural Sciences Lanzhou 730050 P. R. China Institute of Animal Science Chinese Academy of Agricultural Sciences Beijing 100193 P.R. China

The aim of our present study was to construct genetic structure and relationships among Chinese fine-wool sheep breeds. 46 individuals from 25 breeds or strains were genotyped based on the Illumina Ovine 50K SNP array. Meanwhile, genetic variations among 482 individuals from 9 populations were genotyped with 10 microsatellites. In this study, we found high genetic polymorphisms for the microsatellites, while 7 loci in the Chinese superfine Merino strain （Xinjiang types）（CMS） and 5 loci in Gansu alpine superfine-wool sheep strain （GSS） groups were found deviated from Hardy-Weinberg equilibrium （HWE）. Genetic drift FsT=0.019 （P〈0.001） and high gene flows were detected in all the 7 fine-wool sheep populations. Phylogenetic analysis showed fine-wool sheep populations were clustered in a group independent from the Chinese indigenous breeds such that the 7 fine-wool sheep clustered distinct from Liangshan semifine-wool sheep （LS） and Hu sheep （HY） reflected by different population differentiation analyses. Overall, our findings suggested that all fine-wool sheep populations have close genetic relationship, which is consistent with their breeding progress. These populations, therefore, can be regarded as open-breeding populations with high levels of gene flows. Furthermore, the two superfine-wool strains, viz., CMS and GSS, might be formed by strong artificial selection and with frequent introduction of Australian Merino. Our results can assist in breeding of superfine-wool sheep and provide guidance for the cultivation of new fine-wool sheep breeds with different breeding objectives.

关键词： Chinese fine-wool sheep indigenous sheep breeds genetic relationship gene flow microsatellites

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针麻镇痛研究

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针刺研究 2016年第5期41卷 377-387页

作者：韩济生北京大学神经科学研究所北京100083

回顾针麻镇痛的科研道路,可以分为几个阶段:(1)初期探索:1958年上海和西安有一部分医生将针刺技术应用于外科手术,试图不用麻醉药或减少麻醉药用量而完成外科手术,称之为针刺麻醉(针麻)。这一创新性临床实践,引起医学界的广泛兴趣。(2)... 详细信息

回顾针麻镇痛的科研道路,可以分为几个阶段:(1)初期探索:1958年上海和西安有一部分医生将针刺技术应用于外科手术,试图不用麻醉药或减少麻醉药用量而完成外科手术,称之为针刺麻醉(针麻)。这一创新性临床实践,引起医学界的广泛兴趣。(2)临床推展:1965年开始全国许多医院进行仿效;20世纪70年代达到高潮,全国几乎所有医院全部开展针麻;进入20世纪80年代,临床应用针麻逐渐减少。(3)原理探讨:1965年开始,大量基础研究工作者参与进行人体和动物实验研究,从1970年开始的30年间,针麻镇痛研究论文持续发表,这些科研肯定了针刺镇痛疗效,并试图阐明其原理。1997年美国国立卫生研究院(NIH)举办针刺疗法听证会,证明针刺镇痛的有效性和科学性,导致国内和国际上加大了科研资助,针麻镇痛研究在全球广泛开展。(4)重点研究:2007年中国将针麻镇痛列为重点研究项目,在全国9个大医院进一步确定开展临床针麻镇痛的有效性及其相关原理的研究。确认了电针与手针有同样的镇痛效果,研制出了电针仪和经皮穴位电刺激仪器,临床实践证明其可以简化针麻镇痛步骤,便于在手术室推广应用。(5)理论总结:鉴于经络的实质尚待明确,但可以明确的是分布于穴位下的神经纤维是刺激"穴位"发挥镇痛作用不可或缺的重要成分,因此认为,可以用现代神经科学知识理解针麻实质。中国古老的针灸疗法与现代神经科学两者互相促进,提高并扩展了针刺相关疗法的临床应用,更好地实现为患者服务的目的。(6)回归现实:经过半个世纪的实践和发展,针刺具有镇痛作用的事实已得到国际科学界的认可,"针刺辅助麻醉"或"针药复合麻醉"已成为某些特定手术的首选麻醉技术。由于开展针麻镇痛研究而掀起的科研浪潮既促进了针刺疗法在全世界的应用,也推动了针灸疗法本身和神经科学的发展。但理论和实践的转化,基础和临床的交融,是永无止境的。半个世纪的实践值得加以总结,以便深入阐明原理,提高临床效果,纠正可能的错误。

关键词：针麻镇痛历史发展阶段临床应用机制研究展望

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Study for the Mechanisms of Acupuncture Analgesia

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Chinese Journal of Integrative Medicine 1995年第2期1卷 63-67页

作者： $$$$han ji-sheng (韩济生) (Neuroscience Research Center. Beijing Medical University. Beijing ) ( 100083) Neuroscience Research Center Beijing Medical University Beijing

ＳｔｕｄｙｆｏｒｔｈｅＭｅｃｈａｎｉｓｍｓｏｆＡｃｕｐｕｎｃｔｕｒｅＡｎａｌｇｅｓｉａＨａｎＪｉ－ｓｈｅｎｇ（韩济生）；（ＮｅｕｒｏｓｃｉｅｎｃｅＲｅｓｅａｒｃｈＣｅｎｔｅｒ．ＢｅｉｊｉｎｇＭｅｄｉｃａｌＵｎｉｖｅｒ... 详细信息

ＳｔｕｄｙｆｏｒｔｈｅＭｅｃｈａｎｉｓｍｓｏｆＡｃｕｐｕｎｃｔｕｒｅＡｎａｌｇｅｓｉａＨａｎＪｉ－ｓｈｅｎｇ（韩济生）；（ＮｅｕｒｏｓｃｉｅｎｃｅＲｅｓｅａｒｃｈＣｅｎｔｅｒ．ＢｅｉｊｉｎｇＭｅｄｉｃａｌＵｎｉｖｅｒｓｉｔｙ．Ｂｅｉｊｉｎｇ）（１００...

关键词：韩济生

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预应力装配式风机叶片连接段结构模拟分析

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工程力学 2016年第2期33卷 209-215页

作者：许斌韩继龙湖南大学土木工程学院湖南长沙410082 工程结构损伤诊断湖南省重点实验室(湖南大学) 湖南长沙410082

随着风力发电机功率提高,其叶片越来越长,叶片的运输难度和风险增大,成本增高,特别是在山区风场建设中愈发明显。将长叶片分段制造、运输并现场组装是解决此问题的有效途径。该文提出了一种全新的基于高强预应力螺栓连接的装配式风力发... 详细信息

随着风力发电机功率提高,其叶片越来越长,叶片的运输难度和风险增大,成本增高,特别是在山区风场建设中愈发明显。将长叶片分段制造、运输并现场组装是解决此问题的有效途径。该文提出了一种全新的基于高强预应力螺栓连接的装配式风力发电机叶片结构方案。以某兆瓦级玻璃纤维叶片为对象,确定了在离叶根16 m处进行分段时的预应力连接结构方案,利用大型有限元分析软件ABAQUS建立了连接段的精细化有限元模型,对模型在预应力以及挥舞和摆振方向4种设计荷载作用下的应力进行了分析。结果表明:在4种工况下的叶片玻璃纤维材料以及预应力连接螺栓强度均满足要求,验证了该文所提出的基于高强预应力螺栓连接的装配式风机叶片结构方案可行,该研究为解决传统风力发电机叶片的运输难题提供具有应用前景的新方法。

关键词：装配式风机叶片有限元预应力螺栓连接应力分析玻璃钢

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Recovery of natural killer cells is mainly in post-treatment period in chronic hepatitis C patients treated with sofosbuvir plus ledipasvir

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World Journal of Gastroenterology 2018年第40期24卷 4554-4564页

作者： Xiao-Xiao Wang Bi-Fen Luo han-ji jiang Xu Cong Qian jin Dan-Li Ma Lai Wei Bo Feng Peking University Hepatology Institute Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases Peking University People's Hospital

AIM To investigate how natural killer(NK) cells are affected in the elimination of hepatitis C virus(HCV) by sofosbuvir/ledipasvir, two highly effective direct-acting antivirals(DAAs). METHODS Thirteen treatment-na?ve and treatment-experienced chronic hepatitis C(CHC) patients were treated with sofosbuvir/ledipasvir, and NK cells were detected at baseline, weeks 2, 4, 8 and 12 during therapy, and week post of treatment(Pt)-12 and 24 after the end of therapy by multicolor flow cytometry and compared with those from 13 healthy controls. RESULTS All patients achieved sustained virological response. There was a significant decline in CD56^(bright) NK cell frequencies at week 8(P = 0.002) and week 12(P = 0.003), which were altered to the level comparable to healthy controls at week Pt-12, but no difference was observed in the frequency of CD56^(dim) NK cells. Compared with healthy controls, the expression levels of NKG2A, NKp30 and CD94 on NK cells from CHC patients at baseline were higher. NKG2A, NKp30 and CD94 started to recover at week 12 and reached the levels similar to those of healthy controls at week Pt-12 or Pt-24. Before treatment, patients have higher interferon(IFN)-γ and perforin levels than healthy controls, and IFN-γ started to recover at week 8 and reached the normalized level at week Pt-12. CONCLUSION NK cells of CHC patients can be affected by DAAs, and phenotypes and function of NK cells recover not at early stage but mainly after the end of sofosbuvir/ledipasvir treatment.

关键词： Direct-acting antivirals therapy Hepatitis C virus Natural killer cells Natural killer subsets

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Updates on global epidemiology,risk and prognostic factors of gastric cancer

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World Journal of Gastroenterology 2023年第16期29卷 2452-2468页

作者： Wen-Juan Yang He-Ping Zhao Yan Yu ji-han Wang Lei Guo Jun-Ye Liu jie Pu jing Lv Department of Clinical Laboratory Honghui HospitalXi'an Jiaotong UniversityXi'an 710054Shaanxi ProvinceChina Institute of Medical Research Northwestern Polytechnical UniversityXi'an 710072Shaanxi ProvinceChina Department of Spinal Surgery Honghui HospitalXi'an Jiaotong UniversityXi'an 710054Shaanxi ProvinceChina Department of Cardiology Shaanxi Provincial People’s HospitalXi'an 710068Shaanxi ProvinceChina

Gastric cancer(GC)is defined as the primary epithelial malignancy derived from the stomach,and it is a complicated and heterogeneous disease with multiple risk *** its overall declining trend of incidence and mortality in various countries over the past few decades,GC remains the fifth most common malignancy and the fourth leading cause of cancer-related death *** the global burden of GC has shown a significant downward trend,it remains severe in certain areas,such as *** ranks third in incidence and mortality among all cancer types in China,and it accounts for nearly 44.0%and 48.6%of new GC cases and GC-related deaths in the world,*** regional differences in GC incidence and mortality are obvious,and annual new cases and deaths are increasing rapidly in some developing ***,early preventive and screening strategies for GC are urgently *** clinical efficacies of conventional treatments for GC are limited,and the developing understanding of GC pathogenesis has increased the demand for new therapeutic regimens,including immune checkpoint inhibitors,cell immunotherapy and cancer *** present review describes the epidemiology of GC worldwide,especially in China,summarizes its risk and prognostic factors,and focuses on novel immunotherapies to develop therapeutic strategies for the management of GC patients.

关键词： Gastric cancer Epidemiology Risk factors Prognosis Treatment Immunotherapy

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