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Journal of Integrative Plant Biology 2015年第3期57卷 313-324页

作者： ji-hee Min Jung-Sung Chung Kyeong-Hwan Lee Cheol Soo Kim Department of Plant Biotechnology Chonnam National University Department of Agronomy Gyeongsang National University Department of Rural and Biosystems Engineering Chonnam National University

The precise roles of the B-box zinc finger family of transcription factors in plant stress are poorly *** analysis was performed on AtCOL4,an Arabidopsis thaliana ***-like 4 protein that is a putative novel transcription factor,and which contains a predicted transcriptional activation *** of an AtCOL4 promoter-b-glucuronidase（GUS） construct revealed substantial GUS activity in whole *** expression of AtCOL4 was strongly induced by abscisic acid（ABA）,salt,and osmotic *** in atcol4 resulted in increased sensitivity to ABA and salt stress during seed germination and the cotyledon greening *** contrast,AtCOL4-overexpressing plants were less sensitive to ABA and salt stress compared to the wild ***,in the presence of ABA or salt stress,the transcript levels of other ABA biosynthesis and stress-related genes were enhanced induction in AtCOL4-overexpressing and WT plants,rather than in the atcol4 ***,AtCOL4 is involved in ABA and salt stress response through the ABA-dependent signaling *** together,these findings provide compelling evidence that AtCOL4 is an important regulator for plant tolerance to abiotic stress.e

关键词： Abscisic acid B-box zinc finger family transcription factor salt stress

Laboratory characteristics of recent hepatitis A in Korea:Ongoing epidemiological shift

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World Journal of Gastroenterology 2010年第9期16卷 1115-1118页

作者： hee Won Moon jin hee Cho Mina Hur Yeo-Min Yun Won Hyeok Choe So Young kwon Chang Hong Lee Department of Laboratory Medicine Konkuk University School of MedicineKonkuk University Medical Center Department of Internal Medicine Konkuk University School of MedicineKonkuk University Medical Center

AIM:To evaluate seroprevalence of hepatitis A virus (HAV) antibody and investigate demographic,clinical,and laboratory features of recent cases in ***:For the evaluation of hepatitis A seroprevalence,we analyzed the data from 3127 subjects including,healthcare workers and patients who visited Konkuk University Hospital,a secondary referral center,from January to October *** sera with positive IgM were excluded from seroprevalence data for total HAV *** retrospectively reviewed the electronic medical records of 419 patients with HAV,who were diagnosed by the presence of serum IgM antibodies against *** patients presented at Konkuk University Hospital between August 2005 and September ***:Among 3127 sera tested,1428 (45.7%)were positive for anti-HAV *** seroprevalence was very low in teenagers or those in their twenties,increased in those in their thirties,and was > 90% in older *** children younger than 10 years,seroprevalence was increased *** patients with HAV hepatitis were in their twenties and *** γ-glutamyl transpeptidase increased with age and was significantly higher in patients older than 30 *** of severity,such as decreased albumin and increased bilirubin,were also more prominent in the older age group;however,the leukocyte count was higher and the frequency of leukopenia was lower in younger patients than in older ***:There has been an apparent epidemiological shift in HAV seroprevalence and a change in the peak age of HAV *** study could provide baseline data of recent hepatitis A in Asia.

关键词： Hepatitis A virus Seroprevalence Epidemiology Korea

Inhibitory Mechanisms of Water Extract of Oplopanax elatus on Lipopolysaccharide-lnduced Inflammatory Responses in RAW 264.7 Murine Macrophage Cells

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Chinese Journal of Integrative Medicine 2020年第9期26卷 670-676页

作者： Ki Sun kwon Hyun Lim Yong Soo kwon Myong Jo Kim ji Hye Yoo Nam Ho Yoo Hyun Pyo Kim College of Pharmacy Kangwon National UniversityChuncheon(24341)Republic of Korea Department of Bio-Resource Sciences Kangwon National UniversityChuncheon(24341)Republic of Korea Bioherb Research Institute Kangwon National UniversityChuncheon(24341)Republic of Korea

Objective:To study the anti-inflammatory action and cellular mechanism of Oplopanax ***:A hot water extract of OE(WOE)was prepared and a major constituent,syringin,was successfully *** content in WOE was found to be 214.0 p.g/g dried plant(w/w).Their anti-inflammatory activities were examined using RAW 264.7 macrophages and a mouse model of croton oil-induced ear ***:In lipopolysaccharide(LPS)-treated RAW 264.7 cells,a mouse macrophage cell line,WOE was found to significantly and strongly inhibit cyclooxygenase-2(COX-2)-induced prostaglandin E2(PGE2)production[half maximal inhibitory concentration(IC50)=135.2μg/mL]and inducible nitric oxide synthase(iNOS)-induced NO production(IC50=242.9μg/mL).In the same condition,WOE was revealed to inhibit NO production by downregulating iNOS expression,mainly by interrupting mitogen activated protein kinases(MAPKs)/activator protein-1(AP-1)*** activation of all three major MAPKs,p38 MAPK,extracellular signal-regulated kinase(ERK),and c-Jun N-terminal kinase,was inhibited by WOE(50-300μg/mL).On the other hand,WOE reduced PGE2 production by inhibiting COX-2 enzyme activity,but did not affect COX-2 expression *** addition,WOE inhibited the production of proinflammatory cytokines such as interleukin-6 and tumor necrosis factor-α.In croton oil-induced ear edema in mice,oral administration of WOE(50-300 mg/kg)dose-dependently inhibited edematic ***:Water extract of OE exhibited multiple anti-inflammatory action mechanisms and may have potential for treating inflammatory disorders.

关键词： Oplopanax elatus Chinese medicine stem syringin anti-inflammation RAW 264.7

Tetramic acid-motif natural products from a marine fungus Tolypocladium cylindrosporum FB06 and their anti-Parkinson activities

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Marine Life Science & Technology 2024年第1期6卷 84-92页

作者： Yuna Jung Chaesun kwon Taeyeon Kim jin Woo Lee Min-Kyoo Shin Sang hee Shim Natural Products Research Institute College of PharmacySeoul National UniversitySeoul 08826Republic of Korea College of Pharmacy and Research Institute of Pharmaceutical Sciences Seoul National UniversitySeoul 08826Republic of Korea College of Pharmacy Duksung Women’s UniversitySeoul 01369Republic of Korea

Tetramic acid-containing natural products are attracting significantly increasing attention from biologists and chemists due to their intriguing structures and biological *** the present study,two new tetramic acid alkaloids tolypyridone I(1)and tolypyridone J(2),together with five known ones(3–7),were isolated from cultures of a marine fungus Tolypocladium cylindrosporum FB06 isolate obtained from a marine sediment in Beaufort sea of North *** structures were elucidated using 1D,2D NMR,and *** configurations were established on the basis of 1H coupling constants,ROESY correlations and DP4 *** 2 was isolated as mixtures of rotational isomers with C-3 to C-7 axis between 4-hydroxy-2-pyridone and 1-ethyl-3,5-dimethylcyclohexane,hindering *** our unbiased screening to discover neuroprotective compounds in an in vitro Parkinson’s disease(PD)model,SH-SY5Y dopaminergic cells were treated with isolated compounds followed by treatment with 1-methyl-4-phenylpyridinium(MPP^(+)),a parkinsonian *** tested compounds,F-14329(7)significantly protected cells from MPP^(+)-induced ***^(+)-mediated cell death is known to be related to the regulation of Bcl-2 family proteins,specifically the down-regulation of anti-apoptotic Bcl-2 and the up-regulation of pro-apoptotic Bax *** with 2 mmol/L of MPP^(+)for 24 h significantly reduced Bcl-2 levels compared to control treated with ***,treatment with F-14329(7)attenuated such *** study demonstrates that tetramic acid-motif compounds could be potential lead compounds for treating PD.

关键词： Tolypocladium cylindrosporum Tetramic acid Tolypyridone Parkinson’s disease

Small cell carcinoma of the liver and biliary tract without jaundice

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World Journal of Gastroenterology 2013年第44期19卷 8146-8150页

作者： Jae-Min Jo Yoo-Kyung Cho Chang-Lim Hyun Kyoung-hee Han ji-Young Rhee Jung-Mi kwon Woo-Kun Kim Sang-Hoon Han Department of Internal Medicine Jeju National University Hospital Jeju-si 890-716 Jeju Self-Governing Province South Korea Department of Pathology Jeju National University Hospital Jeju-si 890-716 Jeju Self-Governing ProvinceSouth Korea Jeju National University School of Medicine Jeju-si 890-716 Jeju Self-Governing Province South Korea

An 80-year-old woman presenting with chest pain was found to have a large,lobulated soft tissue mass in the liver and nearby tissues on abdominal computed tomography(CT).The tumor had invaded the common hepatic artery and main portal *** developed 4 wk later,at which point,a pancreas and biliary CT scan revealed a large mass in the right lobe of the liver and a hilar duct obstruction,which was found to be a small cell *** its rarity,liver and bile duct small cell carcinoma should be considered in the differential diagnosis of atypical chest pain without jaundice.

关键词： Extrapulmonary small cell carcinoma Jaundice Liver mass Bile duct mass Neuroendocrine tumor

Orostachys japonicus ethyl acetate fraction suppresses MRSA biofilm formation

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Asian Pacific Journal of Tropical Medicine 2020年第1期13卷 38-45页

作者： Jae-Hyeon Kim Su-Yeon Han ji-Hye kwon Dong-Seok Lee Department of Smart Foods and Drugs Graduate School of Inje UniversityGimhae 50834Republic of Korea

Objective:To investigate the effect of Orostachys(O.)japonicus,a perennial herbaceous plant of the Family Crassulaceae,on biofilm formed by methicillin-resistant Staphylococcus aureus(MRSA).Methods:Powdered *** was extracted by 95%methanol,concentrated,and then,systematically fractionated with n-hexane,dichloromethane(DCM),ethyl acetate(EtOAc),n-butanol,and H2 O according to *** them,the flavonoid-rich EtOAc fraction demonstrated the highest antibacterial activity and was used in this *** the biofilm inhibition assay,cell-surface attachment assay,confocal laser scanning microscopy,latex agglutination assay,and real time qRT-PCR,we examined whether the EtOAc fraction inhibited the formation of MRSA ***:The EtOAc fraction exhibited distinct activity against biofilm formation and cell-surface attachment of MRSA up to 1 mg/m L through down-regulating the expression of mec A gene and the production and agglutination of penicillin-binding protein 2 a as solidly observed in biofilm inhibition assay,cell-suface attachment assay,confocal laser scanning microscopy,latex agglutination assay,and real time qRT-PCR ***:These results suggest that *** could be utilized as a potential resource for the development of new antibiofilm formation of MRSA and antibacterial agents in the future.

关键词： Orostachys japonicus MRSA Biofilm formation

Uterine rupture due to adenomyosis in an adolescent:A case report and review of literature

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World Journal of Clinical Cases 2023年第32期11卷 7888-7894页

作者： Nah Ihm Kim ji Shin Lee Jong hee Nam Department of Pathology Chonnam National University HospitalGwangju 61469South Korea Department of Pathology Chonnam National University Hwasun HospitalHwasun 58128South Korea Department of Pathology Chonnam National University Medical SchoolGwangju 61469South Korea

BACKGROUND Uterine rupture is a fatal medical complication with a high mortality *** cases of uterine rupture occur in late pregnancy or during labor and are mainly related to uterine scarring due to previous surgical *** is a possible risk factor for uterine ***,spontaneous uterine rupture due to severe adenomyosis in a non-gravida-teenaged female has not been reported in the literature to *** SUMMARY A 16-year-old girl was referred to our hospital for acute abdominal pain and hypovolemic shock with a blood pressure of 90/50 *** studies revealed a huge endometrial mass with multiple nodules in the lung,suggesting lung *** patient underwent an emergency total hysterectomy and wedge resection of the lung ***,the uterus showed diffuse adenomyosis with glandular and stromal *** nodules were endometrioma with massive *** demonstrated that the tumor cells were positive for PAX8,ER,and PR expression,leading to a final diagnosis of pulmonary endometriosis and uterine *** surgery,the patient remains in good condition without *** This is the first case of spontaneous uterine rupture due to adenomyosis in a nongravida adolescent.

关键词： Uterus Adenomyosis Malignancy Endometrioma Case report

Design of 512-bit logic process-based single poly EEPROM IP

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Journal of Central South University 2011年第6期18卷 2036-2044页

作者：金丽妍 JANG ji-Hye 余忆宁 HA Pan-Bong KIM Young-hee Department of Electronic Engineering Changwon National University

A single poly EEPROM cell circuit sharing the deep N-well of a cell array was designed using the logic process. The proposed cell is written by the FN tunneling scheme and the cell size is 41.26 μm2, about 37% smaller than the conventional cell. Also, a small-area and low-power 512-bit EEPROM IP was designed using the proposed cells which was used for a 900 MHz passive UHF RFID tag chip. To secure the operation of the cell proposed with 3.3 V devices and the reliability of the used devices, an EEPROM core circuit and a DC-DC converter were proposed. Simulation results for the designed EEPROM IP based on the 0.18μm logic process show that the power consumptions in read mode, program mode and erase mode are 11.82, 25.15, and 24.08 ~tW, respectively, and the EEPROM size is 0.12 mm2.

关键词： single poly EEPROM cell Fowler-Nordheim tunneling logic process radio frequency identification small area

Correlation between hydration properties and electrochemical performances on Ln cation size effect in layered perovskite for protonic ceramic fuel cells

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Journal of Energy Chemistry 2024年第1期88卷 1-9,I0001页

作者： Inhyeok Cho jiwon Yun Boseok Seong Junseok Kim Sun hee Choi Ho-Il ji Sihyuk Choi Department of Mechanical Engineering Kumoh National Institute of TechnologyGumi 39177GyeongbukRepublic of Korea Department of Aeronautics Mechanical and Electronic Convergence EngineeringKumoh National Institute of TechnologyGumi 39177GyeongbukRepublic of Korea Center for Energy Materials Research Korea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Center for Hydrogen and Fuel Cell Research Clean Technology Research DivisionKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Department of Energy and Environmental Engineering University of Science and TechnologySeoul 02792Republic of Korea Nanomaterials Science and Engineering Korea University of Science and Technology(UST)KIST CampusSeoul 02792Republic of Korea

PrBa_(0.5)Sr_(0.5)Co_(1.5)Fe_(0.5)O_(5+δ)(PrBSCF) has attracted much research interest as a potential triple ionic and electronic conductor(TIEC) electrode for protonic ceramic fuel cells(PCFCs). The chemical formula for Pr BSCF is AA'B_(2)O_(5+δ), with Pr(A-site) and Ba/Sr(A'-site) alternately stacked along the c-axis. Due to these structural features, the bulk oxygen ion diffusivity is significantly enhanced through the disorder-free channels in the PrO layer;thus, the A site cations(lanthanide ions) play a pivotal role in determining the overall electrochemical properties of layered perovskites. Consequently, previous research has predominantly focused on the electrical properties and oxygen bulk/surface kinetics of Ln cation effects,whereas the hydration properties for PCFC systems remain unidentified. Here, we thoroughly examined the proton uptake behavior and thermodynamic parameters for the hydration reaction to conclusively determine the changes in the electrochemical performances depending on LnBa_(0.5)Sr_(0.5)Co_(1.5)Fe_(0.5)O_(5+δ)(LnBSCF,Ln=Pr, Nd, and Gd) cathodes. At 500 ℃, the quantitative proton concentration of PrBSCF was 2.04 mol% and progressively decreased as the Ln cation size decreased. Similarly, the Gibbs free energy indicated that less energy was required for the formation of protonic defects in the order of Pr BSCF < Nd BSCF < Gd BSCF. To elucidate the close relationship between hydration properties and electrochemical performances in LnBSCF cathodes, PCFC single cell measurements and analysis of the distribution of relaxation time were further investigated.

关键词： Protonic ceramic fuel cell Cathode Triple ionic and electronic conductor Hydration property Proton uptake Gibbs free energy

Theoretical Simulation of Surface Evolution Using the Random Deposition and Surface Relaxation for Metal Oxide Film in Atomic Layer Deposition

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Journal of Materials Science & Technology 2010年第4期26卷 371-374页

作者： ji-Hoon Ahn Se-Hun kwon jin-Hyock Kim Ja-Yong Kim Sang-Won Kang Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology373-1Kusong-dongYusong-guTaejon 305-701Korea Hynix Semiconductor Incorporated San 136-1Ami-riBubal-eubIcheon-siKyongki-do467-701Korea

Atomic layer deposition （ALD） has become an essential deposition method for forming nanometer scale thin films in the microelectronics industry, and its applications have been extended to multi-component thin films, as well as to single metal oxide films. In order to investigate the development of the surface structure of ultra-thin film qualitatively as well as quantitatively, ALD processes are simulated with a molecular scale. For this simulation, the film materials are deposited on a imaginary substrate that consists of small lattice. The deposition behaviors are described by using random deposition （RD） model or random deposition with surface relaxation （RDSR） model as the ALD growth mode, and the proposed model was applied to the deposition of SrO-TiO2 thin films. Through this work, growth characteristics such as surface morphology, deposited film coverage can be predicted.

关键词： Atomic layer deposition Random deposition SrO-TiO2