检索结果-南通市图书馆

Risk stratification for disease progression in pT3 prostate cancer after robot-assisted radical prostatectomy

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2017年第6期19卷 700-706页

作者： Jeong hee Hong Young Suk kwon Isaac Yi Kim Section of Urologic Oncology Rutgers Cancer Institute of New Jersey Division of Urology Rutgers Robert Wood Johnson Medical School Rutgers The State University of New Jersey New Brunswick NJ 08903 USA Department of Urology Dankook University College of Medicine Cheonan 31116 South Korea.

The aim of this study is to identify optimal patients for adjuvant radiation therapy （ART） in pT3 prostate cancer. The role of ART for patients with adverse pathologic features after radical prostatectomy （RP） has been demonstrated, but over- or under-treatment remains a significant concern. Two-hundred and five patients with pT3NOMO who underwent robot-assisted RP without ART were analyzed. Multivariate Cox proportional regression analyses were used to identify predictors of biochemical recurrence （BCR） and clinical progression （CP）. The estimated 5-year BCR-free survival （BCRFS） and CP-free survival （CPFS） were 52.8% and 85.6%, respectively. Preoperative prostate-specifc antigen （PSA）：〉10 ng m1-1 （hazard ratio [HR]： 3.288-6.027; P = 0.003）, pathologic Gleason score （pGS）：〉8 （HR： 4.146; P = 0.014）, and lymphovascular invasion （LVI）（HR： 2.167; P = 0.026） were associated with BCR. Based on these factors, a risk stratification tool was developed. Patients with no risk factors （PSA 〈10 ng m1-1, pGS 6, and absent LVI） showed excellent BCRFS and CPFS at 5 years （91.9% and 100.0%, respectively）, but those with two or more risk factors （PSA ：〉10 ng ml-1, pGS ≥8, or present LVI） had poor BCRFS and CPFS （12.1% and 54.6%, respectively）. In addition, the multivariate analysis revealed that pathologic stage pT3b （HR： 5.393; P = 0.025） was the only predictor of CP. Our study demonstrated the heterogeneity of oncologic outcomes in patients with pT3 prostate cancer. The proposed risk stratification can be used to identify patients who are at risk for disease progression and may aid in identifying the best patients for ART.

关键词： prostatectomy prostate-specific antigen recurrence survival

Fracture Characteristics of Frit Bonding through In-Situ Nano-Indentation Testing

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2016年第11期32卷 1204-1210页

作者： Won Je Jo hee-Jun Ahn Jong Hyoung Kim Dongil kwon Department of Materials Science and Engineering Seoul National University

Because frit bonding material is brittle, sudden impacts such as dropping may damage the bonding significantly. Strain-rate-controlled in-situ nano-indentation testing, which can determine localized material properties, was carried out on the frit-bonded specimen, especially on the frit bonding matrix and the filler. The results were compared with the drop-impact fracture behavior to understand the fracture characteristics. Mechanical properties at static condition or low strain rate did not show proper relationship with the fracture tendency of the drop tested result of the frit bonding. From the relationship between fracture toughness and the ratio of modulus/hardness, fracture characteristics at the drop impact situation could be estimated by the values at the high strain rate nano-indentation. The ratio between modulus and hardness on frit matrix showed close relationship with drop impact fracture. Though crack propagation path deflected at filler interface, filler property gave less influence on fracture tendency of drop impact fracture due to its small volume fraction. The properties of frit matrix were crucial to the fracture characteristics of the frit bonding.

关键词： Nanoindentation Bonding Fracture behavior

Association between scrub typhus encephalitis and diffusion tensor tractography detection of Papez circuit injury:A case report

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2021年第13期9卷 3194-3199页

作者： Hyeok Gyu kwon Jeong-hee Yang Jee-Hyun kwon Dongseok Yang Department of Physical Therapy College of Health ScienceEulji UniversitySanseong-daero 13135Gyeonggi-doSouth Korea Department of Plastic Surgery Biomedical Research InstituteSeoul National University HospitalJongno-gu 03080SeoulSouth Korea Department of Neurology University of Ulsan College of MedicineUlsan University HospitalDong-gu 44033UlsanSouth Korea Department of Physical Medicine and Rehabilitation University of Ulsan College of MedicineUlsan University HospitalDong-gu 44033UlsanSouth Korea

BACKGROUND It is difficult to restore the cognitive functions of patients with impaired cognition caused by brain *** tensor imaging can visualize the integrity of neural tracts in the white matter(WM)*** is unclear whether encephalitis following scrub typhus damages the *** the first time,we aimed to report diffusion tensor tractography(DTT)findings in a chronic patient with cognitive impairment following scrub typhus encephalitis,which revealed injury to the Papez circuit of the *** SUMMARY A 70-year-old male patient was affected by encephalitis caused by scrub typhus that occurred 23 years *** had poor cognition and his clinical examination findings were as follows:Mini-Mental Status Examination score,14;and handgrip strength(right/left,kg),32.3/*** revealed serious injuries of the left thalamocingulate tract and right mammillothalamic tract in the Papez circuit,and a partial injury of the anterior part of the *** Using DTT,we found a relationship between cognitive impairment and the integrity of the Papez circuit following scrub typhus.

关键词： Diffusion tensor imaging Scrub typhus Encephalitis White matter Papez circuit Cognition Case report

SMARCA4-deficient undifferentiated thoracic tumor:A case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2023年第11期11卷 2521-2527页

作者： hee Jung kwon Min Hye Jang Department of Pathology Yeungnam University Medical CenterDaegu 42415South Korea

BACKGROUND SMARCA4-deficient undifferentiated tumors(SMARCA4-DUTs)present with diverse clinical manifestations and progress to metastasis and even cause death within a few *** novel subset of undifferentiated tumors occurs in the middle-aged population and is strongly associated with a smoking ***-guishing it from other malignancies is *** SUMMARY A 62-year-old man presented with chest pain for 7 *** patient had no respiratory symptoms and normal pulmonary function test *** patient had been a smoker for 8 years and quit smoking 2 years *** computed tomography revealed a huge mass involving the left upper and lower lung lobes with pericardial invasion and multiple *** samples were obtained using open frozen biopsy,after several unsuccessful *** tumor was composed of sheets of undifferentiated disclosive cells with vesicular nuclei and prominent *** differential diagnosis included high-grade lymphoma,germ cell tumor,NUT carcinoma,undifferentiated carcinoma,and *** tumor cells were large,arranged in sheets,and did not exhibit glandular or squamous *** foci of necrosis were *** was no evidence of epithelial differentiation on immunohistochemical *** SMARCA4 stain showed complete loss of expression of SMARCA4,which is *** In the present case,thoracic SMARCA4-DUT was diagnosed based on clinical features,absence of epithelial differentiation,and negative SMARCA4 expression.

关键词： SMARCA4 BRG1 Deficient Undifferentiated tumor Thoracic Case report

Enhancement of magnetic properties of hot pressed/die-upset Dy-free Nd-Fe-B magnets with Cu/Nd coating by wet process

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rare Metals 2020年第1期39卷 48-54页

作者： Jeehye kwon Dajeong Lee Dayoung Yoo Seongkyu Park hee-Ryoung Cha Hae-Woong kwon Junggoo Lee Dongyun Lee Department of Advanced Circuit Interconnection Pusan National UniversityBusan46241Republic of Korea Department of Nano Fusion Technology Pusan National UniversityBusan46241Republic of Korea Powder and Ceramics Department Korea Institute of Machinery and MaterialsChangwon51508Republic of Korea Department of Materials Science and Engineering Pukyong National UniversityBusan48513Republic of Korea Department of Nanoenergy Engineering Pusan National UniversityBusan46241Republic of Korea

A grain boundary diffusion process(GBDP)was adopted to improve magnetic properties of Dy-free highly coercive Nd-Fe-B permanent magnet by coating thin layers of Nd and Cu in grain *** GBDP of Nd and Cu,Nd and Cu were coated by wet process,e.g.,electrochemical and electroless on Nd-Fe-B magnets,which was fabricated by hot-deformed/die-upset with meltspun *** treatment was performed for 20 min at 600℃followed by several different cooling *** cooling conditions after heat treatment were varied to understand distribution and micros tructural effects of Nd and Cu species in grain *** coercivity increased from 1.565 to 1.637 T in oil cooling rate but remanence decreased,while remanence jumped with little decrease in coercivity in furnace *** tructure analyses suggested that the coercivity was closely related to the cooling rate as well as distribution of *** mechanism of coercivity enhancement due to the cooling rate was discussed based on the results presented here and those in the literature.

关键词： Magnetic materials Electrochemical deposition Diffusion Scanning electron microscopy Coercivity

On the factors of Bitcoin’s value at risk

在线全文

学校读者我要写书评

暂无评论

Financial Innovation 2021年第1期7卷 1855-1885页

作者： ji Ho kwon College of Business Gachon University1342 Seongnam‑daeroSujeong‑guSeongnam‑siGyeonggi‑doRepublic of Korea

This study investigates the factors of Bitcoin’s tail risk,quantified by Value at Risk(VaR).Extending the conditional autoregressive VaR model proposed by Engle and Manganelli(2004),I examine 30 potential drivers of Bitcoin’s 5%and 1%*** the 5%VaR,quantity variables,such as Bitcoin trading volume and monetary policy rate,were positively significant,but these effects were attenuated when new samples were *** 5%VaR responds positively to the Internet search index and negatively to the fluctuation of returns on commodity variables and the Chinese stock market *** the 1%VaR,variables related to the macroeconomy play a key *** consumer sentiment index exerts a strong positive effect on the 1%VaR.I also find that the 1%VaR has positive relationships with the US economic policy uncertainty index and the fluctuation of returns on the corporate bond index.

关键词： Bitcoin Value at risk CAViaR

Impact of nonalcoholic fatty liver disease on the risk of gallbladder polyps in lean and non-obese individuals:A cohort study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2024年第6期23卷 573-578页

作者： Nam hee Kim ji Hun Kang Hong Joo Kim Division of Gastroenterology Department of Internal MedicineKangbuk Samsung HospitalSungkyunkwan University School of MedicineSeoulKorea Department of Radiology Hanyang University Guri HospitalHanyang University College of MedicineGuriKorea

Background:The association between non-obese or lean nonalcoholic fatty liver disease(NAFLD)and gallbladder polyps(GBPs)has not yet been *** aimed to determine whether NAFLD is an independent risk factor for the development of GBPs,even in non-obese and lean ***:We analyzed a cohort of 331208 asymptomatic adults who underwent abdominal ultrasonography(US).The risk of GBP development was evaluated according to the obesity and NAFLD ***:The overall prevalence of NAFLD and GBPs≥5 mm was 28.5%and 2.9%,*** prevalence of NAFLD among 160276 lean,77676 overweight and 93256 obese participants was 8.2%,31.2%,and 61.1%,*** with NAFLD had a significantly higher incidence of GBPs with a size of≥5 mm[adjusted odds ratio(OR)=1.18;95%confidence interval(CI):1.11–1.25].A higher body mass index and its categories were also significantly associated with an increased risk of GBPs≥5 ***,risk of GBPs≥5 mm was significantly increased even in NAFLD individuals who are not obese(lean:adjusted OR=1.36,95%CI:1.19-1.54;overweight:adjusted OR=1.14,95%CI:1.03–1.26,respectively).Conclusions:Non-obese/lean NAFLD is an independent risk factor for GBP development,suggesting that NAFLD may play an important role in the pathogenesis of GBPs regardless of the obesity ***,a more thorough evaluation for GBPs may be necessary when hepatic steatosis is detected on abdominal US,even in non-obese or lean individuals.

关键词： Nonalcoholic fatty liver disease Non-obese Lean Gallbladder polyps

Unilateral spontaneous lens absorption and dislocation of the empty capsular bag into the anterior chamber

在线全文

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2017年第1期10卷 161-164页

作者： Bo hee Kim Deoksun Cha Sunmin Yim ji-Won kwon Won Ryang Wee Young Keun Han Department of Ophthalmology Seoul National University College of MedicineSeoul 03080Korea Department of Ophthalmology Seoul Metropolitan Gover-nment Seoul National University Boramae Medical CenterSeou107061Korea Department of Ophthalmology Myongji Hospital Seonam University College of MedicineGoyang 10475Korea

Cases involving spontaneous aphakic change in the visual axis are rare in Outpatient Clinics. However, we can often ascertain the past events affecting the patient＇s eye by examining its current status. The placement of the dislocated internal material of the lens, the remnant lens capsular bag status, lens and zonular status of the contralateral eve.

关键词： Unilateral spontaneous lens absorption and dislocation of the empty capsular bag into the anterior chamber Figure IOL

Two macrophages, osteoclasts and microglia: from development to pleiotropy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bone Research 2021年第2期9卷 143-152页

作者： ji-Won Lee In-hee Lee Tadahiro Iimura Sek Won Kong Department of Nephrology Transplant Research ProgramBoston Children’s HospitalBostonMA 02115USA Department of Pharmacology Graduate School of Dental MedicineHokkaido UniversitySapporo 060-8586Japan Computational Health Informatics Program Boston Children’s HospitalBostonMA 02115USA Department of Pediatrics Harvard Medical SchoolBostonMA 02115USA

Tissue-resident macrophages are highly specialized to their tissue-specific microenvironments,activated by various inflammatory signals and modulated by genetic and environmental *** and microglia are distinct tissue-resident cells of the macrophage lineage in bone and brain that are responsible for pathological changes in osteoporosis and Alzheimer’s disease(AD),*** is more frequently observed in individuals with AD compared to the prevalence in general *** of AD is often delayed until underlying pathophysiological changes progress and cause irreversible damages in structure and function of *** such earlier diagnosis and intervention of individuals at higher risk would be indispensable to modify clinical *** is the phenomenon that a genetic variant affects multiple traits and the genetic correlation between two traits could suggest a shared molecular *** this review,we discuss that the Pyk2-mediated actin polymerization pathway in osteoclasts and microglia in bone and brain,respectively,is the horizontal pleiotropic mediator of shared risk factors for osteoporosis and AD.

关键词： diagnosis osteoporosis osteoclast