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Micro-flow structure at regime transition from bubbling to turbulent fluidization in a fluidized bed

Particuology 2024年第6期89卷 117-130页

作者： Chaoyu Yan Yue Yuan Xiaoyang Wei jesse Zhu State Key Laboratory of Heavy Oil Processing Beijing Key Laboratory of Process Fluid Filtration and SeparationCollege of Mechanical and Transportation EngineeringChina University of PetroleumBeijing 102249China China Beacons Institute The University of NottinghamNingbo315100China Department of Chemical and Biochemical Engineering University of Western OntarioLondonOntarioN6A 5B9Canada

Gas-solid fluidized beds have found extensive utilization in frontline manufacturing,in particular as low-velocity *** fluidization status,the bubbling or turbulent flow regime and the transition in between,determine the system performance in practical *** the convoluted hydrodynamics are quantitively evaluated through numerous data-processing methodologies,none of them alone can reflect all the critical information to identify the transition from the bubbling to the turbulent ***,this study was to exploit a coupling data processing methodology,in the combination of standard deviation,power spectrum density,probability density function,wavelet transform,and wavelet multiresolution method,to jointly explain the micro-flow structure at the regime transition from bubbling to turbulent *** transient differential pressure fluctuation was measured for the evaluation in a fluidized bed(0.267 m i.d.×2.5 m height)with FCC catalysts(d_(p)=65μm,ρ_(p)=1780kg/m^(3))at different superficial gas velocities(0.02–1.4 m/s).The results show that the onset of turbulent fluidization starts earlier in the top section of the bed than in the bottom *** wavelet decomposition displays that the fluctuation of differential pressure mainly concentrates on the sub-signals with an intermediate frequency *** sub-signals could be synthesized into three types of scales(micro-scale,meso-scale,and macro-scale),representing the multi-scale hydrodynamics in the fluidized *** micro-scale signal has the characteristic information of bubbling fluidization,and the characteristic information of turbulent fluidization is mainly represented by the meso-scale *** work provides a systematic comprehension of fluidization status assessment and serves as an impetus for more coupling analysis in this sector.

关键词： Flow regime transition Bubbling fluidization Turbulent fluidization Micro-flow structure Differential pressure fluctuation

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Glioblastoma stem cells resistant to temozolomide-induced autophagy

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Chinese Medical Journal 2009年第11期122卷 1255-1259页

作者： FU Jun LIU Zhi-gang LIU Xiao-mei CHEN Fu-rong SHI Hong-liu pang jesse Chung-sean NG Ho-keung CHEN Zhong-ping State Key Laboratory for Cancer Research in Southern China and Department of Neurosurgery/Neuro-oncology Cancer Center Sun Yat-sen University Guangzhon Guangdong 510060 China Department of Anatomical & Cellular Pathology Chinese University of Hong Kong Shatin N.T. Hong Kong China

Background Recent studies have demonstrated the existence of a small fraction of cells with features of primitive neural progenitor cells and tumor-initiating function in brain tumors. These cells might represent primary therapeutic target for complete eradication of the tumors. This study aimed to determine the resistant phenotype of glioblastoma stem cells （GSCs） to temozolomide （TMZ） and to explore the possible molecular mechanisms underlying TMZ resistance. Methods Freshly resected glioblastoma specimen was collected and magnetic isolation of GSCs was carried out using the Miltenyi Biotec CD133 Cell Isolation kit. The cytotoxic effect of TMZ on CD133^＋ and CD133^- glioblastoma cells was determined by using the 3-（4,5-dimethylthiazol-2-yl）-2,5-diphenyltetrazolium bromide （MTT） assay. Autophagy-related proteins （Beclin-1, LC3 and Atg5） and cleaved caspase-3 （p17） were analyzed by Western blotting. Immunofluorescent staining was used to detect Atg5, glial fibrillary acidic protein （GFAP） and CD133 expression in glioblastoma cells. Statistical analysis was carried out using SPSS 10.0 software. For all tests, the level of statistical significance was set at P 〈0.05. Results CD133^＋ glioblastoma ceils exhibited neurosphere-like growth in vitro and high expression of CD133 stem cell marker. The growth-inhibiting rate in CD133- glioblastoma cells treated with 5 or 50 pmol/L TMZ was significantly higher than that in CD133^＋ glioblastoma cells （（14.36±3.75）% vs （2.54±1.36）% or （25.95±5.25）% vs （2.72±1.84）%, respectively, P 〈0.05）. Atg5, LC3-11 and Beclin-1 levels were significantly lower in CD133^＋ glioblastoma cells than those in autologous CD133^- cells after TMZ treatment （P 〈0.05）. Caspase-3 was mildly activated only in CD133^- glioblastoma cells after exposure to TMZ （P 〈0.05）. Immunofluorescent staining revealed elevated expression of Atg5 in GFAP^＋ cells following TMZ treatment. Conclusions The GSCs display strong capability of tumor＇s resistance to TMZ. This resis

关键词： glioblastoma neoplastic stem cells chemoresistance temozolomide

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PAPST1 siRNA抑制髓母细胞瘤细胞系DAOY增殖活性的研究

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第三军医大学学报 2014年第9期36卷 860-863页

作者：徐庆福李立超朱潇鹏 jesse Chung-Sean pang 符星刘景平吕胜青第三军医大学新桥医院神经外科重庆400037 兰州大学第一医院神经外科兰州730000 香港中文大学解剖与细胞病理学系香港999077 中南大学湘雅医院神经外科长沙410008

目的研究3'-磷酸腺苷-5'-磷酰硫酸转运体1(adenosine-3-phospho-5-phosphosulfate transporter 1,PAPST1)在髓母细胞瘤中的表达情况,探讨其对髓母细胞瘤细胞系增殖活性的影响。方法采用qRT-PCR法检测25例髓母细胞瘤标本、1例原代培养髓... 详细信息

目的研究3'-磷酸腺苷-5'-磷酰硫酸转运体1(adenosine-3-phospho-5-phosphosulfate transporter 1,PAPST1)在髓母细胞瘤中的表达情况,探讨其对髓母细胞瘤细胞系增殖活性的影响。方法采用qRT-PCR法检测25例髓母细胞瘤标本、1例原代培养髓母细胞瘤细胞、3例髓母细胞瘤细胞系PAPST1表达,并与正常小脑组织比较,利用免疫组织化学检测PAPST1在髓母细胞瘤中的表达分布,采用PAPST1 siRNA处理髓母细胞瘤细胞系DAOY,利用qRT-PCR、Western blot法检测PAPST1表达变化,CCK-8法检测处理后的DAOY细胞系增殖活性。结果与正常小脑组织相比,PAPST1在18/25(72%)的髓母细胞瘤标本及DAOY、ONS-76细胞系中呈2倍以上的高表达,免疫组化显示PAPST1定位于细胞质中,且染色明显强于正常小脑组织,PAPST1 siRNA在mRNA及蛋白的水平明显干扰了PAPST1的表达(P<0.05),DAOY细胞的增殖活性受到明显抑制(P<0.05)。结论 PAPST1在髓母细胞瘤中有广泛的高表达,下调PAPST1的表达可以降低髓母细胞瘤细胞的增殖活性。

关键词：髓母细胞瘤 3’-磷酸腺苷-5’-磷酰硫酸转运体1 细胞增殖

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Separation density prediction of geldart A^(-)dense medium in gas-solid fluidized bed coal beneficiators

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Particuology 2024年第9期92卷 251-262页

作者： Chenyang Zhou Chengguo Liu Yue Yuan Zhijie Fu jesse Zhu Chenlong Duan School of Chemical Engineering and Technology China University of Mining and TechnologyXuzhou221116China Particle Technology Research Centre Western UniversityLondonOntarioN6A 5B9Canada

Gas-solid Fluidized Bed Coal Beneficiator(GFBCB)process is a crucial dry coal beneficiation fluidization *** work employs the GFBCB process alongside a novel Geldart A^(-)dense medium,consisting of Geldart A magnetite particles and Geldart C ultrafine coal,to separate small-size separated objects in the *** effects of various operational conditions,including the volume fraction of ultrafine coal,the gas velocity,the separated objects size,and the separation time,were investigated on the GFBCB's separation *** results indicated that the probable error for 6∼3 mm separated objects could be controlled within 0.10 g/cm^(3).Compared to the traditional Geldart B/D dense medium,the Geldart A/A^(-)dense medium exhibited better size-dependent separation performance with an overall probable error 0.04∼0.12 g/cm^(3).Moreover,it achieved a similar separation accuracy to the Geldart B/D dense medium fluidized bed with different external energy for the small-size object *** work furthermore validated a separation density prediction model based on theoretical derivation,available for both Geldart B/D dense medium and Geldart A/A^(-)dense medium at different operational conditions.

关键词： GFBCB Geldart A^(-)dense medium Separation density Separated objects size Prediction model

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Correlation between MGMT methylation status and the development of pseudoprogression

Correlation between MGMT methylation status and the developm...

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中国抗癌协会神经肿瘤专业委员会第八届学术会议

作者： Danny TM Chan Rebecca YT Ng XL Zhu Deyond YW Siu Michael KM Kam Brigette BY Ma jesse pang HK Ng WS Poon The CUHK Brain Tumour Centre Prince of Wales Hospital The Chinese University of Hong Kong

＜正＞Background With the introduction of the oral chemotherapeutic agent,temozolomide,it is now the standard of care to offer concomitant chemoradiotherapy to patients with glioblastoma *** was reported that around 2...

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胶质母细胞瘤染色体13q上肿瘤抑制基因存在的可能性

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复旦学报（医学版） 2001年第2期28卷 107-109,112页

作者：胡杰江澄川吴浩强彭颂先唐婉君复旦大学附属华山医院神经病学研究所上海200040 香港中文大学病理解剖及细胞学系香港

目的　寻找胶质母细胞瘤 (glioblastoma ,GBM ) 13号染色体上可能存在肿瘤抑制基因的杂合性丢失(LOH)区域 ,为发现和定位肿瘤抑制基因 (TSG)提供线索和依据。方法　应用聚合酶链反应 (PCR)方法 ,采用荧光标记的引物和 377型DNA序列自动... 详细信息

目的　寻找胶质母细胞瘤 (glioblastoma ,GBM ) 13号染色体上可能存在肿瘤抑制基因的杂合性丢失(LOH)区域 ,为发现和定位肿瘤抑制基因 (TSG)提供线索和依据。方法　应用聚合酶链反应 (PCR)方法 ,采用荧光标记的引物和 377型DNA序列自动分析仪 ,分析了 2 0例GBM 13号染色体上 14个微卫星多态性标记的LOH。结果　在 6 0 %GBM的 13号染色体上观察到LOH ,在 45 .8%可提供信息位点存在LOH。其中 13q的LOH率明显高于 13p ,13q和 13p的LOH率分别为 6 0 %、2 7%。在 13q上的下列位点上检测到较高的LOH率(>5 0 % ) :13q14.1 14.3上D13S15 3,13q12 14.2上的D13S2 17 D13S2 6 3 ,13q2 1.2 32上的D13S15 6 D13S2 6 5。结论　 13号染色体可能在GBM的分子发病机制中发挥着重要作用 ,在 13q14.1 14.3上的D13S15 3位点、13q12 14.2上的D13S2 17 D13S2 6 3和 13q2 1.2 32上的D13S15 6 D13S2 6 5间区域可能存在多个与GBM相关的肿瘤抑制基因。

关键词：杂合性丢失胶质母细胞瘤肿瘤抑制基因 LOH TSG GBM

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A Machine Learning-Based Web Application for Heart Disease Prediction

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Intelligent Control and Automation 2024年第1期15卷 9-27页

作者： jesse Gabriel Independent Researcher Port Moresby Papua New Guinea

This work leveraged predictive modeling techniques in machine learning (ML) to predict heart disease using a dataset sourced from the Center for Disease Control and Prevention in the US. The dataset was preprocessed and used to train five machine learning models: random forest, support vector machine, logistic regression, extreme gradient boosting and light gradient boosting. The goal was to use the best performing model to develop a web application capable of reliably predicting heart disease based on user-provided data. The extreme gradient boosting classifier provided the most reliable results with precision, recall and F1-score of 97%, 72%, and 83% respectively for Class 0 (no heart disease) and 21% (precision), 81% (recall) and 34% (F1-score) for Class 1 (heart disease). The model was further deployed as a web application.

关键词： Heart Disease US Center for Disease Control and Prevention Machine Learn-ing Imbalanced Data Web Application

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Chromosome 14q may harbor multiple tumor suppressor genes in primary glioblastoma multiforme

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Chinese Medical Journal 2002年第8期115卷 1201-1204页

作者：胡杰江澄川吴浩强彭颂先唐婉君复旦大学附属华山医院神经外科上海200040 香港中文大学病理解剖及细胞学系

OBJECTIVE: To evaluate whether deletion of chromosome 14q is involved in the carcinogenesis of primary glioblastoma multiforme and to identify possibly common deletion regions. METHJODS: Fourteen fluorescent dye-labeled polymorphic markers were used and polymerase chain reaction-based microsatellite analysis was employed to investigate loss of heterozygosity (LOH) on chromosome 14q in 20 primary glioblastoma multiforme (GBM). RESULTS: Ten of twenty (50%) GBM displayed LOH at one or more of the markers on chromosome 14q. Five tumors showed either LOH or non-informative on all markers tested. The most frequent LOH was observed at locus D14S65 (57.1%) on 14q32.1, and in the chromosomal region spanning from D14S63 (47.1%) to D14S74 (46.7%) on 14q23-31. None of the informative loci exhibited microsatellite instability. CONCLUSIONS: Allelic deletion on chromosome 14q plays an important role in the pathogenesis of GBM.　 Chromosomal regions at locus D14S65 on 14q32.1 and spanning from D14S63 to D14S74 on 14q23-31 may harbor multiple tumor suppressor genes associated with GBM.

关键词： Chromosomes, Human, Pair 14 Genes, Tumor Suppressor Loss of Heterozygosity Adult Aged Female Glioblastoma Humans Male Microsatellite Repeats Middle Aged

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Transparency:The Missing Link to Boosting AI Transformations in Chemical Engineering

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Engineering 2024年第8期39卷 45-60页

作者： Yue Yuan Donovan Chaffart Tao Wu jesse Zhu Ningbo Institute of Digital Twin Eastern Institute of TechnologyNingbo 315200China Department of Chemical and Biochemical Engineering The University of Western OntarioLondonON N6G 5B8Canada College of Engineering Eastern Institute of TechnologyNingbo 315200China China Beacons Institute University of Nottingham Ningbo ChinaNingbo 315100China

The issue of opacity within data-driven artificial intelligence(AI)algorithms has become an impediment to these algorithms’extensive utilization,especially within sensitive domains concerning health,safety,and high profitability,such as chemical engineering(CE).In order to promote reliable AI utilization in CE,this review discusses the concept of transparency within AI utilizations,which is defined based on both explainable AI(XAI)concepts and key features from within the CE *** review also highlights the requirements of reliable AI from the aspects of causality(i.e.,the correlations between the predictions and inputs of an AI),explainability(i.e.,the operational rationales of the workflows),and informativeness(i.e.,the mechanistic insights of the investigating systems).Related techniques are evaluated together with state-of-the-art applications to highlight the significance of establishing reliable AI applications in ***,a comprehensive transparency analysis case study is provided as an example to enhance ***,this work provides a thorough discussion of this subject matter in a way that—for the first time—is particularly geared toward chemical engineers in order to raise awareness of responsible AI *** this vital missing link,AI is anticipated to serve as a novel and powerful tool that can tremendously aid chemical engineers in solving bottleneck challenges in CE.

关键词： Transparency Explainable AI Reliability Causality Explainability Informativeness Hybrid modeling Physics-informed

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Little Tyrants

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The World of Chinese 2024年第3期 94-98页

作者： jesse Young Cai Tao 不详

A new generation of researchers and archivists examines the underappreciated history of China-made video game *** living room is peak late-1990s China—wall calendar,upholstered sofa,tape deck,and Titanic film *** of place belongs to a boxy analog TV,hooked up to the device that perhaps most defines that era of tech:Little Tyrant,or Xiaobawang(小霸王),a clone of Nintendo’s Famicom video game console cleverly marketed as a study device and famously endorsed by Jackie *** a generation(or two),Little Tyrant was their first introduction to gaming.

关键词： video hook 小霸王

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