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Neural membrane repair at the core of regeneration

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Neural Regeneration Research 2024年第7期19卷 1399-1400页

作者： Catarina Dias jesper Nylandsted Danish Cancer Institute Membrane IntegrityCopenhagenDenmark Champalimaud Research Champalimaud FoundationLisbonPortugal Department of Molecular Medicine University of Southern DenmarkOdenseDenmark

Loss of plasma membrane integrity can compromise cell functioning and *** countera ct this eminent threat,euka ryotic cells have developed efficient repair mechanisms,which seem to have co-evolved with the emergence of vital membrane processes(Cooper and McNeil,2015).This relationship between basic cellular functioning and membrane repair highlights the fundamental significance of preserving membrane integrity for cellular life.

关键词： repair preserving integrity

数字政府缘何生成行政负担?--对丹麦数字ID升级项目的审视

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中国行政管理 2024年第4期40卷 93-106页

作者： [丹麦]施雷格任运月杨峰浙江工商大学公共管理学院杭州310018 四川大学公共管理学院成都610064

在世界各国默认数字化进程中,普遍存在数字化减轻民众与政府互动过程中行政负担的乐观期望。然而,审视数字化“最佳实践”国丹麦的数字身份系统升级项目,可以发现各行动者有意无意的利益考量和行为模式反而导致了行政负担的形成和加重... 详细信息

在世界各国默认数字化进程中,普遍存在数字化减轻民众与政府互动过程中行政负担的乐观期望。然而,审视数字化“最佳实践”国丹麦的数字身份系统升级项目,可以发现各行动者有意无意的利益考量和行为模式反而导致了行政负担的形成和加重。个中缘由包括不同行动者角色认知和价值判断差异化的影响,数字技术自身的兼容性难题和可及性障碍产生的自动不平等加重了行政负担分配性,数字政府制度建构过程中工具理性扩张带来的“数字牢笼”潜在风险。因此,有必要从建立良好的行动者关系的角度出发寻求减轻民众行政负担之策,以确保数字政府转型升级的顺利进行,要明确政企合作网络中政府“核心行动者”的角色地位,将数字政府注意力转向改善政府与民众关系。

关键词：行政负担数字政府数字身份政商关系

Multifunctional landscapes—perspectives for the future

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Journal of Environmental Sciences 2003年第2期15卷 187-192页

作者： jesper Brandt Department of Geography and International Development Studies Roskilde University

New methods in landscape ecology to study the link between landscape heterogeneity and landscape functionality are needed. Heterogeneity is a basic characteristic of landscape, and landscape function is the capacity to change the structural heterogeneity of a landscape system. In most developed countries the industrialisation of agriculture has in general resulted in a change of agricultural landscapes from a small-grained heterogeneous pattern towards more monotonous and monofunctional landscapes. During the 1990's this trends seems to have changed due to a diversification of rural land use and new trends in urbanisation. Weather these phases of landscape development should be expected in developing countries is a totally open question. Dealing with the study of multifunctionality of landscapes it is proposed to distinguish between ecological functionality of landscape ecosystems, functionality pertaining to land use and social functionality. Further, the relation between function, space and scale is important by the determination of spatial and time segregation as well as spatial and time integration of multifunctionality in landscapes.

关键词： landscape heterogeneity monotonisation multifunctionality spatial segregation time segregation landscape development

Application of heat shock protein expression for detecting natural adaptation and exposure to stress in natural populations

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Current Zoology 2010年第6期56卷 703-713页

作者： jesper Givskov SφRENSEN National Environmental Research Institute Aarhus UniversityDepartment of Terrestrial Ecology

Heat-shock proteins （HSPs） play an undisputed role for maintaining cellular functioning under environmental challenges and protein denaturing conditions. Compelling evidence points to an evolutionary important role of HSPs and a strict evolutionary control of these proteins as a balance between benefits and costs. While there is a great potential for using HSP expression for detecting natural adaptation and exposure to stress in natural populations, some obstacles and key issues await investigation. From an ecological perspective these key issues needs to be resolved in order to fully appreciate the complex responses and adaptations to stress and to increase our understanding of HSPs and other molecular chaperones for stress adaptation and potential use as biomarkers. Here, the current knowledge and understanding of HSPs is reviewed and a number of key issues including the interpretation of elevated HSP levels, the complications of extrapolating between laboratory and field conditions, the effects of choice of traits and methodology and the larger intra-and extracellular networks of interactions that HSPs participate in are discussed [Current Zoology 56 （6）： 703-713, 2010].

关键词： Biomarker Hsp Molecular chaperone Thermal adaptation Thermal stress

Modeling and scale analysis of gaseous fuel reactors in chemical looping combustion systems

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Particuology 2017年第6期15卷 31-41页

作者： jesper Aronsson David Pallares Anders Lyngfelt Division of Energy Technology Department of Energy and Environment Chalmers University of Technology SE-41296 Gothenburg Sweden

This work investigates the scale-up of chemical looping combustion （CLC）, a next-generation technology for carbon capture and storage, to the industrial scale. The study focused on the bottom bed of the unit, which was considered to be the critical region during scale-up due to the large solids inventory in this zone combined with relatively inefficient gas-solids contact. Two CLC reactors of vastly different sizes （bench and utility scale） were studied to discern their difference related to scale-up via a one-dimensional model. This model considered kinetics that varied with the degree of oxidation and population distribution of the oxygen carriers, the mixing of which accounts for both convective and dispersive transport. The model was validated against bench scale data, and was used to evaluate the performance of a 1000 MWth CLC fuel reactor using either syngas or methane as fuels. Sensitivity analyses were also carried out with this model to determine the effects of several parameters on fuel conversion, including solids circulation, oxygen carrier reactivity, bed height, and maximum bubble size. The results show that the mass transfer of gas from bubbles to the emulsion phase represents a significant limiting factor for fuel conversion in the bottom bed of a utility scale fuel reactor.

关键词： Chemical looping combustion Semi-empirical modeling Fluidization Up scaling

省级地方政府公共服务治理领域的人工智能准备度评估

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信息技术与管理应用 2024年第2期3卷 32-44页

作者： [丹麦]施雷格冯显莺浙江工商大学公共管理学院

人工智能技术的广泛应用为地方政府履行公共服务供给和治理职责提供了更多的工具和手段,推动了公共服务高质量发展的进程。为研究地方政府发展和应用人工智能技术于公共服务领域治理实践活动的准备程度,本文建立了省级地方政府公共服务... 详细信息

人工智能技术的广泛应用为地方政府履行公共服务供给和治理职责提供了更多的工具和手段,推动了公共服务高质量发展的进程。为研究地方政府发展和应用人工智能技术于公共服务领域治理实践活动的准备程度,本文建立了省级地方政府公共服务治理领域的人工智能准备度评估指标体系,从政府、技术部门、基础设施三个维度展开评估。研究发现,我国省级地方政府要应用人工智能技术提高公共服务治理实践,目前在政府、技术部门、基础设施条件方面的准备度整体水平还有待提升。增强政府数字能力、提升AI技术部门整体竞争力、优化和完善基础设施建设以实现更好地探索和利用人工智能技术,将是人工智能时代背景下地方政府的重要任务。

关键词：人工智能技术地方政府公共服务治理准备度

3D X-ray microscopy with a CsPbBr3 nanowire scintillator

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Nano Research 2023年第1期16卷 1084-1089页

作者： Hanna Dierks Zhaojun Zhang Nils Lamers jesper Wallentin Lund University Synchrotron Radiation Research and NanoLundBox 118SE-22100 LundSweden

X-ray microscopy is an essential imaging method in many scientific fields,which can be extended to three-dimensional(3D)using ***,metal halide perovskite(MHP)nanomaterials have become a promising candidate for X-ray scintillators,due to their high light yield,high spatial resolution,and easy *** requires many projections and therefore scintillators with excellent *** is challenging for MHPs,which often suffer from fast degradation under X-ray irradiation and ambient ***,we demonstrate that MHP scintillators of CsPbBr3 nanowires(diameter:60 nm,length:5–9μm)grown in anodized aluminum oxide(CsPbBr3 NW/AAO)have sufficient stability for X-ray micro-tomography.A tomogram was taken with a Cu X-ray source over 41 h(dose 4.2 Gyair).During this period the scintillator brightness fluctuated less than 5%,which enabled a successful reconstruction.A long-term study with 2 weeks of continuous X-ray exposure(37.5 Gyair)showed less than 14%fluctuations in brightness and no long-term degradation,despite variations in the ambient relative humidity from 7.4%RH to 34.2%*** resolution was stable at(180±20)lp·mm−1,i.e.,about 2.8 *** demonstrates that CsPbBr3 NW/AAO scintillators are promising candidates for high resolution X-ray imaging detectors.

关键词： tomography perovskites scintillators X-ray imaging micrometer spatial resolution

N-cluster correlations in four-and five-dimensional percolation

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Frontiers of physics 2020年第4期15卷 5-16页

作者： Xiao-Jun Tan You-Jin Deng jesper Lykke Jacobsen Hefei National Laboratory for Physical Sciences at Microscale and Department of Modern Physics University of Science and Technology of ChinaHefei 230026China CAS Center for Ercellence and Synergetic Innovation Center in Quantun Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China Laboratoire de Physique de I'Ecole Normale Superieure ENSUniversite PSLCNRSSorbonne UniversiteUniversite de ParisParisFrance Sorbnne Universite Eecole Normale SuperieureCNRSLaborutoire de Physique(LPENS)75005 ParisFrance Institut de Physique Theorique Universite Paris SaclayCEACNRS91191 Gif-sur-YvetteFrance

We study N-cluster correlation functions in four-and five-dimensional(4D)and 5D)bond percolation by extensive Monte Carlo *** reformulate the transfer Monte Carlo algorithm for percolation[***.E 72,016126(2005)]using the disjoint-set data structure,and simulate a cylindrical geometry Ld^-1×∞,with the linear size up to L=512 for 4D and 128 for *** determine with 1 high precision all possible N-cluster exponents,for N=2 and 3,and the universal amplitude for a logarithmic correlation *** the symmetric correlator with N=2,we obtain the correlation-length critical exponent as 1/v=1.4610(12)for 4D and 1/v=1.737(2)for 5D,significantly improving over the existing *** for the other exponents and the universal logarithmic amplitude have not been reported before to our *** work demonstrates the validity of logarithmic conformal field theory and adds to the growing knowledge for high-dimensional percolation.

关键词： critical exponents percolation logarithmic conformal field theory Monte Carlo algorithm

Single cell profiling reveals window for immunotherapy in liver cancers

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Hepatobiliary Surgery and Nutrition 2018年第1期7卷 48-51页

作者： jesper B.Andersen Biotech Research&Innovation Centre(BRIC) Department of Health and Medical SciencesUniversity of CopenhagenCopenhagenDenmark

Primary liver cancer has the second highest mortality rate with more than 700,000 *** carcinoma(HCC),the most prevalent tumor type in the liver,arises predominantly from hepatocytes and is often related to known etiologies such as chronic hepatitis B or C virus,obesity,diabetes mellitus,metabolic liver diseases and life style factors(for example,alcohol).

关键词： liver mortality Primary