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Complementary roles of glial cells in generating region-specific neuroinflammatory responses and phagocytosis in Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria s.Aymerich Universidad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Universidad de Navarra PamplonaSpain IdisNA Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is associated with Parkinson’s disease:Reactive gliosis and neuroinflammation are hallmarks of Parkinson’s disease(PD),a multisystem neurodegenerative disorder characterized by a progressive loss of dopaminergic *** has long been considered a mere consequence of neuronal loss,but whether it promotes PD or is a key player in disease progression remains to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

Understanding activity of butyrate at a cellular level

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Neural Regeneration Research 2025年第8期20卷 2323-2324页

作者： Prapti Chakraborty Angela s.Laird Macquarie University Motor Neuron Disease Research Centre Macquarie Medical SchoolFaculty of MedicineHealth and Human SciencesMacquarie UniversitySydneyAustralia

Butyrate is a short-chain fatty acid of four carbons in length that is a by-product produced by the microbial fermentation of dietary fiber and undigested carbohydrates within the *** the years,butyrate has attracted ... 详细信息

关键词： carbons butyrate fiber

Microglial dysfunction and genetic risk for neurodegenerative disease

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Neural Regeneration Research 2025年第5期20卷 1401-1402页

作者： Debra s.MacDonald Jay Penney Department of Biomedical sciences AVCUniversity of Prince Edward IslandCharlottetownPECanada

Neurodegenerative disorders such as Alzheimer's and Parkinson's diseases a re increasing in prevalence as world populations *** tremendous progress has been made,our understanding of the mechanisms that underlie the development of these diseases remains far from com *** troubling,despite the growing emotional and financial toll being to ken by neurodegenerative disorders,existing treatment options are limited almost exclusively to those that help manage symptoms but that lack the ability to alter the progression of the disease(Liu et al.,2022).

关键词： degenerative diseases

Primary malignant melanoma of the biliary tract: A case report and literature review

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World Journal of Clinical Cases 2019年第16期7卷 2302-2308页

作者： soledad Cameselle-García José Luis Fírvida Pérez María C Areses jesús Daniel Fernández de Castro Juan Mosquera-Reboredo jesús García-Mata Department of Medical Oncology Complejo Hospitalario Universitario de OurenseSERGASOurense 32005Spain Department of Digestive Complejo Hospitalario Universitario de OurenseSERGASOurense 32005Spain Department of Pathology Hospital San RafaelA Coruna 15009Spain

BACKGROUND Primary malignant melanoma of the biliary tract (MBT) is a rare condition whose diagnosis requires excluding a primary origin in another *** paper reviews the most important characteristics of MBT cases published in the literature and reports a new *** patient reported here is the first case of primary malignant melanoma of the biliary tract with pulmonary metastasis treated with *** patient remains disease-free 36 mo after the treatment of metastatic lung *** sUMMARY A 51-year-old man was admitted to the gastrointestinal department to study obstructive jaundice of a 1 wk clinical *** resonance cholangiopancreatography revealed dilatation of the intrahepatic biliary tract and stenosis of the common hepatic *** the suspicion of biliary tract neoplasia,cholecystectomy and resection of the common hepatic duct were performed with hepatic jejunostomy free of ***-pathological diagnosis was *** intervention,the patient was referred to the Department of Medical Oncology,where a primary origin was excluded in the skin,mucosa,and *** confirmed diagnosis of primary biliary tract *** tomography was performed 12 mo after the procedure revealed several subcentimetric lung *** resection was *** confirming the diagnosis of pulmonary metastasis of primary melanoma of the biliary tract,the patient was started on immunotherapy with *** to treatment was *** patient remains disease-free 36 mo after the treatment of metastatic lung *** The patient reported here is the first case of primary malignant melanoma of the biliary tract with lung metastases successfully treated with immunotherapy.

关键词： Biliary tract Case report Immunotherapy Malignant melanoma

Folate Metabolism Interferes with Plant Immunity through 1C Methionine synthase-Directed Genome-wide DNA Methylation Enhancement

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Molecular Plant 2019年第9期12卷 1227-1242页

作者： Beatriz Gonzalez Pablo vera Instituto de Biologia Molecular y Celular de Plantas Universidad Politecnica de Valencia-C.S.I.CCiudad Politecnica de la InnovacionEdificio 8EIngeniero Fausto Elios/n.46022 ValenciaSpain

Plants rely on primary metabolism for flexible adaptation to environmental ***,through a combination of chemical genetics and forward genetic studies in Arabidopsis plants,we identified that the essential folate metabolic pathway exerts a salicylic acid-independent negative control on plant *** of the folate pathway promotes enhanced resistance to Pseudom onas syringae DC3000 via activation of a primed immune state in plants,whereas its implementation results in enhanced *** proteomics analysis using immune-defective mutants identified a methionine synthase(METs1),in charge of the synthesis of Met through the folate-dependent 1C metabolism,acting as a nexus between the folate pathway and plant *** of METs1 represses plant immunity and is accompanied by genome-wide global increase in DNA methylation,revealing that imposing a methylation pressure at the genomic level compromises plant *** together,these results indicate that the folate pathway represents a new layer of complexity in the regulation of plant defense responses.

关键词： folate pathway plant immunity methionine DNA methylation

Boron in Plants: Deficiency and Toxicity

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Journal of Integrative Plant Biology 2008年第10期50卷 1247-1255页

作者： Juan J. Camacho-Cristóbal jesús Rexach Agustín Gonzlez-Fontes Departamento de Fisiología Anatomía y Biología Celular Facultad de Ciencias Experimentales Universidad Pablo de OlavideE-41013 Sevilla Spain

Boron （B） is an essential nutrient for normal growth of higher plants, and B availability in soil and irrigation water is an important determinant of agricultural production. To date, a primordial function of B is undoubtedly its structural role in the ceil wall; however, there is increasing evidence for a possible role of B in other processes such as the maintenance of plasma membrane function and several metabolic pathways. In recent years, the knowledge of the molecular basis of B deficiency and toxicity responses in plants has advanced greatly. The aim of this review is to provide an update on recent findings related to these topics, which can contribute to a better understanding of the role of B in plants.

关键词： boron-binding molecules boron transporter cell wall-related genes gene expression nitrogen metabolism,

An Inactivated Vaccine from a Field strain of Bovine Herpesvirus-1(BoHV-1) has High Antigenic Mass and Induces strong Efficacy in a Rabbit Model

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Virologica sinica 2013年第1期28卷 36-42页

作者： Julian Ruiz-sáenz Jairo Jaime Victor vera Microbiology and Epidemiology Group Faculty of Veterinary Medicine and Animal Science National University of Colombia Grupo de Investigación CENTAURO Agrarian Sciences Faculty Universidad de Antioquia A.A. 1226

Bovine Herpesvirus-1 （BoHV-1） is a DNA virus belonging to the family Herpesviridae, subfamily Alfaherpesvirinae; it is a worldwide pathogen, causing serious economic losses in livestock. In Colombia there have been multiple isolates of BoHV-1 that have been subjected to molecular characterization, classifying most of the country isolates as BoHV-I.1. In the present study we developed and evaluated an ethyleneimine binary inactivated isolate from the native BoHV-1 strain （C6rdoba-2） in a rabbit model of vaccination and infection. The vaccine was evaluated in two phases, one of immunogenicity with vaccination and a booster after 21 days, and an evaluation phase of protection against challenge with a highly virulent reference strain. The results demonstrate optimum serum-conversion, with protective neutralizing antibody titers 28 days post vaccination and optimal protection against challenge with the reference strain with decreased clinical signs of infection, protection against the onset of fever and decrease of virus excretion post challenge. In conclusion, our results show the enormous potential that an immunogenic inactivated vaccine has produced from the native BoHV-I.1 strain, which produces a high antigen mass to the vaccine to induce optimal immunity and protection, and it is a strong candidate for evaluation and possible future use in different cattle populations.

关键词： Antigenic Mass Adjuvant Binary Ethyleneimine Bovine Herpesvirus-1 Vaccine

Periodic solutions in Unbounded Domains for the Boussinesq system

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Acta Mathematica sinica,English series 2010年第5期26卷 837-862页

作者： Elder jesús VILLAMIZAR-ROA María ngeles RODRíGUEZ-BELLIDO Marko Antonio ROJAs-MEDAR Escuela de Matemáticas Universidad Nacional de Colombia Dpto. Ecuaciones Diferenciales y Análisis Numérico Universidad de Sevilla Aptdo Dpto. de Ciencias Básicas Facultad de Ciencias Universidad del Bío BíoCampus Fernando May

Assuming that the external forces of the system are small enough, the reference temperature being a periodic function, we study the existence, the uniqueness and the regularity of time-periodic solutions for the Boussinesq equations in several classes of unbounded domains of Rn. Our analysis is based on the framework of weak-Lp spaces.

关键词： Boussinesq equations strong periodic solutions unbounded domains

Assessing vegetation community distribution characteristics and succession stages in mountainous areas hosting coming Winter Olympics Games

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Journal of Mountain science 2021年第11期18卷 2870-2887页

作者： ZHANG Heng-shuo ZHA Tong-gang YU Yang JI Xiao-dong jesÚs Rodrigo-Comino school of soil and Water Conservation Beijing Forestry UniversityQinghua East Road 35Beijing 100083China Jixian National Forest Ecosystem Research Network station CNERNBeijing Forestry UniversityBeijing 100083China Departamento de Análisis Geográfico Regional y Geografía Física Facultad de Filosofía y LetrasCampus Universitario de CartujaUniversity of Granada18071 GranadaSpain

Alpine mountain ecosystem shows strong interactions between abiotic and biotic *** also receive high attention from human activities(natural tourism,trekking,skiing,etc.).However,as the potential disturbance risk areas in alpine mountains are increasing,it is necessary to understand the relationship between environmental factors and plant *** is also the key consideration for the coming international events such as the Winter Olympic Games,which could generate uncontrolled ecosystem issues not previously *** Yin Mountains in Chongli district,Zhangjiakou City,Hebei Province,China will be the core area of the 2022 Winter Olympic *** hypothesize that disturbances will be caused,therefore,the previous relationships between the habitat factors and plant community and the main environmental limiting factors before hosting them must be assessed to design future restoration ***,we used the two-way indicator species analysis(TWINsPAN)and market basket analysis(MBA)for vegetation classification in 91 sampling *** community and relationships among environmental variables(altitude,slope position,aspect,direction,inclination,soil porosity,soil bulk density,organic matter content and soil pH)were investigated through the trend correspondence(DCA)and canonical correspondence analyses(CCA).Also,the TWINsPAN was used to classify the vegetation into 6 different *** analysis showed that i)the spatial variation of soil moisture and the content of soil organic matter are the main factors limiting the development of shrub and herb communities;ii)the distribution of different forest communities was mainly affected by terrain factors(altitude,aspect and slope position);iii)the dynamic changes of vegetation communities in different altitudes were affected by the fluctuation of environmental factors and human disturbance,and the shrubs and herbaceous plants in mid-to-high altitude areas(above 1400 m)generally show the process o

关键词： Vegetation classification Topographic factors Community distribution Winter Olympic Games