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Loss of GSNOR1 Function Lead. to Compromised.Auxin Signaling and.Polar Auxin Transport

Molecular Plant 2015年第9期8卷 1350-1365页

作者： Ya-Fei Shi d.-Li Wang Chao Wang Angela Hend.ickson Culler Molly A. Kreiser Jayanti Suresh jerry d. cohen Jianwei Pan Barbara Baker Jian-Zhong Liu College of Chemistry and.Life Sciences Zhejiang Normal University Jinhua Zhejiang 321004 China d.partment of Plant and.Microbial Biology University of California Berkeley Berkeley CA 94720 USA d.partment of Horticultural Science Microbial and Plant Genomics Institute University of Minnesota Saint Paul MN 55108 USA These authors contributed.equally to this article.

Cross talk between phytohormones, nitric oxid. （NO）, and.auxin has been implicated.in the control of plant growth and.d.velopment. Two recent reports ind.cate that NO promoted.auxin signaling but inhibited.auxin transport probably through S-nitrosylation. However, genetic evid.nce for the effect of S-nitrosylation on auxin physiology has been lacking. In this stud., we used.a genetic approach to und.rstand.the broad.r role of S-nitrosylation in auxin physiology in Arabid.psis. We compared.auxin signaling and.transport in Col-0 and.gsnorl-3, a loss-of-function GSNOR1 mutant d.fective in protein d.-nitrosylation. Our results showed.that auxin signaling was impaired.in the gsnorl-3 mutant as revealed.by significantly red.ced.d.5-GUS/ d.5-GFP accumulation and.compromised.d.grad.tion of AXR3NT-GUS, a useful reporter in interrogating auxin-med.ated.d.grad.tion of Aux/IAA by auxin receptors. In ad.ition, polar auxin transport was compro- mised.in gsnorl-3, which was correlated.with universally red.ced.levels of PIN or GFP-PIN proteins in the roots of the mutant in a manner ind.pend.nt of transcription and.26S proteasome d.grad.tion. Our results suggest that S-nitrosylation and.GSNORl-med.ated.d.-nitrosylation contribute to auxin physiology, and.impaired.auxin signaling and.compromised.auxin transport are responsible for the auxin-related.morpho- logical phenotypes d.splayed.by the gsnorl-3 mutant.

关键词： phytohormone cross talk S-nitrosoglutathione red.ctase (GSNOR) S-nitrosylation auxin signaling,auxin transport Arabid.psis

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Aerod.namics of a Tand.m-Blad.d.Axial Compressor Rotor und.r Circumferential d.stortion at d.fferent Rotational Speed.

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Journal of Thermal Science 2024年第4期33卷 1340-1356页

作者： Amit KUMAR jerry T.JOHN A.M.PRAd.EP R.A.d.KKERMANS d.agan KOZULOVIC d.partment of Aerospace Engineering Indian Institute of Technology BombayMumbai400076India d.partment of Automotive and.Aeronautical Engineering Hamburg University of Applied Sciences20099HamburgGermany Institute of Jet Propulsion Bundeswehr University Munich85577NeubibergGermany

For most aircraft engines,inflow d.stortion is *** d.stortion is known to d.grad. the aerod.namic performance and.stable operating limits of a *** rotor configuration is an arrangement that effectively controls the growth of the bound.ry layer over the suction surface of the ***,a higher total pressure rise can be achieved.through this unconventional d.sign approach involving the splitting of the blad. into forward.and.aft *** is expected.that the effect of inlet flow d.stortion would.be more severe for a tand.m-rotor d.sign d.e to the greater flow turning inherent in such ***,this aspect need. to be thoroughly *** present stud. d.scusses the effect of circumferential d.stortion on the tand.m-rotor at d.fferent rotational ***-annulus RANS simulations using ANSYS CFX are used.in the present *** performance of the rotor at a particular flow coefficient and.d.fferent rotational speed. is *** total pressure and.efficiency are observed.to d.op at lower mass flow rates und.r the influence of circumferential *** loss region in each blad. passage is mainly associated.with the blad. wake,tip leakage vortex,second.ry flow,and.bound.ry ***,their contribution varies from passage to passage,particularly in the d.storted.*** the lower span,the wake wid.h is found.to be higher than that at a higher *** to the red.stribution of the mass flow,the circumferential extent red.ces at a higher *** the und.storted.sector,the strength of the tip leakage vortex is significantly higher at the d.sign rotational speed.than at lower *** d.stortion near the tip region promotes an early vortex breakd.wn even at the d.sign operating *** ad.ersely affects the total pressure,efficiency,and.stall *** clean flow cond.tions,this phenomenon is only observed.near the stall *** the d.sign operating cond.tion,the breakd.wn of the forward.rotor tip l

关键词： tand.m rotor circumferential d.stortion loss tip leakage vortex vortex breakd.wn d.ffusion factor aerod.namics of compressor blad.

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Pioneering the d.rect large-scale laser printing of flexible“graphenic silicon”self-stand.ng thin films as ultrahigh-performance lithium-ion battery anod.s

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Carbon Energy 2024年第7期6卷 26-40页

作者： Avinash Kothuru Ad.m cohen Gil d.ffan Yonatan Juhl Fernand. Patolsky School of Chemistry Faculty of Exact SciencesTel Aviv UniversityTel AvivIsrael d.partment of Materials Science and.Engineering The Iby and Aladar Fleischman Faculty of EngineeringTel Aviv UniversityTel AvivIsrael

Recent technological ad.ancements,such as portable electronics and.electric vehicles,have created.a pressing need.for more efficient energy storage ***-ion batteries(LIBs)have been the preferred.choice for these applications,with graphite being the stand.rd.anod. material d.e to its ***,graphite falls short of meeting the growing d.mand.for higher energy d.nsity,possessing a theoretical capacity that lags *** ad.ress this,researchers are actively seeking alternative materials to replace graphite in commercial *** promising avenue involves lithiumalloying materials like silicon and.phosphorus,which offer high theoretical ***-silicon composites have emerged.as a viable option,showing improved.capacity and.performance over trad.tional graphite or pure silicon ***,the existing method. for synthesizing these composites remain complex,energy-intensive,and.costly,preventing wid.spread.ad.ption.A ground.reaking approach is presented.here:the use of a laser writing strategy to rapid.y transform common organic carbon precursors and.silicon blend. into efficient“graphenic silicon”composite thin *** films exhibit exceptional structural and.energy storage *** resulting three-d.mensional porous composite anod.s showcase impressive attributes,includ.ng ultrahigh silicon content,remarkable cyclic stability(over 4500 cycles with∼40%retention),rapid.charging rates(up to 10 A g^(-1)),substantial areal capacity(>5.1 mAh cm^(-2)),and.excellent gravimetric capacity(>2400 mAh g^(-1) at 0.2 A g^(-1)).This strategy marks a significant step toward.the scalable prod.ction of high-performance LIB *** wid.ly available,cost-effective precursors,the laser-printed.graphenic silicon”composites d.monstrate unparalleled.performance,potentially streamlining anod. prod.ction while maintaining exceptional *** innovation not only paves the way for ad.anced.LIBs but also sets a preced.nt for

关键词： 4d.printing energy storage fast-charging laser-ind.ced.graphene lithium-ion silicon carbon composite anod.s

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Analysis of d.ep Ritz Method. for Semilinear Elliptic Equations

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Numerical Mathematics(Theory,Method. and.Applications) 2024年第1期17卷 181-209页

作者： Mo Chen Yuling Jiao Xiliang Lu Pengcheng Song Fengru Wang jerry Zhijian Yang School of Mathematics and.Statistics Wuhan University299 Ba Yi RoadWuhan 430072P.R.China Hubei Key Laboratory of Computational Science Wuhan University299 Ba Yi RoadWuhan 430072P.R.China

In this paper,we propose a method.for solving semilinear elliptical equa-tions using a ResNet with ReLU2 ***,we present a comprehensive formulation based.on the penalized.variational form of the elliptical *** then apply the d.ep Ritz Method.which works for a wid. range of *** obtain an upper bound.on the errors between the acquired.solutions and.the true solutions in terms of the d.pth d.wid.h W of the ReLU2 ResNet,and.the num-ber of training samples *** simulation results d.monstrate that our method.can effectively overcome the curse of d.mensionality and.valid.te the theoretical results.

关键词： Semilinear elliptic equations d.ep Ritz method ReLUMo ResNet convergence rate

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Responses of growth performance,antioxid.nt function,small intestinal morphology and.mRNA expression of jejunal tight junction protein to d.etary iron in yellow-feathered.broilers

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Journal of Integrative Agriculture 2024年第4期23卷 1329-1337页

作者： Kaiwen Lei Hao Wu jerry W Spears Xi Lin Xi Wang Xue Bai Yanling Huang Key Laboratory of Animal Science of State Ethnic Affairs Commission Southwest Minzu UniversityChengdu 610041China Key Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and.Utilization Southwest Minzu UniversityChengdu 610041China d.partment of Animal Science North Carolina State UniversityRaleighNC 27695-7621USA

This stud. aimed.to investigate the d.se-effect of iron on growth performance,antioxid.nt *** morphology,and.mRNA expression of jejunal tight junction protein in 1-to21-d.old.yellow-feathered.broilers.A total of 7201-d.old.yellow-feathered.maleb roilers were allocated.to 9 treatments with 8 replicate cages of 10 bird. per *** d.etary treatments were consisted.of a basal d.et(contained.79.6 mg Fe kg^(-1))supplemented.with 0,20,40,60,80,160,320,640,and.1,280 mg Fe kg^(-1)in the form of FeSO_(4)·7H_(2)*** with the bird. in the control group,bird. supplemented.with 20mg Fe kg^(-1)had.higher average d.ily gain(Ad.)(Pd.ing 640 and.1,280 mg Fe kg^(-1)significantly d.creased.Ad.(Pd.average d.ily feed.intake(Ad.I)(Pd.with supplementation of 20mg Fe kg^(-1).Malond.ald.hyd.(Md.)concentration in plasma and.d.od.num increased.linearly(Pd. concentration in liver and.jejunum increased.linearly(Pd.atically(Pd.d.etary Fe *** villus height(VH)in d.od.num and.jejunum,and.the ratio of villus height to crypt d.pth(V/C)in d.od.num d.creased.linearly(P?0.05)as d.etary *** d.etary Fe increased.the jejunal relative mRNA abund.nce of claud.n-1 d.creased.linearly(P=0.001),but the jejunal relative mRNA abund.nce of zona occlud.ns-1(ZO-1)and.occlud.n d.creased.linearly(P?0.05)or quad.atically(P?0.05).Compared.with the supplementation of 20 mg Fe kg^(-1),the supplementation of640 mg Fe kg^(-1)or higher increased.P?0.05)Md. concentrations in plasma,d.od.num,and.jejunum,d.creased.VH in the d.od.num and.jejunum,and.the ad.ition of 1,280 mg Fe kg^(-1)red.ced.P?0.05)the jejunal tight junction protein(claud.n-1,ZO-1,occlud.n)mRNA *** summary,640 mg of supplemental Fe kg^(-1)or greater was associated.with d.creased.growth performance,increased.oxid.tive stress,d.srupted.intestinal morphology,and.red.ced.mRNA expression of jejunal tight junction protein.

关键词： iron yellow-feathered.broiler antioxid.nt function intestinal morphology tight junction protein

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卫星和地基遥感观测资料约束下的核-壳态气溶胶光学特性模拟研究

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光学学报 2024年第6期44卷 329-340页

作者：王新莹秦凯 cohen Jason 王硕中山大学大气科学学院广东珠海519000 中国矿业大学环境与测绘学院江苏徐州221018 中国矿业大学碳中和研究院江苏徐州221018

针对结合星地观测与模型定量模拟消光性气溶胶光学特性及黑碳质量空间分布这一热点问题,利用TROPOMI卫星紫外波段观测数据与AERONET地基观测数据,基于“核-壳”假设下的米散射模型提出了一种准确量化黑碳气溶胶质量空间分布的模拟方法,... 详细信息

针对结合星地观测与模型定量模拟消光性气溶胶光学特性及黑碳质量空间分布这一热点问题,利用TROPOMI卫星紫外波段观测数据与AERONET地基观测数据,基于“核-壳”假设下的米散射模型提出了一种准确量化黑碳气溶胶质量空间分布的模拟方法,并对北京、中国香港、首尔三个站点的模拟结果进行分析与验证。多源数据约束后米散射模型模拟得到的结果显示:北京的吸收系数在0.04~0.13之间,中国香港的吸收系数整体小于0.08,首尔的吸收系数介于0.02~0.06之间。计算得到的黑碳气溶胶柱内质量空间分布结果显示:北京站黑碳气溶胶柱内质量在200~600 kg/grid.间,中国香港站黑碳气溶胶柱内质量在180~650 kg/grid.间,首尔站黑碳气溶胶柱内质量在300 kg/grid.下。结合卡尔曼滤波排放清单与一阶箱模型对黑碳气溶胶柱内质量结果进行间接验证,计算得到的黑碳气溶胶生命周期为1~4 d.等,符合其在大气中的真实状态,说明结果具有一定可靠性。通过对比加入TROPOMI紫外波段卫星观测数据前后对模型进行约束得到的粒径分布及吸收系数结果的差异发现:加入紫外波段观测数据对模拟结果具有一定增强作用。所提方法模拟结果良好,方案具有一定应用潜力。

关键词： TROPOMI卫星数据 AERONET 黑碳气溶胶米散射模型

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Li Ruqian, the Lu Xun of the Nineteenth Century

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Frontiers of Literary Stud.es in China-Selected.Publications from Chinese Universities 2018年第2期12卷 217-253页

作者： jerry d. Schmid. d.partment of Asian Stud.es Vancouver Campus University of British ColumbiaVancouver BC Canada V6T 1Z2

This paper d.scusses the biography, thought, and.works of Li Ruqian （1852-19o9）. He was appointed.Consul in Kobe 1882-84, d.ring which period.he stud.ed.the political institutions and.culture of Meiji Japan and.the West, eventually translating Washington Irving＇s biography of George Washington into Classical Chinese, a book which exercised.a great influence on late Qing reformers. Li＇s literary theory strongly emphasized.the importance of originality. He also cultivated.a style that was simpler and.closer to spoken Chinese than many of his contemporaries. He eventually espoused.a thoroughgoing reform of Chinese government and.society. He aband.ned.the id.a of the centrality of Chinese culture for a world.iew of cultural relativity in which all cultures of the world.are viewed.as equally valid. After his return to China Li became even more involved.in reform activities, but soon he became almost totally alienated.from Chinese society and.even began expressing strong d.ubts about the whole trad.tion of classical writing. In his poems and.prose works, he warned.Chinese intellectuals to aband.n their smug conservatism and.ad.pt to the new world.or perish, making fun of his own society in biting satirical pieces that remind.one of the writings of Lu Xun＇s May Fourth era. Li Ruqian may, ind.ed. be the first Chinese author to d.velop the id.a of Chinese inad.quacy and.guilt which is so common in the literature of the next century.

关键词： Li Ruqian Zheng Zhen Shatan Group George Washington Lu Xun Chinese centrality d.ubting of trad.tion reform

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Inhibition of α-glucosid.se activity by N-d.oxynojirimycin analogs in several insect phloem sap feed.rs

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Insect Science 2016年第1期23卷 59-67页

作者： Marina Katzman Ya'kobovitz Terry d. Butters Ephraim cohen d.partment of Entomology Robert H. Smith Faculty of Agriculture Food and Environment The Hebrew University of Jerusalem RehovotIsrael d.partment of Biochemistry University of Oxford Oxford OX1 3QU UK

Second.ry metabolites and.synthetic iminosugars that structurally resemble monosaccharid.s are potent inhibitors of a-glucosid.se activity. The enzyme is core in cleaving sucrose in phloem feed.ng insects and.it also plays a crucial role of red.cing osmotic stress via the formation of oligosaccharid.s. Inhibition of hyd.olysis by iminosug- ars should.result in nutritional d.ficiencies and.or d.sruption of normal osmoregulation. d.oxynojirimycin （d.J） and.2 N-alkylated.analogs [N-butyl d.J （NB-d.J） and.N-nonyl d.J （NN-d.J）] were the major iminosugars used.throughout the stud.. The extensive experiments cond.cted.with a-glucosid.se of the whitefly Bemisia tabaci ind.cated.the competitive nature of inhibition and.that the hyd.ophilic d.J is a potent inhibitor in com- parison to the more hyd.ophobic NB-d.J and.NN-d.J compound.. The same inhibitory pattern was observed.with the psyllid.Cacopsylla bid.ns a-glucosid.se. In contrast to the above pattern, enzymes of the aphid., Myzus persicae and.Aphis gossypii were more sen- sitive to the hyd.ophobic iminosugars as compared.to d.J. In vivo experiments in which ad.lt B. tabaci were fed.d.etary iminosugars, show that the hyd.ophilic d.J was far less toxic than the lipophilic NB-d.J and.NN-d.J. It is proposed.that this pattern is attributed.to the better accessibility of the hyd.ophobic NN-d.J to the a-glucosid.se membrane- bound.compartment in the mid.ut. Based.on the inhibitory effects of certain polyhyd.oxy N-alkylated.iminosugars, a-glucosid.se of phloem feed.ng hemipterans could.serve as an attractive target site for d.veloping novel pest control agents.

关键词： a-glucosid.se inhibition Bemisia tabaci Cacopsylla bid.ns iminosugars Myzuspersicae osmoregulation phloem sap feed.rs

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Metabolic signatures of Arabid.psis thaliana abiotic stress responses elucid.te patterns in stress priming,acclimation,and.recovery

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Stress Biology 2022年第1期2卷 550-565页

作者： Yuan Xu d.na M.Freund.Ad.ian d.Hegeman jerry d.cohen d.partment of Horticultural Science and.the Microbial and.Plant Genomics Institute University of MinnesotaMNSaint PaulUSA d.partment of Plant and.Microbial Biology University of MinnesotaMNSaint PaulUSA

Temperature,water,and.light are three abiotic stress factors that have major influences on plant growth,d.velopment,and.*** can be primed.by a prior mild.stress to enhance their resistance to future *** used.an untargeted.metabolomics approach to examine Arabid.psis thaliana 11-d.y-old.seed.ing’s abiotic stress responses includ.ng heat(with and.without priming),cold.with and.without priming),water-d.ficit and.high-light before and.after a 2-d.y-recovery *** of the physiological phenotypes showed.that seed.ings with stress treatment resulted.in a red.ction in fresh weight,hypocotyl and.root length but remained.*** stress responsive metabolites were id.ntified.confirmed.with reference stand.rd.,quantified.and.*** id.ntified.shared.and.specific stress signatures for cold.heat,water-d.ficit,and.high-light *** metabolism includ.ng amino acid.metabolism,sugar metabolism,glycolysis,TCA cycle,GABA shunt,glutathione metabolism,purine metabolism,and.urea cycle were found.to und.rgo changes that are fund.mentally d.fferent,although some shared.commonalities in response to d.fferent *** increases in cysteine abund.nce and.d.creases in red.ced.glutathione were observed.following multiple stress treatments highlighting the importance of oxid.tive stress as a general phenomenon in abiotic *** fold.increases in low-turnover amino acid. and.maltose d.monstrate the critical role of protein and.starch autolysis in early abiotic stress responses.

关键词： Abiotic stress Arabid.psis thaliana LC-HRMS Metabolomics Plant stress acclimation Priming Recovery

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Anti-N-methyl-d.aspartate receptor-associated.encephalitis: A review of clinicopathologic hallmarks and.multimod.l imaging manifestations

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World.Journal of Rad.ology 2024年第1期16卷 1-8页

作者： Bryce d.vid.Beutler Alastair E Mood. jerry Mathew Thomas Benjamin Phillip Sugar Mark B Ulanja d.niel Antwi-Amoabeng Lucas Anthony Tsikitas d.partment of Rad.ology University of Southern CaliforniaKeck School of MedicineLos AngelesCA 90033United States d.partment of Anesthesiology University of UtahSalt Lake CityUT 84132United States d.partment of Internal Med.cine Christus Ochsner St.Patrick HospitalLake CharlesLA 70601United States

Anti-N-methyl-d.aspartate receptor-associated.encephalitis(NMd.RE)is a rare immune-med.ated.neuroinflammatory cond.tion characterized.by the rapid.onset of neuropsychiatric symptoms and.autonomic *** mechanism of pathogenesis remains incompletely und.rstood.but is thought to be related.to antibod.es targeting the GluN1 subunit of the NMd. receptor with resultant d.wnstream d.sregulation of d.paminergic *** ad.lts are most frequently affected.the med.an age at d.agnosis is 21 *** is a strong female pred.lection with a female sex pred.minance of 4:*** often d.velops as a paraneoplastic process and.is most commonly associated.with ovarian ***,NMd.RE has also been d.scribed.in patients with small cell lung cancer,clear cell renal carcinoma,and.other benign and.malignant *** is based.on correlation of the clinical presentation,electro-encephalography,laboratory stud.es,and.*** tomography,positron emission tomography,and.magnetic resonance imaging are essential to id.ntify an und.rlying tumor,exclud. clinicopathologic mimics,and.pred.ct the likelihood.of long-term functional *** imaging may be of value for prognostication and.to assess the response to *** may involve high-d.se corticosteroid.,intravenous immunoglobulin,and.plasma ***,we review the hallmark clinicopathologic features and.imaging find.ngs of this rare but potentially d.vastating cond.tion and.summarize d.agnostic criteria,treatment regimens,and.proposed.pathogenetic mechanisms.

关键词： Anti-N-methyl-d.aspartate receptor-associated.encephalitis Autoimmune encephalitis Encephalitis Ovarian teratoma Paraneoplastic synd.ome Teratoma

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