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Silicone matrices for controlled dexamethasone release:toward a better understanding of the underlying mass transport mechanisms

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Regenerative Biomaterials 2023年第1期10卷 498-509页

作者： Thitiphorn Rongthong Adam Qnouch maria maue Gehrke Laurent Paccou Paulo Oliveira Florence Danede jeremy Verin Christophe Vincent Jean-Francois Willart Florence Siepmann Juergen Siepmann Univ.Lille INSERMCHU LilleU1008F-59000 LilleFrance Univ.Lille UMR CNRS 8207UMETF-59655 Villeneuve d’AscqFrance

Dexamethasone-loaded silicone matrices offer an interesting potential as innovative drug delivery systems,*** the treatment of inner ear diseases or for ***,very long drug release periods are targeted:several years/*** renders the development and optimization of novel drug products cumbersome:experimental feedback on the impact of the device design is obtained very slowly.A better understanding of the underlying mass transport mechanisms can help facilitating research in this field.A variety of silicone films were prepared in this study,loaded with amorphous or crystalline *** polymorphic drug forms were investigated,the film thickness was altered and the drug optionally partially/completely exchanged by much more water-soluble dexamethasone‘phosphate’.Drug release studies in artificial perilymph,scanning electron microscopy,optical microscopy,differential scanning calorimetry,X-ray diffraction and Raman imaging were used to elucidate the physical states of the drugs and polymer,and of the systems’structure as well as dynamic changes thereof upon exposure to the release *** particles were initially homogeneously distributed throughout the *** hydrophobicity of the matrix former very much limits the amounts of water penetrating into the system,resulting in only partial drug *** mobile drug molecules diffuse out into the surrounding environment,due to concentration ***,Raman imaging revealed that even very thin silicone layers(m)can effectively trap the drug for prolonged periods of *** physical state of the drug(amorphous,crystalline)did not affect the resulting drug release kinetics to a noteworthy extent.

关键词： silicone matrix drug release mechanism dexamethasone dexamethasone phosphate Raman imaging

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Climate change,air pollution,and allergic respiratory diseases:a call to action for health professionals

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Chinese medical Journal 2020年第13期133卷 1552-1560页

作者： Shi-Zhou Deng Bin BJalaludin Josep mAnto jeremy JHess Cun-Rui Huang School of Public Health Sun Yat-sen UniversityGuangzhouGuangdong 510080China Shanghai Key Laboratory of meteorology and Health Shanghai Meteorological ServiceShanghai 200030China School of Public Health and Community medicine University of New South WalesSydneyAustralia ISGIobal Centre for Research in Environmental Epidemiology(CREAL)BarcelonaSpain ImIm(Hospital del mar Research Institute) BarcelonaSpain CIBER Epidemiologla y Salud Publica(CIBERESP) BarcelonaSpain Universitat Pompeu Fabra(UPF) BarcelonaSpain Departments of Emergency medicine Environmental and Occupational Health Sciencesand Global HealthSchools of Medicine and Public HealthUniversity of WashingtonSeattleWAUSA School of Public Health Zhengzhou UniversityZhengzhouHenan 450001China Shanghai Typhoon Institute China Meteorological AdministrationShanghai 200030China

Rising emissions of greenhouse gases in the atmosphere have warmed the planet substantially and are also accompanied by poor air *** increased prevalence of allergic airway disease worldwide can be partially attributed to those global environmental *** change and air pollution pose adverse impacts on respiratory allergies,and that the mechanisms are complex and *** weather conditions,such as extreme temperatures,can act directly on the respiratory tract to induce allergic respiratory *** and floods can alter the production and distribution of aeroallergens while wildfires and dust storms increase air pollution,and therefore indirectly enhance health *** of particulate matter and ozone in the air have been projected to increase with climate warming and air stagnation,and the rising temperatures and CO2 increase pollen,molds,and spores,which escalate the risk of allergic respiratory *** synergistic effects of extreme heat and aeroallergens intensify the toxic effect of air pollutants,which in turn augment the allergenicity of *** the Earth’s climate change,migration of humans and plants shift the living environments and allergens of susceptible *** residents are exposed to multiple factors while children are sensitive to environmental *** climate change may pose many unexpected and persistent effects on allergic respiratory diseases,health professionals should advocate for effective mitigation and adaptation strategies to minimize its respiratory health effects.

关键词： Respiratory allergy Climate change Air pollution Extreme weather events Aeroallergen

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In-vivo evaluation of molybdenum as bioabsorbable stent candidate

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Bioactive materials 2022年第8期7卷 262-271页

作者： malgorzata Sikora-Jasinska Lea m.morath maria P.Kwesiga margaret E.Plank Alexia L.Nelson Alexander A.Oliver martin L.Bocks Roger J.Guillory II jeremy Goldman Department of Biomedical Engineering Michigan Technological UniversityUSA Department of Biomedical Engineering and Physiology Mayo Clinic Graduate School of Biomedical SciencesUSA Case Western Reserve University School of medicine UH Rainbow Babies&Children’s HospitalClevelandOHUSA

Biodegradable stents have tremendous theoretical potential as an alternative to bare metal stents and drug-eluting stents for the treatment of obstructive coronary artery *** bioresorbable or biodegradable scaffold material needs to possess optimal mechanical properties and uniform degradation behavior that avoids local and systemic ***,molybdenum(mo)has been investigated as a potential novel biodegradable material for this *** its proven moderate degradation rate and excellent mechanical properties,mo may represent an ideal source material for clinical cardiac and vascular *** present study was performed to evaluate the mechanical performance of metallic mo in vitro and the biodegradation properties in *** results demonstrated favorable mechanical behavior and a uniform degradation profile as desired for a new generation ultra-thin degradable endovascular stent ***,mo implants in mouse arteries avoided the typical cellular response that contributes to *** was minimal neointimal hyperplasia over 6 months,an absence of excessive smooth muscle cell(SmC)proliferation or inflammation near the implant,and avoidance of significant harm to regenerating endothelial cells(EC).Qualitative inspection of kidney sections showed a potentially pathological remodeling of kidney Bowman’s capsule and glomeruli,indicative of impaired filtering function and development of kidney disease,although quantifications of these morphological changes were not statistically ***,the results suggest that the products of mo corrosion may exert beneficial or inert effects on the activities of inflammatory and arterial cells,while exerting potentially toxic effects in the kidneys that warrant further investigation.

关键词： Biodegradable stent molybdenum Biocompatibility Degradation

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Perfusability and immunogenicity of implantable pre-vascularized tissues recapitulating features of native capillary network

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Bioactive materials 2023年第12期30卷 184-199页

作者： Dhavan Sharma Archita Sharma Linghao Hu Te-An Chen Sarah Voon Kayla J.Bayless jeremy Goldman Alex J.Walsh Feng Zhao Department of Biomedical Engineering Texas A&M UniversityCollege StationTXUnited States School of medicine Texas A&M UniversityCollege StationTXUnited States Department of Biomedical Engineering Michigan Technological UniversityHoughtonMIUnited States

Vascularization is a key pre-requisite to engineered anatomical scale three dimensional(3-D)constructs to ensure their nutrient and oxygen supply upon ***,engineered pre-vascularized 3-D tissues are limited to only micro-scale hydrogels,which meet neither the anatomical scale needs nor the complexity of natural extracellular matrix(ECm)*** scale perfusable constructs are critically needed for translational *** overcome this challenge,we previously developed pre-vascularized ECm sheets with long and oriented dense microvascular *** present study further evaluated the patency,perfusability and innate immune response toward these pre-vascularized ***-co-cultured prevascularized constructs were evaluated in vitro to confirm micro-vessel patency and perturbations in macrophage *** implanted pre-vascularized constructs remained viable and formed a functional anastomosis with host vasculature within 3 days of *** completely biological pre-vascularized construct holds great potential as a building block to engineer perfusable anatomical scale tissues.

关键词： Pre-vascularization micro-vasculature mesenchymal stem cells Extracellular matrix Fluorescence lifetime imaging

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用涡度相关法测定网室内香蕉树蒸散量

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农业工程学报 2008年第9期24卷 1-5页

作者：刘海军黄冠华 Josef Tanny Shabtain cohen 北京师范大学水科学研究院水沙科学教育部重点实验室北京100875 中国农业大学水利与土木工程学院北京100083 Institute of Soil Water and Environmental Sciences Agricultural Research Organization The Volcani Center Israel

为了研究涡度相关法在网室内的适用性,于2005年6月在一个长、宽、高分别为352m、228m和6m的香蕉树种植网室内进行试验,测定的参数主要有网室内的潜热和感热、网室内的净辐射,土壤热通量和表层土壤热量。研究发现涡度相关法测定的能量和... 详细信息

为了研究涡度相关法在网室内的适用性,于2005年6月在一个长、宽、高分别为352m、228m和6m的香蕉树种植网室内进行试验,测定的参数主要有网室内的潜热和感热、网室内的净辐射,土壤热通量和表层土壤热量。研究发现涡度相关法测定的能量和和小气候仪器测定的能量一致,说明涡度相关法可用来准确测定网室内作物的蒸散量。在试验期间(6月7日-20日),涡度相关法测定的网室内香蕉树的蒸散量在4.83～6.50mm/d之间,考虑到当地每年4～10月之间气象要素变化较小,则该文测定的蒸散量可用来指导当地网室内香蕉树的灌溉。

关键词：涡度相关能量平衡蒸散量香蕉树

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Urothelial Carcinoma:Two Diseases

Urothelial Carcinoma:Two Diseases

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第四届中国肿瘤学术大会暨第五届海峡两岸肿瘤学术会议

作者： Samuel m. cohen Sonny L.Johansson Department of Pathology and microbiology and Eppley Institute for Cancer Research University of Nebraska medical Center OmahaNE 68198 Havlik-Wall Professor of Oncology Amelia F. and Austin L. Vickery Jr. Chair of Pathology

＜正＞INTRODUCTION Cancer of the lower urinary tract predominantly involves the urothelium, whether the renal pelvis,ureters, or urinary bladder （Eble et al. ,2004） .The majority of these tumors occur in the urinary bladder,but the histologic classification is the same in all of these tissues. The preponderance of tumors of the urothelium are classified as having urothe-lial differentiation, what used to be referred to as transitional cell *** account for 90% -95% of all

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In Situ Iodide Passivation Toward Efficient CsPbI_(3) Perovskite Quantum Dot Solar Cells

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Nano-micro Letters 2023年第10期15卷 28-39页

作者： Junwei Shi Ben cohen‑Kleinstein Xuliang Zhang Chenyu Zhao Yong Zhang Xufeng Ling Junjun Guo Doo‑Hyun Ko Baomin Xu Jianyu Yuan Wanli ma Department of materials Science and Engineering Southern University of Science and TechnologyShenzhen 518055People’s Republic of China Institute of Functional Nano&Soft materials(FUNSOm) Soochow University199 Ren‑Ai RoadSuzhou Industrial ParkSuzhou 215123People’s Republic of China Department of Electrical and Computer Engineering University of British Columbia2329 West MallVancouverBC V6T 1Z4Canada Department of Chemistry Sungkyunkwan UniversitySuwon 16419Republic of Korea Jiangsu Key Laboratory of Advanced Negative Carbon Technologies Soochow University199 Ren‑Ai RoadSuzhou Industrial ParkSuzhou 215123People’s Republic of China Jiangsu Key Laboratory for Carbon‑Based Functional materials&Devices Soochow University199 Ren‑Ai RoadSuzhou Industrial ParkSuzhou 215123People’s Republic of China

All-inorganic CsPbI_3 quantum dots(QDs) have demonstrated promising potential in photovoltaic(PV) applications. However, these colloidal perovskites are vulnerable to the deterioration of surface trap states, leading to a degradation in efficiency and stability. To address these issues, a facile yet effective strategy of introducing hydroiodic acid(HI) into the synthesis procedure is established to achieve high-quality QDs and devices. Through an in-depth experimental analysis, the introduction of HI was found to convert PbI_2 into highly coordinated [PbI_m]~(2-m), enabling control of the nucleation numbers and growth kinetics. Combined optical and structural investigations illustrate that such a synthesis technique is beneficial for achieving enhanced crystallinity and a reduced density of crystallographic defects. Finally, the effect of HI is further reflected on the PV performance. The optimal device demonstrated a significantly improved power conversion efficiency of 15.72% along with enhanced storage stability. This technique illuminates a novel and simple methodology to regulate the formed species during synthesis, shedding light on ofurther understanding solar cell performance, and aiding the design of future novel synthesis protocols for high-performance optoelectronic devices.

关键词： CsPbI_(3)perovskite quantum dots In situ passivation Surface trap states Perovskite solar cell

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Utilizing Solar Thermal Energy for Post-Combustion C02 Capture

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Journal of Energy and Power Engineering 2011年第3期5卷 195-208页

作者： Stuart m. cohen michael E. Webber and Gary T. Rochelle Department of mechanical Engineering The University of Texas at Austin Austin TX 78712 USA Department of Chemical Engineering The University of Texas at Austin Austin TX 78712 USA

Post-combustion amine absorption and stripping can remove 90% of the CO2 from power plant flue gas, but systems can reduce electrical output by approximately 30% due to energy requirements for stripping CO2 from solvent and CO2 compression. The CO2 capture energy penalty can be reduced while developing renewable energy technologies by meeting CO2 capture energy requirements with a solar thermal energy system, particularly when electricity demand and prices are the highest. This study presents an initial review of solar thermal technologies for supplying CO2 capture energy, with a focus on high temperature systems. Parabolic troughs and central receivers are technically able to provide energy for CO2 capture. However, the solar system＇s capital costs would be roughly half that of the base coal-fired plant with CO2 capture, and high electricity prices are required to offset the costs of operating the solar thermal system. For high temperature solar thermal systems, direct electricity generation is likely a more efficient way to use solar energy to replace output lost to CO2 capture energy. However, low temperature solar thermal systems might integrate better with solvent stripping equipment, and more rigorous analysis is required to definitively assess the feasibility of using solar energy for CO2 capture.

关键词： Carbon capture carbon dioxide solar thermal climate change electric power.

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Deductions from the Quaternion Form of maxwell’s Electromagnetic Equations

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Journal of modern Physics 2020年第9期11卷 1361-1371页

作者： jeremy Dunning-Davies Richard Lawrence Norman Departments of mathematics and Physics (retd) University of Hull Kingston upon Hull England Institute for Basic Research Palm Harbor FL USA Thunder Energies Corporation Palm Harbor FL USA

It is often claimed that maxwell’s electromagnetic equations were originally written in terms of quaternions. Once returned to that form and treated with left and right hand operators as in the mathematics of P. m. ... 详细信息

It is often claimed that Maxwell’s electromagnetic equations were originally written in terms of quaternions. Once returned to that form and treated with left and right hand operators as in the mathematics of P. M. Jack, a new seventh scalar electromagnetic field component emerges with possible relations to clean energy extraction and gravitation. It is the purpose here to examine this approach afresh and see how it might link up with other fairly recent, but little known, work in the field. Again, as with the usual form of Maxwell’s equations, a new scalar wave equation is derived but, on this occasion, due to the presence of the scalar component of the quaternion, that equation exhibits a wave speed greater than the speed of light. Historical and present uses within military and humanitarian contexts are considered briefly.

关键词： Electromagnetic Field Quaternion Gravity maxwell Energy Scalar Wave

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Layer-by-layer functionalized nanotube arrays:A versatile microfluidic platform for biodetection

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microsystems & Nanoengineering 2015年第1期1卷 1-7页

作者： Allison L.Yost Setareh Shahsavari Grinia m.Bradwell Roberta Polak Fabio Fachin Robert E.cohen Gareth H.mcKinley mehmet Toner michael F.Rubner Brian L.Wardle Department of mechanical Engineering Massachusetts Institute of Technology77 Massachusetts AvenueCambridgeMA 02139USA Department of materials Science and Engineering Massachusetts Institute of Technology77 Massachusetts AvenueCambridgeMA 02139USA Department of Chemical Engineering Massachusetts Institute of Technology77 Massachusetts AvenueCambridgeMA 02139USA Department of Aeronautics and Astronautics Massachusetts Institute of Technology77 Massachusetts AvenueCambridgeMA 02139USA Center for Engineering in medicine and BiomEmS Resource Center Massachusetts General HospitalHarvard Medical Schooland Shriners Hospital for ChildrenBostonMA 02139USA

We demonstrate the layer-by-layer(LbL)assembly of polyelectrolyte multilayers(PEm)on three-dimensional nanofiber *** porosity(99%)aligned carbon nanotube(CNT)arrays are photolithographically patterned into elements that act as textured scaffolds for the creation of functionally coated(nano)porous ***-scale bilayers of poly(allylamine hydrochloride)/poly(styrene sulfonate)(PAH/SPS)are formed conformally on the individual nanotubes by repeated deposition from aqueous solution in microfluidic *** and experimental results show that the LbL deposition is dominated by the diffusive transport of the polymeric constituents,and we use this understanding to demonstrate spatial tailoring on the patterned nanoporous elements.A proof-of-principle application,microfluidic bioparticle capture using N-hydroxysuccinimide-biotin binding for the isolation of prostate-specific antigen(PSA),is demonstrated.

关键词： layer-by-layer carbon nanotube microfluidic nanoporous functionalization bioparticle capture

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