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Comparative study for predictability of type 1 gastric variceal rebleeding after endoscopic variceal ligation:High-frequency intraluminal ultrasound study

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World Journal of Clinical Cases 2021年第34期9卷 10566-10575页

作者： jeong Hwan Kim Won Hyeok Choe sun-Young Lee So Young Kwon In-Kyung sung Hyung Seok park Department of Internal Medicine Konkuk University School of MedicineKonkuk University Medical CenterSeoul 05030South Korea Department of Internal Medicine Konkuk University Medical CenterSeoul 143729South Korea Department of Internal Medicine Konkuk University School of MedicineSeoul 05030South Korea Department of Internal Medicine Digestive Disease CenterKonkuk University School of MedicineSeoul 05030South Korea

BACKGROUND The efficacy of endoscopic ultrasonography for the follow-up of gastric varices treated with endoscopic variceal ligation(EVL)has not been *** To evaluate the diagnostic correlation of esophagogastroduodenoscopy(EGD)and high-frequency intraluminal ultrasound(HFIUS)for type 1 gastric varices(GOV1)after EVL and to identify the predictability for rebleeding of EGD and *** In liver cirrhosis patients with GOV1,we performed endoscopic follow-up using EGD and HFIUS synchronously after EVL for hemorrhage from *** grading and red color signs were analyzed using EGD,and the largest variceal cross-sectional areas were measured using *** addition,1-year follow-up was *** rebleeding was defined as the presence of hematemesis,hematochezia,or melena without other evidence of bleeding on endoscopic *** In 26 patients with GOV1,variceal cross-sectional areas on HFIUS of GOV1 was poorly correlated with EGD grading of GOV1(r=0.36).In 17 patients who completed the 1-year follow-up,variceal cross-sectional areas on HFIUS was a good predictor of subsequent rebleeding,whereas EGD grading was not a predictor of subsequent *** HFIUS measurement is more predictive of GOV1 rebleeding than EGD grading,so HFIUS measurement may be necessary for endoscopic follow-up after EVL in patients with GOV1.

关键词： Endoscopic variceal ligation Esophagogastroduodenoscopy High-frequency intraluminal ultrasound Rebleeding Type 1 gastric varices

Symptomatic accessory soleus muscle:A cause for exertional compartment syndrome in a young soldier:A case report

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World Journal of Clinical Cases 2022年第35期10卷 13022-13027页

作者： Inha Woo Chul Hyun park Hongfei Yan jeong Jin park Department of Orthopaedic Surgery Yeungnam University HospitalDaegu 42492South Korea Department of Orthopaedics Yeungnam University HospitalDaegu 42415South Korea

BACKGROUND Accessory soleus muscle(ASM)is a rare congenital variation that is almost asymptomatic,but several papers have recently described symptomatic *** clinical features of this condition are similar to tarsal tunnel syndrome(TTS)and include pain and numbness around the medial side of the *** commonly originates from the fibula or soleus muscle and inserts into the Achilles tendon or ***,it is identified as posteromedial swelling and definitely diagnosed by magnetic resonance *** most cases,treatment is observation,but surgical excision can be considered if symptoms are *** SUMMARY A 23-year-old male Korean soldier presented with complaints of bilateral foot and ankle pain and a swelling medial to the Achilles tendon that was more pronounced on the right *** first occurred after playing soccer 10 mo before this presentation,worsened after physical exertion,and were relieved by *** had no medical history,and no one in his family had the *** results were *** tests were performed to exclude common diseases such as tumors or ***,MRI revealed a bulky accessory soleus muscle in both feet,though the patient complained of more severe pain on the right side during physical ***,surgical resection was *** surgery,a large accessory soleus muscle was noted anterior to the Achilles tendon with distinctive insertion from a normal soleus *** 12 mo after surgery,there was no pain,numbness,or swelling of the right foot or ankle,no evidence of recurrence,and the patient could do all sports *** Accessory soleus muscle should be added to the list of differential diagnosis if a patient has pain,sole numbness or swelling of the posteromedial ankle.

关键词： Accessory soleus muscle Posteromedial ankle pain Exertional compartment syndrome Tarsal tunnel syndrome Sole numbness Case report

Investigation of prodromal features in metabolic syndrome based on transcriptome analysis

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Genes & Diseases 2023年第3期10卷 708-711页

作者： Sang-Min park Musun park Hyo-jeong Ban Su-Jin Baek Soo Yeon Kim Siwoo Lee Hee-jeong Jin Korean Medicine(KM)Data Division Korea Institute of Oriental MedicineDaejeon 34054Republic of Korea College of Pharmacy Chungnam National UniversityDaejeon 34134Republic of Korea

Metabolic syndrome(MetS)is a complex condition that significantly increases the risk of several diseases,including heart disease and *** with MetS show both pro-inflammatory and pro-thrombotic states;however,the state... 详细信息

关键词： diseases Metabolic Patients

The role of Eph receptors in lens function and disease

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Science China(Life Sciences) 2012年第5期55卷 434-443页

作者： SON Alexander I. park jeong Eun Department of Chemical Biology Ernest Mario School of PharmacyRutgersThe State University of New Jersey

Cataract is the single largest contributor to blindness in the world,with the disease having a strong genetic *** recent years the Eph family of receptor tyrosine kinases has been identified as a key regulator in lens... 详细信息

关键词： cataract lens EphA2 ephrin-A5

Guidance on the Choice of Threshold for Binary Forecast Modeling

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Advances in Atmospheric Sciences 2008年第1期25卷 83-88页

作者： Keon Tae SOHN sun Min park Department of Statistics Pusan National University

This paper proposes useful guidance on the choice of threshold for binary forecasts. In weather forecast systems, the probabilistic forecast cannot be used directly when estimated too smoothly. In this case, the binary forecast, whether a meteorological event will occur or not, is preferable to the probabilistic forecast. A threshold is needed to generate a binary forecast, and the guidance in this paper encompasses the use of skill scores for the choice of threshold according to the forecast pattern. The forecast pattern consists of distribution modes of estimated probabilities, occurrence rates of observations, and variation modes. This study is performed via Monte-Carlo simulation, with 48 forecast patterns considered. Estimated probabilities are generated by random variate sampling from five distributions separately. Varying the threshold from 0 to 1, binary forecasts are generated by threshold. For the assessment of binary forecast models, a 2×2 contingency table is used and four skill scores （Heidke skill score, hit rate, true skill statistic, and threat score） are compared for each forecast pattern. As a result, guidance on the choice of skill score to find the optimal threshold is proposed.

关键词： binary forecast Monte-Carlo simulation threshold skill score

Risk factor analysis for meta plastic gastritis in Koreans

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World Journal of Gastroenterology 2006年第16期12卷 2584-2587页

作者： Soonami Choi Yun jeong Lim Sue Kyung park Center for Health Promotion Samsung Medical CenterSeoulKorea Department of Internal Medicine Dongguk University International HospitalDongguk University College of MedicineGoyangKorea Department of Preventive Medicine Seoul National University College of MedicineSeoulKorea

AIM： To conduct a retrospective study to determine the risk factors for development of metaplastic gastritis in Korean population. METHODS： The database of 113449 subjects who underwent a gastroscopy for the purpose of a regular check-up at center for health promotion, Samsung medical center during 5 years was collected and retrospectively analyzed. Among them, 5847 subjects who had endoscopically diagnosed as a metaplastic gastritis or 10076 normal as well as answered to questionnaire were included for present study. The subjects were divided into 2 groups; Group Ⅰ, normal and Group Ⅱ, metaplastic gastritis. Age, gender, Helicobacter pylori （H pylori） seropositivity, body mass index （BMI）, family history of cancer, smoking, alcohol consumption, total daily calories, folate and salt intake and dietary habit （out-eating, overeating, irregular eating） were retrieved from questionnaire or electronic medical record and compared between group Ⅰ and group Ⅱ. RESULTS： The prevalence of group Ⅱwas 11% （13578/113449） increasing its prevalence with age （P=0.000）. But, there was no significant association between 2 groups in BMI, family history of cancer, alcohol consumption, total daily calories, folate and salt intake and dietary habit （out-eating, overeating, irregular eating）. Old age （P=0.000）, male gender （P=0.000）, H pylori seropositivity （P= 0.010） and current smoker （P=0.000） were significantly more common in group II at multiple logistic regression model. CONCLUSION： Our data suggested that old age, male gender, H pylori seropositivity and smoking were risk factors for metaplastic gastritis, precancerous lesion of gastric cancer.

关键词： Intestinal metaplasia Risk factors

An Efficient Data Dissemination Scheme for Spatial Query Processing

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Journal of Computer Science & Technology 2007年第1期22卷 131-134页

作者： Kwangjin park Hyunseung Choo Chong-sun Hwang School of Information and Communication Engineering Sungkyunkwan University 440-746 Suwon Korea Department of Computer Science and Engineering Korea University 5-1 Anam-Dong Seongbuk-Ku Seoul 136-701 Korea

Due to the personal portable devices and advances in wireless communication technologies, Location Dependent Information Services （LDISs） have received a lot of attention from both the industrial and academic communities. In LDISs, it is important to reduce the query response time, since a late query response may contain out-of-date information. In this paper, we study the issue of LDISs using a Voronoi Diagram. We introduce a new NN search method, called the Exponential Sequence Scheme （ESS）, to support NN query processing in periodic broadcast environment. This paper aims to provide research directions towards minimizing both the access latency and energy consumption for the NN-query processing.

关键词： air index wireless data broadcasting mobile computing

Pemetrexed in Previously Treated Non-small Cell Lung Cancer Patients with Poor Performance Status

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中国肺癌杂志 2011年第1期14卷 33-38页

作者： sun Young JUNG Su Jin YOO Ji Young SHIN Ji Won park jeong Eun LEE Hee sun park Ju Ock KIM sun Young KIM Department of Internal Medicine Chungnam National University Hospital

Background and objective Pemetrexed have been approved for the treatment of patients affected by advanced non-small cell lung cancner(NSCLC) in progression after first-line *** evaluated the activity and feasibility of pemetrexed in previously treated *** Patients with histologically or cytologically confirmed NSCLC were evaluated from April 2007 to March *** patients had relapsed or progressed after prior chemotherapy ***(500 mg/m2) was administered intravenously once every 3 weeks after progression to prior *** tumor response was evaluated according to RECIST criteria by chest CT at every 2 cycles of *** A total 61 patients were eligible for *** status of them(100%) was over *** response rate and disease control rate were 14.7% and 37.7% ***-squamous cell carcinoma histology was significantly associated with a superior response rate(P=0.045) and disease control rate(P=0.008).The median survival time and the median progression free survival(PFS) time were 6.11 months and 2.17 months,*** the efficacy of pemetrexed in these two settings [second-line versus(12/61) more than third(49/61)],there was no significant difference in regard to median survival(11.18 months vs 11.46 months,P=0.922,5),but PFS was more longer in third-or further-line groups than second-line group(1.39 months vs 2.25 months,P=0.015,3).Conclusion Pemetrexed is a feasible regimen in previously treated NSCLC with poor performance status.

关键词：肺癌症状化学疗法临床治疗

Regular moderate aerobic exercise improves high-fat diet-induced nonalcoholic fatty liver disease via monoacylglycerol O-acyltransferase 1 pathway suppression

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Journal of Sport and Health Science 2020年第5期9卷 472-478页

作者： Kyung-Wan Baek jeong-An Gim Jung-Jun park Division of Sport Science Pusan National UniversityBusan 46241Korea Department of Biological Sciences College of Natural SciencesPusan National UniversityBusan 46241Korea

Purpose:Monoacylglycerol O-acyltransferase 1(MGAT1)is reported to play a key role in the development of diet-induced nonalcoholic fatty liver disease(NAFLD).Thus,this study investigated the effect of exercise on suppression of the MGAT1 pathway in NAFLD tissue of high-fat diet(HFD)-induced obese ***:Male Sprague-Dawley rats were fed an HFD containing 45%fat for 6 *** confirmation that NAFLD had been induced in the obese animals,they were divided into HFD-fed groups provided with exercise(HFD+EXE)or without exercise(HFD)and a group given dietary adjustment(DA)only,for a further 6 weeks of intervention *** 6-week regular moderate aerobic exercise consisted of an accommodation phase with increasing *** accumulation in the liver tissue was determined by Oil Red O *** MGAT1 and liver lipogenic gene mRNA levels were measured by qPCR,and their protein levels by western blot ***:Oil Red O staining showed that NAFLD was successfully induced by *** gene expression of MGAT1 was significantly lower in HFD+EXE than ***,there was no significant difference between HFD+EXE and *** protein expression of MGAT1 was significantly lower in HFD+EXE than both HFD and *** RNA and protein expression of other lipogenic genes were not different among *** data indicate that exercise suppresses MGAT1 pathway regardless of HFD feeding;in part,this effect could be greater than ***:Our data suggest that exercise can improve NAFLD,which is probably due to suppression of MGAT1 pathway.

关键词： Exercise High-fat diet Monoacylglycerol O-acyltransferase 1 Nonalcoholic fatty liver disease Obesity