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Risk of ischaemic stroke in patients with transient global amnesia: a propensity-matched cohort study

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Stroke & Vascular Neurology 2022年第2期7卷 101-107页

作者： Sang Hun lee Keon-Yeup Kim jeong-Woo lee So-jeong Park Jin-Man Jung Department of Neurology Korea University Ansan HospitalKorea University College of MedicineAnsanRepublic of Korea Data Science Team Hanmi Pharm.Co.LtdSeoulRepublic of Korea Korea University Zebrafish Translational Medical Research Center AnsanRepublic of Korea

Background The exact pathophysiological mechanism of transient global amnesia(TGA)is *** is debatable whether TGA is a risk factor for ***,here we investigated the possibility of TGA as a risk factor for stroke in a real-world setting using large-scale nationwide health claims *** We used health claims data from the Korean National Health Insurance Service(NHIS).Patients diagnosed with TGA between 2007 and 2013 were *** initially extracted patients without TGA who were preferentially matched for age and sex with the patients with TGA at a ratio of 10:1 from the whole ***,we performed 1:2 propensity score matching analysis to balance the baseline characteristics between the two *** the propensity score-matched dataset,we performed multivariable Cox regression analysis to investigate the association between TGA and stroke type,including ischaemic,haemorrhagic and all stroke *** Patients with TGA(n=14673)were selected from the NHIS *** extracting from the whole database(n=140486)and propensity score matching their data at a 1:2 ratio,a total of 10448 and 20442 patients were finally assigned to the TGA and control groups,*** multivariable Cox regression analysis demonstrated that the TGA group had a higher risk of ischaemic stroke and all types of stroke(adjusted HR=1.194;95%CI:1.043 to 1.368;and HR=1.197;95%CI:1.056 to 1.357,respectively).Conclusions Analysis of the nationwide claims database showed that TGA could be an important risk factor for stroke,especially for ischaemic stroke.

关键词： patients matched transient

Parameterization and Application of Storm Surge/Tide Modeling Using a Genetic Algorithm for Typhoon Periods

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Advances in Atmospheric Sciences 2011年第5期28卷 1067-1076页

作者： Sung Hyup YOU Yong Hee lee Woo jeong lee Marine Meteorology Division Observation Infrastructure Bureau/KMA Korea Forecast Research Laboratory National Institute of Meteorological Research/KMA Korea Global Environment System Research Laboratory National Institute of Meteorological Research/KMA Korea

A genetic algorithm was used to optimize the parameters of the two-dimensional Storm Surge/Tide Operational Model （STORM） to improve sea level *** genetic algorithm was applied to nine typhoons that affected the Korean Peninsula during *** following model parameters were used：the bottom drag coefficient,the background horizontal diffusivity,Smagorinski＇s horizontal viscosity,and the sea level pressure ***,the simulation results using the optimized,mean,and median parameter values improved sea level *** four estimated parameters improved the sea level prediction by 76% and 54% in the bias and root mean square error for Typhoon Kalmaegi （0807） in 2008,***-month simulations of February and August 2008 were also improved using the estimated *** study demonstrates that parameter optimization on STORM can improve sea level prediction.

关键词： genetic algorithm STORM sea level typhoon

Successful treatment of relapsed acute promyelocytic leukemia with arsenic trioxide in a hemodialysis-dependent patient: A case report

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World Journal of Clinical Cases 2020年第21期8卷 5347-5352页

作者： Hee jeong lee Sang-Gon Park Department of Hemato-Oncology Chosun University HospitalGwang-ju 501-717South Korea Department of Internal Medicine Hemato-oncologyChosun University HospitalGwangju 61453South Korea

BACKGROUND Arsenic trioxide(ATO)is recommended for patients who do not achieve molecular remission or who have molecular or morphologic ***,there are no guidelines for adjusting ATO dosage in patients with severe renal failure or on ***,we report the successful treatment of relapsed acute promyelocytic leukemia(APL)in a patient on hemodialysis with ATO single agent and review the cases in *** SUMMARY A 46-year-old woman who has been on hemodialysis to chronic glomerulonephritis for 15 years visited our hospital for *** had been seen for pancytopenia 3 years ago and had been diagnosed with *** also received chemotherapy for APL but unfortunately was lost to follow-up after her second consolidation *** was noted to have pancytopenia by her nephrologist during hemodialysis 1 mo *** marrow biopsy and reverse transcriptase-polymerase chain reaction(RT-PCR)tests revealed a diagnosis of relapsed *** for relapsed APL with ATO single agent was started and she achieved molecular remission after administering 24 doses of *** far,four consolidation therapies have been performed with the ATO single agent,and,to date,the molecular remission has been maintained as negative promyelocytic leukemia/retinoic acid receptor-αfusion gene as confirmed by RTPCR testing for two *** This is a rare case of relapsed APL successfully treated with the single agent ATO in a patient on hemodialysis.

关键词： Arsenic trioxide Acute promyelocytic leukemia Pancytopenia Hemodialysis Promyelocytic leukemia/retinoic acid receptor-αfusion gene Case report

Prostate only radiotherapy using external beam radiotherapy:A clinician’s perspective

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World Journal of Clinical Cases 2022年第29期10卷 10428-10434页

作者： jeong Won lee Mi Joo Chung Department of Radiation Oncology Daegu Catholic University School of MedicineDaegu 42472South Korea Department of Radiation Oncology Hanyang University Hanmaeum Changwon HospitalChangwon 51139South Korea

Prostate-only radiotherapy(PORT) is widely used as the definitive treatment for localized prostate *** cancer has an α/β ratio;therefore,radiotherapy(RT) with a large fraction size is biologically effective for tumor *** current external beam RT technique for PORT has been improved from threedimensional conformal RT to intensity-modulated,stereotactic body,and imageguided *** methods are associated with reduced radiation exposure to normal tissues,decreasing urinary and bowel *** trials have shown improved local control with dose escalation through the aforementioned methods,and the efficacy and safety of intensity-modulated and stereotactic body RTs have been ***,the management of RT in patients with prostate cancer has not been fully *** a clinician,there are several concerns regarding the RT volume and dose considering the patient’s age and ***,this review aimed to discuss the radiobiological basis and external beam technical advancements in PORT for localized prostate cancer from a clinician’s perspective.

关键词： Prostate cancer Radiotherapy Radiation dose Radiation technique Radiation volume

Predictive factors for early clinical response in community-onset Escherichia coli urinary tract infection and effects of initial antibiotic treatment on early clinical response

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World Journal of Clinical Cases 2020年第19期8卷 4342-4348页

作者： Young Jun Kim jeong-Mi lee Jae-Hoon lee Department of Internal Medicine Wonkwang University College of MedicineIksan 54538South Korea Department of Public Health Wonkwang University College of MedicineIksan 54538South Korea Department of Internal Medicine and Institute of Wonkwang Medical Science Wonkwang University College of MedicineIksan 54538South Korea

BACKGROUND Urinary tract infection(UTI)is a common *** often requires hospitalization,and severe presentations,including sepsis and other complications,have a mortality rate of 6.7%-8.7%.AIM To evaluate the predictive factors for early clinical response and effects of initial antibiotic therapy on early clinical response in community-onset Escherichia coli(***)urinary tract infections(UTIs).METHODS This retrospective study was conducted at Wonkwang University Hospital in South Korea between January 2011 and December *** patients(aged>18 years)who were diagnosed with community-onset *** UTI were enrolled in this *** A total of 511 hospitalized patients were included.66.1%of the patients had an early clinical *** mean length of hospital stay in patients with an early clinical response were each 4.3 d shorter than in patients without an early clinical *** the multiple regression analysis,initial appropriate antibiotic therapy(OR=2.449,P=0.006),extended-spectrum(3-lactamase(ESBL)-producing ***(OR=2.112,P=0.044),improper use of broad-spectrum antimicrobials(OR=0.411,P=0.006),and a stay in a healthcare facility before admission(OR=0.562,P=0.033)were the factors associated with an early clinical *** broadspectrum antibiotic therapy was not associated with an early clinical *** ESBL producing ***,and the type of residence before hospital admission were the factors associated with an early clinical *** of initial antibiotic therapy was a predictive factor for an early clinical response,but broadspectrum of initial antibiotic therapy did not impact early clinical response.

关键词： Escherichia coli Urinary tract infections Adult Community acquired infections

Dynamic deformation behavior and microstructural evolution during high-speed rolling of Mg alloy having non-basal texture

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Journal of Materials Science & Technology 2019年第4期35卷 473-482页

作者： Sang-Hoon Kim jeong Hun lee Chong Soo lee Jonghun Yoon Sung Hyuk Park School of Materials Science and Engineering Kyungpook National University Ulsan Regional Division Korea Institute of Industrial Technology Graduate Institute of Ferrous Technology Pohang University of Science and Technology Department of Mechanical Engineering Hanyang University

The dynamic deformation behaviors and resultant microstructural variations during high-speed rolling(HSR) of a Mg alloy with a non-basal texture are investigated. To this end, AZ31 alloy samples in which the basal poles of most grains are predominantly aligned parallel to the transverse direction(TD) are subjected to hot rolling with different reductions at a rolling speed of 470 m/min. The initial grains with a TD texture are favorable for {10–12} twinning under compression along the normal direction(ND); as a result, {10–12} twins are extensively formed in the material during HSR, and this consequently results in a drastic evolution of texture from the TD texture to the ND texture and a reduction in the grain size. After the initial grains are completely twinned by the {10–12} twinning mechanism, {10–11} contraction twins and {10–11}-{10–12} double twins are formed in the {10–12} twinned grains by further *** the contraction twins and double twins have crystallographic orientations that are favorable for basal slip during HSR, dislocations easily accumulate in these twins and fine recrystallized grains nucleate in the twins to reduce the increased internal strain energy. Until a rolling reduction of 20%, {10–12}twinning is the main mechanism governing the microstructural change during HSR, and subsequently,the microstructural evolution is dominated by the formation of contraction twins and double twins and the dynamic recrystallization in these twins. With an increase in the rolling reduction, the average grain size and internal strain energy of the high-speed-rolled(HSRed) samples decrease and the basal texture evolves from the TD texture to the ND texture more effectively. As a result, the 80% HSRed sample, which is subjected to a large strain at a high strain rate in a single rolling pass, exhibits a fully recrystallized microstructure consisting of equiaxed fine grains and has an ND basal texture without a TD texture component.

关键词： Magnesium alloy High-speed rolling Texture Dynamic recrystallization Twinning

Emerging role of ^(18)F-fluorodeoxyglucose positron emission tomography for guiding management of hepatocellular carcinoma

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World Journal of Gastroenterology 2019年第11期25卷 1289-1306页

作者： Sang Mi lee Hong Soo Kim Sangheun lee jeong Won lee Department of Nuclear Medicine Soonchunhyang University Cheonan Hospital Department of Internal Medicine Soonchunhyang University Cheonan Hospital Division of Hepatology Department of Internal medicineCatholic Kwandong University College of MedicineInternational St.Mary’s Hospital Institute for Health and Life Science Catholic Kwandong University College of MedicineInternational St.Mary’s Hospital Department of Nuclear Medicine Catholic Kwandong University College of MedicineInternational St.Mary’s Hospital

Hepatocellular carcinoma(HCC) is one of major causes of cancer mortality worldwide. For decades, ^(18)F-fluorodeoxyglucose(FDG) positron emission tomography(PET) has been widely used for staging, predicting prognosis, and detecting cancer recurrence in various types of malignant diseases. Due to low sensitivity of FDG PET for detecting intrahepatic HCC lesions, the clinical value of FDG PET in HCC patients has been limited. However, recent studies with diverse analytic methods have shown that FDG PET has promising role in aiding management of HCC patients. In this review, we will discuss the clinical role of FDG PET for staging, predicting prognosis, and evaluating treatment response in HCC. Further, we will focus on recent clinical studies regarding implication of volumetric FDG PET parameters, the significance of FDG uptake in HCC for selecting treatment and predicting treatment response, and the use of radiomics of FDG PET in HCC.

关键词： Hepatocellular carcinoma Fluorodeoxyglucose F18 Positron emission tomography Staging Prognosis

Statistical Prediction of Heavy Rain in South Korea

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Advances in Atmospheric Sciences 2005年第5期22卷 703-710页

作者： Keon Tae SOHN jeong Hyeong lee Soon Hwan lee Chan Su RYU Pusan National University Busan 609-735 KoreaDong-A University Busan 604-714 Korea Chosun University Gwangju 501-759 KoreaChosun University Gwangju 501-759 Korea

This study is aimed at the development of a statistical model for forecasting heavy rain in South Korea. For the 3-hour weather forecast system, the 10 km×10 km area-mean amount of rainfall at 6 stations （Seoul, Daejeon, Gangreung, （Jwangju, Busan, and Jeju） in South Korea are used. And the corresponding 45 synoptic factors generated by the numerical model are used as potential predictors. Four statistical forecast models （linear regression model, logistic regression model, neural network model and decision tree model） for the occurrence of heavy rain are based on the model output statistics （MOS） method. They are separately estimated by the same training data. The thresholds are considered to forecast the occurrence of heavy rain because the distribution of estimated values that are generated by each model is too skewed. The results of four models are compared via Heidke skill scores. As a result, the logistic regression model is recommended.

关键词： heavy rain model output statistics linear regression logistic regression neural networks,decision tree

Improved tensile properties of AZ31 Mg alloy subjected to various caliber-rolling strains

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Journal of Magnesium and Alloys 2019年第3期7卷 381-387页

作者： jeong Hun lee Byung Je Kwak Taein Kong Sung Hyuk Park Taekyung lee Advanced Forming Process R&D Group Korea Institute of Industrial TechnologyUlsan 44413Republic of Korea School of Mechanical Engineering Pusan National UniversityBusan 46241Republic of Korea School of Materials Science and Engineering Kyungpook National UniversityDaegu 41566Republic of Korea

A multi-pass caliber rolling has attracted attentions as an alternative to severe plastic deformation *** present study enhanced strength and ductility of AZ31 Mg alloy simultaneously through the application of caliber *** improving trends in tensile properties were interpreted with various caliber-rolling *** oval/circular-shaped calibers imposed a high plastic strain at the center of crosssection,leading to effective grain refinement to submicron *** work also confirmed the texture randomizing effect of caliber *** microstructural evolutions gave rise to the fabrication of high-strength ***,the caliber-rolled AZ31 Mg alloys exhibited an improvement in ductility as compared to the as-received sheet-rolled *** was discussed in terms of activation of non-basal slip systems and suppression of mechanical *** study successfully proved the possibility of caliber rolling to produce a bulk Mg rod with enhanced tensile properties.

关键词： Magnesium AZ31 alloy Caliber rolling Grain refinement Texture randomization Mechanical improvement