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Protective effect of hydrogen sulfide on oxidative stress.induced neurodegenerative diseases

Neural Regeneration Research 2020年第2期15卷 232-241页

作者： Rubaiya Tabassum Na Young jeong Junyang Jung Department of Anatomy and Cell Biology College of MedicineDong-A UniversitySeo-guBusanKorea Department of Medicine Graduate SchoolDong-A UniversitySeo-guBusanKorea Department of Anatomy and Neurobiology College of MedicineKyung Hee UniversityDongdaemun-guSeoulKorea

Hydrogen sulfide is an antioxidant molecule that has a wide range of biological effects against oxidative stress. Balanced oxidative stress is also vital for maintaining cellular function in biological system, where reactive oxygen species are the main source of oxidative stress. When the normal redox balance is disturbed, deoxyribonucleic acid, lipid, and protein molecules are oxidized under pathological conditions, like diabetes mellitus that leads to diabetic peripheral neuropathy. In diabetes mellitus.induced diabetic peripheral neuropathy, due to hyperglycemia, pancreatic beta cell(β cell) shows resistance to insulin secretion. As a consequence, glucose metabolism is disturbed in neuronal cells which are distracted from providing proper cell signaling pathway. Not only diabetic peripheral neuropathy but also other central damages occur in brain neuropathy. Neurological studies regarding type 1 diabetes mellitus patients with Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis have shown changes.in the central nervous system because high blood glucose levels(HbA1 c) appeared with poor cognitive function. Oxidative stress plays a role in inhibiting insulin signaling that is necessary for brain function. Hydrogen sulfide exhibits antioxidant effects against oxidative stress, where cystathionine β synthase, cystathionine γ lyase, and 3-mercaptopyruvate sulfurtransferase are the endogenous sources of hydrogen sulfide. This review is to explore the pathogenesis of diabetes mellitus.induced diabetic peripheral neuropathy and other neurological comorbid disorders under the oxidative stress condition and the anti-oxidative effects of hydrogen sulfide.

关键词： Alzheimer's disease amyotrophic lateral sclerosis antioxidant diabetic peripheral neuropathy DNA oxidation hydrogen sulfide mitochondrial dysfunction oxidative stress Parkinson's disease reactive oxygen species

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Peripheral nerve regeneration with cotransplantation of umbilical cord mesenchymal stem cells and schwann cells.in rat sciatic nerve defect

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Neural Regeneration Research 2011年第7期6卷 485-493页

作者： Jin-Yong Lee Hun-Jong Jung Mohammad s. Alrashdan Bohan Li Mi-Ae sung sang BaeYoo soung-Min Kim Myung-Jin Kim jeong Won Jahng Jong-Ho Lee Department of Oral and Maxillofacial surgery School of Dentistry Seoul National University Seoul Korea Department of Occupation and Environment Konkuk Postgraduate Medical School Choong-Ju Korea Department of Craniofacial structure and Functional Biology School of Dentistry Seoul National University Seoul Korea Dental Research Institute School of Dentistry Seoul National University Seoul Korea

Previous research has demonstrated that cotransplantation of umbilical cord mesenchymal stem cells （UCMsCs） and schwann cells （sCs） can repair s.inal nerve injury, but few studies have investigated their use in peripheral nerve regeneration. In the present study, we cotransplanted UCMsCs and sCs to repair 5-mm left sciatic nerve defects.in rats, and compared the effects of UCMsCs ＋ sCs transplantation with UCMsCs or sCs transplantation alone. After UCMsCs ＋ sCs transplantation, nerve conduction velocity of the left sciatic nerve and gait were both improved. Retrograde tracing analysis demonstrated that the mean count of fluorogold-labeled neurons, as well as the mean axon count and axon density, were significantly greater in the left sciatic nerve after UCMsCs ＋ sCs transplantation, compared with UCMsCs or sCs transplantation alone. Improvements.in conduction velocity and increased sheath thickness.in the left sciatic nerve were similar after UCMsCs transplantation and UCMsCs ＋ sCs transplantation. These findings suggest that UCMsCs transplantation can promote the repair of sciatic nerve defects to some extent, but that combined UCMsCs ＋ sCs transplantation has a significantly greater regenerative effect.

关键词： schwann cells human umbilical cord mesenchymal stem cells peripheral nerve re-generation axotomy

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Impact of device resistances.in the performance of graphene-based terahertz photodetectors

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Frontiers of Optoelectronics 2024年第2期 89-99页

作者： óscar Castelló sofía M.López Baptista Kenji Watanabe Takashi Taniguchi Enrique Diez Jesús Enrique Velázquez-Pérez Yahya M.Meziani José M.Caridad Juan A.Delgado-Notario Department of Applied Physics University of Salamanca Unidad de Excelencia en Luz y Materia Estructurada(LUMEs) University of Salamanca Research Center for Electronic and Optical Materials National Institute for Materials Science Research Center for Materials Nanoarchitectonics National Institute for Materials Science Nanotechnology Group USAL–Nanolab University of Salamanca

In recent years, graphene field-effect-transistors(GFETs) have demonstrated an outstanding potential for terahertz(THz) photodetection due to their fast response and high-sensitivity. such features are essential to enable emerging THz applications, including 6G wireless communications, quantum information, bioimaging and security. However, the overall performance of these photodetectors may be utterly compromised by the impact of internal resistances presented in the device, so-called access or parasitic resistances. In this work, we provide a detailed study of the influence of internal device resistances.in the photoresponse of high-mobility dual-gate GFET detectors. such dual-gate architectures allow us to fine tune(decrease) the internal resistance of the device by an order of magnitude and consequently demonstrate an improved responsivity and noise-equivalent-power values of the photodetector, respectively. Our results can be well understood by a series resistance model, as shown by the excellent agreement found between the experimental data and theoretical calculations. These findings are therefore relevant to understand and improve the overall performance of exis.ing high-mobility graphene photodetectors.

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Determination of the number ofψ(3686)events taken at BEsⅢ

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Chinese Physics C 2024年第9期48卷 8-20页

作者： M.Ablikim M.N.Achasov P.Adlarson O.Afedulidis X.C.Ai R.Aliberti A.Amoroso Q.An Y.Bai O.Bakina I.Balos.ino Y.Ban H.-R.Bao V.Batozskaya K.Begzsuren N.Berger M.Berlowski M.Bertani D.Bettoni F.Bianchi E.Bianco A.Bortone I.Boyko R.A.Briere A.Brueggemann H.Cai X.Cai A.Calcaterra G.F.Cao N.Cao s.A.Cetin J.F.Chang G.R.Che G.Chelkov C.Chen C.H.Chen Chao Chen G.Chen H.s.Chen H.Y.Chen M.L.Chen s.J.Chen s.L.Chen s.M.Chen T.Chen X.R.Chen X.T.Chen Y.B.Chen Y.Q.Chen Z.J.Chen Z.Y.Chen s.K.Choi G.Cibinetto F.Cossio J.J.Cui H.L.Dai J.P.Dai A.Dbeyssi R.E.de Boer D.Dedovich C.Q.Deng Z.Y.Deng A.Denig I.Denysenko M.Destefanis F.De Mori B.Ding X.X.Ding Y.Ding Y.Ding J.Dong L.Y.Dong M.Y.Dong X.Dong M.C.Du s.X.Du Y.Y.Duan Z.H.Duan P.Egorov Y.H.Fan J.Fang J.Fang s.s.Fang W.X.Fang Y.Fang Y.Q.Fang R.Farinelli L.Fava F.Feldbauer G.Felici C.Q.Feng J.H.Feng Y.T.Feng M.Fritsch C.D.Fu J.L.Fu Y.W.Fu H.Gao X.B.Gao Y.N.Gao Yang Gao s.Garbolino I.Garzia L.Ge P.T.Ge Z.W.Ge C.Geng E.M.Gersabeck A.Gilman K.Goetzen L.Gong W.X.Gong W.Gradl s.Gramigna M.Greco M.H.Gu Y.T.Gu C.Y.Guan Z.L.Guan A.Q.Guo L.B.Guo M.J.Guo R.P.Guo Y.P.Guo A.Guskov J.Gutierrez K.L.Han T.T.Han F.Hanisch X.Q.Hao F.A.Harris K.K.He K.L.He F.H.Heinsius C.H.Heinz Y.K.Heng C.Herold T.Holtmann P.C.Hong G.Y.Hou X.T.Hou Y.R.Hou Z.L.Hou B.Y.Hu H.M.Hu J.F.Hu s.L.Hu T.Hu Y.Hu G.s.Huang K.X.Huang L.Q.Huang X.T.Huang Y.P.Huang T.Huss.in F.Hölzken N.Hüsken N.in der Wiesche J.Jackson s.Janchiv J.H.jeong Q.Ji Q.P.Ji W.Ji X.B.Ji X.L.Ji Y.Y.Ji X.Q.Jia Z.K.Jia D.Jiang H.B.Jiang P.C.Jiang s.s.Jiang T.J.Jiang X.s.Jiang Y.Jiang J.B.Jiao J.K.Jiao Z.Jiao s.Jin Y.Jin M.Q.Jing X.M.Jing T.Johansson s.Kabana N.Kalantar-Nayestanaki X.L.Kang X.s.Kang M.Kavatsyuk B.C.Ke V.Khachatryan A.Khoukaz R.Kiuchi O.B.Kolcu B.Kopf M.Kuessner X.Kui N.Kumar A.Kupsc W.Kühn J.J.Lane P.Larin L.Lavezzi T.T.Lei Z.H.Lei M.Lellmann T.Lenz C.Li C.Li C.H.Li Cheng Li D.M.Li F.Li G.Li H.B.Li H.J.Li H.N.Li Hui Li J.R.Li J.s.Li Ke Li L.J.Li L.K.Li Lei Li M.H.Li P.R.Li Q.M.Li Q.X.Li R.Li s.X.Li T.Li W.D.Li W.G.Li X.Li X.H.Li X.L.Li X.Z.Li Xi Institute of High Energy Physics Beijing 100049China Beihang University Beijing 100191China Bochum Ruhr-University D-44780BochumGermany Budker Institute of Nuclear Physics sB RAs(BINP) Novosibirsk 630090Russia Carnegie Mellon University PittsburghPennsylvania 15213USA Central China Normal University Wuhan 430079China Central south University Changsha 410083China China Center of Advanced science and Technology Beijing 100190China China University of Geosciences Wuhan 430074China Chung-Ang University Seoul06974Republic of Korea COMsATs University Islamabad Lahore CampusDefence RoadOff Raiwind Road54000LahorePakistan Fudan University Shanghai 200433China GsI Helmholtzcentre for Heavy Ion Research GmbH D-64291DarmstadtGermany Guangxi Normal University Guilin 541004China Guangxi University Nanning 530004China Hangzhou Normal University Hangzhou 310036China Hebei University Baoding 071002China Helmholtz Institute Mainz Staudinger Weg 18D-55099MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China Henan University of science and Technology Luoyang 471003China Henan University of Technology Zhengzhou 450001China Huangshan College Huangshan 245000China Hunan Normal University Changsha 410081China Hunan University Changsha 410082China Indian Institute of Technology Madras Chennai 600036India Indiana University BloomingtonIndiana 47405USA INFN Laboratori Nazionali di Frascati (A)INFN Laboratori Nazionali di FrascatiI-00044FrascatiItaly(B)INFN Sezione di PerugiaI-06100PerugiaItaly(C)University of PerugiaI-06100PerugiaItaly INFN sezione di Ferrara (A)INFN Sezione di FerraraI-44122FerraraItaly(B)University of FerraraI-44122FerraraItaly Inner Mongolia University Hohhot 010021China Institute of Modern Physics Lanzhou 730000China Institute of Physics and Technology Peace Avenue 54BUlaanbaatar 13330Mongolia Instituto de Alta Investigación Universidad de TarapacáCasilla 7DArica 1000000Chile Jilin University Changchun 130012China Joha

The number ofψ(3686)events collected by the BEsⅢdetector during the 2021 run period is determined to be(2259.3±11.1)×10~6 by counting inclusiveψ(3686)hadronic *** uncertainty is systematic and the statistical uncertainty is ***,the numbers ofψ(3686)events collected during the 2009 and 2012run periods are updated to be(107.7±0.6)×10~6 and(345.4±2.6)×10~6,*** numbers are consistent with the previous measurements within one standard *** total number ofψ(3686)events.in the three data samples is(2712.4±14.3)×10~6.

关键词： ψ(3686) inclusive process Hadronic events BEsⅢdetector

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Analytical evaluation and experimental validation on dynamic rocking behavior for shallow foundation considering structural response

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Earthquake Engineering and Engineering Vibration 2022年第1期21卷 37-51页

作者： Kil-Wan Ko jeong-Gon Ha Dong-soo Kim Department of Civil and Environmental Engineering UC BerkeleyCalifornia 94720USA Advanced structures and seismic safety Research Division Daejeon 34057Korea Department of Civil and Environmental Engineering KAISTDaejeon 34141Korea

The challenge in the practical application of rocking foundations is the estimation of its performance,particularly the rotation angle,during a strong *** this study,the dynamic rocking behavior for a shallow foundation considering structural response was evaluated through two analytical approaches:the conventional soil-foundation-structure interaction(sFsI)governing equation of a single-degree-of-freedom(sDOF)structure on a rocking shallow foundation,and the Housner rocking model(i.e.,a rocking rigid block on a rigid base).Both approaches were validated with dynamic centrifuge *** test models consisted of a soft soil deposit,a shallow rectangular foundation,and an sDOF structure dominated by a bending behavior.A total of 11 foundation-structure systems and six seismic waves.including recorded earthquake signals and sinusoidal waves,were *** results showed that the conventional sFsI equation well predicted the maximum rotation during strong ***,this method was less accurate regarding the rotational phase information and maximum rotation of the foundation during weak *** the other hand,although the modified Housner′s rocking model required five parameters relevant to a soil-foundation-structure system,it overestimated the maximum rotation of the foundation when compared with the results from dynamic centrifuge tests.

关键词： soil-foundation-structure interaction maximum rotation angle rocking foundation Housner rocking model dynamic centrifuge test

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基于肿瘤生长速率的LI-RADs生长阈值可提高≤3.0 cm肝细胞癌的诊断效能

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国际医学放射学杂志 2024年第2期 255-255页

作者： B.jeong s.J.Choi s.H.Choi H.J.Jang J.H.Byun H.J.Won 侯唯姝

摘要目的尽管2018版肝脏成像报告和数据系统（LIRADs）对肝脏病变的生长阈值（TG）进行了修订，但确定TG的2次检查之间的适当时间段尚未确定。该研究比较了基于

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Way-out for laser-induced breakdown spectroscopy

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Plasma science and Technology 2020年第7期22卷 1-3页

作者： Zongyu HOU sungho jeong Yoshihiro DEGUCHI Zhe WANG state Key Lab of Power systems International Joint Laboratory on Low Carbon Clean Energy InnovationDepartment of Energy and Power EngineeringTsinghua UniversityBeijing 100084People’s Republic o f China school of Mechanical Engineering Gwangju Institute of Science and TechnologyGwangju 61005Republic of Korea Graduate school of Technology Industrial and Social SciencesTokushima UniversityTokushima 770-8501Japan

Ever since its creation in 1963 [1], laser-induced breakdown spectroscopy(LIBs)has gained considerable attention due to its unique capability for real-time, in situ or online analysis [2, 3]. The future world is headi... 详细信息

关键词： breakdown laser spectroscopy

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2018 update of expert consensus statement on antiplatelet therapy in East Asian patients with ACs or undergoing PCI

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science Bulletin 2019年第3期64卷 166-179页

作者： Yong Huo Young-Hoon jeong Yanjun Gong Daowen Wang Ben He Jiyan Chen Guosheng Fu Yundai Chen Jianping Li Yi Li s.inya Goto Udaya s.Tantry Paul A.Gurbel Jong-Hwa Ahn Hyo-soo Kim Myung Ho jeong Yaling Han sidney C.smith Jr. Junbo Ge Department of Cardiology Peking University First Hospital Department of Internal Medicine Gyeongsang National University School of Medicine and Cardiovascular Center Gyeongsang National University Changwon Hospital Division of Cardiology Internal Medicine Department Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Department of Cardiology Shanghai Chest Hospital affiliated to Shanghai Jiaotong University Department of Cardiology Guangdong General Hospital Department of Cardiology Sir Run Run Shaw Hospital Zhejiang University School of Medicine Department of Cardiology Chinese PLAG General Hospital Department of Cardiology General Hospital of Northern Theater Command Department of Medicine (Cardiology) Tokai University School of Medicine Inova Center for Thrombosis Research and Drug Development Inova Heart and Vascular Institute Cardiovascular Center Department of Internal Medicine Seoul National University Hospital The Heart Research Center Nominated by Korea Ministry of Health and Welfare Chonnam National University Hospital Division of Cardiology University of North Carolina Department of Cardiology Fudan University Zhongshan Hospital

East Asians are the most populous race in the world and their health status is an important global *** with Caucasian populations, East Asian patients have a different benefit/risk ratio when using antithrombotic treatment. Despite this.observation, treatment strategies.in East Asian patients are mostly based on the American and European guidelines. Despite a lower platelet inhibitory response to clopidogrel, East Asian patients show a similar or even a lower rate of ischemic event occurrence and higher bleeding risk compared with Caucasian patients. For potent P2Y_(12) inhibitors(ticagrelor and prasugrel),East Asian patients have shown less favorable net clinical benefits compared with Caucasian patients,which may be related to differences.in pharmacokinetic/pharmacodynamic profiles and therapeutic zone of antiplatelet effect. This updated consensus mainly focuses on state-of-the-art and current controversies.in the East Asian population. In addition, when East Asian patients are administered potent P2Y_(12) receptor inhibitors, the strategies and ongoing trials to overcome the related hurdles are discussed.

关键词： East Asian Coronary artery disease Antiplatelet Bleeding

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Inhibiting focal adhesion kinase:A potential target for enhancing therapeutic efficacy in colorectal cancer therapy

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World Journal of Gastrointes.inal Oncology 2018年第10期10卷 290-292页

作者： Keun--Yeong jeong Division of Research and Development Metimedi Pharmaceuticals

Focal adhesion kinase(FAK) is a major integrin- dep-endent tyrosine phosphorylated protein, recently, FAK association with colorectal cancer(CRC) has gained at-tention. The various cancer-promoting mechanisms that associated with FAK can be implicated in the progression of CRC. The interactions between structural features of FAK and various kinases could be closely related to growth, survival, and metastasis.in CRC cells. These interactions.include human epithelial growth factor re-ceptor, c-Met, platelet-derived growth factor receptor, vascular endothelial growth factor receptor, and src. such interactions can trigger the survival signaling of CRC cells and are also involved signaling downstream of phosphatidylinositol 3-kinase, AKT, and the extracellular regulated kinase. Based on this scientific background, many pharmaceutical companies are taking efforts to develop FAK inhibitors to treat solid cancer including CRC. Although the anti-cancer efficacies have been noted in many studies, the commercial drugs have not been deve-loped yet. Therefore, the FAK research on CRC is expec-ted to gain momentum and be highly appreciated as a potential field for developing the new drugs. Therefore, the studies on FAK that effect on the progression of human CRC s would be possible to suggest various app-roaches to CRC treatment, and FAK could be a potential target as an anticancer candidate for CRC therapies.

关键词： Colorectal cancer Focal adhesion kinase Focal adhesion kinase inhibitor Anticancer effect

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Managing portal hypertension in patients with liver cirrhosis and hepatocellular carcinoma:non-invasive diagnosis and systemic treatment considerations

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Hepatobiliary surgery and Nutrition 2023年第6期12卷 960-962页

作者： Woo Kyoung jeong Department of Radiology and Center for Imaging sciences Samsung Medical CenterSungkyunkwan University School of MedicineSeoulRepublic of Korea

Portal hypertension(PH)represents a crucial complication of liver cirrhosis that significantly impacts a patient’s *** portal venous pressure requires a combination of medical and interventional ***,it’s important to note that the presence of other conditions.in patients,such as hepatocellular carcinoma(HCC),can influence the treatment approaches for PH and subsequently affect the overall *** should consider that condition when developing treatment strategies to enhance patient outcomes(1).

关键词： Portal hypertension(PH) hepatocellular carcinoma(HCC) elastography bevacizumab variceal bleeding

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