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Progress in light-to-frequency conversion circuits based on low dimensional semiconductors

Nano Research 2021年第9期14卷 2938-2964页

作者： Seung Gi Seo Seung Yeob kim Jinheon jeong Sung hun Jin Department of Electronic Engineering Incheon National UniversityAcademy-ro 119Yeongsu-guIncheon 22012Republic of Korea

As the scaling down of Si devices in the range less than few nm has been expedited up to a physical limit of Si,low dimensional materials have been regarded as one of next generation *** a variety of applications,studies on photodetectors have been actively investigated with their novel optical properties as well as astonishing electrical ***,most of research has focused on single device-type photodetector(i.e.,photo-diode or photo-transistor).Contrary to common photodetector,light-to-frequency circuits(LFCs)are based on frequency reading with photosensitive ring oscillators,which has better noise immunity and reduced system complexity,thus,can be utilized to novel application even in internet of things(loT)and bio&medical *** this review,low dimensional materials based circuit level photodetectors,which are core elements as the form of either inverters or ring oscillators for demonstration of LFCs,are *** with the introduction of low dimensional materials and their optical properties for optoelectronics,a fundamental concept for LFCs is specifically ***,research progress on low dimensional material based photosensitive inverters is addressed according to the types of ***,as one of practical method for the improvement of photodetector performance,molecular doping technology is ***,complete system of LFCs and its digitization for demonstration of production level,and potential application in the respective four aspects,(i)medical SpO_(2) detection,(ii)biological fluidic system,(iii)auto-lighting in agriculture,and(iv)optical feedback and sensing systems,are presented as systematic way to address the envisioned practical applications for the future displays including virtual reality and augmented reality,and *** a remark,LFCs based on low dimensional semiconductors are expected to be one of core components in trillion’s sensor area.

关键词： photodetector light-to-frequency conversion circuit transition metal dichalcogenide carbon nanotube

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Brassinosteroids enhance salicylic acid-mediated immune responses by inhibiting BIN2 phosphorylation of clade I TGA transcription factors in Arabidopsis

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Molecular Plant 2022年第6期15卷 991-1007页

作者： Yeong-Woo kim Ji-Hyun Youn Jeehee Roh jeong-Mok kim Seong-Ki kim Tae-Wuk kim Department of Life Science Hanyang UniversitySeoul 04763Republic of Korea Department of Life Science Chung-Ang UniversitySeoul 06973Republic of Korea Research Institute for Convergence of Basic Science Hanyang UniversitySeoul 04763Republic of Korea Hanyang Institute of Bioscience and Biotechnology Hanyang UniversitySeoul 04763Republic of Korea

Salicylic acid (SA) plays an important role in plant immune response, including resistance to pathogens and systemic acquired resistance. Two major components, NONEXPRESSOR OF PATHOGENESIS-RELATED GENES (NPRs) and TGACG motif-binding transcription factors (TGAs), are known to mediate SA signaling, which might also be orchestrated by other hormonal and environmental changes. Nevertheless, the molecular and functional interactions between SA signaling components and other cellular signaling pathways remain poorly understood. Here we showed that the steroid plant hormone brassinosteroid (BR) promotes SA responses by inactivating BR-INSENSITIVE 2 (BIN2), which inhibits the redox-sensitive clade I TGAs in Arabidopsis. We found that both BR and the BIN2 inhibitor bikinin synergistically increase SA-mediated physiological responses, such as resistance to Pst DC3000. Our genetic and biochemical analyses indicated that BIN2 functionally interacts with TGA1 and TGA4, but not with other TGAs. We further demonstrated that BIN2 phosphorylates Ser-202 of TGA4, resulting in the suppression of the redox-dependent interaction between TGA4 and NPR1 as well as destabilization of TGA4. Consistently, transgenic Arabidopsis overexpressing TGA4-YFP with a S202A mutation displayed enhanced SA responses compared to the wild-type TGA4-YFP plants. Taken together, these results suggest a novel crosstalk mechanism by which BR signaling coordinates the SA responses mediated by redox-sensitive clade I TGAs.

关键词： brassinosteroid salicylic acid immune responses BIN2 clade I TGA

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Linking individual attributes and host specialization in brood parasitic cuckoos

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Avian Research 2022年第2期13卷 145-151页

作者： Sue-jeong Jin Hae-Ni kim Geun-Won Bae Jin-Won Lee jeong-Chil Yoo Korea Institute of Ornithology Kyung Hee UniversitySeoul02447Republic of Korea Department of Biology Kyung Hee UniversitySeoul02447Republic of Korea

Generalist avian brood parasites vary considerably in their degree of host specialization(e.g.,number of hosts);some parasitize the nests of just a few host species,whereas others exploit more than 100 *** factors,including habitat range,habitat type,and geographic location,have been suggested to account for these ***,inter-specific differences in individual attributes,such as personality and plasticity,have rarely been considered as potential factors of such variation,despite their potential relationship to,for example,range *** cage experiments,we tested the hypothesis that parasitic species exploiting more host species may be more active and *** this end,we quantified behaviors exhibited by two Cuculus cuckoos(Common Cuckoo *** and Oriental Cuckoo ***)that vary greatly in their number of host ***,we evaluated exploratory behavior displayed by birds in the cage,such as the number of movements,head-turning,wing-flapping,and *** Common Cuckoo,which has a higher number of host species,tended to exhibit higher levels of exploratory behaviors than the Oriental *** study showed that the two cuckoo species exhibited different exploratory levels,as predicted by the differences in their number of *** studies regarding the causality between individual attributes and host specialization with improved experimental methodology would greatly enhance our understanding of the role of individual characteristics in the coevolution of avian brood parasites and their hosts.

关键词： Brood parasitism Common Cuckoo Individual attributes Number of hosts Oriental Cuckoo

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Superinsulating BNNS/PVA Composite Aerogels with High Solar Reflectance for Energy-Efficient Buildings

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Nano-Micro Letters 2022年第3期14卷 292-307页

作者： Jie Yang Kit‑Ying Chan Harun Venkatesan Eunyoung kim Miracle Hope Adegun Jeng‑hun Lee Xi Shen Jang‐Kyo kim Department of Mechanical and Aerospace Engineering The Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongPeople’s Republic of China Department of Aeronautical and Aviation Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong KongPeople’s Republic of China

With the mandate of worldwide carbon neutralization,pursuing comfortable living environment while consuming less energy is an enticing and unavoidable *** composite aerogels with super thermal insulation and high sunlight reflection are developed for energy-efficient buildings.A solvent-assisted freeze-casting strategy is used to produce boron nitride nanosheet/polyvinyl alcohol(BNNS/PVA)composite aerogels with a tailored alignment channel *** effects of acetone and BNNS fillers on microstructures and multifunctional properties of aerogels are *** acetone in the PVA suspension enlarges the cell walls to suppress the shrinkage,giving rise to a lower density and a higher porosity,accompanied with much diminished heat conduction throughout the whole *** addition of BNNS fillers creates whiskers in place of disconnected transverse ligaments between adjacent cell walls,further ameliorating the thermal insulation transverse to the cell wall *** resultant BNNS/PVA aerogel delivers an ultralow thermal conductivity of 23.5 mW m^(−1) K^(−1) in the transverse *** superinsulating aerogel presents both an infrared stealthy capability and a high solar reflectance of 93.8%over the whole sunlight wave-length,far outperforming commercial expanded polystyrene foams with reflective *** anisotropic BNNS/PVA composite aerogel presents great potential for application in energy-saving buildings.

关键词： Boron nitride nanosheets Solvent-assisted freeze-casting Thermally insulating aerogel Solar reflectance Energy-saving buildings

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Delivery of nitric oxide-releasing silica nanoparticles for in vivo revascularization and functional recovery after acute peripheral nerve crush injury

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Neural Regeneration Research 2022年第9期17卷 2043-2049页

作者： Jung Il Lee Ji hun Park Yeong-Rim kim Kihak Gwon Hae Won Hwang Gayoung Jung Joo-Yup Lee jeong-Yun Sun Jong Woong Park Jae Ho Shin Myoung-Ryul Ok Department of Orthopedic Surgery College of MedicineKorea UniversitySeoulRepublic of Korea Medical Sensor Biomaterial Research Institute Kwangwoon UniversitySeoulRepublic of Korea Center for Biomaterials Korea Institute of Science&TechnologySeoulRepublic of Korea Department of Materials Science and Engineering Seoul National UniversitySeoulRepublic of Korea Department of Orthopedic Surgery College of MedicineCatholic UniversitySeoulRepublic of Korea Department of Chemistry Kwangwoon UniversitySeoulRepublic of Korea

Nitric oxide(NO)has been shown to promote revascularization and nerve regeneration after peripheral nerve ***,in vivo application of NO remains challenging due to the lack of stable carrier materials capable of storing large amounts of NO molecules and releasing them on a clinically meaningful time ***,a silica nanoparticle system capable of reversible NO storage and release at a controlled and sustained rate was *** this study,NO-releasing silica nanoparticles(NO-SNs)were delivered to the peripheral nerves in rats after acute crush injury,mixed with natural hydrogel,to ensure the effective application of NO to the *** using a polymer dye and immunohistochemical staining for the detection of CD34(a marker for revascularization)results showed that NO-releasing silica nanoparticles increased revascularization at the crush site of the sciatic *** sciatic functional index revealed that there was a significant improvement in sciatic nerve function in NO-treated *** and anatomical analyses showed that the number of myelinated axons in the crushed sciatic nerve and wet muscle weight excised from NO-treated rats were ***,muscle function recovery was improved in rats treated with *** together,our results suggest that NO delivered to the injured sciatic nerve triggers enhanced revascularization at the lesion in the early phase after crushing injury,thereby promoting axonal regeneration and improving functional recovery.

关键词： crush injury nerve injury,nerve regeneration nitric oxide peripheral nerve revascularization silica nanoparticles

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Pulmonary amyloidosis and multiple myeloma mimicking lymphoma in a patient with Sjogren’s syndrome:A case report

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World Journal of Clinical Cases 2022年第3期10卷 1016-1023页

作者： Joa kim Yun Sung kim Hee jeong Lee Sang Gon Park Department of Internal Medicine RheumatologyChosun University HospitalGwangju 501-717South Korea Department of Internal Medicine Chosun University HospitalGwangju 501-717South Korea Department of Internal Medicine Hemato-OncologyChosun University HospitalGwangju 501-717South Korea

BACKGROUND Sjogren’s syndrome(SS),which affect salivary gland function,is an autoimmune *** may involve extraglandular *** 10 to 20 percent of SS patients have clinically significant lung disease,but presentation of pulmonary amylodosis is extremly *** incidence of benign monoclonal gammopathy in SS patients is high,but multiple myeloma is *** case involving the simultaneous occurrence of two rare diseases,pulmonary amyloidosis and multiple myeloma,in the same patient with SS has been reported so *** SUMMARY A 41-year-old male patient was referred to our hematology department due to incidentally detected gastric *** had been diagnosed with SS four years *** miliary nodules,ground glass opacity in both lung fields,and enlargement of both inguinal lymph nodes was observed on chest and abdomen computer *** on the pathological findings of lung and lymph node biopsied specimens,the patient was diagnosed with pulmonary amyloidosis and multiple *** amyloidosis and multiple myeloma associated with SS has rarely been *** This is an extremely rare case of simultaneous pulmonary amyloidosis and multiple myeloma in the same patient with SS.

关键词： Case report Sjogren’s syndrome Amyloidosis Multiple myeloma Plasmacytoma

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Remarkably slow corrosion rate of high-purity Mg microalloyed with 0.05wt% Sc

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Journal of Magnesium and Alloys 2023年第3期11卷 991-997页

作者： Soo-Min Baek jeong-Ki kim Du-Won Min Sung Soo Park Department of Materials Science and Engineering Ulsan National Institute of Science and TechnologyUlsan 44919Republic of Korea

We report that the corrosion resistance of Mg is significantly improved by adding 0.05wt%*** rates evaluated from weight loss values after room-temperature immersion in 0.6 M NaCl solution for two weeks were 0.27 and 4.0 mm y^(-1)for the high-purity Mg samples with and without microalloyed 0.05wt%Sc,*** beneficial effect of Sc microalloying on the corrosion resistance of Mg is discussed in connection with Sc-induced microstructural modifications.

关键词： Magnesium Microalloying Intermetallic phase Microgalvanic corrosion

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Recurrent Autoencoder Ensembles for Brake Operating Unit Anomaly Detection on Metro Vehicles

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Computers, Materials & Continua 2022年第10期73卷 1-14页

作者： Jaeyong Kang Chul-Su kim jeong Won Kang jeonghwan Gwak Department of Software Korea National University of TransportationChungju27469Korea School of Railroad Engineering Korea National University of TransportationUiwang16106Korea Graduate School of Transportation Korea National University of TransportationUiwang16106Korea Department of AI Robotics Engineering Korea National University of TransportationChungju27469Korea Department of Biomedical Engineering Korea National University of TransportationChungju27469Korea Department of IT Convergence(Brain Korea PLUS 21) Korea National University of TransportationChungju27469Korea

The anomaly detection of the brake operating unit (BOU) in thebrake systems on metro vehicle is critical for the safety and reliability ofthe trains. On the other hand, current periodic inspection and maintenanceare unable to detect anomalies in an early stage. Also, building an accurateand stable system for detecting anomalies is extremely difficult. Therefore,we present an efficient model that use an ensemble of recurrent autoencodersto accurately detect the BOU abnormalities of metro trains. This is the firstproposal to employ an ensemble deep learning technique to detect BOUabnormalities in metro train braking systems. One of the anomalous caseson metro vehicles is the case when the air cylinder (AC) pressures are less thanthe brake cylinder (BC) pressures in certain parts where the brake pressuresincrease before coming to a halt. Hence, in this work, we first extract the dataof BC and AC pressures. Then, the extracted data of BC and AC pressuresare divided into multiple subsequences that are used as an input for bothbi-directional long short-term memory (biLSTM) and bi-directional gatedrecurrent unit (biGRU) autoencoders. The biLSTM and biGRU autoencodersare trained using training dataset that only contains normal subsequences. Fordetecting abnormalities from test dataset which consists of abnormal subsequences, the mean absolute errors (MAEs) between original subsequences andreconstructed subsequences from both biLSTM and biGRU autoencoders arecalculated. As an ensemble step, the total error is calculated by averaging twoMAEs from biLSTM and biGRU autoencoders. The subsequence with totalerror greater than a pre-defined threshold value is considered an *** carried out the experiments using the BOU dataset on metro vehiclesin South Korea. Experimental results demonstrate that the ensemble modelshows better performance than other autoencoder-based models, which showsthe effectiveness of our ensemble model for detecting BOU anomalies onmetro trains.

关键词： Anomaly detection brake operating unit deep learning machine learning signal processing

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Network Intrusion Detection in Internet of Blended Environment Using Ensemble of Heterogeneous Autoencoders(E-HAE)

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Computer Systems Science & Engineering 2023年第9期46卷 3261-3284页

作者： Lelisa Adeba Jilcha Deuk-hun kim Julian Jang-Jaccard Jin Kwak ISAA Lab. Department of AI Convergence NetworkAjou UniversitySuwon16499Korea ISAA Lab. Institute for Information and CommunicationAjou UniversitySuwon16499Korea Department of Computer Science and Information Technology Massey UniversityAuckland0745New Zealand Department of Cyber Security Ajou UniversitySuwon16499Korea

Contemporary attackers,mainly motivated by financial gain,consistently devise sophisticated penetration techniques to access important information or *** growing use of Internet of Things(IoT)technology in the contemporary convergence environment to connect to corporate networks and cloud-based applications only worsens this situation,as it facilitates multiple new attack vectors to emerge *** such,existing intrusion detection systems suffer from performance degradation mainly because of insufficient considerations and poorly modeled detection *** address this problem,we designed a blended threat detection approach,considering the possible impact and dimensionality of new attack surfaces due to the aforementioned *** collectively refer to the convergence of different technology sectors as the internet of blended *** proposed approach encompasses an ensemble of heterogeneous probabilistic autoencoders that leverage the corresponding advantages of a convolutional variational autoencoder and long short-term memory variational *** extensive experimental analysis conducted on the TON_IoT dataset demonstrated 96.02%detection ***,performance of the proposed approach was compared with various single model(autoencoder)-based network intrusion detection approaches:autoencoder,variational autoencoder,convolutional variational autoencoder,and long short-term memory variational *** proposed model outperformed all compared models,demonstrating F1-score improvements of 4.99%,2.25%,1.92%,and 3.69%,respectively.

关键词： Network intrusion detection anomaly detection TON_IoT dataset smart grid smart city smart factory digital healthcare autoencoder variational autoencoder LSTM convolutional variational autoencoder ensemble learning

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β-Arrestin 2 suppresses the activation of YAP by promoting LATS kinase activity

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Genes & Diseases 2023年第2期10卷 348-351页

作者： Minsuh kim Ji Min kim Eun jeong Cho Chang Ohk Sung Joon kim Se Jin Jang Asan Institute for Life Sciences Asan Medical CenterSeoul 05505Republic of Korea University of Ulsan College of Medicine Seoul 05505Republic of Korea Department of Pathology Asan Medical CenterSeoul 05505Republic of Korea Graduate School of Medical Science and Engineering KAISTDaejeon 34141Republic of Korea OncoClew Life Science Co. LtdSeoul 05505Republic of Korea

Dysregulation of the Hippo pathway has been frequently identified in various human cancers. The Hippo pathway is a highly complex pathway involving multiple types of proteins, and the activation of YAP by LATS kinase is the final effector step in the transcription process. In this study, we linked the roles of the multifunctional adapter proteins β-arrestins (β-arrestin 1 and 2) in cooperation with other signaling pathways such as GPCR and Wnt to essential cellular functions involved in carcinogenesis, including the regulation of cell proliferation, migration, and differentiation as well as stem cell properties.1 Although β-arrestin 1 and 2 have high structural similarities, they have different roles in carcinogenesis as β-arrestin 1 aids cancer cell survival and metastasis2 and β-arrestin 2 inhibits tumor growth.1 In the Hippo signaling pathway, β-arrestins function as scaffold proteins that mediate the phosphorylation of key molecules, and their association with human cancers is a major research topic. In this study, we demonstrated that β-arrestin 2 inhibits YAP activation through the formation of the β-arrestin 2-LATS-YAP trimeric complex, which results in the promotion of the kinase activity of LATS in cancer cell lines and patient-derived colon cancer organoids.

关键词： cancer carcinogenesis activation

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