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Neural Regeneration Research 2025年第6期20卷 1525-1540页

作者： Muhammad Junaid Eun jeong lee Su Bin Lim Department of Biochemistry&Molecular Biology Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Graduate School of Ajou UniversitySuwonSouth Korea Department of Brain Science Ajou University School of MedicineSuwonSouth Korea

Elucidating the complex dynamic cellular organization in the hypothalamus is critical for understanding its role in coordinating fundamental body functions. Over the past decade, single-cell and spatial omics technologies have significantly evolved, overcoming initial technical challenges in capturing and analyzing individual cells. These high-throughput omics technologies now offer a remarkable opportunity to comprehend the complex spatiotemporal patterns of transcriptional diversity and cell-type characteristics across the entire hypothalamus. Current single-cell and single-nucleus RNA sequencing methods comprehensively quantify gene expression by exploring distinct phenotypes across various subregions of the hypothalamus. However, single-cell/single-nucleus RNA sequencing requires isolating the cell/nuclei from the tissue, potentially resulting in the loss of spatial information concerning neuronal networks. Spatial transcriptomics methods, by bypassing the cell dissociation, can elucidate the intricate spatial organization of neural networks through their imaging and sequencing technologies. In this review, we highlight the applicative value of single-cell and spatial transcriptomics in exploring the complex molecular-genetic diversity of hypothalamic cell types, driven by recent high-throughput achievements.

关键词： cellular diversity hypothalamus multi-omics single-cell transcriptomics spatial transcriptomics

Ru/NiMnB spherical cluster pillar for highly proficient green hydrogen electrocatalyst at high current density

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Journal of Energy Chemistry 2025年第1期100卷 397-408页

作者： Md Ahasan Habib Shusen Lin Mehedi Hasan Joni Sumiya Akter Dristy Rutuja Mandavkar Jae-Hun jeong Jihoon lee Department of Electronic Engineering College of Electronics and Information Kwangwoon University

Advanced OER/HER electrocatalytic alternatives are crucial for the wide adaptation of green hydrogen ***,Ru/NiMnB spherical cluster pillar （SCP）,denoted as Ru/NiMnB,is synthesized using a combination of electro-deposition and hydrothermal *** investigation of Ru doping in the NiMnB matrix revealed significant improvements in electrocatalytic *** Ru/NiMnB SCPs demonstrate superior OER/HER activity with low overpotentials of 150 and 103 mV at 50mA/cm2in 1 M KOH,making them highly competitive with state-of-the-art ***,the Ru/NiMnB SCPs exhibit a low 2-E cell voltage of 2.80 V at ultra-high current density of 2,000 m A/cm2in 1 M KOH,outperforming the standard benchmark electrodes of RuO2||Pt/C,thereby positioning Ru/NiMnB as one of the best bifunctional *** SCPs exhibit exceptional high-current characteristics,stability and corrosion resistance,as evidenced by continuous operation at 1,000 mA/cm2high-current density for over 150 h in 6 M KOH at elevated temperatures under harsh industrial *** a small amount of Ru incorporation significantly enhances the electrocatalytic performances of NiMnB,attributed to increased active sites and improved intrinsic properties such as conductivity,adsorption/desorption capability and reaction ***,Ru/NiMnB SCPs present a promising bi-functional electrode concept for efficient green H2production.

关键词： Potassium hydroxide

The 5-year functional outcomes after radical prostatectomy： a real-life experience in Korea

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Asian Journal of Andrology 2010年第6期12卷 835-840页

作者： Sung Kyu Hong Seung Hwan Doo Dae Sung Kim Won Ki lee Hong zoo Park Ji Hyun Park Seong Jin jeong Cheol Yong Yoon Seok-Soo Byun Sang Eun lee Department of Urology Seoul National University Bundang Hospital Seongnam Kyunggi-do 463-707 Korea

We investigated the functional outcomes regarding erectile function and urinary continence up to 5 years following radical prostatectomy （RP） in a cohort of Korean men. We retrospectively analyzed the clinicopathologic data of 85 Korean men who received open uni- or bilateral nerve-sparing RP for clinically localized prostate cancer and were followed up for at least 5 years postoperatively. From medical records, patients＇ status regarding urinary and erectile function at baseline and postoperative followups after RP was assessed. At 24 and 60 months after RP, proportions of subjects continent （no pads used） were 89.4% and 97.6%, respectively （P = 0.007）. Excluding subjects （n = 24） who preoperatively reported having severe erectile dysfunction or lacked relevant informations, proportions of subjects capable of having vaginal intercourse regardless of erectile aid usage were 47.5% and 37.7% at 24 and 60 months from RP, respectively （P = 0.022）. Patient＇s age at surgery （P = 0.047） and salvage radiation therapy （P = 0.026） were observed to be significant predictors of having erections sufficient for intercourse at 60 months from RP in multivariate analysis. Our results showed that while patients＇ postoperative status regarding urinary continence at 2 years from RP is generally maintained or improved at 5 year point, erectile function was observed to significantly declined from 2 years to 5 years following RP. Such decline in erectile function following RP may be more significant among men who were relatively older at surgery or those who received salvage therapy during postoperative follow-ups.

关键词： impotence prostatectomy prostatic neoplasm urinary incontinence

Techniques for overcoming atretic changes of the portal vein in living donor liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2020年第4期19卷 311-317页

作者： jeong-Moo lee Kwang-Woong lee Department of Surgery Seoul National University College of Medicine101 Daehak-roJongno-guSeoul 03080Korea

Background:Spontaneous diversion of the portal flow through collateral vessels into the systemic circulation is frequently observed in liver transplant recipients with severe portal *** induces main portal vein atretic change and modifies flow into the collateral even after donor graft *** atretic changes make liver transplantation *** this article we described several methods for overcoming this challenge by appropriate surgical ***:Three anastomotic techniques for living donor liver transplantation were performed in patients with atretic changes in the portal ***:The three techniques were(1)venoplasty to widen the diameter by using the recipient’s portal vein,and the diameter of the recipient’s portal vein was enlarged using their own portal vein stump patch;(2)conduit with cryopreserved vessels,and we dissected around the superior mesenteric vein and splenic vein junction and a conduit was built using the cryopreserved vessels;and(3)left gastric varix to portal vein anastomosis,if the recipients had large gastric varix and variceal wall was sufficiently thick for ***:Selection of optimal methods for portal vein anastomosis is essential in patients with atrophic change on the portal *** these methods are used aptly,they can be considered as favorable methods for overcoming each situation.

关键词： Atretic portal vein Liver transplantation Anastomosis

Crystal plasticity finite element simulations on extruded Mg-10Gd rod with texture gradient

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Journal of Magnesium and Alloys 2024年第8期12卷 3409-3430页

作者： Jaeseong lee Dirk Steglich Youngung jeong Department of Materials Convergence and System Engineering Changwon National University25 Changwondaehak-roChangwonRepublic of Korea Helmholtz-Zentrum Hereon Institute of Material Systems ModelingD-21502 GeesthachtGermany School of Materials Science and Engineering Changwon National University25 Changwondaehak-roChangwonRepublic of Korea

The mechanical properties of an extruded Mg-10Gd sample, specifically designed for vascular stents, are crucial for predicting its behavior under service conditions. Achieving homogeneous stresses in the hoop direction, essential for characterizing vascular stents, poses challenges in experimental testing based on standard specimens featuring a reduced cross section. This study utilizes an elasto-visco-plastic self-consistent polycrystal model(ΔEVPSC) with the predominant twinning reorientation(PTR) scheme as a numerical tool, offering an alternative to mechanical testing. For verification, various mechanical experiments, such as uniaxial tension, compression, notched-bar tension, three-point bending, and C-ring compression tests, were conducted. The resulting force vs. displacement curves and textures were then compared with those based on the ΔEVPSC model. The computational model's significance is highlighted by simulation results demonstrating that the differential hardening along with a weak strength differential effect observed in the Mg-10Gd sample is a result of the interplay between micromechanical deformation mechanisms and deformation-induced texture evolution. Furthermore, the study highlights that incorporating the axisymmetric texture from the as-received material incorporating the measured texture gradient significantly improves predictive accuracy on the strength in the hoop direction. Ultimately, the findings suggest that the ΔEVPSC model can effectively predict the mechanical behavior resulting from loading scenarios that are impossible to realize experimentally, emphasizing its valuable contribution as a digital twin.

关键词： Crystal plasticity Texture Finite element C-ring Three-point bending

Plasma Post Oxidation of Plasma Nitrocarburized SKD 61 Steel

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Journal of Materials Science & Technology 2008年第1期24卷 136-138页

作者： Insup lee Kwang-Ho jeong Department of Advanced Materials Engineering Dongeui University Busan 614-714 Korea

Plasma nitrocarburizing and plasma oxidizing treatments were performed to improve the wear and corrosion resistance of SKD 61 *** nitrocarburizing was conducted for 12 h at 540℃in the nitrogen, hydrogen and methane atmosphere to produce theε-Fe-（2-3）（N,C） *** compound layer produced by plasma nitrocarburising was predominantly composed ofε-phase,with a small proportion ofγ′-Fe-4 （N,C） phase. The thickness of the compound layer and the diffusion layer are about 10μm and about 200μm,respectively. Plasma post oxidation was performed on the nitrocarburized samples with various oxygen/hydrogen ratio at constant temperature of 500℃for 1 *** very thin magnetite （Fe-3O-4） layer of 1-2μm in thickness on top of the compound layer was *** polarization test revealed that plasma nitrocarburizing process contributed a significant improvement of corrosion resistance of SKD 61 ***,the corrosion characteristics of the nitrocarburized compound layer was deteriorated by oxidation treatment.

关键词： Plasma nitrocarburizing Post oxidation ε-Fe2-3(N,C) γ′-Fe4(N,C) Fe3O4

GPU-Driven Scalable Parser for OBJ Models

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Journal of Computer Science & Technology 2018年第2期33卷 417-428页

作者： Sunghun Jo Yuna jeong Sungkil lee Department of Software Sungkyunkwan University Suwon 16419 Korea

This paper presents a scalable parser framework using graphics processing units （GPUs） for massive text-based files. Specifically, our solution is designed to efficiently parse Wavefront OBJ models texts of which specify 3D geometries and their topology. Our work bases its scalability and efficiency on chunk-based processing. The entire parsing problem is subdivided into subproblems the chunk of which can be processed independently and merged seamlessly. The within-chunk processing is made highly parallel, leveraged by GPUs. Our approach thereby overcomes the bottlenecks of the existing OBJ parsers. Experiments performed to assess the performance of our system showed that our solutions significantly outperform the existing CPU-based solutions and GPU-based solutions as well.

关键词： 3D model Wavefront OBJ parser GPU

Effects of foundation damage and water-level change on vibration modal parameters of gravity-type caisson structure

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Science China(Technological Sciences) 2015年第2期58卷 316-329页

作者： lee So-Young KIM jeong-Tae Department of Ocean Engineering Pukyong National University

In this paper,the effects of foundation damage and water-level change on vibration characteristics of gravity-type caisson structure are examined by analyzing modal parameters extracted from output-only *** achieve the objective,the following approaches are ***,vibration response analysis methods are selected to estimate power spectral density and modal parameters such as natural frequency,damping ratio and mode shape of a lab-scale caisson structural ***,vibration tests on the lab-scale caisson system are performed under a series of test scenarios which include three water-level changes and three damage ***,experimental modal parameters corresponding to the damaging cases as well as the water level cases are extracted by frequency domain decomposition method and stochastic subspace identification ***,the effects of the water-level variation and foundation damage on the extracted modal parameters are examined to assess the feasibility of the vibration-based damage detection in gravity-type caisson structures under water-level uncertainty.

关键词： caisson structure gravity-type structure modal parameter effect of water-level foundation damage

Impacts of optimization strategies on performance,power/energy consumption of a GPU based parallel reduction

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Journal of Central South University 2017年第11期24卷 2624-2637页

作者： Phuong Thi Yen lee Deok-Young lee jeong-Gun Smart Computing Lab. Department of Computer EngineeringHallym UniversityChuncheon 24252Korea College of General Education Hallym UniversityChuncheon 24252Korea

In the era of modern high performance computing, GPUs have been considered an excellent accelerator for general purpose data-intensive parallel applications. To achieve application speedup from GPUs, many of performance-oriented optimization techniques have been proposed. However, in order to satisfy the recent trend of power and energy consumptions, power/energy-aware optimization of GPUs needs to be investigated with detailed analysis in addition to the performance-oriented optimization. In this work, in order to explore the impact of various optimization strategies on GPU performance, power and energy consumptions, we evaluate performance and power/energy consumption of a well-known application running on different commercial GPU devices with the different optimization strategies. In particular, in order to see the more generalized performance and power consumption patterns of GPU based accelerations, our evaluations are performed with three different Nvdia GPU generations(Fermi, Kepler and Maxwell architectures), various core clock frequencies and memory clock frequencies. We analyze how a GPU kernel execution is affected by optimization and what GPU architectural factors have much impact on its performance and power/energy consumption. This paper also categorizes which optimization technique primarily improves which metric(i.e., performance, power or energy efficiency). Furthermore, voltage frequency scaling(VFS) is also applied to examine the effect of changing a clock frequency on these metrics. In general, our work shows that effective GPU optimization strategies can improve the application performance significantly without increasing power and energy consumption.

关键词： parallel reduction GPU code optimization power energy voltage frequency scaling