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Avoiding heating interference and guided thermal conduction in stretchable devices using thermal conductive composite islands

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Nano Research 2021年第9期14卷 3253-3259页

作者： Seung Ji Kang Haeleen Hong Chanho jeong Ju Seung Lee Hyewon Ryu Jae-hun Yang Jong Uk Kim Yiel Jae shin Tae-il Kim School of Chemical Engineering Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea Department of Biomedical Engineering Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea Biomedical Institute for Convergence(BICS) Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea

The miniaturization and high integration of devices demand significant thermal management *** technologies for the thermal management of electronics show some limitations in the case of multiple chip arrays.A device in multiple chip array is affected by heat from adjacent devices,along with thermal conductive *** address this problem,we present a nano composite of aligned boron nitride(BN)nanosheet islands with porous polydimethylsiloxane(PDMS)foam to have mechanical stability and non-thermal *** islands of tetrahedrally-structured BN in the composite have a high thermal conductivity of 1.219 W·m^(-1)·K^(-1) in the through-plane direction(11.234W·m^(-1)·K^(-1)in the in-plane direction)with 16 wt.%loading of *** the other hand,porous PDMS foam has a low thermal conductivity of 0.0328W·m^(-1)·K^(-1) in the through-plane direction at 70%*** pathways are then formed only in the structured BN islands of the *** porous PDMS foam can be applied as a thermal barrier between structured BN islands to inhibit thermal interference in multiple device ***,this composite can maintain selective thermal dissipation performance with 70%tensile *** beauty of the work is that it could have guided heat dissipation by assembling of multiple layers which have high vertical thermal conductive islands,while inhibiting thermal *** selective heat dissipating composite can be applied as a heatsink for multiple chip arrays electronics.

关键词： selective thermal conduction non-thermal interference thermal conductive composite island stretchable electronics structured boron nitride nanosheet(s-BN) porous polydimethylsiloxane(p-PDMS)

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Short-term and long-term outcomes of laparoscopic vs open ileocolic resection in patients with Crohn's disease: Propensityscore matching analysis

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World Journal of Gastroenterology 2021年第41期27卷 7159-7172页

作者： shin jeong Pak Young Il Kim Yong Sik Yoon Jong Lyul Lee Jung Bok Lee Chang Sik Yu Department of Colon and Rectal Surgery University of Ulsan College of MedicineAsan Medical CenterSeoul 05505South Korea Department of Clinical Epidemiology and Biostatistics University of Ulsan College of MedicineAsan Medical CenterSeoul 05505South Korea

BACKGROUND Laparoscopic ileocolic resection(LICR)is the preferred surgical approach for primary ileocolic Crohn’s disease(CD)because it has greater recovery benefits than open ICR(OICR).AIM To compare short-and long-term outcomes in patients who underwent LICR and *** Patients who underwent ICR for primary CD from 2006 to 2017 at a single tertiary center specializing in CD were *** who underwent LICR and OICR were subjected to propensity-score matching *** were propensityscore matched 1:1 by factors potentially associated with 30-d perioperative *** included demographic characteristics and disease-and treatment-related *** were compared using univariate and multivariate ***-term surgical recurrence-free survival(SRFS)in the two groups was determined by the Kaplan-Meier method and compared by the log-rank *** During the study period,348 patients underwent ICR,211 by the open approach and 137 ***-score matching yielded 102 pairs of *** rate of postoperative complication was significantly lower(14%versus 32%,P=0.003),postoperative hospital stay significantly shorter(8 d versus 13 d,P=0.003),and postoperative pain on day 7 significantly lower(1.4 versus 2.3,P<0.001)in propensity-score matched patients who underwent LICR than in those who underwent *** analysis showed that postoperative complications were significantly associated with preoperative treatment with biologics[odds ratio(OR):3.14,P=0.01]and an open approach to surgery(OR:2.86,P=0.005).The 5-and 10-year SRFS rates in the matched pairs were 92.9%and 83.3%,respectively,with SRFS rates not differing significantly between the OICR and LICR *** performance of additional procedures was an independent risk factor for surgical recurrence[hazard ratio(HR):3.28,P=0.02].CONCLUSION LICR yielded better short-term outcomes and postoperative recovery than OICR,with no differences in long-ter

关键词： Crohn’s disease Laparoscopic Surgery Postoperative complications Recurrence Propensity score Retrospective study

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Antiinflammatory and analgesic effect of herbal cocktail Hongbaekjeong via inhibition of proinflammatory cytokines and prostaglandin E2 release

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Chinese Science Bulletin 2014年第25期59卷 3127-3133页

作者： Jinwon Lim Hyo-Jung Lee Bonglee Kim jeong-Un Choi Yoeok shin Eun Jung Sohn Sung-Hoon Kim Cancer Preventive Material Development Research Center College of Oriental Medicine Kyung Hee University

Though Hongbaekjeong(HBJ),a hebal mixture of three medicinal plants,has been traditionally used for arthritis and muscular pain,its scientific evidence still remains ***,in the present study,analgesic and anti-inflammatory mechanism of HBJ was evaluated in vitro and in *** significantly reduced NO production and prostaglandin E2(PGE2)release and also attenuated the expression of cyclooxygenase 2(COX-2)in lipopolysaccharides(LPS)and interferon(IFN)-c treated RAW 264.7 ***,HBJ abrogated the production of proinflammatory cytokines such as interleukin(IL)1b,IL-6,IL-8 and monocyte chemoattractant protein-1(MCP-1)in LPS and IFN-c treated RAW 264.7 *** addition,HBJ significantly decreased the number of writhing syndrome induced by acetic acid,and also increased latency in hot-plate method and tail flick test in ***,HBJ significantly reduced the edema volume in the hind paw of the rats with arthritis induced by Freund’s complete adjuvant(FCA)compared to untreated ***,our findings demonstrate the antiinflammatory and analgesic potential of HBJ via inhibition of proinflammatory cytokines and PGE2 release for treatment of arthritis and muscular pain.

关键词：前列腺素E2 炎性细胞因子和镇痛抗炎单核细胞趋化蛋白-1 鸡尾酒 IFN-γ

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DA-9601, a standardized extract of Artemisia asiatica, blocks TNF-α-induced IL-8 and CCL20 production by inhibiting p38 kinase and NF-κ-B pathways in human gastric epithelial cells

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World Journal of Gastroenterology 2006年第30期12卷 4850-4858页

作者： Suck-Chei Choi Eun-Ju Choi Hyun-Mee Oh SungGa Lee jeong-Kun Lee Meung-Su Lee Yong-Il shin Suck-Jun Choi jeong-Ryong Chae Kang-Min Lee Won-Jung Lee Jae-Sik Park Chang-Yell shin Tae-Young Oh Chang-Duk Jun Digestive Disease Research Institute Wonkwang University School of Medicine Iksan Chonbuk 570-749 Korea Department Physical Education Kunsan National University Chonbuk 573-701 Korea Department of Life Science Gwangju Institute of Science and Technology Gwangju 500-712 Korea Department of Leisure Sports Wonkwang Health Science College Iksan Chonbuk 570-749 Korea Division of Biological Sciences College of Natural Science Chonbuk National University Jeonju Chonbuk 561-756 Korea Department of Physiology Kyungpook National University School of Medicine Taegu 700-422 Korea Research Institute Dong-A Pharmaceutical Co. Ltd. Yongin 449-905 Korea

AIM: To investigate whether, or how, DA-9601, which is a new gastroprotective agent, inhibits TNF-α-induced inflammatory signals in gastric epithelial AGS cells. METHODS: Cell viability was determined by MTT assay. IL-8 and CCL20 promoter activities were determined by a luciferease reporter gene assay. NF-κB-dependent transcriptional activity was determined by I-κBαdegradation, NF-κB p65 nuclear translocation and a luciferase activity assay. IL-8 and CCL20 gene expression and protein secretion were determined by RT-PCR and an enzymelinked immunosorbent assay (ELISA). Total and phos-phorylated forms of mitogen-activated protein kinases (MAPKs) were determined by Western blot. RESULTS: Treatment of AGS cells with DA-9601 reduced TNF-α-induced IL-8 and CCL20 promoter activities, as well as their gene expression and protein release. TNF-αalso induced NF-κB-dependent transcriptional activity in AGS cells. In contrast, in cells treated with DA-9601, TNF-α-induced NF-κB activity was significantly blocked. Although all three MAP kinase family members were phosphorylated in response to TNF-α, a selective inhibitor of p38 kinase SB203580 only could inhibit both NF-κB-dependent transcriptional activity and IL-8 and CCL20 production, suggesting a potential link between p38 kinase and NF-κB-dependent pathways in AGS cells. Interestingly, DA-9601 also selectively inhibited p38 kinase phosphorylation induced by TNF-α. CONCLUSION: DA-9601 blocked TNF-α-mediated inflammatory signals by potentially modulating the p38 kinase pathway and/or a signal leading to NF-κBdependent pathways in gastric epithelial cells.

关键词： CCL20 IL-8 Artemisia asiatica DA-9601 TNF-α p38 kinase NF-κB

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How Do Phytochromes Transmit the Light Quality Information to the Circadian Clock in Arabidopsis？

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Molecular Plant 2014年第11期7卷 1701-1704页

作者： Miii Yeom Hyunmin Kim Junhyun Lim Ah- Young shin Sunghyun Hong jeong-II Kim Hong Gil Nam Division of Molecular and Life Sciences PohangUniversity of Science and Technology Hyojadong Pohang Gyeongbuk 790-784 Republic of Korea Integrative Biosciences & Biotechnology in POSTECH Hyojadong Pohang Gyeongbuk 790-784 Republic of Korea Department of Molecular Biotechnology and Kumho Life Science Laboratory Chonnam National University Gwangju 500-757 Republic of Korea Center for Plant Aging Research Institute for Basic Science Daegu 711-873 Republic of Korea Department of New Biology DGIST Hyeongpoong-Myun Dalsung-gun Daegu 711-873 Republic of Korea

Dear Editor, Plants use light as an environmental signal to coor- dinate diverse physiological and developmental processes, thereby increasing their fitness. Light quality, quantity, and photoperiod change periodically under natural condi- tions of daily and seasonal cycles. Plants have developed a circadian clock to respond to these predictable, periodic environmental changes, providing plants with the ability to anticipate daily and seasonal environmental changes.

关键词： STABILITY PROTEIN COP1

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MRI of gastric carcinoma:Results of T and N-staging in an in vitro study

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World Journal of Gastroenterology 2009年第32期15卷 3992-3998页

作者： Il Young Kim Sang Won Kim Hyeong Cheol shin Moon Soo Lee Dong Jun jeong Chang Jin Kim Young Tong Kim Department of Radiology Soonchunhyang University Cheonan Hospital23-20 BongmyungdongCheonanChoongnam 330-720South Korea Department of Surgery Soonchunhyang University Cheonan Hospital23-20 BongmyungdongCheonanChoongnam 330-720South Korea Department of Pathology Soonchunhyang University Cheonan Hospital23-20 BongmyungdongCheonanChoongnam 330-720South Korea

AIM： To determine the accuracy of 1.5-T magnetic resonance imaging （MRI） in the evaluation of gastric wall invasion and perigastric lymph node metastasis in gastric adenocarcinoma.METHODS： Twenty resected gastric specimens containing 20 tumors were studied with a 1.5-T MR system using a commercial head surface coil. MR scanning was performed with a T1 weighted image （TR/TE = 500/20）, and a T2 weighted image （TR/TE = 2500/90）. MR findings were compared with pathologic findings.RESULTS： A T1-weighted image demonstrated three layers in the normal gastric wall. All of the gastric tumors were well demonstrated by lesions and location. In a MRI findings of gastric wall invasion, there was 1 case of T1, 7 of T2, 11 of T3. Pathologic results of resected specimens included 3 cases of pT1, 4 of pT2, and 12 of pT3. The accuracy of T staging with MRI was 74% （14 of 19）. MRI findings of lymph node metastasis included 6 cases of NO, 13 cases of N1. The accuracy of the N staging with MRI was 47% （9 of 19）.CONCLUSION： MRI has a high diagnostic accuracy in the evaluation of the T staging of gastric cancerin vitro and thus potentially enables preoperative histopathologic staging.

关键词： Gastric cancer Magnetic resonance imaging Neoplasm Staging Stomach Depiction of walllayer

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Conservation and Diversification of the SHR-SCR- SCL23 Regulatory Network in the Development of the Functional Endodermis in Arabidopsis Shoots

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Molecular Plant 2016年第8期9卷 1197-1209页

作者： Eun Kyung Yoon Souvik Dhar Mi-Hyun Lee Jae Hyo Song shin Ae Lee Gyuree Kim Sejeong Jang Ji Won Choi jeong-Eun Choe jeong Hoe Kim Myeong Min Lee Jun Lim Department of Systems Biotechnology Konkuk University Seoul 05029 Korea Department of Systems Biology Yonsei University Seoul 03722 Korea Department of Biology Kyungpook National University Daegu 41566 Korea 4TheSe tlRors cotribCited equally/to ttats article Present address: Department of Agricultural Biotechnology National Institute of Agricultural Sciences Jeonju 54874 Korea Present address: Department of Agricultural Biology National Institute of Agricultural Sciences Wanju 55365 Korea

Development of the functional endodermis of Arabidopsis thaliana roots is controlled, in part, by GRAS transcription factors, namely SHORT-ROOT （SHR）, SCARECROW （SCR）, and SCARECROW-LIKE 23 （SCL23）. Recently, it has been shown that the SHR-SCR-SCL23 regulatory module is also essential for spec- ification of the endodermis （known as the bundle sheath） in leaves. Nevertheless, compared with what is known about the role of the SHR-SCR-SCL23 regulatory network in roots, the molecular interactions of SHR, SCR, and SCL23 are much less understood in shoots. Here, we show that SHR forms protein com- plexes with SCL23 to regulate transcription of SCL23 in shoots, similar to the regulation mode of SCR expression. Our results indicate that SHR acts as master regulator to directly activate the expression of SCR and SCL23. In the SHR-SCR-SCL23 network, we found a previously uncharacterized negative feed- back loop whereby SCL23 modulates SHR levels. Through molecular, genetic, physiological, and morpho- logical analyses, we also reveal that the SHR-SCR-SCL23 module plays a key role in the formation of the endodermis （known as the starch sheath） in hypocotyls. Taken together, our results provide new insights into the regulatory role of the SHR-SCR-SCL23 network in the endodermis development in both roots and shoots.

关键词： endodermis gene regulatory network SHORT-ROOT SCARECROW SCARECROW-LIKE 23,transcription factor

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Stochasticity dominates assembly processes of soil nematode metacommunities on three Asian mountains

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Pedosphere 2023年第2期33卷 331-342页

作者： Shuqi ZOU Jonathan ADAMS Zhi YU Nan LI Dorsaf KERFAHI Binu TRIPATHI Changbae LEE Teng YANG Itumeleng MOROENYANE Xing CHEN Jinsoo KIM Hyun jeong KWAK Matthew Chidozie OGWU Sang-seob LEE Ke DONG Department of Integrative Biotechnology Sungkyunkwan University300 Chuncheon-DongSuwon 16419(Korea) School of Geographic and Oceanographic Sciences Nanjing UniversityNanjing 210008(China) Key laboratory of Ministry of Education for Environment Change and Resources Use in Beibu Gulf Guangxi Key Laboratory of Earth Surface Processes and Intelligent SimulationNanning Normal University175 East Mingxiu RoadNanning 530001(China) School of Natural Sciences Department of Biological SciencesKeimyung UniversityDaegu 42601(Korea) Korea Polar Research Institute Incheon 21990(Korea) Department of Forestry Environment and SystemsKookmin UniversitySeoul 02707(Korea) State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of Sciences71 East Beijing RoadNanjing 210008(China) Institut National Recherche Scientifique Institut Armand-Frappier SantéBiotechnologie531 Boulevard des PrairiesLaval H7V1B7(Canada) College of Life Science and Technology Guangxi University100 Daxue RoadNanning 530004(China) Department of Biological Sciences Kyonggi University154-42 Gwanggyosan-roYeongtong-guSuwon-siGyeonggi-do 16227(Korea) School of Biological Sciences Seoul National University1 Gwanak-roSeoul 08826(Korea)

Nematodes play an important role in ecosystems;however,very little is known about their assembly processes and the factors influencing *** studied nematode communities in bulk soils from three Asian mountain ecosystems to determine the assembly processes of free-living nematode metacommunities and their driving *** each mountain,elevations span a range of climatic conditions with the potential to reveal assembly processes that predominate across multiple biomes.A phylogenetic null modeling framework was used to analyze 18S rRNA gene amplicons to quantify various assembly *** found that phylogenetic turnover between nematode communities on all mountains was dominated by stochastic processes,with“undominated processes”being the most predominant stochastic *** has a significant impact on the relative importance of deterministic and stochastic processes.A variety of climatic and edaphic variables significantly influenced the variations in community assembly processes with elevation,even though their impacts were not consistent between the ***,our results indicate that free-living nematode metacommunities in a wide range of environments are largely structured by stochastic processes rather than by niche-based deterministic processes,suggesting that metacommunities of soil free-living nematodes may respond to climate change in a largely unpredictable way.

关键词： climate change ecological drift elevation gradient environmental stress stochastic process

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Identification of Aristolactam Derivatives That Act as Inhibitors of Human Immunodeficiency Virus Type 1 Infection and Replication by Targeting Tat-Mediated Viral Transcription

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Virologica Sinica 2021年第2期36卷 254-263页

作者： Young Hyun shin Chul Min Park Hong Gi Kim Dong-Eun Kim Min Suk Choi jeong-ah Kim Byeong-Sun Choi Cheol-Hee Yoon Division of Viral Disease Research Center for Infectious Disease ResearchKorea National Institute of HealthHeungdeok-guCheongju-siShungbuk 28159Republic of Korea Center for Convergent Research of Emerging Virus Infection Korea Research Institute of Chemical TechnologyYuseong-guDaejeon 34114Republic of Korea

Despite the success of antiretroviral therapy(ART),efforts to develop new classes of antiviral agents have been hampered by the emergence of drug ***-indole-bearing aristolactams are compounds that have been isolated from various plants species and which show several clinically relevant effects,including anti-inflammatory,antiplatelet,and antimycobacterial ***,the effect of these compounds on human immunodeficiency virus type 1(HIV-1)infection has not yet been *** this study,we discovered an aristolactam derivative bearing dibenzo[cd,f]indol-4(5 H)-one that had a potent anti-HIV-1 effect.A structure-activity relationship(SAR)study using nine synthetic derivatives of aristolactam identified the differing effects of residue substitutions on the inhibition of HIV-1 infection and cell *** the compounds tested,1,2,8,9-tetramethoxy-5-(2-(piperidin-1-yl)ethyl)-dibenzo[cd,f]indol-4(5 H)-one(Compound 2)exhibited the most potent activity by inhibiting HIV-1 infection with a half-maximal inhibitory concentration(IC50)of 1.03 lmol/L and a half-maximal cytotoxic concentration(CC50)of 16.91 lmol/L(selectivity index,16.45).The inhibitory effect of the compounds on HIV-1 infection was linked to inhibition of the viral replication ***-of-action studies showed that the aristolactam derivatives did not affect reverse transcription or integration;instead,they specifically inhibited Tat-mediated viral *** together,these findings show that several aristolactam derivatives impaired HIV-1 infection by inhibiting the activity of Tat-mediated viral transcription,and suggest that these derivatives could be antiviral drug candidates.

关键词： Human immunodeficiency virus type 1(HIV-1) Aristolactam Antiviral activity HIV-1 transcription

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Superior electrocatalytic negative electrode with tailored nitrogen functional group for vanadium redox flow battery

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Journal of Energy Chemistry 2023年第3期78卷 148-157,I0005页

作者： Min Gu Kang Wook Ahn Joonhee Kang shin Ae Song Kiyoung Kim Ju Young Woo Yong-Cheol jeong Bonwook Koo Dae Soo Jung Sung Nam Lim Micro/Nano Scale Manufacturing Group Korea Institute of Industrial Technology143 HanggaulroSangrok-guAnsan-siGyeonggi-do 15588Republic of Korea Department of Energy Systems Engineering Soonchunhyang University22 Soonchunhyang-roShinchang-myeonAsan-siChungcheongnam-do 31538Republic of Korea Department of Nanoenergy Engineering Pusan National UniversityBusan 46241Republic of Korea Department of Nano Fusion Technology Pusan National UniversityBusan 46241Republic of Korea Energy Storage Materials Center Energy&Environmental DivisionKorea Institute of Ceramic Engineering&Technology(KICET)101 Soho-roJinju-siGyeongsangnam-doRepublic of Korea

Development of electrodes with high electrocatalytic activity and stability is essential for solving problems that still restrict the extensive application of vanadium redox flow batteries(VRFBs).Here,we designed a novel negative electrode with superior electrocatalytic activity by tailoring nitrogen functional groups,such as newly formed nitro and pyridinic-N transformed to pyridonic-N,from the prenitrogen-doped *** was experimentally confirmed that an electrode with pyridonic-N and nitro fuctional groups(tailored nitrogen-doped graphite felt,TNGF) has superior electrocatalytic acivity with enhanced electron and mass *** functional theory calulations demonstrated the pyridonic-N and nitro functional groups promoted the adsorption,charge transfer,and bond formation with the vanadium species,which is consistent with expermental *** addition,the V2+/V3+redox reaction mechanism on pyridonic-N and nitro functional groups was estabilised based on density functional theory(DFT) *** TNGF was applied to a VRFB,it enabled enhanced-electrolyte utilization and energy efficiencies(EE) of 57.9% and 64.6%,respectively,at a current density of 250 mA cm^(-2).These results are 18.6% and 8.9% higher than those of VRFB with electrode containing graphitic-N and pyridinicN ***,TNGF-based VRFB still operated with an EE of 59% at a high current density of300 mA cm^(-2).The TNGF-based VRFB exhibited stable cycling performance without noticeable decay of EE over 450 charge-discharge cycles at a current density of 250 mA cm^(-2).The results of this study suggest that introducing pyridonic-N and nitro groups on the electrode is effective for improving the electrochemical performance of VRFBs.

关键词： Tailored nitrogen functional group Pyridonic-N Nitro Negative electrode Density functional theory Vanadium redoxﬂow batteries

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