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Does antiviral therapy reduce complications of cirrhosis?

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World Journal of Gastroenterology 2014年第23期20卷 7306-7311页

作者： Goh Eun Chung jeong-hoon lee Yoon Jun Kim Department of Internal Medicine Healthcare Research InstituteGangnam Healthcare CenterSeoul National University HospitalSeoul 135-984South Korea Department of Internal Medicine and Liver Research Institute Seoul National College of MedicineSeoul 110-744South Korea

Chronic hepatitis B infection is associated with the development of cirrhosis, hepatocellular carcinoma, and finally liver-related mortality. Each year, approximately, 2%-5% of patients with hepatitis B virus (HBV)-related compensated cirrhosis develop decompensation, with additional clinical manifestations, such as ascites, jaundice, hepatic encephalopathy, and gastrointestinal bleeding. The outcome of decompensated HBV-related cirrhosis is poor, with a 5-year survival of 14%-35% compared to 84% in patients with compensated cirrhosis. Because the risk of disease progression is closely linked to a patient’s serum HBV DNA level, antiviral therapy may suppress viral replication, stabilize liver function and improve survival. This article briefly reviews the role that antiviral therapy plays in cirrhosis complications, particularly, in decompensation and acute-on-chronic liver failure.

关键词： Antiviral therapy Cirrhosis Complication Hepatitis B Decompensation

Fucoidan protects hepatocytes from apoptosis and inhibits invasion of hepatocellular carcinoma by up-regulating p42/44 MAPK-dependent NDRG-1/CAP43

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Acta Pharmaceutica Sinica B 2015年第6期5卷 544-553页

作者： Yuri Cho Jung-Hwan Yoon jeong-ju Yoo Minjong lee Dong Hyeon lee Eun Ju Cho jeong-hoon lee Su Jong Yu Yoon Jun Kim Chung Yong Kim Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine

Fucoidan is a traditional Chinese medicine suggested to possess anti-tumor *** this study the anti-metastatic effects of fucoidan were investigated in vitro in human hepatocellular carcinoma(HCC) cells(Huh-7 and SNU-761) under normoxic and hypoxic conditions and in vivo using a distant liver metastasis model involving injection of MH134 cells into spleen via the portal *** ability to protect hepatocytes against bile acid(BA)-induced apoptosis was investigated in primary *** was found to suppress the invasion of HCC cells through up-regulation of p42/44 MAPKdependent NDRG-1/CAP43 and partly,under normoxic conditions,through up-regulation of p42/44MAPK-dependent VMP-1 *** also significantly decreased liver metastasis in *** regards its hepatoprotective effect,fucoidan decreased BA-induced hepatocyte apoptosis as shown by the attenuation of caspase-8,and-7 cleavages and suppression of the mobilization of caspase-8 and Fas associated death domain(FADD) into the death-inducing signaling *** summary,fucoidandisplays inhibitory effects on proliferation of HCC cells and protective effects on *** results suggest fucoidan is a potent suppressor of tumor invasion with hepatoprotective effects.

关键词： Fucoidan Hepatocellular carcinoma Invasion Hypoxia Hepatoprotective Cultured hepatocyte NDRG-1/CAP43 VMP-1

Schizonepeta tenuifolia inhibits collagen stimulated platelet function via suppressing MAPK and Akt signaling

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The Journal of Biomedical Research 2019年第4期33卷 250-257页

作者： Bo-Ra Jeon Muhammad Irfan Minki Kim Seung Eun lee jeong hoon lee Man Hee Rhee Laboratory of Physiology and Cell Signaling College of Veterinary MedicineKyungpook National UniversityDaegu 41566Republic of Korea Department of Herbal Crop Research National Institute of Horticultural and Herbal ScienceEumseong 27709Republic of Korea.

The prevalence of cardiovascular diseases(CVDs)is increasing at a rapid pace in developed countries,and CVDs are the leading cause of morbidity and *** products and ethnomedicine have been shown to reduce the risk of ***(S.)tenuifolia is a medicinal plant widely used in China,Korea,and Japan and is known to exhibit anti-inflammatory,antioxidant,and immunomodulatory *** hypothesized that given herbal plant exhibit pharmacological activities against CVDs,we specifically explored its effects on platelet *** aggregation was evaluated using standard light transmission *** calcium mobilization was assessed using Fura-2/AM,and granule secretion(ATP release)was measured in a *** binding to integrin a_(Ⅱb)β_3,was assessed using flow *** of mitogen-activated protein kinase(MAPK)signaling molecules and activation of the protein kinase B(Akt)was assessed using Western blot ***,extract potently and significantly inhibited platelet aggregation,calcium mobilization,granule secretion,and fibrinogen binding to integrin a_(Ⅱb)β_***,all extracts significantly inhibited MAPK and Akt *** extract inhibited platelet aggregation and granule secretion,and attenuated collagen mediated GPVI downstream signaling,indicating the potential therapeutic effects of these plant extracts on the cardiovascular system and platelet *** suggest that *** extract may be a potent candidate to treat platelet-related CVDs and to be used as an antiplatelet and antithrombotic agent.

关键词： S.tenuifolia platelet MAPK Akt natural antithrombotic agent

Anti-quorum sensing and anti-biofilm formation activities of plant extracts from South Korea

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Asian Pacific Journal of Tropical Biomedicine 2018年第8期8卷 411-417页

作者： Okhee Choi Dong-Wan Kang Su Kyung Cho Yeyeong lee Byeongsam Kang Juyoung Bae Seunghoe Kim jeong hoon lee Seung Eun lee Jinwoo Kim Institute of Agriculture & Life Science Gyeongsang National University Gyeonsangnam-do Agriculture Extension Services Department of Plant Medicine Gyeongsang National University Division of Applied Life Science Gyeongsang National University National Institute of Horticultural and Herbal Science Rural Development Administration

Objective: To investigate anti-quorum sensing(anti-QS) and anti-biofilm formation(antiBF) activities of the ethanol extracts of 388 plants. Methods: The anti-QS activity of the plant extracts was evaluated by disc-diffusion assays using the bio-reporter strain, Chromobacterium violaceum CV017. Pseudomonas aeruginosa PAO1, Yersinia enterocolitica ATCC 9610, and Agrobacterium tumefaciens C58, which possess QS systems, were used to evaluate the antiBF activity of the plant extracts. Results: Among 388 plant extracts, the Cornus controversa(C. controversa) and Cynanchum wilfordii extracts exhibited the strongest anti-QS activity. The C. controversa extract exhibited anti-BF activity against Pseudomonas aeruginosa, Yersinia enterocolitica and Agrobacterium tumefaciens, whereas the Cynanchum wilfordii extract exhibited no anti-BF activity against Pseudomonas aeruginosa. In addition, the C. controversa extract suppressed soft rot of cabbage. Conclusions: The C. controversa extract inhibits bacterial QS and BF, and is capable of controlling soft rot. Therefore, this extract has potential for the prevention and treatment of bacterial infections and for the development of alternatives to antibiotics.

关键词： Plant extracts Quorum sensing Biofilm formation Cornus controversa

Timing of upper gastrointestinal endoscopy does not influence short-term outcomes in patients with acute variceal bleeding

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World Journal of Gastroenterology 2018年第44期24卷 5025-5033页

作者： jeong-Ju Yoo Young Chang Eun Ju Cho Ji Eun Moon Sang Gyune Kim Young Seok Kim Yun Bin lee jeong-hoon lee Su Jong Yu Yoon Jun Kim Jung-Hwan Yoon Department of Gastroenterology and Hepatology Soonchunhyang University school of Medicine Bucheon 14584 South Korea Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine Seoul 03080 South Korea Department of Biostatistics Clinical Trial Center Soonchunhyang University Bucheon Hospital Bucheon 14584 South Korea

AIM To examine the association between the timing of endo-scopy and the short-term outcomes of acute variceal bleeding in cirrhotic *** This retrospective study included 274 consecutive patients admitted with acute esophageal variceal bleeding of two tertiary hospitals in Korea. We adjusted confounding factors using the Cox proportional hazards model and the inverse probability weighting （IPW） method. The primary outcome was the mortality of patients within 6 *** A total of 173 patients received urgent endoscopy （ i.e. , ≤ 12 h after admission）, and 101 patients received non-urgent endoscopy （〉 12 h after admission）. The 6-wk mortality rate was 22.5% in the urgent endoscopy group and 29.7% in the non-urgent endoscopy group, and there was no significant difference between the two groups before （P = 0.266） and after IPW （P = 0.639）. The length of hospital stay was statistically different between the urgent group and non-urgent group （P = 0.033）; however, there was no significant difference in the in-hospital mortality rate between the two groups （8.1%vs 7.9%, P = 0.960）. In multivariate analyses, timing of endoscopy was not associated with 6-wk mortality （hazard ratio, 1.297; 95% confdence interval, 0.806-2.089; P = 0.284）.CONCLUSION In cirrhotic patients with acute variceal bleeding, the timing of endoscopy may be independent of short-term mortality.

关键词： Cirrhosis Endoscopy Upper gastrointestinal bleeding Gastroesophageal varices Timing

Reevaluation of the expanded indications in undifferentiated early gastric cancer for endoscopic submucosal dissection

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World Journal of Gastroenterology 2022年第15期28卷 1548-1562页

作者： Jiyoung Yoon Seung-Yeon Yoo Young Soo Park Kee Don Choi Beom Su Kim Moon-Won Yoo In Seob lee jeong Hwan Yook Ga Hee Kim Hee Kyong Na Ji Yong Ahn jeong hoon lee Kee Wook Jung Do hoon Kim Ho June Song Gin Hyug lee Hwoon-Yong Jung Department of Gastroenterology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea Department of Pathology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea Department of Surgery Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea

BACKGROUND Although the criteria for the indication of endoscopic submucosal dissection(ESD)for undifferentiated early gastric cancer(UD-EGC)have been recently proposed,accumulating reports on the non-negligible rate of lymph node metastasis(LNM)after indicated ESD raise questions on the reliability of the current *** To investigate the prevalence and risk factors of LNM in UD-EGC cases meeting the expanded indication for *** We retrospectively reviewed 4780 UD-EGC cases that underwent surgical resection between January 2008 and February 2019 at Asan Medical Center,a tertiary university hospital in *** identify the risk factors of LNM of UDEGC meeting the expanded criteria for ESD,we performed a case-control study by matching the cases with LNM to those without at a ratio of 1:*** reviewed the clinical,endoscopic,and histologic features of the cases to identify features with a significant difference according to the presence of *** and multivariate logistic regression analyses were performed to estimate the odds ratios(ORs).RESULTS Of the 4780 UD-EGC cases,1240(25.9%)were identified to meet the expanded indication for *** the 1240 cases,14(1.1%)cases had *** the various clinical,endoscopic,and histopathological features that were evaluated,mixed histology(tumors consisting of 10%-90%of signet ring cells)had a marginally significant association(P=0.059)with the risk of ***,diffuse blurring of the muscularis mucosae(MM)underneath the tumorous epithelium,a previously unrecognized histologic feature,had a significant association with the absence of LNM(P=0.028).Multivariate logistic regression analysis showed that the blurring of MM was the only explanatory variable significantly associated with a reduced risk of LNM(OR:0.12,95%CI:0.02-0.95;P=0.045).CONCLUSION The risk of LNM is higher than expected when using the current expanded indication for *** evaluation could provide useful clues for reducing the

关键词： Gastric cancer Undifferentiated carcinoma Endoscopic submucosal dissection Lymph node metastasis

Endoscopic submucosal dissection as alternative to surgery for complicated gastric heterotopic pancreas

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World Journal of Clinical Cases 2020年第20期8卷 4708-4718页

作者： Jin Hee Noh Do hoon Kim So-Woon Kim Young Soo Park Hee Kyong Na Ji Yong Ahn Kee Wook Jung jeong hoon lee Kee Don Choi Ho June Song Gin Hyug lee Hwoon-Yong Jung Department of Gastroenterology University of Ulsan College of MedicineAsan Medical CenterSeoul 05505South Korea Department of Pathology University of Ulsan College of MedicineAsan Medical CenterSeoul 05505South Korea

BACKGROUND Gastric heterotopic pancreas(GHP)is generally asymptomatic and rarely features complications such as pancreatitis,pseudocysts,gastric outlet obstruction,bleeding,obstructive jaundice,or ***,the treatment of complicated GHP is challenging and often requires surgical *** To investigate the clinical outcomes of endoscopic submucosal dissection(ESD)as alternative to surgical resection for complicated *** This is a single-center,retrospective *** January 2013 and December 2017,a total of 5 patients underwent ESD for complicated GHP at Asan Medical *** who were diagnosed with complicated GHP were treated conservatively as with general practice for acute *** conservative management for resolving the acute phase of pancreatitis,ESD was performed as definitive treatment for complicated *** was performed using the conventional method under conscious *** clinical features of patients and tumors,procedure-related characteristics,and long-term outcomes were *** The age of the 5 patients ranged from 28-43 *** of the patients were *** lesions were located in the greater curvature of the *** endoscopic ultrasonography during the pain episode,all lesions were located across the muscularis mucosa,submucosa,and proper muscle *** median lesion size was 20[interquartile range(IQR),18-35]during the pain episode at the time of the diagnosis of complicated GHP,and 15 mm(IQR,9-33)at the time of ESD after conservative *** procedure time ranged from 15-120 *** were no procedure-related adverse events such as perforation or *** length of hospital stay after the procedure ranged from 2-4 *** patients were symptom free during the median follow-up period of 46.0 mo(IQR,39-60).CONCLUSION ESD appears to be a feasible and effective treatment option for complicated GHP based on the favorable clinical outcomes.

关键词： Endoscopic submucosal dissection Gastric Heterotopic pancreas Pancreatitis

Cultivation characteristics and flavonoid contents of wormwood (Artemisia montana Pamp.)

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Journal of Agricultural Chemistry and Environment 2013年第4期2卷 117-122页

作者： Yong Joo Kim jeong-hoon lee Sun-Ju Kim Department of Bio-Environmental Chemistry Chungnam National University Daejeon South Korea Department of Herbal Crop Research NIHHS RDA Eumseong South Korea

The aim of this study was to establish the optimum harvesting time and the content of flavonoids in the leaves, stems, and roots of Artemisia montana Pamp. A. montana was monitored from June to October in 2012. The yield of A. montana at high density (30 × 10 cm) was higher than that of A. montana at low density (30 × 20 and 30 cm). Yield in terms of dry weight was increased with an extended growth period and development stage. High yield achieved at 2580 and 2757 kg?10 a?1 in September and October, respectively. Among the leaves, stems, and underground plant organs, jaceosidin and eupatilin were mainly detected in the leaves, and the highest levels were observed in June, at values of 66.6 and 158.2 mg?100 g?1, respectively. In contrast, apigenin was the major compound detected in the underground plant organs, with levels ranging from 21.2 to 29.5 mg?100 g?1 until September. Therefore, optimal harvest times were between September and October, generating a high yield and adding economic value although a higher level of total flavonoids was observed in crops harvested in June.

关键词： Artemisia montana Flavonoids Harvest Time Plant Density

An Auto-Configuration of 4M Group Management Using Wireless Sensor Networks

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Wireless Sensor Network 2010年第5期2卷 402-410页

作者： Suk-Keun Cha jeong-hoon lee Han Gyu Kim Joon Jae Yoo Jung hoon Kang Dong hoon Kim Jun Yeob Song 不详

The first tier of automotive manufacturers has faced to pressures about move, modify, updating tasks for manufacturing resources in production processes from demand response of production order sequence for motor company and process innovation purpose for productivity. For meets this requirements, it has to require absolutely lead time to re-wiring of physical interface for production equipment, needs for change existing program and test over again. For prepare this constraints, it needs studying an auto-configuration functions that build for both visibility and flexibility based on the 4M (Man, Machine, Material, Method) group management which is supports from WSN (Wireless Sensor Network) of the open embedded device called M2M (Machine to Machine) and major functions of middleware including point manager for real-time device communication, real-time data management, Standard API (Application Program Interface) and application template management. To be application system to RMS (Reconfigurable Manufacturing System) for rapidly response from various orders and model from motor company that is beginning to establishing the mapping of manufacturing resources of 4M using WSN.

关键词： Auto-Configuration Wireless Sensor Network Reconfigurable Production Resoureces of 4M Tinyos Machien to Machine Middleware Application Template Manager