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Identification of new skin whitening ingredient: Hei Lao Hu extract reduces melanin synthesis

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Identification of new skin whitening ingredient: Hei Lao Hu ...

第九届中国化妆品学术研讨会

作者： GOH myeong jin NA yong joo TAI mei ling JUNG hae jin YEON jae ho HA jeong cheol HE quan quan CHENG liang KONG de yun LEE hae kwang Cho jun cheol Amore-Pacific Corporation R&D Center

We isolated various extracts from Hei Lao Hu, a well known traditional Chinese medicine, and found inhibitory effect on melanogenesis. Among them, an extract dose-dependently inhibited melanin synthesis in melan-a, mouse melanocytes. The extract showed more effectiveness than arbutin;melanin synthesis inhibitory activity treated with 2ppm of the extract was better than that with 50 ppm of arbutin. Using further high performance liquid chromatography(HPLC) analysis, we identified a novel compound, kadsuralignan F with strong melanin synthesis inhibition in melan-a cells(IC50=2.7ppm). Western blot analysis demonstrated that kadsuralignan F significantly reduced melanogenic proteins including tyrosinase, tyrosinase related protein(TRP)-1, and TRP-2. These results suggested Hei Lao Hu has potential as an effective skin whitening agent.

关键词： Hei Lao Hu melanin Skin whitening

Analysis of Interferential Current Therapy-Induced Skin Changes in Healthy Korean Men

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Natural Science 2018年第11期10卷 436-447页

作者： So-Jung Kim Seung-Min Yang Ju-Hyun Kim jeong-Uk Lee Mee-Young Kim Lim-Kyu Lee Byoung-Sun Park Won-Deok Lee Ji-Woong Noh Yong-Sub Shin Doo-ho Kim Il-Hyun Kim Kong-Sook Noh Junghwan Kim Laboratory of Health Science & Nanophysiotherapy Department of Physical Therapy Graduate School Yongin Uni-versity Yongin-si Republic of Korea Department of Physical Therapy College of Health Welfare Wonkwang Health Science University Iksan-si Republic of Korea Department of Physical Therapy College of Health Science Honam University Gwangju-si Republic of Korea The Team of Safety and Quality Management Yeongwol Combined Cycle Power Plant Division Korea Southern Pow-er Plant Yeongwol-gun Republic of Korea Department of Physical Therapy College of Public Health & Welfare Yongin University Yongin-si Republic of Korea

We examined the changes in numerous skin conditions before and after the ap-plication of interferential current therapy to various regions of healthy male bodies. In this study, we assessed the differences in the skin’s sebum, moisture levels, pores, wrinkles, pigmentation, and elasticity on the shoulders, lower back, and the knees of Korean males in their 20s. A total of 30 healthy males were in-cluded in the study. We used a skin diagnosis meter as a device for measuring the state of the skin. A statistical difference was found when comparing the pre- and post-measurement values in regards to the moisture levels, wrinkles, and pig-mentation. In the correlation analysis results, the sebum and pigmentation, moisture levels and wrinkles, moisture levels and pigmentation, and moisture levels and elasticity were all positively correlated, respectively. The results of this study partially suggest that a change in skin condition is associated with ex-ternal stimulation. The study also found that the effects of the application of in-terferential current therapy on the various skin conditions may differ depending on the region of the body that the application is conducted as well.

关键词： Interferential Current Therapy Korean Men Skin

Repair of heat-induced skin aging by herbal extracts and thermal protection factor(TPF)

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Repair of heat-induced skin aging by herbal extracts and the...

第九届中国化妆品学术研讨会

作者： Hyeon Chung Kim Kuan Chi Hsu Sung Il Park Eui Dong Son Myeong hoon Yeom Dae Jin Min Sang hoon Han Hak Hee Kang Quen Quen He jeong Cheol Ha Su Sun An Jae ho Yeon Amorepacific Corporation R&D Center

Long term exposure of skin to high temperature induces activation of transient receptor potential cation channel subfamily V member 1(TRPV-1), as well as increase of matrix metalloprotease 9(MMP-9), which breaks down extracellular matrix in skin. Thus, along with photo-aging, heat also accelerates skin-aging as a long term effect. Here, heat-absorbing substances with heat energy-blocking effects were screened, and the blockage rate was calculated as "Thermal Protection Factor(TPF)". Herbal plant extracts such as Prunus Mume fruit extract and Chamaecyparis Obtusa polysaccharide were able to reduce skin damage by reducing TRPV-1 activation, heat-induced MMP-9 expression and other heat-induced inflammatory responses such as monocyte chemoattractant protein-1(MCP-1) expression. Also, a cream containing heat-absorbing and modulating actives showed statistically significant skin elasticity and redness-controlling effects in a clinical study.

关键词： Heat,skin aging TPF Prunus Mume Chamaecyparis Obtusa TRPV-1

奇异变形杆菌的L-氨基酸脱氢酶在大肠杆菌中的异源表达和鉴定

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生物工程学报 2008年第12期24卷 2129-2129页

作者： in-Oh Baek jeong-Woo Seo Ohsuk Kwon Su-Il Seong Ik-Hwan Kim Chul ho Kim 韩国生物科学和生物技术研究所(KRIBB)分子生物过程研究中心高丽大学生命科学与生物技术学院 Biotopia公司研发中心

本研究在大肠杆菌中表达了奇异变形杆菌的L-氨基酸脱氢酶,并对产物苯丙酮酸进行了鉴定。奇异变形杆菌的L-氨基酸脱氢酶在大肠杆菌中得到了很好的表达,具有酶活性,并且发现其活性与细胞膜相关。L-氨基酸脱氢酶与细胞膜的密切相关性,对酶... 详细信息

本研究在大肠杆菌中表达了奇异变形杆菌的L-氨基酸脱氢酶,并对产物苯丙酮酸进行了鉴定。奇异变形杆菌的L-氨基酸脱氢酶在大肠杆菌中得到了很好的表达,具有酶活性,并且发现其活性与细胞膜相关。L-氨基酸脱氢酶与细胞膜的密切相关性,对酶活来说可能是必不可少的。

关键词：奇异变形杆菌脱氢酶苯丙氨酸苯丙酮酸苯乳酸

IRG1 induced by heme oxygenase- 1/carbon monoxide inhibits LPS-mediated sepsis and pro-inflammatory cytokine production

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Cellular & Molecular Immunology 2016年第2期13卷 170-179页

作者： Md Jamal Uddin Yeonsoo Joe Seul-Ki Kim Sun Oh jeong Stefan W Ryter Hyun-Ock Pae Hun Taeg Chung School of Biological Sciences University of Ulsan Korea Department of Microbiology and Immunology Wonkwang University School of Medicine Korea Joan and Sanford I. Weill Department of Medicine New York-Presbyterian Hospital Weill Cornell Medical College New York USA

The immunoresponsive gene 1 （IRG 1） protein has crucial functions in embryonic implantation and neurodegeneration. IRG1 promotes endotoxin tolerance by increasing A20 expression in macrophages through reactive oxygen species （ROS）. The cytoprotective protein heme oxygenase-1 （ho-1）, which generates endogenous carbon monoxide （CO）, is expressed in the lung during Lipopolysaccharide （LPS） tolerance and cross tolerance. however, the detailed molecular mechanisms and functional links between IRG1 and ho-1 in the innate immune system remain unknown. In the present study, we found that the CO releasing molecule-2 （CORM-2） and chemical inducers of ho- 1 increased I RG 1 expression in a time- and dose-dependent fashion in RAW264.7 cells. Furthermore, inhibition of ho-1 activity by zinc protoporphyrin IX （ZnPP） and ho-1 siRNA significantly reduced expression of IRG1 under these conditions. In addition, treatment with CO and ho-1 induction significantly increased A20 expression, which was reversed by ZnPP and ho-1 siRNA. LPS-stimulated TNF-a was significantly decreased, whereas IRG1 and A20 were increased by CORM-2 application and ho-1 induction, which in turn were abrogated by ZnPP. Interestingly, siRNA against IRG1 and A20 reversed the effects of CO and ho-1 on LPS-stimulated TNF-a production. Additionally, CO and ho-1 inducers significantly increased IRG1 and A20 expression and downregulated TNF-a production in a LPS-stimulated sepsis mice model. Furthermore, the effects of CO and ho-1 on TNF-α production were significantly reversed when ZnPP was administered. In conclusion, CO and ho-1 induction regulates IRG1 and A20 expression, leading to inhibition of inflammation in vitroand in an in vivomice model.

关键词： A2O anti-inflammatory effects carbon monoxide ho-1 IRG1

Prevalence of clonorchiasis in patients with gastrointestinal disease: A Korean nationwide multicenter survey

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World Journal of Gastroenterology 2009年第1期15卷 86-94页

作者： ho Gak Kim Jimin Han Myung-Hwan Kim Kyu Hyun Cho Im Hee Shin Gwang Ha Kim Jae Seon Kim Jin Bong Kim Tae Nyeun Kim Tae Hyeon Kim Tae Hyo Kim Jae Woo Kim Ji Kon ryu Young-Soo Moon Jong ho Moon Sung Jae Park Chan Guk Park Sung-Jo Bang Chang Heon Yang Kyo-Sang Yoo Byung Moo Yoo Kyu Taek Lee Dong Ki Lee Byung Seok Lee Sang Soo Lee Seung Ok Lee Woo Jin Lee Chang Min Cho Young-Eun Joo Gab Jin Cheon Young Woo Choi Jae Bok Chung Yong Bum Yoon Department of Internal Medicine Catholic University of Daegu School of Medicine Daegu 705-718 South Korea Department of Internal Medicine Asan Medical Center University of Ulsan College of Medicine Seoul 138-736 South Korea Department of Medical Statistics Catholic University of Daegu School of Medicine Daegu 705-718 South Korea Department of Internal Medicine Pusan National University School of Medicine Busan 602-739 South Korea Department of Internal Medicine Korea University College of Medicine Seoul 136-705 South Korea Department of Internal Medicine Hallym University College of Medicine Chuncheon 200-704 South Korea Department of Internal Medicine Yeungnam University College of Medicine Daegu 705-717 South Korea Department of Internal Medicine Wonkwang University College of Medicine Iksan Jeonbuk 570-711 South Korea Department of Internal Medicine Gyeongsang National University School of Medicine Jinju Gyeongnam 660-702 South Korea Department of Internal Medicine Yonsei University Wonju College of Medicine Wonju Gangwon 220-701 South Korea Department of Internal Medicine Seoul National University College of Medicine Seoul 110-799 South Korea Department of Internal Medicine lnje University College of Medicine Seoul 139-713 South Korea Department of Internal Medicine Soonchunhyang University College of Medicine Bucheon Gyunggi 420-767 South Korea Department of Internal Medicine Inje University College of Medicine Busan 614-735 South Korea Department of Internal Medicine Chosun University College of Medicine Gwangju Jeonbuk 501-717 South Korea Department of Internal Medicine Ulsan University Hospital University of Ulsan College of Medicine Ulsan 681-714 South Korea Department of Internal Medicine Dongguk University College of Medicine Gyeongju Gyeongbuk 791-707 South Korea Department of Internal Medicine Hallym University College of Medicine Anyang Gyeonggi 431-070 South Korea Department of Internal Medicine Ajou University School of Medicine Suwon

AIM： To investigate prevalence of C/onorchis sinensis in patients with gastrointestinal symptoms, and the relation of the infection to hepatobiliary diseases in 26 hospitals in Korea. METhoDS： Consecutive patients who had been admitted to the Division of Gastroenterology with gastrointestinal symptoms were enrolled from March to April 2005. Of those who had been diagnosed with clonorchiasis, epidemiology and correlation between infection and hepatobiliary diseases were surveyed by questionnaire. RESULTS： Of 3080 patients with gastrointestinal diseases, 396 （12.9%） had clonorchiasis and 1140 patients （37.2%） had a history of eating raw freshwater fish. Of those with a history of raw freshwater fish ingestion, 238 （20.9%） patients had clonorchiasis. Cholangiocarcinoma was more prevalent in C. sinensis-infected patients than nonnfected patients [34/396 （8.6%） vs 145/2684 （5.4%）, P = 0.015]. Cholangiocarcinoma and clonorchiasis showed statistically significant positive cross-relation （P = 0.008）. Choledocholithiasis, cholecystolithiasis, cholangitis, hepatocellular carcinoma, and biliary pancreatitis did not correlate with clonorchiasis. CONCLUSION： Infection rate of clonorchiasis was still high in patients with gastrointestinal diseases in Korea, and has not decreased very much during the last two decades. Cholangiocarcinoma was related to clonorchiasis, which suggested an etiological role for the parasite.

关键词： Clonorchis sinensis Epidemiology Cholangiocarcinoma Korea Multicenter study Clonorchiasis

Real Time Chatter Vibration Control System in High Speed Milling

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材料科学与工程（中英文A版） 2015年第5期5卷 221-229页

作者： Hyeok Kim Mun-ho Cho Jun-Yeong Koo Jong-Whan Lee jeong-Suk Kim School of Mechanical Engineering Pusan National University Busan 609-735 Republic of Korea Department of Mechtronics Engineering Korea Aviation Polytechnic Busan 616-741 Republic of Korea Department of Mechanical Engineering Pusan National University ERC/NSDM Busan 609-735 Republic of Korea

This paper presents the chatter vibration avoidance method in high speed milling. Chatter vibrations have a bad influence on surface integrity and tool life. So how to get the cutting conditions without chatter vibration is very important. In order to get stable cutting condition, too many parameters are required. So this paper focuses on simplification and real-time control of chatter avoidance program. The developed method uses only microphone signal for chatter vibration sensing. The measuring signal is analyzed by FFT (Fast Fourier transform) method to get whether or not the chatter vibration is generated on cutting condition. If chatter vibration occurs, the developed program suggests stable cutting speed in real time with tool teeth number, damping ratio and chatter frequency. This suggested that the program reliability is confirmed by dynamic cutting forces and surface profiles.

关键词：振动控制系统高速铣削加工实时控制快速傅里叶变换切削颤振刀具寿命切削条件表面完整性

Erratum to: Enzyme-amplified SERS immunoassay with Ag-Au bimetallic SERS hot spots

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Nano Research 2021年第3期14卷 895-895页

作者： Xuan-Hung Pham Eunil Hahm Tae Han Kim Hyung-Mo Kim Sang Hun Lee SangChul Lee homan Kang ho-Young Lee Dae hong jeong Hak Soo Choi Bong-Hyun Jun Department of Bioscience and Biotechnology Konkuk UniversitySeoul143-701Republic of Korea Department of Urology Seoul National University Bundang HospitalSeongnam13620Republic of Korea Gordon Center for Medical Imaging Department of RadiologyMassachusetts General Hospital and Harvard Medical SchoolBostonMA02114USA Department of Chemistry Education Seoul National UniversitySeoul151-742Republic of Korea

Erratum to Nano Research 2020,13(12):3338-3346 htts://***/00.1007/s12274-020-3014-3 One author name and corresponding affiliation of the original version of this article were unfortunately mislabeled.

关键词： SERS bimetallic

鸡毒霉形体F株作为活疫苗免疫蛋鸡的安全性和免疫效力试验

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鸡毒霉形体F株作为活疫苗免疫蛋鸡的安全性和免疫效力试验

第15届世界禽病大会、中国畜牧兽医学会2007年学术年会

作者： Chang-Gok Woo Eun-Ok Jeun Seoung-Hwan Byun jeong-Nyeu Kim Young-Mi Cho ho-Keun Won In-Pil MO 徐福洲 College of Veterinary Medicine Chungbuk National University Cheongju South Korea College of Veterinary Medicine Chungbuk National University Cheongju South Korea College of Veterinary Medicine Chungbuk National University Cheongju South Korea College of Veterinary Medicine Chungbuk National University Cheongju South Korea National Veterinary Research and Quarantine Service Anyang South Korea Choong Ang Vaccine Institute Daejeon South Korea College of Veterinary Medicine Chungbuk National University Cheongju South Korea

简介：家禽感染鸡毒霉形体(Mycoplasma gallisepticum,MG)后将出现呼吸障碍、产蛋下降和饲料转化率降低, 为降低经济损失,养禽场已广泛使用活疫苗和灭活疫苗。鸡毒霉形体 F 株已被广泛的作为活疫苗使用,

关键词：鸡毒霉形体活疫苗疫苗免疫效力试验