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Ontogeny of the mammalian kidney:expression of aquaporins 1,2,3,and 4

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World Journal of Pediatrics 2014年第4期10卷 306-312页

作者： Lu Xing Jian-Guo Wen Jørgen Frøkiær jens Christian Djurhuus Rikke Nørregaard Department of Clinical medicine Aarhus UniversityDenmark Institute of Clinical medicine Pediatric Urodynamic CenterUrologyFirst Affi liated Hospital of Zhengzhou UniversityChina

Background:Determining the expression and functions of aquaporins(AQPs)in the adult kidney has generated important information about the roles of this protein family in the renal regulation of water ***,limited information describes the expression of AQPs in fetal kidneys,and most reports on fetal renal AQPs originate from animal *** there are the maturation and regulation of the renalconcentrating mechanism,the ways in which changes in the expression of AQPs contribute to the formation of urine during the perinatal period remain *** sources:This review summarizes current knowledge about the spatial and temporal expression patterns of AQP1,AQP2,AQP3,and AQP4 in the fetal and postnatal kidneys in different animal species and in human ***:AQP1 and AQP2 expression can be detected earlier in gestation in human beings and sheep compared with mice and ***1 expression is detected earlier in the proximal tubules than the expression of AQP2,AQP3,and AQP4 in the collecting ***:Further studies investigating the regulation of AQPs during kidney development may provide insights into normal water-handling mechanisms and the pathophysiology of fetal kidneys,which may determine new directions for the clinical treatment of kidney diseases.

关键词： aquaporin developing kidney fetal

A Study on multipeutics

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Applied mathematics 2017年第5期8卷 746-773页

作者： jens Christian Larsen Vanlø se Alle 50 2. mf. tv 2720 Vanl&oslash se Copenhagen Denmark

multipeutics is the simultaneous application of m ≥ 4 cancer treatments. m = 4 is quadrapeutics, which was invented by researchers at Rice University, Northeastern University, mD Anderson Cancer Centre and China medical University, see [1]. multipeutics is our idea. From section 6 Summary, it follows that multipeutics can be more potent than quadrapeutics by comparing these two mathematical models. The first two treatments in quadrapeutics are systemically administered nano gold particles G and lysosomal chemo therapeutic drug D. They form mixed clusters m primarily in cancer cells and can be excited by a laser pulse, the third treatment, to form plasmonic nanobubbles N. These nanobubbles can kill the cancer cells by mechanical impact. If they do not the chemo therapeutic drug can be released into the cytoplasm, which might be lethal to the cancer cell. The fourth treatment is x rays X and the cancer cells have been sensitized to x rays by the treatment. We present an ODE (ordinary differential equations) model of quadrapeutics and of multipeutics, which is quadrapeutics and n ≥ 1 immune or chemo therapies. In the present paper we have found a polynomial p of degree at most 2(n + 3), such that a singular point (C, D, G, m, N, I1, …, In) will have p(m) = 0 Here I1, …, In are immune or chemo therapies. So this gives us candidates for singular points. Quadrapeutics is treated extensively. We find in theorem 3 a polynomium s of degree at most six in m such that a positive singular point (C, D, G, m, N) of the quadrapeutics system will have s(m) = 0. The main theorem of the present paper is the multipeutics theorem, saying that the more treatments we apply the lower the cancer burden, even if we take the doses of each treatment smaller. From the proof of this theorem, we can say, that quadrapeutics can outperform chemo radiation if the nanobubble kill rate k21 is sufficiently big. See also Figure 1 and Figure 2 and the text explaining them.

关键词： Cancer mass Action Kinetic System Quadrapeutics Immune Therapy

Extrahepatic complications to cirrhosis and portal hypertension: Haemodynamic and homeostatic aspects

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World Journal of Gastroenterology 2014年第42期20卷 15499-15517页

作者： S?ren m?ller jens H Henriksen Flemming Bendtsen Department of Clinical Physiology and Nuclear medicine Center for Functional and Diagnostic Imaging and Research Copenhagen University Hospital University of Copenhagen Gastro Unit Medical Division Hvidovre Hospital Hvidovre Hospital Faculty of Health Sciences University of Copenhagen

In addition to complications relating to the liver, patients with cirrhosis and portal hypertension develop extrahepatic functional disturbances of multiple organ systems. This can be considered a multiple organ failure that involves the heart, lungs, kidneys, the immune systems, and other organ systems. Progressive fibrosis of the liver and subsequent metabolic impairment leads to a systemic and splanchnic arteriolar vasodilatation. This affects both the haemodynamic and functional homeostasis of many organs and largely determines the course of the disease. With the progression of the disease, the circulation becomes hyperdynamic with cardiac, pulmonary as well as renal consequences for dysfunction and reduced survival. Infections and a changed cardiac function known as cirrhotic cardiomyopathy may be involved in further aggravation of other complications such as renal failure precipitatingthe hepatorenal *** with end-stage liver disease and related complications as for example the hepatopulmonary syndrome can only radically be treated by liver *** a bridge to this treatment,knowledge on the mechanisms of the pathophysiology of complications is essential for the choice of vasoactive drugs,antibiotics,drugs with specific effects on fibrogenesis and inflammation,and drugs that target specific receptors.

关键词： Fibrogenesis Splanchnic haemodynam-ics Inflammatio

Evaluation of Pneumatic Bulge Test Experiments and Corresponding Numerical Forming Simulations

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材料科学与工程（中英文B版） 2011年第4期1卷 472-478页

作者： jens Kappes mathiasLiewald Institute for metal Forming Technology （IFU） Holzgartenstr. 17 Stuttgart 70174 Germany

Superplastic forming of sheet metal exhibits numerous technical and economical advantages for manufacturing complex part geometries, which enables the potential of lightweight production (e. g., of vehicle bodies), especially for niche types. Within virtual engineering tasks, material parameters in combination with numerical sheet metal forming simulations are crucial. In such context, the selected testing procedure should be as similar as possible to the subsequent forming technique. For that reason the pneumatic bulge test represents an appropriate testing procedure for the most common superplastic sheet metal forming process, the blow-forming process [1-4]. This paper deals with pneumatic bulge test experiments at constant forming pressures using the aluminum alloy AA5083 (initial sheet thickness s0 = 1.5 mm). Due to in-situ measurement of strains in pneumatic bulging, material parameters can be determined. These material parameters can be used for an interpolation, in this case the power law, to determine material constant C, strain-hardening exponent n and strain-rate sensitivity index m using the least square error method. Furthermore, the superplastic forming process was simulated by FE modeling with material parameters exclusively determined from pneumatic bulging. The comparison of numerical and experimental results showed good correlation for the observed conditions.

关键词：测试实验成型技术数值模拟气动金属板材成形应变速率敏感性指数材料参数评价

Electrochemical measurement of serotonin by Au-CNT electrodes fabricated on microporous cell culture membranes

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microsystems & Nanoengineering 2020年第1期6卷 494-506页

作者： Ashley A.Chapin Pradeep R.Rajasekaran David N.Quan Liangbing Hu jens Herberholz William E.Bentley Reza Ghodssi Fischell Department of Bioengineering College ParkMD 20742USA Institute for Systems Research College ParkMD 20740USA Department of materials Science and Engineering College ParkMD 20740USA Department of Psychology and Neuroscience and Cognitive Science Program College ParkMD 20740USA Institute for Bioscience and Biotechnology Research RockvilleMD 20850USA Robert E.Fischell Institute for Biomedical Devices RockvilleMD 20850USA Department of Electrical and Computer Engineering College ParkMD 20742USA

Gut–brain axis(GBA)communication relies on serotonin(5-HT)signaling between the gut epithelium and the peripheral nervous system,where 5-HT release patterns from the basolateral(i.e.,bottom)side of the epithelium activate nerve *** have been few quantitative studies of this gut-neuron signaling due to a lack of real-time measurement tools that can access the basolateral gut *** vitro platforms allow quantitative studies of cultured gut tissue,but they mainly employ offline and endpoint assays that cannot resolve dynamic molecular-release ***,we present the modification of a microporous cell culture membrane with carbon nanotube-coated gold(Au-CNT)electrodes capable of continuous,label-free,and direct detection of 5-HT at physiological *** characterization of single-walled carbon nanotube(SWCNT)-coated Au electrodes shows increased electroactive surface area,5-HT specificity,sensitivity,and saturation time,which are correlated with the CNT film drop-cast *** microliters of CNT films,with a 10-min saturation time,0.6μA/μm 5-HT sensitivity,and reliable detection within a linear range of 500 nm–10μm 5-HT,can be targeted for high-concentration,high-time-resolution 5-HT *** films(12.5μL)with a 2-h saturation time,4.5μA/μm 5-HT sensitivity,and quantitative detection in the linear range of 100 nm–1μm can target low concentrations with low time *** electrodes achieved continuous detection of dynamic diffusion across the porous membrane,mimicking basolateral 5-HT release from cells,and detection of cell-released 5-HT from separately cultured RIN14B cell ***-integrated cell culture systems such as this can improve in vitro molecular detection mechanisms and aid in quantitative GBA signaling studies.

关键词： release saturation dynamic

Fiber Fabry-Perot Interferometer for Curvature Sensing

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Photonic Sensors 2016年第4期6卷 339-344页

作者： Catarina S. mONTEIRO1 marta S. FERREIRA Susana O. SILVA jens KOBELKE Kay SCHUSTER JOrg BIERLICH Orlando FRAZAO Department of Physics and Astronomy Sciences Faculty Porto University Rua do Campo Alegre 687 4169-007 Porto Portugal INESC-TEC Rua do Campo Alegre 687 4169-007 Porto Portugal IPHT Jena - Leibniz Institute of Photonic Technology Albert-Einstein-Str. 9 07745 Jena Germany

A curvature sensor based on an Fabry-Perot （FP） interferometer was proposed. A capillary silica tube was fusion spliced between two single mode fibers, producing an FP cavity. Two FP sensors with different cavity lengths were developed and subjected to curvature and temperature. The FP sensor with longer cavity showed three distinct operating regions for the curvature measurement. Namely, a linear response was shown for an intermediate curvature radius range, presenting a maximum sensitivity of 68.52 pm/m-1. When subjected to temperature, the sensing head produced a similar response for different curvature radii, with a sensitivity varying from 0.84 pm/℃ to 0.89 pm/℃, which resulted in a small cross-sensitivity to temperature when the FP sensor was subjected to curvature. The FP cavity with shorter length presented low sensitivity to curvature.

关键词： Curvature measurement Fabry-Perot interferometer optical fiber sensor

Current-induced degradation and lifetime prediction of 310 nm ultraviolet light-emitting diodes

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Photonics Research 2019年第7期7卷 14-18页

作者： Jan Ruschel Johannes Glaab Batoul Beidoun Neysha Lobo Ploch jens Rass Tim Kolbe Arne Knauer markus Weyers Sven Einfeldt michael Kneissl Ferdinand-Braun-Institut Leibniz-Institut fur HochstfrequenztechnikGustav-Kirchhoff-Str.412489 BerlinGermany Technische Universitat Berlin Institut fur FestkorperphysikHardenbergstr.36EW6-710623 BerlinGermany

The impact of operation current on the degradation behavior of 310 nm UV LEDs is investigated over 1000 h of stress. It ranges from 50 to 300 mA and corresponds to current densities from 34 to 201 A/cm^*** separate the impact of current from that of temperature, the junction temperature is kept constant by adjusting the heat sink temperature. Higher current was found to strongly accelerate the optical power reduction during operation. A mathematical model for lifetime prediction is *** indicates that lifetime is inversely proportional to the cube of the current density, suggesting the involvement of Auger recombinati on.

关键词： degradation light-emitting diodes lifetime

Effect of preoperative FOLFOX chemotherapy on CCL20/CCR6 expression in colorectal liver metastases

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World Journal of Gastroenterology 2011年第26期17卷 3109-3116页

作者： Claudia Rubie Vilma Oliveira Frick Pirus Ghadjar mathias Wagner Christoph Justinger Stefan Graeber jens Sperling Otto Kollmar martin K Schilling Department of General VisceralVascular and Paediatric SurgeryUniversity of the Saarland Department of Radiation Oncology InselspitalBern University Hospital and University of Bern Institute of Pathology University of the Saarland Institute of medical Biometrics Epidemiologyand Medical Informatics(IMBEI)University of the Saarland

AIm:To evaluate the influence of preoperative FOLFOX chemotherapy on CCL20/CCR6 expression in liver metastases of stage Ⅳ colorectal cancer(CRC) ***:Using Real Time-PCR,enzyme-linked immunosorbent assay,Western Blots and immunohistochemistry,we have analyzed the expression of CCL20,CCR6 and proliferation marker Ki-67 in colorectal liver metastasis(CRLm) specimens from stage Ⅳ CRC patients who received preoperative FOLFOX chemotherapy(n = 53) and in patients who did not receive FOLFOX chemotherapy prior to liver surgery(n = 29).RESULTS:Of the 53 patients who received FOLFOX,time to liver surgery was ≤ 1 mo in 14 patients,≤ 1 year in 22 patients and > 1 year in 17 patients,*** addition,we investigated the proliferation rate of CRC cells in liver metastases in the different patient *** CCL20 and CCR6 mRNA and protein expression levels were significantly increased in patients who received preoperative FOLFOX chemotherapy ≤ 12 mo before liver surgery(P mparison to patients who did not undergo FOLFOX ***,proliferation of CRLm cells as measured by Ki-67 was increased in patients who underwent FOLFOX ***20 and CCR6 expression levels were significantly increased in CRLm patients who had undergone preoperative FOLFOX ***:This chemokine/receptor up-regulation could lead to increased proliferation/migration through an autocrine mechanism which might be used by surviving metastatic cells to escape cell death caused by FOLFOX.

关键词：肝脏化疗大肠癌增殖率 m细胞结直肠癌蛋白表达 mRNA

Environmental mercury exposure, semen quality and reproductive hormones in Greenlandic Inuit and European men： a cross-sectional study

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Asian Journal of Andrology 2013年第1期15卷 97-104页

作者： Emina mocevic Ina O Specht Jacob L marott Aleksander Giwercman Bo AG Jonsson Gunnar Toft Thomas Lundh jens Peter Bonde Department of Occupational and Environmental medicine Copenhagen University Hospital Bispebjerg Copenhagen NV DK-2400 Denmark Reproductive medicine Centre Sk~ne University Hospital Malm6 Lund University Malm6 SE-20502 Sweden Division of Occupational and Environmental medicine Department of Laboratory Medicine Lund University Lund SE-22185 Sweden Department of Occupational medicine Aarhus University Hospital Aarhus DK-8000 Denmark

Several animal studies indicate that mercury is a male reproductive toxicant, but human studies are few and contradictory. We examined semen characteristics and serum levels of reproductive hormones in relation to environmental exposure to mercury. Blood and semen samples were collected from 529 male partners of pregnant women living in Greenland, Poland and Ukraine between may 2002 and February 2004. The median concentration of the total content of mercury in whole blood was 9.2 ng ml-1 in Greenland （0.2- 385.8 ng ml-1）, 1.0 ng m1-1 in Poland （0.2-6.4 ng ml-z） and 1.0 ng ml-I in Ukraine （0.2-4.9 ng ml-1）. We found a significantly positive association between the blood levels of mercury and serum concentration of inhibin B in men from Greenland （p=0.074, 95% confidence interval （CI）=0.021 to 0.126） and in an analysis including men from all three regions （p=0.067, 95% C1=0.024 to O. 110）. The association may be due to beneficial effects of polyunsaturated fatty acids （PUFAs）, which are contained in seafood and fish. No significant association （P〉O.05） was found between blood concentrations of mercury and any of the other measured semen characteristics （semen volume, total sperm count, sperm concentration, morphology and motility） and reproductive hormones （free androgen index {FAI）, follicle-stimulating hormone （FSH）, luteinizing hormone （LH）, testosterone and LH xtestosterone） in any region. In conclusion, the findings do not provide evidence that environmental mercury exposure in Greenlandic and European men with median whole blood concentration up to 10 ng m1^-1 has adverse effects on biomarkers of male reproductive health.

关键词： blood mercury concentration environmental mercury exposure male fertility reproduction reproductive hormones semen characteristics semen quality