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A comprehensive review on bitter gourd (Momordica charantia L.) as a gold mine of functional bioactive components for therapeutic foods

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Food Production, Processing and Nutrition 2022年第1期4卷 107-120页

作者： K.S.Gayathry jenny ann john Faculty of Ocean Science and Technology Kerala(Department of Food Science and Technology)Kerala University of Fisheries and Ocean Studies(KUFOS)Panangad P.O.KochiKerala682506India

Bitter gourd is a tropical wine grown mainly in India, China and South East Asia. The plant is cultivated mainly for its fruit part which is edible. Bitter gourd is unaccepted widely due to its bitter taste. Nevertheless, the fruit is a source of several key nutrients. The plant, as a whole contains, more than 60 phyto-medicines that are active against more than 30 diseases, including cancer and diabetes. Currently, the incorporation of the bioactive compounds isolated from bitter gourd into functional foods and beverages finds a new horizon. Nanoencapsulation and novel green extraction methods can be employed to improve the yield and quality of extracted compounds and their stability while incorporation into food products. The present review is an attempt to throw light to nutritional aspects, various bioactive compounds present and important nutraceutical properties of the bitter gourd plant in detail.

关键词： Bitter gourd Bioactive Nutraceutical Extraction Encapsulation

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火灾保费高企加州屋主另谋出路

商业周刊（中文版） 2024年第8期 24-25页

作者： adia Lopez john Gittelsohn ann Choi 孟洁冰(译) 不详

●在贝弗利山、贝莱尔和纳帕等富人区,找到火灾保险变得越来越难今年2月,彼得·麦克(PeterMac)即将完成一起房地产交易,这座位于好莱坞山的豪宅有四间卧室、五个浴室和无边泳池,已经挂牌上市两年时间。经过讨价还价后,房价从最初挂牌的4... 详细信息

●在贝弗利山、贝莱尔和纳帕等富人区,找到火灾保险变得越来越难今年2月,彼得·麦克(PeterMac)即将完成一起房地产交易,这座位于好莱坞山的豪宅有四间卧室、五个浴室和无边泳池,已经挂牌上市两年时间。经过讨价还价后,房价从最初挂牌的4800万美元降至2560万美元,此时交易却遇到了麻烦,麦克向买家提供了火灾保险的报价:每年20万美元。“她差点从椅子上掉下来,”The Agency的经纪人麦克说,“她想重新协商价格。”最终,买家找到了一份每年8万美元的替代保单,但是这份保险仅覆盖房屋重建成本的一小部分。

关键词：房地产交易挂牌上市富人区火灾保险讨价还价经纪人

Improving cell transplantation by understanding and manipulating the phagocytic activity of peripheral glia

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Neural Regeneration Research 2022年第2期17卷 313-314页

作者： Lynn Nazareth James St john jenny Ekberg Menzies Health Institute Queensland Griffith UniversitySouthportAustralia Clem Jones Centre for Neurobiology and Stem Cell Research Griffith UniversityNathanAustralia Griffith Institute for Drug Discovery Griffith UniversityNathanAustralia

One of the key challenges in neuroscience is that the central nervous system(CNS;the brain and spinal cord), is largely unable to regene rate after injury. One factor contributing to this lack of repair is the accumulation of cellular and myelin debris at the site of injury. The debris is not efficiently phagocytosed and can persist for years after the initial injury, resulting in an inflammatory environment which inhibits axonal regrowth(Lutz and Barres, 2014).

关键词： debris contributing injury

Assessment of the performance of the TOPGNSS and ann-MB antennas for ionospheric measurements using low-cost u-blox GNSS receivers

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Geodesy and Geodynamics 2024年第3期15卷 291-301页

作者： Daniel Okoh Aderonke Obafaye Oluwakemi Dare-Idowu Babatunde Rabiu Anton Kashcheyev Claudio Cesaroni john Bosco Habarulema Bruno Nava United Nations African Regional Centre for Space Science and Technology Education-English(UN-ARCSSTE-E) Obafemi Awolowo University CampusIle IfeNigeria National Institute for Geophysics and Volcanology(INGV) 00143 RomeItaly Institute for Space Science and Engineering African University of Science and TechnologyAbujaNigeria University of New Brunswick FrederictonCanada South African National Space Agency(SANSA) P.O Box 32Hermanus 7200South Africa Department of Physics and Electronics Rhodes University6140 MakhandaSouth Africa The Abdus Salam International Centre for Theoretical Physics Strada Costiera11I-34151 TriesteItaly

Low-cost GNSS receivers have recently been gaining reliability as good candidates for ionospheric studies. In line with these gains are genuine concerns about improving the performance of these receivers. In this work, we present a comprehensive investigation of the performances of two antennas(the u-blox ann-MB and the TOPGNSS TOP-106) used on a low-cost GNSS receiver known as the u-blox ZED-F9P. The two antennas were installed on two identical and co-located u-blox receivers. Data used from both receivers cover the period from January to June 2022. Results from the study indicate that the signal strengths are dominantly greater for the receiver with the TOPGNSS antenna than for the receiver with the ann-MB antenna, implying that the TOPGNSS antenna is better than the ann-MB antenna in terms of providing greater signal strengths. Summarily, the TOPGNSS antenna also performed better in minimizing the occurrence of cycle slips on phase TEC measurements. There are no conspicuous differences between the variances(computed as 5-min standard deviations) of phase TEC measurements for the two antennas, except for a period around May-June when the TOPGNSS gave a better performance in terms of minimizing the variances in phase TEC. Remarkably, the ann-MB antenna gave a better performance than the TOPGNSS antenna in terms of minimizing the variances in pseudorange TEC for some satellite observations. For precise horizontal(North and East) positioning, the receiver with the TOPGNSS antenna gave better results, while the receiver with the ann-MB antenna gave better vertical(Up) positioning. The errors for the receivers of both antennas are typically within about 5 m(the monthly mean was usually smaller than 1 m) in the horizontal direction and within about 10 m(the monthly mean was usually smaller than 4 m) in the vertical direction.

关键词： GNSS Ionosphere Low-cost Antenna TOPGNSS U-blox

Olfactory ensheathing cells for spinal cord repair: crucial differences between subpopulations of the glia

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Neural Regeneration Research 2015年第9期10卷 1395-1396页

作者： jenny A.K.Ekberg James A.St john Eskitis Institute for Drug Discovery Griffith University School of Biomedical Sciences Queensland University of Technology

OECs for spinal cord repair： Is repairing the iniured spinal cord by olfactory ensheathing cell （OEC） transplantation pos- sible？ A recent human trial in which a paralysed man regained some function after transplantation of partially purified OECs suggests that this therapy may be a successful approach （Ta- bakow et al., 2014）. In another human trial in which olfactory mucosa lamina propria was transplanted, patients recovered some motor and sensory function （Wang et al., 2015）. While these results show promise, it is clear that improvements are needed to provide patients with increased functional output. Strategies to improve the therapeutic use of OECs may include improving the purification of the OECs used for transplantation, using them in combination with growth factors to combat the inhibitory environment and improve anon growth, the use of nerve bridges, advanced physiotherapy and the use of exo- skeleton robotics to reinforce functional connections. Of all these approaches, it is probably is primarily addressed to ensure crucial that the purity of OECs consistency in outcomes.

关键词： cell Olfactory ensheathing cells for spinal cord repair crucial differences between subpopulations of the glia

The link between olfactory ensheathing cell survival and spinal cord injury repair: a commentary on common limitations of contemporary research

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Neural Regeneration Research 2020年第10期15卷 1848-1849页

作者： Ronak Reshamwala Megha Shah James St.john jenny Ekberg Griffith Institute for Drug Discovery Griffith UniversityBrisbaneQLDAustralia Menzies Health Institute Queensland Griffith UniversitySouthportQLDAustraliaClem Jones Centre for Neurobiology and Stem Cell ResearchGriffith UniversityBrisbaneQLDAustralia

Olfactory ensheathing cells(OECs)are crucial players in the continuous regeneration of the olfactory nervous system that occurs through out life and are thought to have unique growth-promoting *** this reason,OEC transplantation has been thoroughly explored for the potential to promote neural repair after both central and peripheral nervous system *** studies have shown that OEC transplantation is safe and can promote recovery after spinal cord injury(SCI),both in animal models and in human clinical *** date,a variety of injury types and time-points after injury,as well as different delivery methods,have been *** have been encouraging(in rodent models including,for example,restoration of locomotion,breathing and climbing ability along with induction of axonal sprouting and some axonal regeneration)but highly variable(Barnett and Riddell,2007;Gomez et al.,2018).

关键词： injuries injury limitations

Neuron-fibrous scaffold interfaces in the peripheral nervous system: a perspective on the structural requirements

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Neural Regeneration Research 2022年第9期17卷 1893-1897页

作者： Sanaz Behtaj James A.St john jenny A.K.Ekberg Maksym Rybachuk Clem Jones Centre for Neurobiology and Stem Cell Research Griffith UniversityQueenslandAustralia Menzies Health Institute Queensland Griffith UniversitySouthportAustralia Griffith Institute for Drug Discovery NathanAustralia School of Engineering and Built Environment Griffith UniversityNathanAustralia Centre for Quantum Dynamics and Australian Attosecond Science Facility Griffith UniversityNathanAustralia

The nerves of the peripheral nervous system are not able to effectively regenerate in cases of severe neural *** can result in debilitating consequences,including morbidity and lifelong impairments affecting the quality of the patient’s *** findings in neural tissue engineering have opened promising avenues to apply fibrous tissue-engineered scaffolds to promote tissue regeneration and functional *** scaffolds,known as neural scaffolds,are able to improve neural regeneration by playing two major roles,namely,by being a carrier for transplanted peripheral nervous system cells or biological cues and by providing structural support to direct growing nerve fibers towards the target ***,successful implementation of scaffold-based therapeutic approaches calls for an appropriate design of the neural scaffold structure that is capable of up-and down-regulation of neuron-scaffold interactions in the extracellular matrix *** review discusses the main challenges that need to be addressed to develop and apply fibrous tissue-engineered scaffolds in clinical *** describes some promising solutions that,so far,have shown to promote neural cell adhesion and growth and a potential to repair peripheral nervous system injuries.

关键词： electrospun scaffold extracellular matrix nerve conduit neural tissue engineering physical lumen filler scaffold topography structural support surface interaction

Radial glia interact with primary olfactory axons to regulate development of the olfactory bulb

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Neural Regeneration Research 2015年第3期10卷 374-376页

作者： Daniel A.Amaya jenny A.K.Ekberg James A.St john Eskitis Institute for Drug Discovery Griffith University School of Biomedical Sciences Queensland University of Technology Brisbane

The developing olfactory system - merging of the periph- eral and central nervous systems： The olfactory system is responsible for the sense of smell and is comprised of a complex topographic map that regenerates throughout life. In rodents each olfactory sensory neuron expresses one of N 1,300 odorant receptors with the neurons being distributed mosaically within the epithelium. The axons of the sensory neurons do not maintain near-neighbour relationships and instead project to disparate topographic targets in the olfac- tory bulb within the central nervous system. The develop- ment of the targets relies on the intermingling of the sensory axons with the interneurons, glia and second order neurons of the olfactory bulb. Thus the formation of the olfactory system involves the coordinated integration of the axons of the peripheral olfactory sensory neurons with the cells of the olfactory bulb.

关键词： Radial glia interact with primary olfactory axons to regulate development of the olfactory bulb

Ndfip1 represses cell proliferation by controlling Pten localization and signaling specificity

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分子细胞生物学报:英文版 2015年第2期7卷 119-131页

作者： Jason Howitt Ley-Hian Low Ulrich Putz Anh Doan jenny Lackovic Choo-Peng Goh jenny Gunnersen john Silke Seong-Seng Tan Brain Development and Regeneration Division Florey Institute of Neuroscience and Mental HealthThe University of MelbourneParkvilleVictoria 3010Australia Department of Anatomy and Neuroscience The University of MelbourneParkvilleVictoria 3010Australia Cell Signalling and Cell Death Laboratory Walter and Eliza Hall InstituteThe University of MelbourneParkvilleVictoria 3010Australia

Pten controls a signaling axis that is implicated to regulate cell proliferation,growth,survival,migration,and *** molecular mechanisms underlying the specificity of Pten responses to such diverse cellular functions are currently poorly *** report the control of Pten activity and signaling specificity during the cell cycle by Ndfip1 regulation of Pten spatial *** deletion of Ndfip1 resulted in a loss of Pten nuclear compartmentalization and increased cell proliferation,despite cytoplasmic Pten remaining active in regulating PI3K/Akt *** lacking nuclear Pten were found to have dysregulated levels of Plk1 and cyclin D1 that could drive cell *** vivo,transgene expression of Ndfip1 in the developing brain increased nuclear Pten and lengthened the cell cycle of neuronal progenitors,resulting in *** results show that local partitioning of Pten from the cytoplasm to the nucleus represents a key mechanism contributing to the specificity of Pten signaling during cell proliferation.

关键词： Akt autism cancer cell cycle microcephaly nuclear trafficking ubiquitin