Neuron-fibrous scaffold interfaces in the peripheral nervous system: a perspective on the structural requirements

作     者：Sanaz Behtaj James A.St John Jenny A.K.Ekberg Maksym Rybachuk Sanaz Behtaj;James A.St John;Jenny A.K.Ekberg;Maksym Rybachuk

作者机构：Clem Jones Centre for Neurobiology and Stem Cell ResearchGriffith UniversityQueenslandAustralia Menzies Health Institute QueenslandGriffith UniversitySouthportAustralia Griffith Institute for Drug DiscoveryNathanAustralia School of Engineering and Built EnvironmentGriffith UniversityNathanAustralia Centre for Quantum Dynamics and Australian Attosecond Science FacilityGriffith UniversityNathanAustralia 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2022年第17卷第9期

页      面：1893-1897页

核心收录：

学科分类：1002[医学-临床医学] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 100204[医学-神经病学] 10[医学] 

基　　金：supported by a Garnett-Passe and Rodney Williams Memorial Foundation grant(to JE) a National Health and Medical Research Council grant,No.APP1183799(to JASJ and JAKE) 

主　　题：electrospun scaffold extracellular matrix nerve conduit neural tissue engineering physical lumen filler scaffold topography structural support surface interaction 

摘      要：The nerves of the peripheral nervous system are not able to effectively regenerate in cases of severe neural *** can result in debilitating consequences,including morbidity and lifelong impairments affecting the quality of the patient’s *** findings in neural tissue engineering have opened promising avenues to apply fibrous tissue-engineered scaffolds to promote tissue regeneration and functional *** scaffolds,known as neural scaffolds,are able to improve neural regeneration by playing two major roles,namely,by being a carrier for transplanted peripheral nervous system cells or biological cues and by providing structural support to direct growing nerve fibers towards the target ***,successful implementation of scaffold-based therapeutic approaches calls for an appropriate design of the neural scaffold structure that is capable of up-and down-regulation of neuron-scaffold interactions in the extracellular matrix *** review discusses the main challenges that need to be addressed to develop and apply fibrous tissue-engineered scaffolds in clinical *** describes some promising solutions that,so far,have shown to promote neural cell adhesion and growth and a potential to repair peripheral nervous system injuries.