检索结果-南通市图书馆

Targeting epigenetic mechanisms in amyloid-β-mediated Alzheimer’s pathophysiology:unveiling therapeutic potential

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第1期20卷 54-66页

作者： jennie Z.Li Nagendran Ramalingam Shaomin Li Ann Romney Center for Neurologic Diseases Brigham and Women’s Hospital and Harvard Medical SchoolBostonMAUSA

Alzheimer’s disease is a prominent chronic neurodegenerative condition characterized by a gradual decline in memory leading to *** evidence suggests that Alzheimer’s disease is associated with accumulating various amyloid-βoligomers in the brain,influenced by complex genetic and environmental *** memory and cognitive deficits observed during the prodromal and mild cognitive impairment phases of Alzheimer’s disease are believed to primarily result from synaptic *** life,environmental factors can lead to enduring changes in gene expression and the emergence of brain *** changes,known as epigenetic modifications,also play a crucial role in regulating the formation of synapses and their adaptability in response to neuronal *** this context,we highlight recent advances in understanding the roles played by key components of the epigenetic machinery,specifically DNA methylation,histone modification,and microRNAs,in the development of Alzheimer’s disease,synaptic function,and activity-dependent synaptic ***,we explore various strategies,including enriched environments,exposure to non-invasive brain stimulation,and the use of pharmacological agents,aimed at improving synaptic function and enhancing long-term potentiation,a process integral to epigenetic ***,we deliberate on the development of effective epigenetic agents and safe therapeutic approaches for managing Alzheimer’s *** suggest that addressing Alzheimer’s disease may require distinct tailored epigenetic drugs targeting different disease stages or pathways rather than relying on a single drug.

关键词： Alzheimer’s disease DNA methylation enriched environments histone modification microRNAs non-invasive brain stimulation synaptic plasticity

Comparison of methods for deriving phenotypes from incomplete observation data with an application to age at puberty in dairy cattle

在线全文

学校读者我要写书评

暂无评论

Journal of Animal Science and Biotechnology 2024年第2期15卷 535-545页

作者： Melissa A.Stephen Chris R.Burke jennie E.Pryce Nicole M.Steele Peter R.Amer Susanne Meier Claire V.C.Phyn Dorian J.Garrick DairyNZ Ltd 605 Ruakura RoadHamilton 3240New Zealand AL Rae Centre for Genetics and Breeding-Massey University RuakuraHamilton 3214New Zealand Agriculture Victoria Research AgriBioCentre for AgriBioscienceBundooraVictoria 3083Australia School of Applied Systems Biology La Trobe UniversityBundooraVictoria 3083Australia AbacusBio DunedinNew Zealand

Background Many phenotypes in animal breeding are derived from incomplete measures,especially if they are challenging or expensive to measure *** include time-dependent traits such as reproductive status,or *** measures for these traits result in phenotypes that are subject to left-,interval-and rightcensoring,where phenotypes are only known to fall below an upper bound,between a lower and upper bound,or above a lower bound *** we compare three methods for deriving phenotypes from incomplete data using age at first elevation(>1 ng/mL)in blood plasma progesterone(AGEP4),which generally coincides with onset of puberty,as an example *** we produced AGEP4 phenotypes from three blood samples collected at about 30-day intervals from approximately 5,000 Holstein–Friesian or Holstein–Friesian×Jersey cross-bred dairy heifers managed in 54 seasonal-calving,pasture-based herds in New *** used these actual data to simulate 7 different visit scenarios,increasing the extent of censoring by disregarding data from one or two of the three *** methods for deriving phenotypes from these data were explored:1)ordinal categorical variables which were analysed using categorical threshold analysis;2)continuous variables,with a penalty of 31 d assigned to right-censored phenotypes;and 3)continuous variables,sampled from within a lower and upper bound using a data augmentation *** Credibility intervals for heritability estimations overlapped across all methods and visit scenarios,but estimated heritabilities tended to be higher when left censoring was *** sires with at least 5 daughters,the correlations between estimated breeding values(EBVs)from our three-visit scenario and each reduced data scenario varied by method,ranging from 0.65 to *** estimated breed effects also varied by method,but breed differences were smaller as phenotype censoring *** Our results indicate that using

关键词： Cattle Gibbs sampler Markov-chain Monte Carlo(MCMC) Puberty

Corn and Soybean Growth as Affected by wastewater-Derived Struvite-Phosphorus Sources and Irrigation water Types

在线全文

学校读者我要写书评

暂无评论

Agricultural Sciences 2024年第4期15卷 472-504页

作者： Machaela Morrison Kristofor R. Brye Gerson Drescher jennie Popp Lisa S. wood Department of Crop Soil and Environmental Sciences University of Arkansas Fayetteville AR USA Department of Agricultural Economics & Agribusiness University of Arkansas Fayetteville AR USA

Struvite (MgNH4PO4·6H2O) produced synthetically from a stock solution of known phosphorus (P) and nitrogen (N) concentrations has been shown to be an effective, alternative fertilizer-P source for various crops, but little is known about the potential agronomic effectiveness of struvite created from an actual municipal wastewater source. The objective of this study was to evaluate the effects of soil [i.e., Creldon silt loam (Oxyaquic Fragiudalf) and Calloway silt loam (Aquic Fraglossudalf) series], fertilizer-P source [i.e., synthetically produced electrochemically precipitated struvite (ECSTsyn), real-wastewater-derived ECST (ECSTreal), chemically precipitated struvite (CPST), monoammonium phosphate (MAP), and an unamended control (UC)], and irrigation water type (i.e., tapwater and struvite-removed wastewater) on corn (Zea mays L.) and soybean [Glycine max (L.) Merr.] growth and N, P, and magnesium (Mg) uptake in a 60-day, greenhouse potted-plant study. Crop growth and N, P, and Mg uptakes for the struvite treatments (i.e., CPST, ECSTsyn, and ECSTreal) were generally similar to or at least 1.2 times greater than MAP. The ECSTsyn material commonly had up to five times greater N, P, and Mg uptake in corn and soybean than any other fertilizer-P source. Struvite-removed wastewater resulted in at least 1.3 times lower dry matter and N, P, and Mg uptake than tapwater. Similar corn and soybean results from the struvite fertilizers among the various soil-water type combinations compared to MAP suggest that struvite generates similar crop responses as at least one widely used, commercially available, multi-nutrient fertilizer-P source.

关键词： Arkansas Corn Production Soybean Production Struvite Recovered Nutrients

Robotic Knee Tracking Control to Mimic the Intact Human Knee Profile Based on Actor-Critic Reinforcement Learning

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

IEEE/CAA Journal of Automatica Sinica 2022年第1期9卷 19-30页

作者： Ruofan wu Zhikai Yao jennie Si He(Helen)Huang School of Electrical Computer and Energy EngineeringArizona State UniversityTempeAZ 85287 USA Department of Biomedical Engineering North Carolina State UniversityRaleighNC 27695 USA University of North Carolina at Chapel Hill Chapel HillNC 27599 USA

we address a state-of-the-art reinforcement learning(RL)control approach to automatically configure robotic pros-thesis impedance parameters to enable end-to-end,continuous locomotion intended for transfemoral amputee ***,our actor-critic based RL provides tracking control of a robotic knee prosthesis to mimic the intact knee *** is a significant advance from our previous RL based automatic tuning of prosthesis control parameters which have centered on regulation control with a designer prescribed robotic knee profile as the *** addition to presenting the tracking control algorithm based on direct heuristic dynamic programming(dHDP),we provide a control performance guarantee including the case of constrained *** show that our proposed tracking control possesses several important properties,such as weight convergence of the learning networks,Bellman(sub)optimality of the cost-to-go value function and control input,and practical stability of the human-robot *** further provide a systematic simulation of the proposed tracking control using a realistic human-robot system simulator,the OpenSim,to emulate how the dHDP enables level ground walking,walking on different terrains and at different *** results show that our proposed dHDP based tracking control is not only theoretically suitable,but also practically useful.

关键词： Automatic tracking of intact knee configuration of robotic knee prosthesis direct heuristic dynamic programming(dHDP) reinforcement learning control

Shortened dual antiplatelet therapy in contemporary percutaneous coronary intervention era

在线全文

学校读者我要写书评

暂无评论

world Journal of Cardiology 2021年第8期13卷 243-253页

作者： jennie Han Nadeem Attar Department of Cardiology Royal Lancaster InfirmaryLancaster LA14RPLancashireUnited Kingdom Department of Cardiology Blackpool Victoria HospitalBlackpool FY38NRLancasUnited Kingdom

Percutaneous coronary intervention with stenting is followed by a duration of dual antiplatelet therapy(DAPT)to reduce stent thrombosis and avoid target lesion *** period of DAPT recommended in international guidelines following drug-eluting stent implantation is 12 mo for most patients with acute coronary syndrome,and 6 mo for patients with chronic coronary syndrome or high bleeding *** new generation of drug-eluting stents have metallic platforms with thinner struts,associated with significantly less stent *** DAPT has been investigated with these stents,with evidence from randomised clinical trials for some individual stents showing non-inferior safety and efficacy *** has to be balanced by the effect of DAPT on secondary prevention of systemic cardiovascular disease especially in high-risk *** review will outline the current evidence for individual stents with regards to DAPT duration for both acute coronary syndrome and chronic coronary syndrome and discuss further directions for research and personalised medicine in this contemporary percutaneous coronary intervention era.

关键词： Coronary artery disease Drug-eluting stent Percutaneous coronary intervention Dual antiplatelet therapy Stent thrombosis Target lesion revascularization

Direct heuristic dynamic programming based on an improved PID neural network

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

控制理论与应用（英文版） 2012年第4期10卷 497-503页

作者： Jian SUN Feng LIU jennie SI Shengwei MEI Department of Electrical Engineering Tsinghua University Department of Electrical Engineering Arizona State University

In this paper, an improved PID-neural network （IPIDNN） structure is proposed and applied to the critic and action networks of direct heuristic dynamic programming （DHDP）. As one of online learning algorithm of approximate dynamic programming （ADP）, DHDP has demonstrated its applicability to large state and control problems. Theoretically, the DHDP algorithm requires access to full state feedback in order to obtain solutions to the Bellman optimality equation. Unfortunately, it is not always possible to access all the states in a real system. This paper proposes a solution by suggesting an IPIDNN configuration to construct the critic and action networks to achieve an output feedback control. Since this structure can estimate the integrals and derivatives of measurable outputs, more system states are utilized and thus better control performance are expected. Compared with traditional PIDNN, this configuration is flexible and easy to expand. Based on this structure, a gradient decent algorithm for this IPIDNN-based DHDP is presented. Convergence issues are addressed within a single learning time step and for the entire learning process. Some important insights are provided to guide the implementation of the algorithm. The proposed learning controller has been applied to a cart-pole system to validate the effectiveness of the structure and the algorithm.

关键词： Approximate dynamic programming (ADP) Direct heuristic dynamic programming (DHDP) ImprovedPID neural network (IPIDNN)

Assessment of toxicology knowledge in the fourth-year medical students:Three years of data

在线全文

学校读者我要写书评

暂无评论

world Journal of Emergency Medicine 2018年第3期9卷 191-194页

作者： jennie Buchanan Daniel windels Jeffrey Druck Kennon Heard Department of Emergency Medicine University of Colorado School of Medicine AuroraDenverCO 80204USA Rocky Mountain Poison and Drug Center-Denver Health&Hospital Authority DenverDenverCO 80204USA Saint Anthony Hospital APEX Emergency GroupLakewoodColorado 80228USA

BACKGROUND:Pharmacology and toxicology are core content knowledge for *** students should demonstrate understanding of general pharmacology and basic treatment of *** objective of this study was to measure the knowledge of the 4th-year medical students(MS4)on these topics over 3 ***:A multiple-choice exam(15 questions)was administered to MS4 students in spring of 2010,2011,and *** were developed by medical toxicologists to evaluate basic knowledge in three areas:pharmacologic effects(PE),treatment of poisoning(TOP),and pharmacokinetics(PK).The students were grouped by intended specialtiesinto pharmacologic intense(anesthesia,emergency medicine,internal medicine,pediatrics,and psychiatry),less pharmacologic intense specialties(dermatology,OB/GYN,ophthalmology,pathology,physical medicine and rehabilitation,radiology,and surgery)and by completion of a pharmacology or toxicology *** group scores were compared using ***:Totally 332 of 401(83%)students completed the *** scores were stable over the three years,higher for students completing a toxicology rotation and for students entering a pharmacologically intense ***:The external validity is limited to a single medical school with incomplete participation and content was limited by the survey *** results over the three-year period and correlation of performance with completing a toxicology rotation and intent to enter a pharmacology intensive specialty suggest this survey may correlate with toxicology *** of required core courses focused on toxicology may improve core content knowledge in fourth year medical students.

关键词： Medical student Education Toxicology Knowledge

Immunological characteristics govern the transition of COVID-19 to endemicity

在线全文

学校读者我要写书评

暂无评论

四川生理科学杂志 2021年第1期43卷 43-43页

作者： jennie S Lavine Department of Biology Emory University Atlanta GA 30322 USA. Department of Biology and Center for Infectious Disease Dynamics The Pennsylvania State University University Park PA 16802 USA.

we are currently faced with the question of how the CoV-2 severity may change in the years *** analysis of immunological and epidemiological data on endemic human coronaviruses(HCoVs)shows that infection-blocking immunity wanes rapidly,but disease-reducing immunity is *** model,incorporating these components of immunity,recapitulates both the current severity of CoV-2 and the benign nature of HCoVs,suggesting that once the endemic phase is reached and primary exposure is in childhood,CoV-2 may be no more virulent than the common cold.

关键词： immunity severity endemic

一种改进的近似动态规划方法及其在SVC的应用

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

电机与控制学报 2011年第5期15卷 95-102页

作者：孙健刘锋 SI jennie 郭文涛梅生伟清华大学电力系统国家重点实验室亚利桑那州立大学电机系

近似动态规划的基本思想是通过近似计算代价函数,从而避免动态规划中的"维数灾"问题。随机选取初值使得近似动态规划方法需要多次的学习才能最终收敛,极大地限制了在实际系统中的应用。针对上述问题,提出一种基于改进PID神经网络的直接... 详细信息

近似动态规划的基本思想是通过近似计算代价函数,从而避免动态规划中的"维数灾"问题。随机选取初值使得近似动态规划方法需要多次的学习才能最终收敛,极大地限制了在实际系统中的应用。针对上述问题,提出一种基于改进PID神经网络的直接启发式动态规划算法,将初始执行网络与PID控制器之间建立起一种等价关系,因此可以利用已经设计好的PID控制器来指导其初值选取,从而使算法收敛性大大提高。改进的神经网络与常规PID神经网络相比,结构简单且具有更好的扩展性,性能上具有更强的鲁棒性。对4机2区系统的静止无功补偿器附加阻尼控制进行仿真测试,仿真结果表明基于改进PID神经网络的直接启发式动态规划算法和初值选取方法的有效性,并且在部分状态反馈和延时两种情况下有着很好的控制效果。

关键词：近似动态规划直接启发式动态规划改进PID神经网络静止无功补偿器附加阻尼控制