Immunological characteristics govern the transition of COVID-19 to endemicity

作     者：Jennie S Lavine 

作者机构：Department of Biology Emory University Atlanta GA 30322 USA. Department of Biology and Center for Infectious Disease Dynamics The Pennsylvania State University University Park PA 16802 USA. 

出 版 物：《四川生理科学杂志》 (Sichuan Journal of Physiological Sciences)

年 卷 期：2021年第43卷第1期

页      面：43-43页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：National Institutes of Health, NIH, (U01 AI150747, U01 HL139483) National Institute of Allergy and Infectious Diseases, NIAID, (U01AI144616) 

主　　题：immunity severity endemic 

摘      要：We are currently faced with the question of how the CoV-2 severity may change in the years *** analysis of immunological and epidemiological data on endemic human coronaviruses(HCoVs)shows that infection-blocking immunity wanes rapidly,but disease-reducing immunity is *** model,incorporating these components of immunity,recapitulates both the current severity of CoV-2 and the benign nature of HCoVs,suggesting that once the endemic phase is reached and primary exposure is in childhood,CoV-2 may be no more virulent than the common cold.