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PROTEIN CHARACTERIZATION USING DYNAMIC AND STATIC LIGHT SCATTERING

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China Particuology 2003年第5期1卷 219-222页

作者： jeffrey yang Kevin Mattison SiberHegner China Ltd. 26/F West Tower Hanwei Plaza No.7 Guanghua Road Beijing 100004 P. R. ChinaMalvern Instruments Inc. 10 Southville Road Southborough MA01772 USA

IntroductionThe stability of a protein formulation to a variety of solution perturbations is critical to its success as a pharmaceutical product. Because of the sensitivity of the protein to solution changes, invasive characterization techniques can be problematic. Light scattering is a non-invasive technique that has received wide acceptance in the area of protein formulation and characterization.

关键词： is on of for PROTEIN CHARACTERIZATION USING DYNAMIC AND STATIC LIGHT SCATTERING SLS Nano in from with that

Does exposure to poultry and wild fowl confer immunity to H5N1 ？

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Chinese Medical Journal 2014年第18期127卷 3335-3343页

作者： Wan yang jeffrey Shaman Department of Environmental Health Sciences Mailman School ofPublic Health Columbia University New York NY 10032 USA

Human outbreaks of highly pathogenic avian influenza （HPAI） such as H5N1 and novel avian strains such as H7N9 have provoked significant public health concern. An outbreak of H5N1 in humans was first reported in Hong Kong （HK）, China in 1997. This event was curtailed by a variety of public health measures including the culling of over 1.5 million chickens in the city.1 HSN1 has since re-emerged in multiple countries with over 600 reported infections and, since 2003, a case fatality of about 59% （World Health Organization （WHO） report, as of January 24, 2014）.

关键词： H5N1 poultry environmental exposure cross-immunity stem antibodies

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如何判断和选择激光粒度分析仪

现代科学仪器 2000年第1期 58-59页

作者：杨正红瑞士华嘉(香港)有限公司

以往的粒度分析方法通常采用筛分或沉降法.常用的沉降法存在着检测速度慢(尤其对小粒子)、重复性差、对非球型粒子误差大、不适用于混合物料(即粒子比重必须一致才能较准确)、动态范围窄等缺点.随着激光衍射法的发明,粒度测量完全克服... 详细信息

以往的粒度分析方法通常采用筛分或沉降法.常用的沉降法存在着检测速度慢(尤其对小粒子)、重复性差、对非球型粒子误差大、不适用于混合物料(即粒子比重必须一致才能较准确)、动态范围窄等缺点.随着激光衍射法的发明,粒度测量完全克服了沉降法所带来的弊端,大大减轻了劳动强度及加快了样品检测速度(从半小时缩短到了1分钟).

关键词：激光粒度分析仪检测器光源检测仪器辐射源米氏理论扫描速度散射光分散器粒度测量散射角激光衍射法

活化的巨噬细胞介导的胰岛异种移植排异反应与细胞因子表达上调的关系

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中南大学学报（医学版） 2007年第1期32卷 26-35页

作者： Abhilash P. Chandra Li Ou-yang jeffrey K. W. Wong Hong Ha Stacey N. Waiters Anita T. Patel Wayne J. Hawthorne Shou-nan YI Centre for Transplantation and Renal Research Westmead Millenium Institute University of Sydney at Westmead Hospital Westmead 2145 Australia

目的：笔者以往的实验证明与猪抗原接触过并被CD4^＋T淋巴细胞激活的巨噬细胞能识剐、排斥猪的异种移植物，但不会排斥鼠的同种移植物，这表明在这种特异性移植物免疫识别及破坏过程中移植物及巨噬细胞之间存在着信号联系。方法：在免... 详细信息

目的：笔者以往的实验证明与猪抗原接触过并被CD4^＋T淋巴细胞激活的巨噬细胞能识剐、排斥猪的异种移植物，但不会排斥鼠的同种移植物，这表明在这种特异性移植物免疫识别及破坏过程中移植物及巨噬细胞之间存在着信号联系。方法：在免疫过继转移之前，将胎猪的胰腺碎片移植到非肥胖糖尿病／严重联合免疫缺陷（NOD／SCID）鼠。再从移植了胎猪的胰腺碎片（FPP）并发生排斥反应的受体Balb／c鼠身上分离出巨噬细胞，将这些外源性巨噬细胞植入NOD／SCID鼠。这些外源性的巨噬细胞通过Ly5．1表面抗原或通过CSFE染色标记来追踪。在移植了FPP异种移植物以后的CCR2，CCR5及它们的趋化因子的基因表达可通过实时PCR来评估。结果：形成免疫过继后较早移植的异种移植物出现了免疫排斥，而不是建立免疫过继较长时间后再移植FFP的NOD／SCID鼠。同时，前者可检测出更高水平的趋化因子的基因表达。而且，与未激活的巨噬细胞比较，已经激活的巨噬细胞CCR2，CCR5基因的表达增强更为明显。结论：趋化因子的上调与巨噬细胞的聚集、胰岛移植物的破坏有关。

关键词：巨噬细胞示踪趋化因子异种移植物聚集

Combined kinematic and static analysis of an articulated lower limb traction device for a rehabilitation robotic system

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Science China(Technological Sciences) 2021年第6期64卷 1189-1202页

作者： LI Yuan ZI Bin yang ZhengMeng GE jeffrey School of Mechanical Engineering Hefei University of TechnologyHefei 230009China Intelligent Interconnected Systems Laboratory of Anhui Province(Hefei University of Technology) Hefei 230009China Department of Mechanical Engineering Stony Brook UniversityStony Brook NY 11794-2300USA

This paper presents a design of an articulated lower limb traction device(ALLTD) with joint torque generators for a cable-driven parallel rehabilitation robotic system(CDPRRS). An earlier version of the ALLTD uses a rigid link to model the lower limbs of a patient. This paper extends this scenario to include articulations in the lower limbs and analyzes the resulting two-link mechanism. Due to the force-displacement coupled structure, the inverse and forward kinematics of the ALLTD model are analyzed in combination with the requirement for static force balance. Examples using the limb parameters of Chinese adults are provided to show the efficacy of our model. The workspaces and cable tensions of the model indicate that the ALLTD could satisfy the rehabilitation training needs of patients with various lengths of lower limbs.

关键词： rehabilitation robotic system cable-link mechanism combined kinematics and statics symmetric structure

Regenerative potential of targeting glycogen synthase kinase-3 signaling in neural tissues

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Neural Regeneration Research 2015年第12期10卷 1912-1913页

作者： Eui-Man Jung jeffrey J.Moffat Woo-yang Kim Department of Developmental Neuroscience Munroe-Meyer InstituteUniversity of Nebraska Medical Center

Multiple roles of glycogen synthase kinase-3（GSK-3）in neural tissues：GSK-3 is a serine/threonine kinase that has two isoforms encoded by two different genes,GSK-3αand GSK-3β,in ***-3 has several sites of serine a... 详细信息

关键词： GSK Regenerative potential of targeting glycogen synthase kinase-3 signaling in neural tissues

Microstructure refinement in biodegradable Zn-Cu-Ca alloy for enhanced mechanical properties,degradation homogeneity,and strength retention in simulated physiological condition

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Journal of Materials Science & Technology 2022年第30期125卷 1-14页

作者： Nan yang Nagasivamuni Balasubramani jeffrey Venezuela Helle Bielefeldt-Ohmann Rachel Allavena Sharifah Almathami Matthew Dargusch Queensland Centre for Advanced Materials Processing and Manufacturing(AMPAM)School of Mechanical and Mining Engineering The University of QueenslandAdvanced Engineering BuildingBld 49Staff House Rd.St LuciaQLD 4072Australia School of Veterinary Science The University of QueenslandGattonQLD 4343Australia School of Chemistry and Molecular Biosciences The University of QueenslandQLD 4072Australia

Zn-1.0Cu-0.5Ca(TA15)alloy has shown promising characteristics of enhanced mechanical properties and biodegradability for absorbable cardiovascular stents,endovascular devices,and wound closure devices *** this study,the TA15 alloy for bioabsorbable biomedical applications is *** the conventionally cast TA15(TA15-C)alloy,CaZn_(13) phase are present as a large dendritic network with an average size of 73.25±112.84μm,Hot rolling of the TA15-C alloy has broken the long and dendritic network of the CaZn_(13) phases,however,the refined phases are observed as segregations and the distribution is *** segregated CaZn_(13) suffered heavy localised corrosion which lead to poor mechanical properties in the as-fabricated condition and after *** treatment(UST)during casting is identified as an effective technique for the refinement and redistribution of CaZn_(13) particles in TA15 alloy,which successfully reduce the size of the CaZn_(13) phase to 10.91±4.65μm in the as-solidified *** hot rolling,the UST processed TA15(TA15-UST)shows improved mechanical properties due to grain refinement and the reduction in microstructural defects,*** broken CaZn_(13) *** of 8-week immersion corrosion tests showed that both alloys possess very similar corrosion ***,TA15-UST has markedly improved corrosion homogeneity compared to TA15-N which favours the retention of mechanical properties even after prolonged exposure to physiological fluids.

关键词： Biodegradable Zn alloy Peritectic phase refinement In vitro corrosion Mechanical property retention Cytocompatibility

microRNAs, an active and versatile group in cancers

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International Journal of Oral Science 2011年第4期3卷 165-175页

作者： jeffrey Liu Min Zheng Ya-ling Tang Xin-hua Liang Qin yang Department of Biological Sciences University of Delaware Nowak DE 19716 USA State Key Laboratory of Oral Diseases Sichuan University Chengdu 610041 China Department of Oral and Maxillofacial Surgery West China School of Stomatology Sichuan University Chengdu 610041 China Cancer Biology Division School of Medicine Washington University St. Louis MO 63108 USA

microRNAs （miRNAs） are a class of non-coding RNAs that function as endogenous triggers of the RNA interference pathway. Studies have shown that thousands of human protein-coding genes are regulated by miRNAs, indicating that miRNAs are master regulators of many important biological processes, such as cancer development, miRNAs frequently have deregulated expression in many types of human cancers, and play critical roles in tumorigenesis, which functions either as tumor suppressors or as oncogenes. Recent studies have shown that miRNAs are highly related with cancer progression, including initiating, growth, apoptosis, invasion, and metastasis. Furthermore, miRNAs are shown to be responsible for the cancer-related inflam- mation, anti-cancer drug resistance, and regulation of cancer stem ceils. Therefore, miRNAs have generated great interest as a novel strategy in cancer diagnosis and therapy. Here we review the versatile roles of miRNAs in cancers and their potential applications for diagnosis, prognosis, and treatment as biomarkers.

关键词： microRNAs cancer epithelial-mesenchymal transition inflammation cancer stem cells drug resistance

Mineralogical characteristics and photocatalytic properties of natural sphalerite from China

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Journal of Environmental Sciences 2020年第3期32卷 156-166页

作者： Can Shen Xiangping Gu Bin yang Dexian Zhang Zhilin Wang Zhengxiang Shu jeffrey Dick Anhuai Lu Key Laboratory of Metallogenic Prediction of Nonferrous Metals and Geological Environment Monitoring Ministry of Education Central South UniversityChangsha 410083China School of Geoscience and Info-physics Central South UniversityChangsha 410083China

Different natural sphalerites have a range of photocatalytic properties that can potentially be exploited for environmental remediation *** develop value in the exploitation of sphalerite,samples were collected from 19 ore deposits in China and characterized for their mineralogical and photocatalytic properties.X-ray diffraction(XRD) and electron probe micro analysis(EPMA) measurements indicated that all the natural sphalerites from various localities crystallized in cubic phases with various chemical *** substitution of Fe for Zn ranged from 0.235% to 14.826% by weight,Mn from 0.004% to4.868%,Cu from 0.009% to 5.529% and Cd from 0.133% to 1.576%.As Fe became more abundant,the color of natural sphalerite darkened,becoming almost black;and higher Fe content was associated with stronger visible light *** spectra showed emission mainly related to S-vacancies and progressively decreasing fluorescence intensity with increasing Fe *** of the photocatalytic degradation of methyl orange indicated that the sample with the highest Cd content but moderate Fe content had the highest photocatalytic ***,the degradation of Methyl Orange(30 mg/L)attained 82.11% efficiency under visible light irradiation for 4 hr of natural sphalerite with4.262% Fe and 1.576% ***,the Fe content in sphalerite was found to contribute to the visible light absorption ability and the recombination rate of photo-generated electrons and holes,while substitution by Cd was observed to have a greater effect on the photocatalytic *** findings provide a scientific basis for the profitable utilization of base metal resources like sphalerite.

关键词： Natural sphalerite Mineralogical properties Band gap Photodegradation of Methyl Orange