microRNAs, an active and versatile group in cancers

作     者：Jeffrey Liu Min Zheng Ya-ling Tang Xin-hua Liang Qin Yang 

作者机构：Department of Biological Sciences University of Delaware Nowak DE 19716 USA State Key Laboratory of Oral Diseases Sichuan University Chengdu 610041 China Department of Oral and Maxillofacial Surgery West China School of Stomatology Sichuan University Chengdu 610041 China Cancer Biology Division School of Medicine Washington University St. Louis MO 63108 USA 

出 版 物：《International Journal of Oral Science》 (国际口腔科学杂志（英文版）)

年 卷 期：2011年第3卷第4期

页      面：165-175页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by National Natural Science Foundation of China grants (No. 30872889, 81072215, 81001210, 81172580) Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry (No. 20098-8-2) State Key Laboratory of Oral Diseases Open Funding (SKLODOF2010-05) the Fundamental Research Funds of the Central Universities of China (2011) 

主　　题：microRNAs cancer epithelial-mesenchymal transition inflammation cancer stem cells drug resistance 

摘      要：microRNAs （miRNAs） are a class of non-coding RNAs that function as endogenous triggers of the RNA interference pathway. Studies have shown that thousands of human protein-coding genes are regulated by miRNAs, indicating that miRNAs are master regulators of many important biological processes, such as cancer development, miRNAs frequently have deregulated expression in many types of human cancers, and play critical roles in tumorigenesis, which functions either as tumor suppressors or as oncogenes. Recent studies have shown that miRNAs are highly related with cancer progression, including initiating, growth, apoptosis, invasion, and metastasis. Furthermore, miRNAs are shown to be responsible for the cancer-related inflam- mation, anti-cancer drug resistance, and regulation of cancer stem ceils. Therefore, miRNAs have generated great interest as a novel strategy in cancer diagnosis and therapy. Here we review the versatile roles of miRNAs in cancers and their potential applications for diagnosis, prognosis, and treatment as biomarkers.