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Hepatobiliary & Pancreatic Diseases International 2015年第5期14卷 543-547页

作者： Fabien Le Roux Charles Sabbagh Brice Robert Thierry Yzet Laurent Dugue jean-paul Joly jean-Marc Regimbeau Department of Digestive and Oncological Surgery Amiens University Hospital Jules Verne University of Picardie Department of Interventional and Diagnostic Imaging Amiens University Hospital Jules Verne University of Picardie Department of Digestive Surgery Saint-Camille Hospital Department of Hepatogastroenterology Amiens University Hospital Jules Verne University of Picardie

Mirizzi syndrome, a rare complication of gallstones, is defined by obstruction of the main bile duct. This obstruction may worsen and thus result in cholecystobiliary fistula. Surgical management of Mirizzi syndrome is complicated by the presence of inflamed tissue around the hepatic pedicle, making it impossible to distinguish between the main bile duct and the gallbladder. The surgeon＇s first task is to perform subtotal cholecystotomy（from the fundus of the gallbladder to the neck） without trying to locate the cystic duct. In a second step, the gallstones are extracted and the main bile duct is then repaired. In most cases, a T-tube is used to drain the main bile duct, and abdominal drainage is left in place（in case a bile fistula forms）. This study concluded that preoperative drainage of the main bile duct in the treatment of Mirizzi syndrome types II and III is feasible and might help to decrease the postoperative complication rate.

关键词： jaundice Mirizzi syndrome cholecystobiliary fistula endoscopic treatment cholecystectomy T-tube drain

Impact of homogeneous pathologic response to preoperative chemotherapy in patients with multiple colorectal liver metastases

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World Journal of Gastroenterology 2017年第45期23卷 8027-8034页

作者： Charles Sabbagh Denis Chatelain Christophe Attencourt jean-paul Joly Bruno Chauffert Cyril Cosse jean-Marc Regimbeau Depart-ment of Digestive and Oncologic Surgery Amiens University Medical Center INSERM U1088 Jules Verne University of Picardie University of Picardie Department of Anatomic Pathology Amiens University Medical Center Department of Hepatogastroenterology Amiens University Medical Center Department of Medical Oncology Amiens University Medical Center EA4294 Jules Verne University of Picardie

AIM To analyze the homogeneity of pathologic response to preoperative chemotherapy(PRPC) after chemotherapy in patients with multiple liver metastases(LM).METHODS From September 2011 to August 2014,patients with at least two LM undergoing preoperative chemotherapy prior to resection were included in this retrospective,single-center study. The endpoints were PRPC homogeneity(according to both the Rubbia-Brandt and MD Anderson classifications),the impact of PRPC on the MDT decision,factors associated with homogeneous PRPC and overall survival of patients with vs. without homogeneous *** seventy-three patients with a total of 88 liver resections(including 15 two-stage procedures) were included in the study. The homogeneous PRPC rate was 55% according to the Rubbia-Brandt classification and 53% according to the MD Anderson classification. The MDT decision was modified by the PRPC in only 2.7% of patients(n = 2). CONCLUSION The PRPC was homogeneous in only one half of patients and had very little influence on the MDT decision.

关键词： Liver metastases Pathological response Homogeneity Preoperative chemotherapy Colorectal cancer

The breakfast imperative： The changing context of global food security

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Journal of Integrative Agriculture 2016年第6期15卷 1179-1185页

作者： YE Li-ming jean-paul Malingreau TANG Hua-jun Eric Van Ranst Institute of Agricultural Resources and Regional Planning Chinese Academy of Agricultural SciencesBeijing 100081P.R.China CAAS-UGent Joint Laboratory of Global Change and Food Security Beijing 100081P.R.China Department of Geology and Soil Science(WE13) Ghent University9000 GentBelgium Earth and Life Institute Universite Catholique de Louvain1348 Louvain-la-NeuveBelgium

The debate on global food security has regained vigor since the food crisis of 2008, when a sudden spike in the prices of staple food commodities dramatically demonstrated that securing the supply and accessibility of food for a world of nine billion people in 2050 cannot be taken for grant- ed （Godfray etal. 2010; Swinnen and Squicciarini 2012;

关键词： The breakfast imperative The changing context of global food security

On the Flammable Limits of Gas Mixtures

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化工进展 2005年第7期24卷 822-824页

作者： Henri Le Chatelier O.Boudouard jean-paul lacoursiere.P.E. University of sherbrookesherbrooke quebec Canada

INTRODUCTIONCarbon monoxide occupies a special place among combustible gases. The high flammable limit, the slowness of its flame propagation, and the role of water vapor in its combustion all suggest a resistance to oxidation that its heat of combustion would not have allowed us to anticipate. It behaves among gases a little like aluminum among metals. We thought that it would be interesting to define its flammable conditions slightly more precisely than previously *** monoxide was prepared by decomposing sodium formiate with sulfuric acid; recovered in a small water gas holder, the gas contained 7% air at time of *** Flammable LimitsThese limits were determined in defined conditions by one of us as the most favorable for this type of test, that is, in a test tube 40 mm in diameter and 20 cm in length, with ignition by a 1-cm flame through the opening held in

关键词：气体混合物一氧化碳可燃性压力

Hydrodynamic Regimes,Knudsen Layer,Numerical Schemes:Definition of Boundary Fluxes

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Advances in Applied Mathematics and Mechanics 2011年第5期3卷 519-561页

作者： Christophe Besse Saja Borghol Thierry Goudon Ingrid Lacroix-Violet jean-paul Dudon Project-Team SIMPAF INRIA Lille Nord Europe Research CenterPark Plazza40 av.Halley59650 Villeneuve d’Ascq France Labo P.Painleve UMR 8524 CNRS-Universite des Sciences et Technologies Lille Thales Alenia Space Cannes La Bocca

We propose a numerical solution to incorporate in the simulation of a system of conservation laws boundary conditions that come from a microscopic modeling in the small mean free path *** typical example we discuss is the derivation of the Euler system from the BGK *** boundary condition relies on the analysis of boundary layers formation that accounts from the fact that the incoming kinetic flux might be far from the thermodynamic equilibrium.

关键词： Hydrodynamic regimes Knudsen layer finite volume scheme initial-boundary value problems for conservation laws Evaporation-condensation problem

Exploring system architectures in AADL via Polychrony and SynDEx

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Frontiers of Computer Science 2013年第5期7卷 627-649页

作者： Huafeng YU Yue MA Thierry GAUTIER Loc BESNARD jean-Pierre TALPIN paul Le GUERNIC Yves SOREL INRIA Rennes-Bretagne Atlantique 263 av. du Général LeclercRennes 35042 France IRISA/CNRS 263 av. du Général LeclercRennes 35042 France INRIA Paris-Rocquencourt Domaine de VoluceauBP 105Le Chesnay Cedex 78153 France

Architecture analysis&design language(AADL)has been increasingly adopted in the design of embedded systems,and corresponding scheduling and formal verification have been well ***,little work takes code distribution and architecture exploration into account,particularly considering clock constraints,for distributed multi-processor *** this paper,we present an overview of our approach to handle these concerns,together with the associated toolchain,***,in order to avoid semantic ambiguities of AADL,the polychronous/multiclock semantics of AADL,based on a polychronous model of computation,is *** synthesis is then carried out in Polychrony,which bridges the gap between the polychronous semantics and the synchronous semantics of *** same timing semantics is always preserved in order to ensure the correctness of the transformations between diferent *** distribution and corresponding scheduling is carried out on the obtained SynDEx model in the last step,which enables the exploration of architectures originally specified in *** contribution provides a fast yet efcient architecture exploration approach for the design of distributed real-time and embedded *** avionic case study is used here to illustrate our approach.

关键词： Polychrony Signal AADL SynDEx architecture exploration modeling timing analysis scheduling distribution

Microbial starch-binding domains are superior to granule-bound starch synthase I for anchoring luciferase to potato starch granules

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Progress in Natural Science:Materials International 2006年第12期16卷 1295-1299页

作者： jean-paul VINCKEN Luc C.J.M. SUURS Richard G.F. VISSER Laboratory of Plant Breeding Department of Plant Sciences Wageningen University Wageningen The Netherlands

Microbial starch-binding domains (SBD) and granule-bound starch synthase I (GBSSI) are proteins which are accumulated in potato starch granules. The efficiency of SBD and GBSSI for targeting active luciferase reporter proteins to granules during starch biosynthesis was compared. GBSSI or SBD sequences were fused to the N- or C-terminus of the luciferase (LUC) gene, via an artificial Pro-Thr encoding linker sequence. The genes were introduced into an amylose-free (amf) potato mutant. It appeared that SBD was superior to GBSSI as a targeting sequence, mainly because the luciferase retained higher activity in the SBD-containing fusion proteins than in the GBSSI-containing ones.

关键词： luciferase GBSS I SBD amf potato.

Geochemical characterization of the metasedimentary rocks of the Yaounde Group within the southernmost North Equatorial tectonic belt:insights into geodynamic evolution

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Acta Geochimica 2023年第6期42卷 1017-1034页

作者： Simon Pierre Mbola Ndzana Moise Christian Balla Ateba Germain Marie Monespérance Mboudou Moussa Nsangou Ngapna jean paul Sep Nlongang Solange Ipan Moise Bessong jean Bosco Olinga Joseph Mvondo Ondoa Sébastien Owona paul Bilong Department of Earth Sciences Faculty of ScienceUniversity of YaoundéIP.O.Box:812Yaounde´Cameroon Institute for Geological and Mining Research P.O.Box:4110NlongkakYaounde´Cameroon Department of Earth Sciences Faculty of ScienceUniversity of DoualaP.O.Box:24157DoualaCameroon Department of Geology Faculty of ScienceThe University of BueaP.O.Box:67BueaCameroon

The Proterozoic metasedimentary rocks of the Yaounde Group on the northern edge of the Congo Shield in Central Africa were investigated to understand their provenance and depositional ***,geochemistry,and field evidence helped to subdivide the metasediments into paragneiss,mica schist,chlorite schist,and quartzite which were derived from greywacke,shale,quartz arenite,litharenite *** are immature with some mature samples,moderately weathered and reworked Neo-and Post-Archean *** earth element signatures(Chondrite Eu/Eu^(*)≤1),enrichment of light rare earth elements over the heavy ones,and the La/Sc ratio(>0.7)are compatible with those of the intermediate and felsic sources from the upper continental *** metasediments were deposited in the continental arc setting and have evolved during Proterozoic times according to the Wilson cycle to form the West Gondwana including NE Brazil.

关键词： West Gondwana North Equatorial orogenic belt Yaounde Group Neoproterozoic basin Geochemistry of metasedimentary rocks Geodynamic evolution

Genome Editing with CRISPR-Cas9:Can It Get Any Better?

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Journal of Genetics and Genomics 2016年第5期43卷 239-250页

作者： Maximilian Haeussler jean-paul Concordet Santa Cruz Genomics Institute MS CBSE1156 High StreetUniversity of California Laboratoire Structure et Instabilite des Genomes Inserm U1154CNRS UMR7196Museum national d'Histoire naturelle

The CRISPR-Cas revolution is taking place in virtually all fields of life *** DNA cleavage with the CRISPR-Cas9 system of Streptococcus pyogenes has proven to be extraordinarily simple and efficient,relying only on the design of a synthetic single guide RNA（sgRNA） and its co-expression with ***,we review the progress in the design of sgRNA from the original dual RNA guide for *** and Staphylococcus aureus Cas9（SpCas9 and SaCas9）.New assays for genome-wide identification of offtargets have provided important insights into the issue of cleavage specificity in *** the same time,the on-target activity of thousands of guides has been *** data have led to numerous online tools that facilitate the selection of guide RNAs in target *** appears that for most basic research applications,cleavage activity can be maximized and off-targets minimized by carefully choosing guide RNAs based on computational ***,recent studies of Cas proteins have further improved the flexibility and precision of the CRISPR-Cas toolkit for genome *** by the crystal structure of the complex of sgRNA-SpCas9 bound to target DNA,several variants of SpCas9 have recently been engineered,either with novel protospacer adjacent motifs（PAMs） or with drastically reduced *** Cas9 and Cas9-like proteins called Cpf 1 have also been characterized from other bacteria and will benefit from die insights obtained from *** editing with CRISPR-Cas9 may also progress with better understanding and control of cellular DNA repair pathways activated after Cas9-induced DNA cleavage.

关键词： Genome editing CRISPR-Cas9 system Guide RNA

Why Does Newton’s Apple Fall Vertically to the Ground: The Gravitation Code

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Journal of Modern Physics 2016年第13期7卷 1702-1711页

作者： jean-paul Auffray Ex: Courant Institute of Mathematical Sciences New York University New York NY USA

No, Isaac Newton did not “explain” gravitation. What he did, and this certainly constituted all and by itself a great achievement, was to recognize (to “assert”) the universal character of gravitation: all material objects (bodies) attract each other by gravitation. But how does gravitation perform its deeds? This remained a mystery to Newton. In a “desperate move” at the end of his life, he introduced the concept of “Particles which are moved by certain active Principles [our emphasis]—such as is that of Gravity” he said. We resurrect this scheme, we provide it with a quantum structure—a stunning new insight into the workings of gravitation obtains.

关键词： Gravitation Newton Fatio de Duillier Ethereal Particles I-Meteons