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Differences in characteristics of patients with and without known risk factors for hepatocellular carcinoma in the United States

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World Journal of Gastroenterology 2007年第5期13卷 781-784页

作者： Jon D Dorfman Richard Schulick Michael A Choti jean-Francois H Geschwind Ihab Kamel Michael Torbenson paul J Thuluvath Department of Surgery The Johns Hopkins University School of Medicine Baltimore MD 21205 United States Department of Radiology The Johns Hopkins University School of Medicine Baltimore MD 21205 United States Department of Pathology The Johns Hopkins University School of Medicine Baltimore MD 21205 United States Department of Medicine The Johns Hopkins University School of Medicine Baltimore MD 21205 United States

AIM： To examine the clinical characteristics of a subgroup of patients with hepatocellular carcinoma （HCC） and compare them to those with known risk factors. METHODS： We used the HCC database of 306 patients seen at our institution from January 1, 1995 to December 31, 2001. Of the 306 patients, 63 （20%, group 1） had no known risk factors （hepatitis C virus, hepatitis B virus, alcohol, hemochromatosis or cirrhosis from any cause） and 243 （group 2） had one or more risk factors. RESULTS： The median age was similar in both groups, but there were disproportionate numbers of younger （〈 30 years old）, older （〉 80 years） patients, women （33% vs 18%）, and Caucasians （81% vs 52%） in group 1 as compared to group 2. There were fewer Asians （2% vs 11%） and African Americans （13% vs 27%） in group 1. Abdominal pain （70% vs 37%） was more common while gastrointestinal bleeding （0% vs 11%） and ascites （4% vs17%） were less common in group i compared to group 2. Group 1 had larger tumor burden （median size 9.4 cm vs 5.7 cm） at the time of presentation, but there were no differences in the site （right, left or bilateral lesions）, or number of tumors between the two groups. CONCLUSION： HCC patients without identifiable risk factors have different characteristics and clinical presentation compared to those with known risk *** of cirrhosis and larger tumor burden may explain the differences in the presenting symptoms.

关键词： Hepatocellular carcinoma Patient charaocteristics Risk factors

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Disaster Risk Management Through the Design Safe Cyberinfrastructure

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International Journal of Disaster Risk Science 2020年第6期11卷 719-734页

作者： jean-paul Pinelli Maria Esteva Ellen M.Rathje David Roueche Scott J.Brandenberg Gilberto Mosqueda Jamie Padgett Frederick Haan Department of Mechanical and Civil Engineering Florida Institute of TechnologyMelbourneFL 32901USA Texas Advanced Computing Center University of Texas at AustinAustinTX 78712USA Department of Civil Engineering University of Texas at AustinAustinTX 78712USA Department of Civil Engineering Auburn UniversityAuburnAL 36849USA Department of Civil and Environmental Engineering University of California in Los AngelesLos AngelesCA 90095USA Department of Structural Engineering University of California in San DiegoLa JollaCA 92093USA Department of Civil and Environmental Engineering Rice UniversityHoustonTX 77005USA Engineering Department Calvin CollegeGrand RapidsMI 49546USA

Design Safe addresses the challenges of supporting integrative data-driven research in natural hazards *** is an end-to-end data management,communications,and analysis platform where users collect,generate,analyze,curate,and publish large data sets from a variety of sources,including experiments,simulations,field research,and post-disaster *** achieves key objectives through:(1)integration with high performance and cloud-computing resources to support the computational needs of the regional risk assessment community;(2)the possibility to curate and publish diverse data structures emphasizing relationships and understandability;and(3)facilitation of real time communications during natural hazards events and disasters for data and information *** resultant services and tools shorten data cycles for resiliency evaluation,risk modeling validation,and forensic *** article illustrates salient features of the *** summarizes its design principles,architecture,and *** focus is on case studies to show the impact of Design Safe on the disaster risk *** Next Generation Liquefaction project collects and standardizes case histories of earthquake-induced soil liquefaction into a relational database—Design Safe—to permit users to interact with the *** can correlate in Design Safe building dynamic characteristics based on data from building sensors,with observed damage based on ground motion *** groups upload,curate,and publish wind,seismic,and coastal damage data they gather during field reconnaissance missions,so these datasets are available shortly after a *** a part of the education and community outreach efforts of Design Safe,training materials and collaboration space are also offered to the disaster risk management community.

关键词： Cyberinfrastructure Design Safe Disaster risk management Natural hazard data management

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Petrogenesis, LA-ICP-MS zircon U-Pb geochronology and geodynamic implications of the Kribi metavolcanic rocks,Nyong Group, Congo craton

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Acta Geochimica 2022年第3期41卷 470-495页

作者： Hermine Mvodo Sylvestre Ganno Gus Djibril Kouankap Nono Donald Hermann Fossi Philomene Estelle Nga Essomba Marvine Nzepang Tankwa jean paul Nzenti Department of Earth Sciences University of YaoundéIP.O.Box 812YaoundeCameroon Department of Geology HTTCUniversity of BamendaP.O.Box 39BambiliBamendaCameroon Institute for Geological and Mining Research P.O.Box 4110YaoundéCameroon Faculty of Mines and Petroleum Industries University of MarouaKaélé08MarouaCameroon

Metavolcanic rocks are well-exposed in the Kribi area within the Nyong Group, Congo craton, but their origin, age, and tectonic significance are poorly *** we report integrated field mapping and petrography,geochemistry, and LA-ICP-MS zircon U-Pb ages of these metavolcanic rocks to constrain their petrogenesis and geodynamic implications. The studied rocks consist of mafic granulite, garnet-amphibole gneiss, and garnet-biotite gneiss, and occur interbanded with sharp contact and intruded by syenite dyke. These metavolcanic rocks are classified as MORB-like tholeiitic to calc-alkaline basalts,basaltic andesite, and rhyodacite rocks with within-plate setting geochemical signatures. The metabasite rocks(basalt to basaltic andesite protolith) are likely the equivalent of a spinel peridotite product representing ~ 2–5 %partial melting of metasomatized mantle source, while the metarhyodacite rocks are derived from the fractional crystallization of the same parental magma. Zircon U-Pb data revealed that the rhyodacite rocks initially formed at2671 ± 51 Ma and underwent later metamorphism at2065 ± 55 Ma. The Neoarchean protolith age is comparable to the ca. 2628 Ma tholeiitic magmatism and ca.2666 Ma high-K granites, suggesting bimodal Neoarchean magmatic event within the Ntem Complex, while the metamorphic ages fall within the ca. 2100–2000 Ma highgrade tectono-metamorphic event attributed to Eburnean/Trans-Amazonian orogeny. At the regional scale,metavolcanic rocks with similar origins and ages are documented in the Sa o Francisco Craton in Brazil, suggesting comparable geodynamic evolution on both sides of the south Atlantic during the Paleoproterozoic.

关键词： Metavolcanic rocks MORB Within plate volcanic zone Mantle source Fractional crystallization Congo craton Cameroon

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Compound screening platform using human induced pluripotent stem cells to identify small molecules that promote chondrogenesis

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Protein & Cell 2012年第12期3卷 934-942页

作者： Sheng-Lian Yang Erica Harnish Thomas Leeuw Uwe Dietz Erika Batchelder paul SWright Jane Peppard paul August Cecile Volle-Challier Francoise Bono jean-Marc Herbert Juan Carlos Izpisua Belmonte Gene Expression Laboratories The Salk Institute for Biological Studies10010 N.Torrey Pines Rd.La JollaCA 92037USA Sanofi US R&DEarly to Candidate UnitTucson Research Center2090 E.Innovation Park DriveTucsonAZ 85755USA Sanofi Deutschland GmbH R&DTSU Aging Quality of LifeIndustriepark HoechstFrankfurt am Main 65926Germany Sanofi R&D Early to Candidate Unit195Route d'Espagne-BP 13669ToulouseFrance Center of Regeneration Medicine Dr.Aiguader 88Barcelona 08003Spain

Articular cartilage,which is mainly composed of collagen Ⅱ,enables smooth skeletal *** of collagen Ⅱ can be caused by various events,such as injury,but degeneration especially increases over the course of normal ***,the body does not fully repair itself from this type of degeneration,resulting in impaired ***,an articular cartilage repair surgical technique,has been commonly used in the clinic to induce the repair of tissue at damage *** stem cells(MSC)have also been used as cell therapy to repair degenerated ***,the therapeutic outcomes of all these techniques vary in different patients depending on their age,health,lesion size and the extent of damage to the *** repairing tissues either form fibrocartilage or go into a hypertrophic stage,both of which do not reproduce the equivalent functionality of endogenous hyaline *** of the reasons for this is inefficient chondrogenesis by endogenous and exogenous *** that promote chondrogenesis could be used to induce self-repair of damaged cartilage as a non-invasive approach alone,or combined with other techniques to greatly assist the therapeutic *** recent development of human induced pluripotent stem cell(iPSCs),which are able to self-renew and differentiate into multiple cell types,provides a potentially valuable cell resource for drug screening in a“more relevant”cell *** we report a screening platform using human iPSCs in a multi-well plate format to identify compounds that could promote chondrogenesis.

关键词： hESC hiPSC chondrogenesis compound screening platform

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镰状细胞对内皮诱导一氧化氮的清除能力低下(英文)

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Acta Pharmacologica Sinica 2002年第11期23卷 9-15页

作者： Leopoldo OLMOS,jean-Vivien MOMBOULI,Nathan WASSERSTRUM,paul MVANHOUTTE Center for Experimental Therapeutics Baylor College of Medicine Houston TX 77030 USA University of Marien Ngouabi Brazzaville Republic of Congo Center for Experimental Therapeutics Baylor College of Medicine Houston TX 77030 USA lnstitut de Recherches Internationales Servier 92415 Courbevoie Cedex France

AIM: To assess the ability of sickle cells to interfere with the release or transfer of endothelium-derived relaxing factor (EDRF) in comparison to normal erythrocytes. METHODS: A perfusion-superfusion bioassay system was used a canine carotid artery with endothelium (donor of EDRF) and a ring of the same vessel without endothelium (detector) were separated by tubing resulting in a five second interval for transfer of EDRF from donor to detector. Changes in isometric tension were monitored in both the donor and the detector preparations. Release of EDRF, as determined by sustained relaxations during the contractions to phenylephrine, was induced by infusing acetylcho-line through the donor artery. RESULTS: Supervision with normal and sickle erythrocytes caused impairment of the endothelium-dependent relaxations in both detector and donor tissues. When infused through the transfer line, sickle cells were less potent than normal erythrocytes in inhibiting relaxation in the detector tissues. In contrast, i

关键词：镰状细胞贫血内皮血管平滑肌红细胞微循环一氧化氮

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Expert group syndrome at high altitude

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Sports Medicine and Health Science 2022年第3期4卷 215-218页

作者： jean-paul Richalet Marie-Anne Magnan Alice Gavet Pierre Lafère UniversitéSorbonne Paris Nord Laboratoire Hypoxie et PoumonUMR INSERM U1272BobignyFrance Institut National des Sports de l’Expertise et de la PerformancePôle médicalParisFrance Hôpitaux universitaires de Genève Département de médecine aiguëUnitéde médecine subaquatique et hyperbareGenevaSwitzerland Hôpitaux du Mont-Blanc Soins de suite et réadaptationChamonixFrance Universitéde Bretagne Occidentale Laboratoire ORPHYEA 44324BrestFrance HauteÉcole Bruxelles-Brabant(HE2B) EnvironmentalOccupationalAgeing(Integrative)Physiology LaboratoryBrusselsBelgium

During a training session for the university diploma of Mountain medicine delivered by University Sorbonne Paris Nord for medical doctors,one of the participants developed signs of maladaptation to high altitude at 3600 m,the severity of which was incorrectly *** was sparingly given by the patient(an anesthetist)to several of his colleagues and no one was in charge to collect clinical data,take a history,and provide appropriate *** combination of the absence of designation of a supervising doctor and the difficulty of communicating with the patient led to a lack of coordinated management and to an evolution of the symptoms towards severe acute mountain ***,the very rapid management of the patient and a rapid helicopter evacuation,as soon as the symptoms worsened towards the onset of a suspected high altitude cerebral and/or pulmonary edema,allowed rapid resolution without ***,medical,psychological,and managerial factors led to this Expert Group Syndrome.

关键词： Acute mountain sickness High altitude cerebral edema Psychology Group management

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A Xon Signature in the Electron Spin

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Journal of Modern Physics 2013年第11期4卷 9-13页

作者： jean-paul Auffray (ex) Courant Institute of Mathematical Sciences New York University New York USA

The elementary particles listed in the Standard Model of particle physics have all in common a quantum mechanical attribute which has the dimension of the xon, suggesting that the xon might be a structural ingredient ... 详细信息

关键词： Observable Universe Dark Matter Standard Model Ordinary Matter Electron Spin Xon Photon Gravitomagnetism Smolin Haroche Arbab

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Saponins as adipokines modulator: A possible therapeutic intervention for type 2 diabetes

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World Journal of Diabetes 2017年第7期8卷 337-345页

作者： Olusola Olalekan Elekofehinti Oluwamodupe Cecilia Ejelonu jean paul Kamdem Oluwaseun Benedicta Akinlosotu Isaac Gbadura Adanlawo Department of Biochemistry University of Ado-Ekiti Department of Biochemistry Adekunle Ajasin University Departamento de Ciências Biológicas Universidade Regional do Cariri-URCA Campus Pimenta Department of Biochemistry Federal University of TechnologyAkure

Development of type 2 diabetes has been linked to β-cell failure coupled with insulin resistance and obesity. Adipose tissue, known as the fat store, secretes a number of hormones and proteins collectively termed adipokines some of which regulate insulin sensitivity. Dysregulation in the secretion of adipokines has been linked to insulin resistance and type 2 diabetes. In this review, we sum-marized evidence of the role of adipokines with focus on leptin, adiponectin, adipsin, visfatin and apelin in the pathogenesis of type 2 diabetes and discussed the potential of saponins to modify the ill-regulated adipokines secretions, which could promote the use of this class of phytochemicals as potential antidiabetics agents.

关键词： Adipokines Adipose tissue Insulin resistance Antidiabetic Obesity

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Economy of Adaptation to High Altitude

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青海医学院学报 2004年第4期25卷 241-244页

作者： jean-paul Richalet 'Réponses cellulaires et fonctionnelles àl'hypoxie' EA 2363 UFR Santé Médecine Biologie Humaine Université Paris 1374 rue Marcel Cachin

The international meeting that will be held in Xining and Lhasa in August 2004 will be a wonderful occasion to share facts and concepts dealing with adaptation to high altitude. Life at high altitude is a challenge for thousands of animal species and millions of humans residing or visiting high altitude regions of the world. To try to understand the physiological mechanisms involved in the adaptation processes to high altitude hypoxia, it is convenient to start by defining what is 'extreme' from a biological point of view.

关键词：高海拔国际会议西宁市拉萨市氧不足高原医学英国

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Is Dark Matter Made up of Xons?

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Journal of Modern Physics 2013年第8期4卷 121-125页

作者： jean-paul Auffray ex Courant Institute of Mathematical Sciences New York University New York USA

Three months before his untimely death in Paris in July 1912, Henri Poincaré formulated the conjecture that Planck’s action element could (should) be regarded as constituting a “véritable atome”, i.e. an “atom of motion”, whose integrity arises from the fact that the “points” it contains are equivalent to one another from the standpoint of probability. In this paper we investigate the possibility that this conjecture provides a clue to the origin and nature of dark matter.

关键词： Smolin Poincaré Action Space Vacuum Scale Relativity Nottale Dark Matter Xons

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