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Chinese Optics Letters 2019年第8期17卷 71-75页

作者： Yafeng Xie Saifeng Zhang Xiaoyan Zhang Ningning Dong Ivan M.Kislyakov Song Luo Zhanghai Chen jean-michel Nunzi Long Zhang Jun Wang Laboratory of Micro-Nano Photonic and Optoelectronic Materials and Devices Key Laboratory of Materials for High- Power Laser Shanghai Institute of Optics and Fine Mechanics Chinese Academy of Sciences Shanghai 201800 China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences Beijing 100049 China State Key Laboratory of Surface Physics Key Laboratory of Micro and Nano Photonic Structures of Ministry of Education Department of Physics Collaborative Innovation Center of Advanced Microstructures Fudan University Shanghai 200433 China Department of Physics Engineering Physics Sz Astronomy and Department of Chemistry Queers University Kingston K7L-3N6 Ontario Canada State Key Laboratory of High Field Laser Physics Shanghai Institute of Optics and Fine Mechanics Chinese Academy of Sciences Shanghai 201800 China

Mechanical exfoliation(ME) and chemical vapor deposition(CVD) MoS2 monolayers have been extensively studied, but the large differences of nonlinear optical performance between them have never been clarified. Here,we prepared MoS2 monolayers using ME and CVD methods and investigated the two-photon absorption(TPA)response and its saturation. We found that the TPA coefficient of the ME monolayer was about(1.88 ± 0.21)× 10^3 cm/GW, nearly two times that of the CVD one at(1.04 ± 0.15)× 10^3 cm/GW. Furthermore,we simulated and compared the TPA-induced optical pulse modulation in multilayer cascaded structures, which is instructive and meaningful for the design of optical devices such as a beam shaper and optical limiter.

关键词： ME CVD limiter

Influence of Cell Confluency on the Expression of the α4 Integrin Subunit of Retinal Pigment Epithelial Cells

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Advances in Biological Chemistry 2015年第2期5卷 73-82页

作者： jean-michel Bourget Mohib Morcos Karine Zaniolo Sylvain L. Guérin Stéphanie Proulx Centre de recherche du CHU de Québec and Centre de recherche en organogénèse expérimentale de l’Université Laval/LOEX axe médecine régénératrice Hopital du Saint-Sacrement Québec Canada Département d’anatomie et de cytologie pathologiques CHU de Québec Hopital du Saint-Sacrement Québec Canada Département de biologie moléculaire biochimie médicale et pathologie Faculté de médecine Université Laval Québec Canada Département d’Ophtalmologie Faculté de médecine Université Laval Québec Canada

Integrins are a family of transmembrane glycoproteins that mediate cell-cell and cell-extracellular matrix interactions. The integrin α4 subunit is widely expressed by cells from the immune system and its expression by non-hematopoietic cells is scarce. In the present study, gene and protein expression of this integrin subunit was characterized in proliferating and quiescent human RPE cells. Immunofluorescent studies confirm that the α4 subunit is expressed in vitro by RPE cells, a result that has been validated by immunofluorescence and FACS analyses. The accumulation of the α4 integrin at cell-cell junctions in post-confluent RPE cell cultures negatively correlated with the level of expression of the mRNA transcript. Accordingly, transient transfection analyses reveal that the α4 promoter activity is considerably reduced when RPE cells form a confluent monolayer. Moreover, transfection of recombinant constructs bearing 5’-deletions of the α4 promoter segment allows the localization of strong negative regulatory elements on the -76 to -300 region of the α4 gene suggesting that its expression is intimately linked to the proliferative state of primary cultured RPE cells.

关键词： Retinal Pigment Epithelium Integrin Alpha 4 Subunit Cell Culture Confluency Promoter

Comparison of alternative arterial anastomosis site during liver transplantation when the recipient’s hepatic artery is unusable

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Hepatobiliary Surgery and Nutrition 2022年第1期11卷 1-12页

作者： jean Marie Beaurepaire Francesco Orlando Giovanni Battista Levi Sandri Caroline Jezequel Edouard Bardou-Jacquet Christophe Camus Mohamed Lakehal Veronique Desfourneaux Aude Merdrignac Elodie Gaignard Alexandre Thobie Damien Bergeat Bernard Meunier michel Rayar CHU Rennes Service de Chirurgie Hépatobiliaire et DigestiveRennesFrance UniversitéRennes 1 Facultéde MédecineRennesFrance CHU Rennes Service des Maladies du FoieRennesFrance INSERM CIC 1414RennesFrance CHU Rennes Service de Maladies Infectieuses et Réanimation MédicaleRennesFrance

Background:Few studies have analyzed outcomes of liver transplantation(LT)when the recipient hepatic artery(HA)was not ***:We retrospectively evaluated the outcomes of LT performed using the different alternative sites to ***:Between 2002 and 2017,1,677 LT were performed in our institution among which 141(8.4%)with unusable recipient HA were *** groups were defined according to the site of anastomosis:the splenic artery(SA group,n=26),coeliac trunk(CT group,n=12),aorta using or not the donor’s vessel(Ao group,n=91)and aorta using a vascular prosthesis(Ao-P group,n=12)as *** median number of intraoperative red blood cell transfusions was significantly increased in the Ao and Ao-P groups(5,5,8.5 and 16 for SA,CT,Ao and Ao-P group respectively,P=0.002),as well as fresh frozen plasma(4.5,2.5,10,17 for the SA,CT,Ao and Ao-P groups respectively,P=0.001).Hospitalization duration was also significantly increased in the Ao and Ao-P groups(15,16,24,26.5 days for the SA,CT,Ao and Ao-P groups respectively,P<0.001).The occurrence of early allograft dysfunction(EAD)(P=0.07)or arterial complications(P=0.26)was not statistically *** of factor V,INR,bilirubin and creatinine during the 7th postoperative days(POD)was significantly improved in the SA *** difference was observed regarding graft(P=0.18)and patient(P=0.16)***:In case of unusable HA,intraoperative and postoperative outcomes are improved when using the SA or CT compared to aorta.

关键词： Liver transplantation(LT) hepatic artery(HA) arterial anastomosis splenic artery(SA)

Hospital Hygiene Maternity Hospital Public Lubumbashi Democratic Republic of Congo

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Open Journal of Preventive Medicine 2017年第4期7卷 74-85页

作者： Kaj Francoise Malonga Hendrick Lukuke Mbutshu jean-Jacques Lunda Ngandu Mukengeshayi Abel Ntambue michel Makoutode School of Public Health University of LubumbashiLubumbashiDR Congo Regional Institute of Public Health OuidahBenin Republic

Introduction: Public hospitals in the DRC are of significant disrepair, while there is a strong link between the failure of hospital hygiene and the incidence of nosocomial infections. We have conducted a study with the objective of evaluating the structural-functional conditions of hospital hygiene maternity wards of public hospitals in Lubumbashi. Methodology: It was a descriptive cross-sectional study and structural-functionalist whose population consisted of nurses responsible for 7 of 12 maternity hospitals which were selected based on the inclusion criteria. The observation with an observation guide and maintenance using a questionnaire we used to collect data. Results: The results showed that hospital hygiene conditions in maternity wards of public hospitals in Lubumbashi are not good because almost all maternity services and surgery are not always water in the taps (14.3%). The bins were a means for care units, no coding system exists to distinguish the type of waste. The medical waste are mixed and the other waste are burned in the open or in makeshift incinerator with other types of waste. Conclusion: These maternity wards have poor hygiene, staff responsible for this sector did not follow any training in this area. There is need to regulate the sector and train them.

关键词： Hospital Hygiene Maternity Hospital Waste Management

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静止的时光威尼斯安缦大运河酒店

室内设计与装修 2015年第10期 118-123页

作者： jean-michel Gathy viola

威尼斯安缦大运河酒店（AMAN CANAL GRANDE VENJCE）是座拥有两个金色方形尖塔的古老建筑，恢弘大气，是难得一见的建筑精品。它由两栋相邻的五层建筑组成，其中的帕帕多波利宫（Palazzo Papadopoli）始建于16世纪，在19世纪时由富豪Ald... 详细信息

威尼斯安缦大运河酒店（AMAN CANAL GRANDE VENJCE）是座拥有两个金色方形尖塔的古老建筑，恢弘大气，是难得一见的建筑精品。它由两栋相邻的五层建筑组成，其中的帕帕多波利宫（Palazzo Papadopoli）始建于16世纪，在19世纪时由富豪Aldobrandini兄弟买下重新装饰，并增建了当时并不常见的私人花园，时至今日，两者皆镀上了岁月的隽永光泽。

关键词：大运河威尼斯酒店静止 GRANDE 古老建筑建筑精品装饰

"激光组装线"与"兆焦耳激光器"的发展前景与进展

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激光与光电子学进展 2005年第4期42卷 7-9,6页

作者： Claude Carallier No■l Fleurot Lonjaret T jean-michel Di-Nicola 罗山法国原子能委员会军事应用局法国原子能委员会/军事应用局阿基坦科技研究中心

法国原于能委员会渡尔多市阿基坦科技研究中心(CESTA)实验室建造的"兆焦耳激光器"(LMJ)是一个240束的激光装置,它是珐国原子能委员会"模拟计划"(相当于美国的核武器"存贮与管理计划")的基石。

关键词：兆焦耳激光器发展前景法国原子能委员会组装线激光装置研究中心管理计划实验室波尔多核武器

Liver angiogenesis as a risk factor for hepatocellularcarcinoma development in hepatitis C virus cirrhotic patients

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World Journal of Gastroenterology 2007年第37期13卷 5009-5014页

作者： Roberto Mazzanti Luca Messerini Camilla E Comin Lorenzo Fedeli Nathalie Gannè-Carrie michel Beaugrand Dipartimento di Medicina Interna Sezione di Oncologia Medica Centro di Eccellenza DENOthe Azienda Ospedaliero-Universitaria Careggi Istituto Toscano Tumori Università degli Studi di Firenze Florence Italy Dipartimento di Patologia Umana ed Oncologia Istituto Toscano Tumori Università degli Studi di Firenze Florence Italy Nathalie Gannè-Carrie Michel Beaugrand Service d'Hepato-Gastroenterologie Hopital Jean Verdier Assistance Publique-Hopitaux de Paris et UFR SMBH-Universite Paris XIII Bondy France Nathalie Gannè-Carrie Michel Beaugrand Service d’Hepato-Gastroenterologie Hopital Jean Verdier Assistance Publique-Hopitaux de Paris et UFR SMBH-Universite Paris XIII Bondy France

AIM： To evaluate the predictive value of hepatocyte proliferation and hepatic angiogenesis for the occurrence of Hepatocellular carcinoma （HCC） in hepatitis C virus （HCV） cirrhotic patients.METHODS： One hundred-five patients （69 males, 36 females; age range, 51-90 year; median 66 year） with biopsy proven HCV cirrhosis were prospectively monitored for HCC occurrence for a median time of 64 too. Angiogenesis was assessed by using microvessel density （MVD）, hepatocyte turnover by MIB1 and PCNA indexes at inclusion in liver biopsies.RESULTS： Forty six patients （43.8%） developed HCC after a median time of 55 （6-120） mo while 59 （56.2%） did not. Patients were divided into two groups according to the median value of each index. The difference between patients with low （median MVD = 3; range 0-20） and high （median MVD = 7; range 1-24） MVD was statist（caUy s（gn（ficant （χ^2= 22.06; P 〈 0.0001） wh（ch was not the case for MIB1 or PCNA （MIB-I： χ^2 = 1.41; P = 0.2351; PCNA： χ^2 = 1.27; P = 0.2589）. The median MVD was higher in patients who developed HCC than in those who did not. HOe-free interval was significantly longer in patients with the MVD ≤ 4 （P = 0.0006）. No relationship was found between MIB1 or PCNA and MVD （MIB-1 r^2 = 0.00007116, P = 0.9281; PCNA： P =0.001950; P = 0.6692）. MVD only was able to predict the occurrence of HCC in these patients. Among other known risk factors for HCC, only male sex was statistically associated with an increased risk. CONCLUSION： Liver angiogenesis has a role for in HCV- related liver carcinogenesis and for defining patients at higher risk.

关键词： Liver cancer Hepatitis C virus Angiogenesis Proliferating cell nuclear antigen

High-performance waveguide-integrated germanium PIN photodiodes for optical communication applications[Invited]

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Photonics Research 2013年第3期1卷 140-147页

作者： Léopold Virot Laurent Vivien jean-Marc Fédéli Yann Bogumilowicz jean-michel Hartmann Frédéric Bœuf Paul Crozat Delphine Marris-Morini Eric Cassan Institut d’Electronique Fondamentale(IEF) Univ.Paris-SudCNRSBât 220F-91405 OrsayFrance CEA LETIMinatec Campus17 rue des MartyrsF-38054 GrenobleFrance STMicroelectronics Silicon Technology DevelopmentCrollesFrance

This paper reports on high-performance waveguide-integrated germanium photodiodes for optical communications applications.200 mm wafers and production tools were used to fabricate the *** over 97%were obtained for three different compact photodiodes(10×10μm and intrinsic region width of 0.5,0.7,and 1μm)within the same batch of three *** photodiodes exhibit low dark currents under reverse bias with median values of 74,62,and 61 nA for intrinsic widths of 0.5,0.7,and 1μm,respectively,over a full *** up to 0.78 A∕W at 1550 nm and zero bias were *** bias operation is possible for 25 and 40 Gbps with receiver sensitivity estimated to−13.9 and−12.3 dBm,respectively.

关键词： waveguide optical communication

Excessive Weight Gain during Pregnancy and Prognosis of Childbirth in Douala (Cameroun)

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Open Journal of Obstetrics and Gynecology 2019年第2期9卷 242-250页

作者： Henri Essome Valere Mve Koh michel Ekono Merlin Boten jean Paul Engbang Matio Bewekedi Pascal Foumane Douala Laquintinie Hospital Douala Cameroon Faculty of Medicine and Pharmaceutical Sciences University of Douala Douala Cameroon University Hospital Center of Yaoundé Yaoundé Cameroon Faculty of Medicine and Biomedical Sciences University of Yaoundé 1 Yaoundé Cameroon Gyneco-Obstetrics and Pediatric Hospital of Yaoundé Yaoundé Cameroon

The objective was to describe the maternofetal outcome of childbirth in women with excessive weight gain during pregnancy. We conducted a cross-sectional analytical study over a period of 03 months in the Obstetrics Department of Laquintinie Hospital in Douala (HLD). Our study population consisted of any pregnant in labor or waiting for a caesarean section. We compared two groups of pregnant women with excessive weight gain during pregnancy (exposed) and those without excessive weight gain during pregnancy (unexposed). We recorded 240 pregnant women who gave birth at the HLD maternity, 59 of whom had excessive weight gain during pregnancy, which gave us a proportion of 24.6%. The only sociodemographic characteristic associated with excessive weight gain during pregnancy was the married marital status of the pregnant women (OR: 2.0 (1.1 - 3.8) P = 0.023). Pregnant women with maternal complications associated with excessive weight gain had an average elevated uterine height of 35.4 (P = 0.007). The increase in caesarean section rate (P = 0.094) and the onset of pregnancy-related hypertension (HTA) showed differences close to significance (P = 0.063). Mean birth weight was higher (P = 0.023) in pregnant women with excessive weight gain during pregnancy. Ultimately, excessive weight gain during pregnancy has deleterious effects on the course of pregnancy and childbirth. It promotes the onset of pregnancy HTA and macrosomia.

关键词： Excessive Weight Gain Pregnancy Maternofoetal Outcome

New proteins and protein species identified in human umbilical vein endothelial cells by Fourier transform ion cyclotron resonance-mass spectrometry

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Natural Science 2013年第8期5卷 919-924页

作者： Bruno Baudin Arnaud Bruneel Pascal Pernet michel Vaubourdolle Iman Haddad Paulo Marcelo jean Rossier Joelle Vinh Biochimie A Hopital Saint-AntoinePole de Biologie Médicale et PathologieHopitaux Universitaires de l’Est Parisien(AP-HP)ParisFrance EA 4530 UniversitéParis-SudChâtenay-MalabryFrance CNRS USR 3149 Spectrométrie de Masse Biologique et ProtéomiqueESPCI-ParisTechParisFrance

For many years, ***1 public database provides biological data relative to the proteome of human umbilical vein endothelial cells (HU-VECs), which are the most used human endothelial cell model in vascular biology. The proteins were identified using two-dimensional gel electrophoresis (2-DGE) for protein separation coupled with Matrix Assisted Laser Desorption-Ionization Mass Spectrometry (MALDI-TOF-MS) for identification. We present here an important update of *** with 521 protein identifications as determined using Fourier transformed ion cyclotron resonance-mass spectrometry (FTICR-MS) applied to an unstained 2-DGE gel cut in 221 squared pieces;each identified protein being accompanied by a semi-quantitative three dimensional visualization is called “score imaging”. The squared analyzed gel and the alphabetical list of identified proteins, linked with their corresponding three-dimensional score imaging, are available at ***. This original approach led to the establishment of the most protein-rich and informative database for HUVECs, as well as to the identification of some protein species, in particular with phosphorylation.

关键词： Database 2-DGE Endothelium HUVEC FTICR Tubulins