Liver angiogenesis as a risk factor for hepatocellularcarcinoma development in hepatitis C virus cirrhotic patients

作     者：Roberto Mazzanti Luca Messerini Camilla E Comin Lorenzo Fedeli Nathalie Gannè-Carrie Michel Beaugrand 

作者机构：Dipartimento di Medicina Interna Sezione di Oncologia Medica Centro di Eccellenza DENOthe Azienda Ospedaliero-Universitaria Careggi Istituto Toscano Tumori Università degli Studi di Firenze Florence Italy Dipartimento di Patologia Umana ed Oncologia Istituto Toscano Tumori Università degli Studi di Firenze Florence Italy Nathalie Gannè-Carrie Michel Beaugrand Service d'Hepato-Gastroenterologie Hopital Jean Verdier Assistance Publique-Hopitaux de Paris et UFR SMBH-Universite Paris XIII Bondy France Nathalie Gannè-Carrie Michel Beaugrand Service d’Hepato-Gastroenterologie Hopital Jean Verdier Assistance Publique-Hopitaux de Paris et UFR SMBH-Universite Paris XIII Bondy France 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2007年第13卷第37期

页      面：5009-5014页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by Grants from the Italian Ministry of University, Scientific and Technological Research (MIUR, Progetto Nazionale cofinanziato COFIN No. 2002067115) the University of Florence to R. M 

主　　题：Liver cancer Hepatitis C virus Angiogenesis Proliferating cell nuclear antigen 

摘      要：AIM： To evaluate the predictive value of hepatocyte proliferation and hepatic angiogenesis for the occurrence of Hepatocellular carcinoma （HCC） in hepatitis C virus （HCV） cirrhotic patients. METHODS： One hundred-five patients （69 males, 36 females; age range, 51-90 year; median 66 year） with biopsy proven HCV cirrhosis were prospectively monitored for HCC occurrence for a median time of 64 too. Angiogenesis was assessed by using microvessel density （MVD）, hepatocyte turnover by MIB1 and PCNA indexes at inclusion in liver biopsies. RESULTS： Forty six patients （43.8%） developed HCC after a median time of 55 （6-120） mo while 59 （56.2%） did not. Patients were divided into two groups according to the median value of each index. The difference between patients with low （median MVD = 3; range 0-20） and high （median MVD = 7; range 1-24） MVD was statist（caUy s（gn（ficant （χ^2= 22.06; P 〈 0.0001） wh（ch was not the case for MIB1 or PCNA （MIB-I： χ^2 = 1.41; P = 0.2351; PCNA： χ^2 = 1.27; P = 0.2589）. The median MVD was higher in patients who developed HCC than in those who did not. HOe-free interval was significantly longer in patients with the MVD ≤ 4 （P = 0.0006）. No relationship was found between MIB1 or PCNA and MVD （MIB-1 r^2 = 0.00007116, P = 0.9281; PCNA： P =0.001950; P = 0.6692）. MVD only was able to predict the occurrence of HCC in these patients. Among other known risk factors for HCC, only male sex was statistically associated with an increased risk. CONCLUSION： Liver angiogenesis has a role for in HCV- related liver carcinogenesis and for defining patients at higher risk.