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World Journal of Stem Cells 2014年第2期6卷 134-143页

作者： Florence Appaix marie-France Nissou Boudewijn van der Sanden Matthieu Dreyfus Franois Berger jean-Paul Issartel Didier Wion INSERM U836 Grenoble Institut des NeurosciencesBatiment Edmond J SafraUniversité Joseph Fourier INSERM U1167 CLINATEC Centre de Recherche Edmond J SafraMINATEC Campus CEA

Multipotent mesenchymal stromal cells(MSC),have the potential to differentiate into cells of the mesenchymal lineage and have non-progenitor functions including *** demonstration that MSCs are perivascular cells found in almost all adult tissues raises fascinating perspectives on their role in tissue maintenance and ***,some controversies about the physiological role of the perivascular MSCs residing outside the bone marrow and on their therapeutic potential in regenerative medicine *** brain,perivascular MSCs like pericytes and adventitial cells,could constitute another stem cell population distinct to the neural stem cell *** demonstration of the neuronal potential of MSCs requires stringent criteria including morphological changes,the demonstration of neural biomarkers expression,electrophysiological recordings,and the absence of cell *** recent finding that brain cancer stem cells can transdifferentiate into pericytes is another facet of the plasticity of these *** suggests that the perversion of the stem cell potential of pericytes might play an even unsuspected role in cancer formation and tumor progression.

关键词： Stem cell Mesenchymal stem cell Pericyte Brain Cell plasticity Cancer stem cell Glioma Neurodegenerative disease

Epidemiology, Diagnosis and Survival of Breast Cancer: Data from the Population-Based Cancer Registry of the City of Parakou from 2017 to 2021

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Open Journal of Pathology 2023年第1期13卷 9-27页

作者： Luc Valère Codjo Brun Rachidi Sidi Imorou Nukunté David Lionel Togbenon marie-Claire Assomption Oloufoudi Balle Pognon Mawuton Alphonse Renaud Aholou Sèdjro Raoul Atade Oumou Boukari Freddy Houéhanou Rodrigue Gnangnon Salmane Amidou Falilath Séidou Hierrhum Aboubacar Bambara Kabibou Salifou marie Thérèse Akélé Akpo Faculty of Medicine University of Parakou Parakou Benin Saint jean de Dieu Hospital of Tanguiéta Tanguiéta Benin Institute of Nursing and Obstetrical Care (IFSIO) University of Parakou Parakou Benin Faculty of Health Sciences University of Abomey Calavi Cotonou Benin National Program for the Control of Non-Communicable Diseases Ministry of Health Cotonou Benin Oncology and Clinical Hematology Department of the CHU Bogodogo Joseph Ki-Zerbo University Ouagadougou Burkina Faso

Background: Breast cancer mortality remains high in the majority of developing countries. The Ministry of Health has established two population-based cancer registries in Benin: the first one in Cotonou in 2014 and the second one in Parakou in 2017. However, there is a scarcity of data on breast cancer survival and prognosis in Benin Republic. Objective: This study sought to investigate epidemiological, diagnostic, and survival aspects of breast cancer in Parakou, based on data from its population-based cancer registry from 2017 to 2021. Method: For descriptive and analytical purposes, we used a retrospective cohort design. From January 24, 2022 to August 31, 2022, data were collected in all health facilities covered by the Parakou population-based cancer registry using an individual questionnaire. Survival and prognosis analysis were performed using KAPLAN MEIER method and David COX proportional hazard model respectively. Result: A total of 81 patients have been included in this study. The incidence rate of breast cancer in Parakou was 17.5 per 100,000 person-years with a mortality rate of 2.76 per 100,000 person-years. The median age at diagnosis was 44.50 years with extremes ranging from 19 to 76 years and a predominance of 40 - 50 years age group. The median survival time was estimated at 30 months with an overall 5-year survival of 47%. Young age at diagnosis (p-value = 0.002) and advanced stage at diagnosis (p-value = 0.000) had a negative impact on survival in women. The combination of surgery and chemotherapy improved survival (p-value = 0.018). Conclusion: Breast cancer is still a public health issue in Parakou. It comes out mandatory that resources be made available to make screening, early diagnosis and appropriate treatment of breast cancer affordable.

关键词： Breast Cancer Survival Cancer Registry Parakou (Benin Republic)

Effects of indole-3-butyric acid and age of stem cuttings on root morphology,growth,and survival of Cornus sericea

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Isolation and Authentication of Local Rhizobia Nodulating Common Bean (Phaseolus vulgaris L.) in Different Agro-Ecological Zones of Côte d’Ivoire

林业研究（英文版） 2023年第2期

作者： Sahari Inoue Chibuzo Ilogu jean-marie Sobze

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Advances in Microbiology 2023年第9期13卷 435-447页

作者： marie-Paule Aboueuh Atsé Mako François De Paul N’Gbesso Ibrahim Konaté Noupé Diakaria Coulibaly Kouadio Amani Katiénapariga Tayourou Yéo Louis Butare Department of Biochemistry-Microbiology Jean Lorougnon Guédé University (UJLoG) Daloa Côte d’Ivoire Research Station on Food Crops National Center for Agronomic Research (CNRA) Bouaké Côte d’Ivoire Crop Research Institute (CRI) Alliance of Biodiversity International and CIAT. C/O CSIR Kumasi Ghana

Legumes such as common bean (Phaseolus vulgaris L.) have been introduced into cropping systems for sustainable soil management. Consequently, the loss of fertility of the latter remains a major constraint to bean production because this legume is rarely fertilized, yet it is considered to be a poor nitrogen fixer in the absence of inoculation. To overcome this, this study was undertaken with the objective of seeking efficient local rhizobia in order to propose a bean inoculum formulation. To do this, soil samples taken from twelve localities in the Centre, North and West areas of C?te d’Ivoire were used to trap bean nodulating rhizobia. The ROBA1 bean accession used was sown in pots containing the sampled soils. Seedlings were uprooted at the start of flowering and nodulation was assessed. The isolates obtained were purified and then characterized phenotypically. The infectivity and symbiotic efficacy of these isolates were determined in vitro by the authentication test in which the purified isolates were reinoculated to their original host plant. A total of 24 rhizobium isolates were obtained from the soils of six localities. During morphological characterization, the isolates showed typical characteristics of Rhizobium. With the exception of RPC501, RPC505 and RPC522, all isolates were authenticated and able to nodulate the host plant in controlled culture. Isolates RPC502, RPC507, and RPC508 were effective and significantly increased (P < 0.05) nodule number and weight, height, and plant biomass. This study has, therefore, revealed the presence of effective local rhizobia in Ivorian soils and capable of nodulating common beans. A genetic characterization of efficient rhizobia identified after experimentation in different environmental conditions should be considered before being recommended as bean rhizobia inoculant.

关键词： Trapping Native Rhizobia Nodulation Common Bean Côte d’Ivoire

Novel Mannich Bases of Benzimidazole Derivatives: An Antibacterial Study of Environmental Bacterial Strains

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Advances in Biological Chemistry 2023年第5期13卷 182-191页

作者： Evrard Ablo Ouehi Dosso Bakary Coulibaly Kouassi Franscesco Adingra Penayori marie-Aimée Coulibaly Armand Patrick Achi Tchambaga Etienne Camara Souleymane Coulibaly Siomenan Coulibali Laboratoire de Constitution et Réaction de la Matière UFR Sciences des Structures de la Matière et Technologie Université Félix Houphou&#235t-Boigny de Cocody Abidjan C&#244te d’Ivoire Laboratoire des Procédés Industriels de Synthèse de l’Environnement et des énergies Nouvelles (LAPISEN) Institut National Polytechnique Félix Houphou&#235t-Boigny Yamoussoukro C&#244te d’Ivoire Laboratoire d’Agrovalorisation Département de Biochimie-Microbiologie UFR Agroforesterie Université Jean Lorougnon Guédé Daloa C&#244te d’Ivoire

A previous study was conducted on the synthesis and antibacterial evaluation of Mannich bases of 2-(thioalkyl)-1H-methylbenzimidazole derivatives. The results of this study showed that certain 2-(thioalkyl)-1H-methylbenzimidazole and 2-(thioalkyl)-methyl-1-(piperidin-1-ylmethyl)benzimidazole derivatives possess antibacterial activities against clinical strains, such as Escherichia coli, Klebsiella pneumonia (Gram-negative bacteria), Staphylococcus aureus and Pseudomonas aeruginosa (Gram-positive bacteria). Following these favorable results, we extended the antibacterial evaluation of this series of molecules to environmental strains. The aim of this study was to assess the impact of the methyl-piperidine group fixed at position-1 of this new series of benzimidazoles on the antibacterial activity of environmental strains. In addition, we first evaluated the antibacterial activity of four 2-(thioalkyl)methylbenzimidazole derivatives and then that of five 2-(thioalkyl)-methyl-1-(piperidin-1-ylmethyl) benzimidazole derivatives. This study allowed us to show that compounds 1d and 1e could inhibit bacterial growth in vitro of the Enterobacteria P1 strain with inhibition diameters of 17.3 ± 0.6 mm and 10 ± 0.0 mm, respectively. However, addition of methyl-piperidinyl in this series showed that five (5) of 2-(thioalkyl)-methyl-1-(piperidin-1-ylmethyl) benzimidazole derivatives had an inhibitory effect on the in vitro growth of bacterial strains used except on Enterobacteria P2 with inhibition diameters between 10.0 ± 0.8 mm and 27.9 ± 1.4 mm. The introduction of the methyl-piperidinyl group at the 1-position of 2-(thioalkyl)-1H-methylbenzimidazole derivatives greatly improved the antibacterial activity against environmental bacteria such as Escherichia coli A1, A2, A3, and A4 and two Enterobacteria P1.

关键词： Methylbenzimidazole Derivatives Inhibit Bacterial Growth Mannich Base Enterobacteria Escherichia coli

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建筑创作 2005年第10期 28-29页

作者：让.玛利.杜地耶尔艾蒂安.特里郭 AREP公司

出于文化和友谊中国是另一个千年文化的发源地。五千年前在西方的埃及和希腊，东方的中国出现了第个王朝。

关键词：发源地文化中国

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AREP在中国

建筑创作 2005年第10期 29-31页

作者：让.玛利.杜地耶尔艾蒂安.特里郭 AREP公司

2005年,AREP在华的首批工程在北京(首都博物馆、西直门交通枢纽)与天津(泰达金融中心、泰丰住宅区)拉开了序幕.

关键词：中国首都博物馆金融中心交通枢纽西直门住宅区工程

Subclinical proximal tubulopathy in hepatitis B:The roles of nucleot(s)ide analogue treatment and the hepatitis B virus

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World Journal of Hepatology 2020年第12期12卷 1326-1340页

作者： Anais Brayette marie Essig Paul Carrier Marilyne Debette-Gratien Anais Labrunie Sophie Alain Marianne Maynard Nathalie Ganne-Carrie Eric Nguyen-Khac Pauline Pinet Victor De Ledinghen Christophe Renou Philippe Mathurin Claire Vanlemmens Vincent Di Martino Anne Gervais Juliette Foucher Fouchard-Hubert Isabelle Julien Vergniol Isabelle Hourmand-Ollivier Daniel Cohen Xavier Duval Thierry Poynard Marc Bardou Armand Abergel Manh-Thong Dao Thierry Thevenot jean-Baptiste Hiriart Valerie Canva Guillaume Lassailly Christine Aurières Nathalie Boyer Dominique Thabut Pierre-Henri Bernard Matthieu Schnee Dominique Larrey Bertrand Hanslik Severine Hommel Jeremie Jacques Veronique Loustaud-Ratti U1248 INSERM Department of Hepatology and GastroenterologyUniv.LimogesCHU LimogesLimoges F-87000France U1248 INSERM Department of Nephrology and TransplantationCHU LimogesLimoges F-87000France Department of Center of Epidemiology Biostatistics and Research MethodologyCHU LimogesLimoges F-87000France U1092 INSERM Department of VirologyCHU LimogesLimoges F-87000France Department of Hepatology Croix-Rousse University Hospital of LyonLyon 69004France Department of Hepatology Jean Verdier University Hospital of BondyBondy 93140France Department of Hepato-Gastroenterology Amiens University HospitalAmiens 80054France Department of Infectious Diseases CHU LimogesLimoges F-87000France Department of Hepatology Haut Leveque HospitalBordeaux University HospitalPessac 33604France Department of Gastroenterology Hyeres HospitalHyeres 83407France Department of Hepato-Gastroenterology Claude Huriez University HospitalLille 59037France Department of Hepatology Jean Minjoz University HospitalBesançon 25030France Department of Infectious Diseases Bichat University HospitalParis 75018France Department of Hepatology University Hospital of AngersAngers 49933France Department of Hepato-Gastroenterology and Nutrition University Hospital of CaenCaen 14033France Department of General Medecine University Hospital of CaenCaen 14000France Department of Hepatology La Pitié-Salpêtrière University HospitalParis 75651France Department of Hepatology and Gastroenterology Dijon University HospitalDijon 21079France Department of Hepatology and Gastroenterology Estaing University HospitalClermont Ferrand 63003France Department of Hepatology Beaujon University HospitalClichy 92110France Department of Hepatology Saint-AndréUniversity HospitalBordeaux 33000France Department of Hepatology and Gastroenterology La Roche-Sur-Yon Hospital CenterLa Roche-Sur-Yon 85000France Department of Hepatology and Gastroenterology University Hospital of MontpellierMontpellier 34295France Department of Addictology Hospita

BACKGROUND The recommended monitoring tools for evaluating nucleot(s)ide analogue renal toxicity,such as estimated glomerular filtration rate(eGFR)and phosphatemia,are late markers of proximal *** early markers are available,but no consensus exists on their *** To determine the 24 mo prevalence of subclinical proximal tubulopathy(SPT),as defined with early biomarkers,in treated vs untreated hepatitis B virus(HBV)-monoinfected *** A prospective,non-randomized,multicenter study of HBV-monoinfected patients with a low number of renal comorbidities was *** patients were separated into three groups:Naïve,starting entecavir(ETV)treatment,or starting tenofovir disoproxil(TDF)*** on the early markers of SPT,the eGFR and phosphatemia,were collected *** was defined as a maximal tubular reabsorption of phosphate/eGFR below 0.8 mmoL/L and/or uric acid fractional excretion above 10%.The prevalence and cumulative incidence of SPT at month 24(M24)were *** data were analyzed using analyses of variance or Kruskal-Wallis tests,whereas chi-squared or Fisher’s exact tests were used to analyze qualitative *** analyses were used to adjust for any potential confounding *** Of the 196 patients analyzed,138(84 naïve,28 starting ETV,and 26 starting TDF)had no SPT at *** M24,the prevalence of SPT was not statistically different between naïve and either treated group(21.1%vs 30.7%,P<0.42 and 50.0%vs 30.7%,P=0.32 for ETV and TDF,respectively);no patient had an eGFR lower than 50 mL/min/1.73 m²or phosphatemia less than 0.48 mmoL/*** the multivariate analysis,no explanatory variables were identified after *** cumulative incidence of SPT over 24 mo(25.5%,13.3%,and 52.9%in the naïve,ETV,and TDF groups,respectively)tended to be higher in the TDF group vs the naïve group(hazard ratio:2.283,P=0.05).SPT-free survival at M24 was 57.6%,68.8%,and 23.5%for the naïve,ETV,and TD

关键词： Hepatitis B virus Proximal tubulopathy Biomarkers Renal insufficiency Nucleoside analogues

Contribution of Automated Antigen Tests, the LumiraDx Ag Test in the Response during the Second Wave of the COVID-19 Pandemic in Bangui

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Journal of Tuberculosis Research 2023年第4期11卷 173-183页

作者： Clotaire Donatien Rafaï Pierre Somse Wilfrid Sylvain Nambei Ernest Lango-Yaya marie-Roseline Darnycka Belizaire Ulrich Vickos Narcisse Patrice Komas Oscar Senzongo Luc Salva Heredeibona Ulrich Jeffrey Kotemossoua Rabbi Mermoz Senekian Simon Pounguinza Jephté Estimé Kaleb Kandou Christian-Diamant Mossoro-Kpinde Laurent Bélec jean De Dieu Longo Norbert Richard Ngbale Abdoulaye Sepou François-Xavier Mbopi-Keou Gérard Grésenguet Boniface Koffi National Laboratory of Clinical Biology and Public Health Bangui Central African Republic Faculty of Health Sciences University of Bangui Bangui Central African Republic Ministry of Health and Population Bangui Central African Republic World Health Organization Bangui Central African Republic Institut Pasteur de Bangui Bangui Central African Republic Virology Laboratory Georges Pompidou European Hospital Université Paris Cité Paris France Hôpital Communautaire of Bangui Bangui Central African Republic Faculty of Medicine and Biomedical Sciences University of Yaounde I Yaounde Cameroon

Context and objective: The COVID-19 pandemic has become a major public health problem and has mobilized many innovative means of diagnosis. The Central African Republic is not spared. The emergence of variants and their impact require health monitoring despite the obligation of vaccination. The purpose of this campaign was to determine the circulation of pending second-wave variants. Patients and Methods: A second mass screening campaign took place from 02 to 22 July 2021 in the main land and river entry points of Bangui (Exit North-PK12, Exit South-PK9, Port Beach) and at the LNBCSP. Antigenic and RT-PCR tests carried out on nasopharyngeal samples made it possible to select strains which were finally sequenced. Results: Of 2687 participants included in the study, 53 (1.97%) were positive for SARS-CoV-2. Thirteen (1.53%) were male and 40 (2.18%) female. The analyses carried out on the LumiraDx analyzer were positive for 109 samples against 53 on the RT-PCR. The prevalence was higher in the most tested age groups (30 to 50 years) with two clusters identified. B.1.617.2 (Delta) variants were predominant (57%). Conclusion: SARS-CoV-2 continues to circulate. The acquisition of automated antigenic tests (LumiraDx®) with sensitivity and specificity close to those of the reference test (RT-PCR) will allow better mass diagnosis for an optimization of the surveillance of COVID-19 in our countries with limited resources. The predominance of the B.1.617.2 (Delta) variant would suggest a third wave in the Central African Republic.

关键词： COVID-19 Automated Antigen Testing

Universal switching of plasmonic signals using optical resonator modes

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Light(Science & Applications) 2016年第1期5卷 135-142页

作者： Cillian PT McPolin Nicolas Olivier jean-Sebastien Bouillard Daniel O’Connor Alexey V Krasavin Wayne Dickson Gregory A Wurtz Anatoly V Zayats Department of Physics King’s College LondonStrandLondon WC2R 2LSUK Present address:University of Sheffield Hounsfield RoadSheffield S37RHUK Present address:University of Hull Cottingham RoadHull HU67RXUK Present address:National Physical Laboratory Hampton RoadTeddingtonMiddlesex TW110LWUK University of North Florida 1 UNF DriveJacksonvilleFL 32224USA

We propose and investigate,both experimentally and theoretically,a novel mechanism for switching and modulating plasmonic signals based on a Fano interference process,which arises from the coupling between a narrow-band optical Fabry–Pérot cavity and a surface plasmon polariton(SPP)*** SPP wave emitted from the cavity is actively modulated in the vicinity of the cavity resonances by altering the cavity Q-factor and/or resonant *** experimentally demonstrate dynamic SPP modulation both by mechanical control of the cavity length and all-optically by harnessing the ultrafast nonlinearity of the Au mirrors that form the *** electro-optical modulation scheme is also proposed and numerically *** operation of the switch via mechanical means yields a modulation in the SPP coupling efficiency of~80%,while the all-optical control provides an ultrafast modulation with an efficiency of 30%at a rate of~0.6 *** experimental observations are supported by both analytical and numerical calculations of the mechanical,all-optical and electro-optical modulation methods.

关键词： Fano resonances optical signal processing plasmonics ultrafast switching