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疱疹病毒性脑炎人类遗传免疫缺陷机制研究:Toll样受体3诱导性免疫反应的重要作用

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疱疹病毒性脑炎人类遗传免疫缺陷机制研究:Toll样受体3诱导性免疫...

中华医学会全国第九次感染病学学术会议

作者： Emmanuelle JOUANGUY Laurent ABEL jean-Laurent CASANOVA 张申英张欣欣 Laboratoire de Génétique Humaine des Maladies Infectieuses Université de Paris René Descartes-INSERM U550Faculté de Médecine NeckerParis 75015 France 上海瑞金医院中法基因组与生命科学合作研究中心

I型单纯疱疹病毒(Herpes simplex virus 1,HSV-1)是一个人群广泛易感的病毒,全球约80％的青年人群受HSV-1感染但绝大部分临床表现轻微甚至缺如。疱疹病毒性脑炎(Herpes simplex encephalitis, HSE)是由HSV-1在少数人(发病率约1／250,000...

I型单纯疱疹病毒(Herpes simplex virus 1,HSV-1)是一个人群广泛易感的病毒,全球约80％的青年人群受HSV-1感染但绝大部分临床表现轻微甚至缺如。疱疹病毒性脑炎(Herpes simplex encephalitis, HSE)是由HSV-1在少数人(发病率约1／250,000)所引起的罕见的严重HSV-1感染,在阿昔洛维用于治疗前,HSE病人的死亡率约为70％,且治愈病人大多伴有严重后遗症。

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巴西磷矿泥浆中磷灰石的回收（英文）

武汉工程大学学报 2017年第6期39卷 519-528页

作者： MATIOLO Elves COUTO Hudson jean Bianquini TEIXEIRA Michelle Fernanda de Lira FREITAS Amanda Soaresde ALMEIDA Renata Nigride 矿物工艺学中心(CETEM/MCTIC) 巴西RJ21941-908 Copebras-CMOC公司巴西GO75701-970

巴西磷酸盐工业一工厂的磷灰石的生产流程一般包括:磨矿;粗细粒分级;磁选(弱磁和强磁);脱泥工艺(除去颗粒小于10μm);重晶石浮选和磷灰石浮选。研究了位于巴西戈亚斯州的Copebras工业磷矿厂的泥浆样品中的磷灰石含量,结果显示原矿中含有... 详细信息

巴西磷酸盐工业一工厂的磷灰石的生产流程一般包括:磨矿;粗细粒分级;磁选(弱磁和强磁);脱泥工艺(除去颗粒小于10μm);重晶石浮选和磷灰石浮选。研究了位于巴西戈亚斯州的Copebras工业磷矿厂的泥浆样品中的磷灰石含量,结果显示原矿中含有13.2%P_2O_5;14%CaO;19.7%SiO_2和27.7%Fe_2O_3,相当于含磷灰石(32%),针铁矿(25%),石英(18%),磷钡铝矿(5.2%).颗粒尺寸分布特征表明:特征直径(D_(32),D_(10),D_(50)和D_(90))分别为2.6μm,1.0μm,5.7μm和25μm。考虑水力旋流器(40 mm)将工艺流程分两个阶段进行脱泥,然后通过浮选柱进行磷灰石浮选,得到含有35.6%P_2O_5和主要杂质为Fe_2O_3(4.0%)和SiO_2(5.1%)的精矿,考虑到脱泥和浮选过程的质量平衡,总体回收率约为11%,P2O5回收率为30%.

关键词：磷灰石浮选矿泥浮选柱

Study of Biofilm Formation and Antibiotic Resistance Pattern of Bacteria Isolated from Diabetic Foot Ulcers in Hôpital de Référence Saint Joseph, Kinshasa, Democratic Republic of Congo

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Advances in Microbiology 2021年第5期11卷 283-295页

作者： jean-Marie Liesse Iyamba Victoire Marie Hermine Ngo Bassom Cyprien Mbundu Lukukula Joseph Welo Unya Benjamin Kodondi Ngbandani Grégoire Mbusa Vihembo Nelson Nsiata Ngoma José Mulwahali Wambale Paul Tshilumbu Kantola N. B. Takaisi-Kikuni Laboratory of Experimental and Pharmaceutical Microbiology Faculty of Pharmaceutical Sciences University of Kinshasa Kinshasa Democratic Republic of Congo Centre Universitaire de Référence de Surveillance de la Résistance aux Antimicrobiens Faculty of Pharmaceutical Sciences University of Kinshasa Kinshasa Democratic Republic of Congo Service de Microbiologie H&ocirc pital de Référence Saint Joseph Limete-Kinshasa Democratic Republic of Congo

Foot infections resulting from biofilm producers and multi-drug resistant organisms is one of the most important complications of diabetes mellitus, as it can impede the wound healing process. This study was carried out in order to determine the antibiotic resistance pattern and the biofilm production in diabetic foot ulcers isolates. Clinical samples were collected from patients suffering from diabetic foot ulcers by using sterile swabs. Antibiotic susceptibility test was done using disk diffusion method on Mueller Hinton Agar. Biofilm formation was assessed by Crystal Violet Staining Method. Staphylococcus aureus isolates were resistant to ofloxacin (83.3%), ciprofloxacin (75.0%), trimethoprim-sulphamethoxazole (75.0%), and gentamicin (58.8%) but very sensitive to oxacillin (100.0%) and vancomycin (91.7%). Pseudomonas aeruginosa isolates showed resistance to the commonly used antibiotics such as ofloxacin, cefotaxime, ampicillin (81.8%), ceftazidime and imipenem (72.7%). The majority of bacteria studied were biofilm producers. This study showed that bacteria isolated from diabetic foot ulcers were biofilm producers and presented resistance to commonly used antibiotics. Knowledge on antibiotic sensitivity pattern and biofilm phenotype of the isolates will be helpful in determining the drugs for the treatment of diabetic ulcers.

关键词： Biofilm Formation Antibiotic Resistance Diabetic Foot Ulcers Democratic Republic of Congo

Large Basilar Trunk Aneurysm Discovered Incidentally in a Patient with Ischaemic Stroke: Case Report

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World Journal of Cardiovascular Diseases 2023年第11期13卷 811-817页

作者： Wendlassida Martin Nacanabo Yannick Laurent Tchenadoyo Bayala Abdoul Nassir Porgo Emilie Agathe Carama Bademain jean Fabrice Ido Taryètba André Arthur Seghda Wendlassida Léa Francoise Sawadogo Sidy Mahamoud Guebre Abdoul-Aziz Christian Napon André K. Samadoulougou Cardiology Department Bogodogo University Hospital Ouagadougou Burkina Faso Rheumatology Department Bogodogo University Hospital Ouagadougou Burkina Faso Neurology Department Bogodogo University Hospital Ouagadougou Burkina Faso

Summary: Many anomalies can be observed in the basilar trunk, such as aneurysms. Basilar trunk aneurysms are rare with a low reported prevalence. In this study, we describe a case of ischaemic stroke revealed by a basilar trunk aneurysm associated with venous thromboembolic disease. The patient was 60 years old and had no specific pathological history. She was seen for a sudden onset of right hemiplegia associated with dysarthria that had been present for 12 hours. The physical examination revealed a pyramidal syndrome and an altered general condition. An emergency cerebral computed tomography (CT) scan showed evidence of a cerebrovascular accident associated with a saccular aneurysm. We adopted the diagnosis of a deep left sylvian stroke associated with a superficial right sylvian stroke in the setting of an incidentally discovered basilar trunk aneurysm. On the 9ème day of hospitalisation, the patient experienced sudden onset of respiratory distress in conjunction with a warm, painful swelling of the right leg. TTE revealed signs of pulmonary embolism, with thrombi in the inferior vena cava and right atrium. Pulmonary embolism was highly probable, with a modified Geneva score of 15. We adopted the diagnosis of DVA complicated by pulmonary embolism in the setting of a basilar trunk aneurysm. The patient was transferred to the cardiology department, where she received oxygen therapy and thrombolysis with streptokinase. The immediate outcome 6 hours later was the sudden death of the patient due to the onset of cardiogenic shock.

关键词： Aneurysm Ischemic Stroke Thrombolysis

Storage lesion:History and perspectives

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World Journal of Hematology 2015年第4期4卷 54-68页

作者： Julien Delobel Olivier Garraud Stefano Barelli jean-Jacques Lefrère Michel Prudent Niels Lion jean-Daniel Tissot Transfusion Interrégionale CRS Institut National de Transfusion Sanguine Faculty of Medicine University of Lyon Saint-Etienne

Red blood cell concentrates(RBCCs) are the major labile blood component transfused worldwide to rescue severe anemia symptoms. RBCCs are frequently stored in additive solutions at 4 ℃ for up to 42 d, which induces cellular lesion and alters red blood cell metabolism, protein content, and rheological properties. There exists a hot debate surrounding the impact of storage lesion, with some uncertainty regarding how RBCC age may impact transfusion-related adverse clinical outcomes. Several studies show a tendency for poorer outcomes to occur in patients receiving older blood products; however, no clear significant association has yet been demonstrated. Some age-related RBCC alterations prove reversible, while other changes are irreversible following protein oxidation. It is likely that any irreversible damage affects the blood component quality and thus the transfusion efficiency. The present paper aims to promote a better understanding of the occurrence of red blood cell storage lesion, with particular focus on biochemical changes and microvesiculation, through a discussion of the historical advancement of blood transfusion processes.

关键词： Ageing Blood cells Exosomes Microparticles Microvesicles Proteomics Storage Transfusion

黑曲霉β-葡萄糖苷酶基因在大肠杆菌中的克隆与表达

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安徽医药 2012年第5期16卷 576-578页

作者：李泰明庄舰峰 jean Louis Didier MEKOO 谷春娇邢芸刘景晶中国药科大学天然药物活性物质与功能国家重点实验室江苏南京210009

目的构建糖类标记载体筛选克隆。方法以pPIC9K-βGl2为模板,通过PCR扩增得到全长的Bgl2基因片段,克隆至pET-28a载体,转化*** BL21(DE3),Cel-M9培养基筛选阳性克隆,经DNA测序分析,成功构建pET28a-Bgl2表达载体。SDS-PAGE显示,重组菌经IPT... 详细信息

目的构建糖类标记载体筛选克隆。方法以pPIC9K-βGl2为模板,通过PCR扩增得到全长的Bgl2基因片段,克隆至pET-28a载体,转化*** BL21(DE3),Cel-M9培养基筛选阳性克隆,经DNA测序分析,成功构建pET28a-Bgl2表达载体。SDS-PAGE显示,重组菌经IPTG诱导后表达了目的蛋白,其相对分子质量与预期结果相符。结果 PCR扩增得到Bgl2基因片段,SDS-PAGE显示蛋白以包涵体形式表达,克隆可用Cel-M9培养基筛选。结论用Cel-M9培养基筛选出阳性克隆为构建食品级载体奠定基础。

关键词：黑曲霉 β-葡萄糖苷酶纤维二糖

Perception of Local Populations of Bouba-Ndjidda National Park on Indigenous Knowledge and the Impact of Climate Change on Biodiversity Conservation

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Open Journal of Ecology 2023年第11期13卷 865-881页

作者： Ghislain Noé Kougoum Piebeng Samuel Christian Tsakem Kalgongbe Kiebfiene Tikela Bakwo Fils Eric Moise Simon Awafor Tamungang Michel Babale jean-Pierre Mate Mweru Isaac Diansambu Makanua Bouba Hotta Vincent Zoalang Mala Krossy Mavakala Raoul Sambieni Kouakou Baudouin Michel Department of Biological Sciences Faculty of Science University of Maroua Maroua Cameroon Garoua Wildlife School Garoua Cameroon Department of Forestry and Wildlife Management College of Technology University of Bamenda Bamenda Cameroon Regional Post-Graduate Training School on Integrated Management of Tropical Forests and Lands Kinshasa Democratic Repub-lic of the Congo Faculty of Science University of Kinshasa Kinshasa Democratic Republic of the Congo

This study deals with the perceptions of indigenous knowledge in the field of conservation and the impact of climate change on biodiversity in the peripheral villages of the Bouba-Ndjidda National Park (PNBN), Department of Mayo-Rey, Cameroon. To this end, 23 out of 70 villages in the study area were selected, for a sample of 368 households surveyed through a questionnaire addressed to the heads of households. Data collection took place from August 27 to December 22, 2022. The results reveal that 70.7% of the population living near the PNBN practice agriculture as their main income-generating activity, followed by livestock (23.3%) and trade (6%). Knowledge in the field of the conservation of natural resources is rooted in occultism through rituals and sacrifices (99.50%) offered to the geniuses of nature and prohibitions on the felling of trees and sacred animals (13.00%). The populations perceive climate change through the variation of the seasons (97.60%), the increase in temperature (84.80%), the reduction in the duration of the rainy seasons (54.60%), the drop in agricultural yield (84.80%) and floods (74.70%). The consequence of these changes on wildlife is the disappearance of animal species such as the Rhinoceros, the Wild Dog, the Cheetah and the Ostrich. In order to cope with climate change, the natives have developed strategies such as the adoption of early crop varieties (maize, millet, soybeans, etc.), the reorganization of the agricultural calendar, the practice of reforestation, extension of field surfaces, the cessation of excessive deforestation and uncontrolled bush fires, the construction of fired brick houses, the practice of irrigation, seasonal migration and occultism. This indigenous knowledge is a perfect adaptation to climate change and makes it possible to better take into account the vision of local populations in the conservation of biodiversity.

关键词： Perception Indigenous Knowledge Climate Change Biodiversity Conservation Bouba-Ndjidda National Park

Management of Trauma to the External Genitalia at the Nianankoro-Fomba Hospital in Segou Mali

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Open Journal of Urology 2022年第6期12卷 376-382页

作者： Sory Ibrahim Koné Abdoulaye Kassogué Brehima Samaké Mahamoudou Keita Tidiani Traore Abdoulaye Nouhoum Coulibaly Mamadou Adama Togo Thierno Boubacar Bagayoko Adama Bah Aminata Fofana Alpha Sanogo Damissa Coulibaly Sidi Modibo Doucouré Honoré jean Gabriell Berthé Urology Department The Nianankoro Fomba Hospital Ségou Mali Paediatric Ward The Nianankoro Fomba Hospital Ségou Mali General Surgery Department The Nianankoro Fomba Hospital Ségou Mali Obstetrics and Gynaecology Department The Nianankoro Fomba Hospital Ségou Mali Ophthalmology Department The Nianankoro Fomba Hospital Ségou Mali Forensic Medicine Department The Nianankoro Fomba Hospital Ségou Mali ENT Department The Nianankoro Fomba Hospital Ségou Mali Cardiology Department The Nianankoro Fomba Hospital Ségou Mali Department of General Medicine The Nianankoro Fomba Hospital Ségou Mali Social Security Fund Ségou Mali Department of Urology CHU du Point G Bamako Mali

Trauma to the male genitalia is not very common and mainly affects a young population. There is probably a particular instinct in men to defend their external genitalia;indeed, in the flaccid state, the penis is little exposed, and fairly well protected and its mobility allows it to move with the impact of trauma and thus reduce the vulnating force. Open trauma is rare, as is testicular dislocation, the most common being closed trauma. Testicular trauma is an uncommon accident that affects young people. Trauma is most often caused by road and traffic accidents. Animal bites are rare, as is genital self-mutilation related to a psychiatric disorder. Surgical exploration is the rule except in cases of moderate testicular trauma. Our objective was to report our experience in an emergency context where treatment is poorly codified and to review the literature. We recorded four patients with external genitalia trauma managed in the urology department from April 2013 to March 2022. Our patients were children with open genitalia trauma following a traffic accident, scrotal injuries were encountered in three patients, and additional penile injuries in one patient. All patients were treated surgically. The follow-up was straightforward.

关键词： Trauma Genitalia Open Segou

2008年青海大柴旦MS6.3地震的连续GPS观测记录及其发震构造意义

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2008年青海大柴旦MS6.3地震的连续GPS观测记录及其发震构造意义