检索结果-南通市图书馆

Carbene chemistry for unnatural biosynthesis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2024年第1期67卷 204-207页

作者： Jing Huang jay.d.keasling department of Chemical and Biomolecular Engineering University of CaliforniaBerkeley 94720USA Joint BioEnergy Institute Lawrence Berkeley National LaboratoryEmeryville 94608USA Biological Systems and Engineering division Lawrence Berkeley National LaboratoryBerkeley 94720USA Novo Nordisk Foundation Center for Biosustainability Technical University of DenmarkKongens Lyngby 2800Denmark department of Bioengineering University of CaliforniaBerkeley 94720USA Synthetic Biochemistry Center Institute for Synthetic BiologyShenzhen Institutes for Advanced TechnologiesShenzhen 518055China

Previously,chemists working in synthesis were jealous of biologists since the enzymes found in nature usually exhibited great catalytic properties(e.g.,high catalytic efficiency,excellent selectivity such as substrate selectivity,regioselectivity and stereoselectivity).However,biological systems lack many counterparts of reactions widely used in chemical synthesis.

关键词： synthesis selectivity catalytic

Honey vesicle-like nanoparticles protect aged liver from non-alcoholic steatohepatitis

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2024年第8期14卷 3661-3679页

作者： Baolong Liu Phuong Linh Nguyen Han Yu Xingzhi Li Huiren Wang Tram Gia Bao Nguyen Prakash Kumar Sahoo Meghna Sur jay Reddy Sarah Sillman Stephen d.Kachman Bara Altartouri Guoqing Lu Sathish Kumar Natarajan Mahesh Pattabiraman Jiujiu Yu department of Nutrition and Health Sciences University of Nebraska-LincolnLincolnNE 68583USA Shaanxi Key Laboratory of Molecular Biology for Agriculture College of Animal Science and TechnologyNorthwest A&F UniversityYangling 712100China department of Nutrition Case Western Reserve UniversityClevelandOH 44106USA School of Veterinary Medicine and Biomedical Sciences University of Nebraska-LincolnLincolnNE 68583USA department of Statistics University of Nebraska-LincolnLincolnNE 68583USA Center for Biotechnology University of Nebraska-LincolnLincolnNE 68588USA department of Biology University of Nebraska OmahaOmahaNE 68182USA department of Chemistry University of Nebraska-KearneyKearneyNE 68849USA

Non-alcoholic steatohepatitis(NASH),an advanced form of non-alcoholic fatty liver disease(NAFLd),has emerged as the leading cause of liver failure and related ***,no medication is specifically approved to treat NAFLd or *** we report that oral administration of honey vesiclelike nanoparticles(H-VLNs)to naturally aged mice protects the liver from NASH development.H-VLNs are dominantly taken up by Kupffer cells in the liver and suppress hepatic chronic inflammation and further development of fibrosis and nodule formation in aged *** their reported antiinflammasome function,H-VLNs are found to inhibit the transcriptional activities of C-JUN and nuclear factor-kappa B(NF-κB).MicroRNAs miR5119 and miR5108 and phenolic compound luteolin in H-VLNs are identified in suppressing both the C-JUN and NF-kB ***,oral intake of H-VLNs represents a promising new user-friendly modality to prevent the development of NASH.

关键词： Honey Extracellular vesicles Exosomes Nanoparticles microRNAs Aging Inflammation Non-alcoholic steatohepatitis

Arabinosylation of a Yariv-Precipitable Cell Wall Polymer Impacts Plant Growth as Exemplified by the Arabidopsis Glycosyltransferase Mutant ray1

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Molecular Plant 2013年第4期6卷 1369-1372页

作者： Sascha Gille Vaishali Sharma Edward E.K. Baidoo jay d. keasling Henrik Vibe Scheller Markus Pauly Energy Biosciences Institute University of California Berkeley CA 94720 USA Joint BioEnergy Institute Emeryville CA 94608 USA Physical Biosciences division Lawrence Berkeley National Laboratory Berkeley CA 94720 USA department of Chemical and Biomolecular Engineering Department of Bioengineering University of California Berkeley CA 94720 USA department of Plant and Microbial Biology University of California Berkeley CA 94720 USA

dear Editor, Plant cells are encased by cell walls--rigid yet highly dynamic composite structures, which consist of cellulose, hemicelluloses, pectic polysaccharides, glycoproteins, and the polyphenol lignin （Somerville et al., 2004）. Biosynthesis of the wall polysaccharides is facilitated by donor- and acceptor- substrate-specific glycosyltransferases catalyzing the transfer of the sugar moiety from a nucleotide sugar to form a specific glycosidic linkage. Glycosyltransferases have been grouped into families based on primary structure, one of which is fam- ily GT77 （***/GT77_***）.

关键词： Yariv-Precipitable Exemplified Arabidopsis Glycosyltransferase

Adding Value to Crop Production Systems by Integrating Forage Cover Crop Grazing

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

American Journal of Plant Sciences 2024年第3期15卷 180-192页

作者： Robert B. Mitchell daren d. Redfearn Kenneth P. Vogel Terry J. Klopfenstein Galen Erickson P. Stephen Baenziger Bruce E. Anderson Mary E. drewnoski jay Parsons Steven d. Masterson Marty R. Schmer Virginia L. Jin USdA-ARS Wheat Sorghum and Forage Research Unit University of Nebraska-Lincoln Lincoln NE USA department of Agronomy and Horticulture University of Nebraska-Lincoln Lincoln NE USA department of Animal Science University of Nebraska-Lincoln Lincoln NE USA department of Agricultural Economics University of Nebraska-Lincoln Lincoln NE USA USdA-ARS Agroecosystem Management Research Unit University of Nebraska-Lincoln Lincoln NE USA

In addition to their value as cereal grains, wheat (Triticum aestivum L.) and triticale (× Triticosecale Wittmack) are important cool-season annual forages and cover crops. Yearling steer (Bos taurus) performance was compared in the spring following autumn establishment as for age cover crops after soybean [Glycine max (L.) Merr.] grain harvest. Replicated pastures (0.4 ha) were no-till seeded in three consecutive years into soybean stubble in autumn, fertilized, and grazed the following spring near Ithaca, NE, USA. Each pasture (n = 3) was continuously stocked in spring with four yearling steers (380 ± 38 kg) for 17, 32, and 28 d in 2005, 2006, and 2007, respectively. In 2005, average daily gain (AdG) for steers grazing triticale exceeded the AdG for wheat by 0.31 kghd-1d-1. In 2006, wheat AdG exceeded that for triticale by 0.12 kghd-1d-1. In 2007, steers grazing wheat lost weight, while steers grazing triticale gained 0.20 kghd-1d-1. Based on the 3-year average animal gains valued at $1.32 kg-1, mean net return ($ ha-1 yr-1) was $62.15 for triticale and $22.55 for wheat. Since these grazed cover crops provide ecosystem services in addition to forage, grazing could be viewed as a mechanism for recovering costs and adds additional value to the system. Based on this 3-year grazing trial, triticale was superior to wheat and likely will provide the most stable beef yearling performance across years with variable weather for the western Cornbelt USA.

关键词： Cover crops Soybean Triticale Wheat

A FAIR-compliant parts catalogue for genome engineering and expression control in Saccharomyces cerevisiae

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Synthetic and Systems Biotechnology 2022年第2期7卷 657-663页

作者： Vasil d’Ambrosio Lea G.Hansen Jie Zhang Emil d.Jensen dushica Arsovska Marcos Laloux Tadas Jakociunas Pernille Hjort davide de Lucrezia Serena Marletta jay.d.keasling Michael K.Jensen Novo Nordisk Foundation Center for Biosustainability Technical University of DenmarkKgs.LyngbyDenmark Explora Biotech Srl Italy Joint BioEnergy Institute EmeryvilleCAUSA Biological Systems and Engineering division Lawrence Berkeley National LaboratoryBerkeleyCAUSA department of Chemical and Biomolecular Engineering Department of BioengineeringUniversity of CaliforniaBerkeleyCAUSA Center for Synthetic Biochemistry Institute for Synthetic BiologyShenzhen Institutes of Advanced TechnologiesShenzhenChina

The synthetic biology toolkit for baker’s yeast,Saccharomyces cerevisiae,includes extensive genome engineering toolkits and parts ***,with the increasing complexity of engineering tasks and versatile applications of this model eukaryote,there is a continued interest to expand and diversify the rational engineering capabilities in this chassis by FAIR(findable,accessible,interoperable,and reproducible)*** this study,we designed and characterised 41 synthetic guide RNA sequences to expand the CRISPR-based genome engineering capabilities for easy and efficient replacement of genomically encoded ***,we characterize in high temporal resolution 20 native promoters and 18 terminators using fluorescein and LUdOX CL-X as references for GFP expression and Od600 measurements,***,all data and reported analysis is provided in a publicly accessible jupyter notebook providing a tool for researchers with low-coding skills to further explore the generated data as well as a template for researchers to write their own *** expect the data,parts,and databases associated with this study to support a FAIR-compliant resource for further advancing the engineering of yeasts.

关键词： gRNA Promoter Terminator Yeast Standardization

Biodegradation of alkylates under less agitated aquifer conditions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2013年第8期25卷 1529-1538页

作者： jay J. Cho Makram T. Suidan Albert d. Venosa URS Corporation 7720N 16th St. Ste 100 Phoenix AZ 85020 USA Faculty of Engineering and Architecture American University of Beirut Dean's officeP.O.Box 11-0236 Riad El Solh 1107 2020 Beirut Lebanon US Environmental Protection Agency National Risk Management Research LaboratoryCincinnati OH 45268 USA

The biodegradability of three alkylates （2,3-dimethylpentane, 2,4-dimethylpentane and 2,2,4-trimethylpentane） under less agitated aquifer conditions was investigated in this study. All three alkylates biodegraded completely under these conditions regardless of the presence or absence of ethanol or benzene, toluene, ethylbenzene, and xylenes （BTEX） in the feed. In the presence of ethanol, alkylates degradation was not inhibited by ethanol. However, alkylates degraded more slowly in the presence of BTEX suggesting competitive inhibition to microbial utilization of alkylates. In the sterile controls, alkylates concentrations remained unchanged throughout the experiments.

关键词： biodegradation alkylates inhibition BTEX ethanol

Crohn’s disease:Evidence for involvement of unregulated transcytosis in disease etio-pathogenesis

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2011年第11期17卷 1416-1426页

作者： jay Pravda Inflammatory disease Research Centre PO Box 32632 West Palm BeachFloridaFL 33420United States

Crohn’s disease(Cd)is a chronic inflammatory bowel *** has identified genetic predisposition and environmental factors as key elements in the development of the ***,the precise mechanism that initiates immune activation remains *** pathway for luminal antigenic molecules to enter the sterile lamina propria and activate an immune response is via ***,although tightly regulated by the cell,has the potential for transepithelial transport of bacteria and highly antigenic luminal molecules whose uncontrolled translocation into the lamina propria can be the source of immune *** as a whole,the evidence suggests that unregulated intestinal epithelial transcytosis is involved in the inappropriate presentation of immunogenic luminal macromolecules to the intestinal lamina *** fulfilling the role of an early pre-morbid mechanism that can result in antigenic overload of the lamina propria and initiate an immune response culminating in chronic inflammation characteristic of this *** is the aim of this paper to present evidence implicating enterocyte transcytosis in the early etio-pathogenesis of Cd.

关键词： Crohn’s Transcytosis Endocytosis

Significant methodologic variations in calculating renal function changes following kidney tumor surgery:A quality reporting issue?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Oncology 2015年第5期6卷 89-91页

作者： Ruth d Blum jay d Raman division of Urology Penn State Milton S.Hershey Medical Center

Renal tumor surgery places patients at increased risk for chronic kidney disease(CKd). Accurate quantification of kidney function changes before and after surgery is essential to determine the magnitude of decline attributable to an index procedure. Current literature, however, highlights heterogeneity and inconsistencies in measurement techniques thereby contributing to ambiguity amongst studies. Further efforts are necessary to standardize reporting of kidney function outcomes related to renal surgery.

关键词： Radical nephrectomy Partial nephrectomy Nephroureterectomy Glomerular filtration rate Chronic kidney disease

Comparative susceptibility and immune responses of Asian and European honey bees to the American foulbrood pathogen, Paenibacillus larvae

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Insect Science 2019年第5期26卷 831-842页

作者： Sasiprapa Krongdang jay d.Evans Yanping Chen Wannapha Mookhploy Panuwan Chantawannakul 1Bee Protection Laboratory Department of BiologyFaculty of ScienceChiang Mai UniversityChiang MaiThailand Interdisciplinary Program in Biotechnology Graduate SchoolChiang Mai UniversityChiang MaiThailand USdA-ARS Bee Research LaboratoryBeltsvilleMarylandUSA Environmental Science Research Center Faculty of ScienceChiang Mai UniversityChiang MaiThailand

American foulbrood (AFB) disease is caused by Paenibacillus larvae. Currently, this pathogen is widespread in the European honey bee— Apis mellifera. However, little is known about infectivity and pathogenicity of P. lan'ae in the Asiatic cavity-nesting honey bees, Apis cerana. Moreover, comparative knowledge of P. larvae infectivity and pathogenicity between both honey bee species is scarce. In this study, we examined susceptibility, larval mortality, survival rate and expression of genes encoding antimicrobial peptides (AMPs) including defensin, apidaecin, abaecin, and hymenoptaecin in A. mellifera and A. cerana when infected with P. larvae. Our results showed similar effects of P. larvae on the survival rate and patterns of AMP gene expression in both honey bee species when bee larvae are infected with spores at the median lethal concentration (LC5 0 ) for A. mellifera. All AMPs of infected bee larvae showed significant upregulation compared with noninfected bee larvae in both honey bee species. However, larvae of A. cerana were more susceptible than A. mellifera when the same larval ages and spore concentration of P. larvae were used. It also appears that A. cerana showed higher levels of AMP expression than A. mellifera. This research provides the first evidence of survival rate, LC50 and immune response profiles of Asian honey bees, A. cerana, when infected by P. larvae in comparison with the European honey bee, A. mellifera.

关键词： Apis cerana Apis mellifera honey bee immune gene Paenibacillus larvae susceptibility