检索结果-南通市图书馆

Chinese Physics B 2018年第4期27卷 214-227页

作者： jay prakash Singh Binoy Krishna Roy Zhouchao Wei Department of Electrical Engineering National Institute of Technology Silchar Silchar 788010 India School of Mathematics and Physics China University of Geosciences Wuhan 430074 China

This paper presents a new four-dimensional（4 D） autonomous chaotic system which has first Lyapunov exponent of about 22 and is comparatively larger than many existing three-dimensional（3 D） and 4 D chaotic *** proposed system exhibits hyperbolic curve and circular paraboloid types of *** system has all zero eigenvalues for a particular case of an equilibrium *** system has various dynamical behaviors like hyperchaotic,chaotic,periodic,and *** system also exhibits coexistence of *** behavior of the new system is validated using circuit *** an interesting switching synchronization phenomenon is proposed for the new chaotic *** adaptive global integral sliding mode control is designed for the switching synchronization of the proposed *** the switching synchronization,the synchronization is shown for the switching chaotic,stable,periodic,and hybrid synchronization *** of the controller designed in the paper is compared with an existing controller.

关键词： new hyperchaotic system maximum chaos an infinite number of equilibria hidden attractors switching synchronization global sliding mode control

An improvised in vitro vegetative propagation technique for Bambusa tulda： influence of season, sterilization and hormones

在线全文

学校读者我要写书评

暂无评论

Journal of Forestry Research 2018年第4期29卷 1059-1064页

作者： Deepti Bhadrawale jay prakash Mishra Yogeshwar Mishra Tropical Forest Research Institute P.O.-R.F.R.C. Mandla Road Jabalpur Madhya Pradesh 482021 India

Season and concentration of sterilizing agents play a significant role for establishment of aseptic in vitro shoot cultures and sprouting of nodal explants from field growing culms of bamboo species. In the present investigation the nodal segment explants of Bambusa tulda Roxb collected in different seasons and treated with various concentrations of HgC12 showed significant variation in aseptic culture establishment and bud break. The rainy season （July-August） recorded with highest of 78% aseptic culture establishment whereas autumn recorded with lowest 46%. Summer and winter seasons emerged to be the best period, registering 〉 60% in vitro bud break. On the other hand, the autumn season had the lowest value for bud break, i.e. 42%. Among different doses of sterilizing agent tried, HgC12 0.1% found to be suitable for maximum aseptic culture establishment （66%） as well as bud break （59%）. However, among the interactions, summer season and the dose of 0.1% HgC12 exhibited maximum of 73% response for both aseptic culture establishment and bud break. MS medium （liquid） enriched with 5.0 μM BA ＋5.0 μM Kn [Kinetin （N6-Furfuryladenine）] with additional supplementation of 100 μM glutamine ＋ 0.1 μM IAA supported a maximum in vitro shoot multiplication of 4.75 fold. The proliferated shoots were successfully rooted on MS medium （liquid） supplemented 40 μM coumarin. The plantlets transferred to the polythene bags showed 98% survival.

关键词： Aseptic culture Bambusa tulda Roxb Bud sprouting Season

Exposure to Electromagnetic Fields from Mobile Phones and Fructose consumption Coalesce to Perturb Metabolic Regulators AMPK/SIRT1-UCP2/FOXO1 in Growing Rats

在线全文

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2023年第11期36卷 1045-1058页

作者： Ruchi Tripathi Sanjay Kumar Banerjee jay prakash Nirala Rajani Mathur Department of Pharmacology Delhi Institute of Pharmaceutical Sciences & ResearchDelhi Pharmaceutical Sciences and Research University(DPSR-U))New DelhiINDIA Drug Discovery Research Centre Translational Health Science and Technology InstituteFaridabadINDIA Department of Biotechnology National Institute of Pharmaceutical Education and ResearchGuwahatiINDIA School of Environmental Sciences Jawaharlal Nehru UniversityNew DelhiINDIA

Objective In this study,the combined effect of two stressors,namely,electromagnetic fields(EMFs)from mobile phones and fructose consumption,on hypothalamic and hepatic master metabolic regulators of the AMPK/SIRT1-UCP2/FOXO1 pathway were elucidated to delineate the underlying molecular mechanisms of insulin *** Weaned Wistar rats(28 days old)were divided into 4 groups:Normal,Exposure Only(ExpO),Fructose Only(FruO),and Exposure and Fructose(EF).Each group was provided standard laboratory chow ad libitum for 8 ***,the control groups,namely,the Normal and FruO groups,had unrestricted access to drinking water and fructose solution(15%),***,the respective treatment groups,namely,the ExpO and EF groups,received EMF exposure(1,760 MHz,2 h/day x 8 weeks).In early adulthood,mitochondrial function,insulin receptor signaling,and oxidative stress signals in hypothalamic and hepatic tissues were assessed using western blotting and biochemical *** In the hypothalamic tissue of EF,SIRT1,FOXO 1,p-PI3K,p-AKT,ComplexⅢ,UCP2,MnSOD,and catalase expressions and OXPHOS and GSH activities were significantly decreased(P<0.05)compared to the Normal,ExpO,and FruO *** hepatic tissue of EF,the p-AMPKα,SIRT1,FOXO1,IRS1,p-PI3K,ComplexⅠ,Ⅱ,Ⅲ,Ⅳ,Ⅴ,UCP2,and MnSOD expressions and the activity of OXPHOS,SOD,catalase,and GSH were significantly reduced compared to the Normal group(P<0.05).Conclusion The findings suggest that the combination of EMF exposure and fructose consumption during childhood and adolescence in Wistar rats disrupts the closely interlinked and multi-regulated crosstalk of insulin receptor signals,mitochondrial OXPHOS,and the antioxidant defense system in the hypothalamus and liver.

关键词： EMF-mobile phone Fructose Childhood-adolescence Insulin receptor signal Mitochondrial OxPHOS Antioxidant system Hypothalamic insulin resistance Hepatic insulin resistance

Synergistic effect of Mucuna pruriens and Withania somnifera in a paraquat induced Parkinsonian mouse model

在线全文

学校读者我要写书评

暂无评论

Advances in Bioscience and Biotechnology 2013年第11期4卷 1-9页

作者： jay prakash Satyndra Kumar Yadav Shikha Chouhan Satya prakash Surya Pratap Singh 1Department of Biochemistry Faculty of Science Banaras Hindu University Varanasi India Biomedical Technology and Cell Therapy Research Laboratory Department of Biomedical Engineering Faculty of Medicine McGill University Montreal Canada Department of Biochemistry Faculty of Science Banaras Hindu University Varanasi India

Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the development of rigidity, resting tremors and postural instability. Recently, the focus of PD’s treatment has shifted towards herbal medicines. Mucuna pruriens (Mp) and Withania somnifera (Ws) are traditional herbal medicines known to have neuro-protective effects due to the L-DOPA present in Mp seed powder and withanoloides present in Ws root extract. Here, the synergistic effect of Mp and Ws in Parkinsonian mice induced by chronic exposure to paraquat was evaluated. Co-treatment with Mp and Ws for 9 weeks, significantly decreased the elevated nitrite levels and lipid peroxidation found in Parkinsonian mice. In behavioural tests, Mp and Ws treated mice showed a significant decrease in the time taken to cross a narrow beam, an increase in the time of stay on drum in rotarod test and an improvement in the hanging time. Furthermore, it was found that the use of Mp and Ws considerably improved the tyrosine hydroxylase expression in the substantianigra region of the brain. The results suggest that Mp and Ws may provide a platform for future drug discoveries and novel treatment strategies for PD.

关键词： Withinia somnifera Mucuna pruriens Oxidative Stress Tyrosine Hydroxylase Parkinson’s Disease Substantia nigra Motor Dysfunctions

Primary malignant melanoma of the spinal cord:a case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Cancer Metastasis and Treatment 2016年第1期2卷 144-146页

作者： Ashutosh Das Sharma Jyoti Poddar Ubrangala Suryanarayan Kunikullaya jay prakash Neema Department of Radiotherapy Gujarat Cancer and Research InstituteAsarwa 380016AhmedabadIndia

Primary malignant melanoma of the central nervous system is rare,and the events involving the spinal cord are even more infrequent.A 30-year-old male presented with a mass lesion of the spinal *** radiological workup,the mass was resected in December *** histopathological examination report and immunohistochemistry suggested malignant ***-CT scan,brain MRI,and funduscopic examination did not reveal malignant melanoma elsewhere in the *** patient received postoperative radiotherapy until March ***,the patient is asymptomatic with normal neurological functions.

关键词： Malignant melanoma cervical spine spinal cord intramedullary central nervous system

Honey vesicle-like nanoparticles protect aged liver from non-alcoholic steatohepatitis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2024年第8期14卷 3661-3679页

作者： Baolong Liu Phuong Linh Nguyen Han Yu Xingzhi Li Huiren Wang Tram Gia Bao Nguyen prakash Kumar Sahoo Meghna Sur jay Reddy Sarah Sillman Stephen D.Kachman Bara Altartouri Guoqing Lu Sathish Kumar Natarajan Mahesh Pattabiraman Jiujiu Yu Department of Nutrition and Health Sciences University of Nebraska-LincolnLincolnNE 68583USA Shaanxi Key Laboratory of Molecular Biology for Agriculture College of Animal Science and TechnologyNorthwest A&F UniversityYangling 712100China Department of Nutrition Case Western Reserve UniversityClevelandOH 44106USA School of Veterinary Medicine and Biomedical Sciences University of Nebraska-LincolnLincolnNE 68583USA Department of Statistics University of Nebraska-LincolnLincolnNE 68583USA Center for Biotechnology University of Nebraska-LincolnLincolnNE 68588USA Department of Biology University of Nebraska OmahaOmahaNE 68182USA Department of Chemistry University of Nebraska-KearneyKearneyNE 68849USA

Non-alcoholic steatohepatitis(NASH),an advanced form of non-alcoholic fatty liver disease(NAFLD),has emerged as the leading cause of liver failure and related ***,no medication is specifically approved to treat NAFLD or *** we report that oral administration of honey vesiclelike nanoparticles(H-VLNs)to naturally aged mice protects the liver from NASH development.H-VLNs are dominantly taken up by Kupffer cells in the liver and suppress hepatic chronic inflammation and further development of fibrosis and nodule formation in aged *** their reported antiinflammasome function,H-VLNs are found to inhibit the transcriptional activities of C-JUN and nuclear factor-kappa B(NF-κB).MicroRNAs miR5119 and miR5108 and phenolic compound luteolin in H-VLNs are identified in suppressing both the C-JUN and NF-kB ***,oral intake of H-VLNs represents a promising new user-friendly modality to prevent the development of NASH.

关键词： Honey Extracellular vesicles Exosomes Nanoparticles microRNAs Aging Inflammation Non-alcoholic steatohepatitis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

电针联合二甲双胍对创伤性脑损伤的治疗作用

解剖科学进展 2023年第4期29卷 348-350,358页

作者：李怡萱李波唐旭东 jay prakash PRASAD KUMAL 许凤燕孙亮吴树亮哈尔滨医科大学基础医学院人体解剖学教研室黑龙江哈尔滨150081 黑龙江中医药大学附属三院黑龙江哈尔滨150040

目的探讨二甲双胍与电针对创伤性脑损伤(TBI)的治疗作用。方法以C57BL/6小鼠为研究对象,分为对照组(Control),TBI组,TBI+E(Electroacupuncture,E)组,TBI+M(Metformin,M)组和TBI+E+M组。对照组仅摘除颅骨,TBI组实施重物坠落法造成脑损伤,TBI+E组在损伤后第二天以电针治疗,TBI+M组在损伤后第二天以二甲双胍治疗,TBI+E+M组在损伤后第二天以电针和二甲双胍联合治疗。在TBI后7d,通过新物体识别试验检测认知功能,通过组织病理学实验检测组织缺损、小胶质细胞的募集活化和髓鞘再生。结果TBI+E+M组小鼠认知功能恢复明显强于TBI组,TBI组出现组织缺损、皮层空洞;TBI+E组、TBI+M组和TBI+E+M组小胶质细胞数目均出现降低,TBI+E+M组恢复到对照组水平,小胶质细胞的募集活化受到明显抑制;TBI+E+M组髓鞘含量明显多于TBI+E组和TBI+M组,髓鞘再生能力明显增强。结论二甲双胍联合电针治疗脑损伤改善小鼠认知功能障碍,抑制小胶质细胞的募集活化和促进髓鞘再生。

关键词：脑损伤二甲双胍电针髓鞘再生小胶质细胞 C57BL/6小鼠

Tetrahydro-dibenzo[a,d]Annulene-5,11-Dihydrazone and Magnesium Oxide Used to Control the Corrosion of Aluminium in Chloride Ions Environment

在线全文

学校读者我要写书评

暂无评论

Journal of Metallic Material Research 2020年第2期3卷 47-53页

作者： Rajesh Kumar Singh jay prakash Singh Dharmendar Kumar Department of Chemistry Jagdam CollegeJ P UniversityChapra841301India

Chloride ions interact with aluminium in marine atmosphere to form corrosion *** to this corrosion reaction occurs on their surface,aluminium is oxidized into Al3+.The corrosion reaction accelerates deterioration in metal and it produces galvanic,pitting,stress,crevice,intergranular *** ions decrease internal and external strength of aluminium *** is a very important metal so used in different appliances for ***,water,air transports,housing,railways and other *** and electrospray techniques used to check the corrosion of aluminium *** nanocoating and electrospray materials applied tetrahydro-dibenzo[a,d][7]annulene-5,11-dihydrazone and *** materials formed composite barrier and developed a passive surface for *** barrier reduced the corrosion rate of *** spray and chemical vapour deposition technique used for coating *** corrosion rate of metal was determined by gravimetric *** potential and current density were calculated by *** composite barrier formation was confirmed by activation energy,heat of adsorption,free energy,enthalpy and *** thermal parameters were obtained by Arrhenius equation,Langmuir isotherm and Transition state *** adsorption of tetrahydro-dibenzo[a,d][7]annulene-5,11-dihydrazone and MgO electrospray on aluminium surface was depicted by Langmuir,Frundlich and Temkin *** results of surface coverage area and coating efficiency were noticed that both materials were mitigated the corrosion rate of aluminium in chloride ions environment.

关键词： Chloride ions Aluminium Corrosion Electrospray Thermal parameters Marine environment

坐骨神经预损伤对脊髓损伤后小鼠神经功能恢复的影响

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

解剖科学进展 2019年第5期25卷 552-555页

作者：毛东升李怡萱许凤燕唐旭东 jay prakash PRASAD KUMAL 吴迪孙亮吴树亮哈尔滨医科大学基础医学院人体解剖学教研室

目的研究坐骨神经预损伤对脊髓损伤后小鼠神经功能恢复的影响。方法以C57BL/6小鼠为研究对象,分为假手术组(对照组,Control),脊髓损伤(spinal cord injury, SCI)组和坐骨神经预损伤(sciatic nerve injury,SNI)组。假手术组仅移除小鼠T8-... 详细信息

目的研究坐骨神经预损伤对脊髓损伤后小鼠神经功能恢复的影响。方法以C57BL/6小鼠为研究对象,分为假手术组(对照组,Control),脊髓损伤(spinal cord injury, SCI)组和坐骨神经预损伤(sciatic nerve injury,SNI)组。假手术组仅移除小鼠T8-T10椎骨上棘暴露胸髓,SCI组移除小鼠T8-T10椎骨上棘暴露胸髓给予外力打击造成标准损伤,SNI组小鼠手术切断右腿坐骨神经,在预损伤7d后进行脊髓损伤。在恢复期(即脊髓损伤14d后),通过电生理实验检测运动神经传导功能,通过组织病理学检验检测组织缺损恢复、髓鞘再生及小胶质细胞的募集活化。结果电生理实验表明SNI组小鼠运动传导功能恢复明显强于SCI组;HE染色结果说明SNI组脊髓组织缺损恢复情况明显强于SNI组;以MBP为指标的免疫荧光结果显示SNI组髓鞘含量明显多于SCI组,髓鞘再生能力明显增强;以IBA-1为指标的免疫荧光结果显示SNI组小胶质细胞明显增多,坐骨神经预损伤明显增强了小胶质细胞的募集活化作用。结论坐骨神经预损伤处理可促进小鼠脊髓损伤后组织形态恢复、小胶质募集活化作用、髓鞘再生作用和神经传导功能的恢复。

关键词：脊髓损伤坐骨神经预损伤髓鞘再生

A Prospective, Multicentric, Post Marketing Surveillance to Evaluate Efficacy & Safety of Ranitidine HCl (150 & 300 mg IR/CR) in Indian Patients with Gastroesophageal Reflux Disease (PROGRADE)

在线全文

学校读者我要写书评

暂无评论

Open Journal of Gastroenterology 2023年第7期13卷 237-249页

作者： Akash Shukla Anil Kumar Awasthi Ramesh Rao Dawesh prakash Yadav Nilesh Nolkha Rajesh Pendlimari Sanjiv Dua Shrish Bhatnagar Ravindra Mote Ashish Birla jay Savai Kapil Mehta Shashank Salunke Department of Gastroenterology Gastro Universe Mumbai India Department of Medicine Ajanta Research Centre Ajanta Hospital & IVF Centre Lucknow India Departmentof Nephrology Sanjeevani Kidney Care Mumbai India Department of Gastroenterology Institute of Medical Sciences Banaras Hindu University Varanasi India Department of Rheumatology Wockhardt Hospitals Mumbai India Department of Gastroenterology Rajalakshmi Hospital and Research Center Bangalore India Department of General Surgery SaiKripa Hospital Mumbai India Department of Gastroenterology Sparsh Child Care and Gastro Centre Lucknow India Department of Clinical Research Mediclin Clinical Research Mumbai India Department of Medical Affairs JB Chemicals & Pharmaceuticals Ltd. Mumbai India

Purpose: Ranitidine hydrochloride (HCl) remains an important medication for treating acid-peptic ailments such as Gastroesophageal reflux disease (GERD). The main objective of this Post Marketing Surveillance (PMS) clinical study was to test the efficacy and safety of Ranitidine HCl in Indian patients suffering from GERD. Patients and Methods: Data of 2446 patients (1307 males;1121 females) from 21 centers across India were analyzed. Patients received either of the three treatments: Ranitidine HCl 150 mg twice a day (BID) (ARM-A), Ranitidine HCl 300 mg once daily (OD) or BID (ARM-B), and Ranitidine HCl 300 mg OD (ARM-C). Gastroesophageal Reflux Disease Symptom Assessment Scale (GSAS) score and Heartburn Severity score were used to assess the drug’s efficacy. The adverse events reported by patients or investigators were analyzed to assess the safety profile of Ranitidine. Results: Of the 2446 subjects screened, 2428 were enrolled. There was a significant reduction in GSAS scores from baseline to the end of the study visit in all three ARMs. The GSAS scores reduced from 2.02 to 0.23 in ARM-A, 2.01 to 0.24 in ARM-B, and 2.07 to 0.26 in ARM-C patients. In ARM A, 72.82% had 24 hours heartburn-free days, and 66.89% had 7 consecutive heartburn-free days, which was more significant than the other two ARMs. 128 (5.27%) patients reported ADRs due to Ranitidine HCl at different doses. The most frequently reported ADR was constipation (17.18%), followed by oliguria (14.06%), cold (13.28%), and dysuria (12.5%). Of 128 ADRs, 113 (88.28%) were mild, and only 11 (8.59%) ADRs were related to the study drug. No severe ADRs were reported during the study. Conclusion: Ranitidine HCl 150/300 mg tablet was found to be an effective and safe H2-receptor antagonist for treating GERD in Indian Patients.

关键词： Ranitidine Hydrochloride GERD Heartburn H2-Receptor Antagonists