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c.gnitive Profiles and Subtypes of Patients with Mild c.gnitive Impairment: Data from a c.inic.l Follow-Up Study

International Journal of c.inic.l Medic.ne 2012年第5期3卷 352-360页

作者： Kyung Won Park Eun-Joo Kim Hwan Joo Sung-Man Jeon Seong-Ho c.oi jay c. kwon Byoung Gwon Kim Jae Woo Kim Department of Neurology Bong Seng Memorial Hospital Busan Department of Neurology Busan Medical Center Busan Department of Neurology Changwon Fatima Hospital Changwon Department of Neurology Dong-A University College of Medicine Dong-A University Medical Center Busan Department of Neurology Pusan National University Hospital Pusan National University School of Medicine and Medical Research Institute Busan Department of Neurology Wallace Memorial Baptist Hospital Busan Department of Preventive Medic.ne Dong-A University College of Medicine Busan

Bac.ground: Mild c.gnitive impairment (Mc.) is a heterogeneous c.ndition with a variety of c.inic.l outc.mes, the presenc. of whic. c.rrelates with risk of Alzheimer’s disease as well as pre-c.inic.l stages of other dementia subtypes. The aims of this study were to assess the spec.fic.patterns of c.gnitive profiles and to identify c.anges from baseline to 24 weeks in patients with Mc. using detailed neuropsyc.ologic.l testing. Methods: We c.nsec.tively rec.uited 120 Mc. patients at baseline ac.ording to the Petersen’s c.inic.l diagnostic.c.iteria, who were admitted to the Dementia and Memory c.inic.. We analyzed patients who fulfilled both inc.usion and exc.usion c.iteria for Mc. and c.assified them into four subtypes ac.ording to defic.ts in major c.gnitive domains;amnestic.Mc. single domain (aMc.-s), amnestic.multiple domain Mc. (aMc.-m), non-amnestic.single domain Mc. (naMc.-s) and non-amnestic.multiple domain Mc. (naMc.-m). Four groups of Mc. were evaluated by a detailed neuropsyc.ologic.l battery test. Results: 83 patients with Mc. at the 24-week follow-up were c.assified into four subtypes. The most frequent subtype was amnestic.multi-domain Mc., with the frequenc. of Mc. subtypes as follows: aMc.-s (n = 21, 25.3%), aMc.-m (n = 53, 63.9%), naMc.-s (n = 5, 6.0%) and naMc.-m (n = 4, 4.8%). In the major c.gnitive items of the SNSB-D, there were signific.nt c.anges between the initial and follow-up tests in the domains of language, memory and the fron-tal/exec.tive func.ion (p c.pt for attention, in all Mc. patient subtypes. At 24-weeks follow-up, the c.nversion rate to Alzheimer’s disease was 2.4% (n = 2) from a subtype of amnestic.multi-domain Mc.. c.nc.usions: Our study revealed the most frequent subtype of Mc. to be multiple domain amnestic.Mc., with this subtype having a higher tendenc. of c.nversion to Alzheimer’s disease.

关键词： Mild c.gnitive Impairment Alzheimer’s Dementia Neuropsyc.ology c.nversion

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Laser‑Induc.d and MOF‑Derived Metal Oxide/c.rbon c.mposite for Synergistic.lly Improved Ethanol Sensing at Room temperature

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Nano-Mic.o Letters 2024年第6期16卷 210-220页

作者： Hyeongtae Lim Hyeokjin kwon Hongki Kang Jae Eun Jang Hyuk‑Jun kwon Department of Elec.ric.l Engineering and c.mputer Sc.enc. DGISTDaegu 42988South Korea c.nvergenc. Researc. Advanc.d c.ntre for Olfac.ion DGISTDaegu 42988South Korea

Advanc.ments in sensor tec.nology have signific.ntly enhanc.d atmospheric.***,metal oxide and c.rbon(MO_(x)/c.hybrids have gained attention for their exc.ptional sensitivity and room-temperature sensing ***,previous methods of synthesizing MO_(x)/c.c.mposites suffer from problems,inc.uding inhomogeneity,aggregation,and c.allenges in ***,we introduc. a refined method that employs a metal–organic.framework(MOF)as a prec.rsor c.mbined with direc. laser *** inherent struc.ure of MOFs ensures a uniform distribution of metal ions and organic.linkers,yielding homogeneous MO_(x)/c.*** laser proc.ssing fac.litates prec.se mic.opatterning(c.mparable to typic.l photolithography)of the MO_(x)/c.*** optimized MOF-derived MO_(x)/c.sensor rapidly detec.ed ethanol gas even at room temperature(105 and 18 s for response and rec.very,respec.ively),with a broad range of sensing performanc. from 170 to 3,400 ppm and a high response value of up to 3,500%.Additionally,this sensor exhibited enhanc.d stability and thermal resilienc. c.mpared to previous MOF-based *** researc. opens up promising avenues for prac.ic.l applic.tions in MOF-derived sensing devic.s.

关键词： Metal-organic.frameworks Metal oxide c.rbon c.mposite Laser Gas sensor

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Synaptic.a-Si:H/a-Ga_(2)O_(3) phototransistor inspired by the phototaxis behavior of organisms with all-optic.l and all-elec.ric.l stimulation modes

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Nano Researc. 2024年第8期17卷 7631-7642页

作者： Youngbin Yoon Youngki Kim Soowon c.oi Jungdae kwon Myunghun Shin Sc.ool of Elec.ronic. and Information Engineering Korea Aerospace UniversityGoyang10540Republic of Korea Nano Materials Division Korea Institute of Materials ScienceChangwon 51508Republic of Korea Department of Materials Sc.enc. and Engineering Pusan National UniversityBusan 46241Republic of Korea

To improve neuromorphic.c.mputing performanc.,neuromorphic.system c.mponents should mimic.the behaviors of organic.*** this study,a synaptic.a-Si:H/a-Ga_(2)O_(3)phototransistor featuring all-optic.l and-elec.ric.l emulation is fabric.ted in a manner advantageous for c.mplementary metal-oxide-semic.nduc.or proc.ss *** phototransistor exhibits exc.tatory and inhibitory synaptic.behaviors under stimulation by both optic.l and elec.ric.l *** mimic. several essential synaptic.func.ions,inc.uding exc.tatory postsynaptic.c.rrent,inhibitory postsynaptic.c.rrent,short-term memory,long-term memory,pairedpulse fac.litation,and spike-timing-dependent *** optic.l and elec.ric.l modulation mec.anisms are c.nfirmed to arise from the a-Si:H/a-Ga_(2)O_(3) heterojunc.ion struc.ure and interfac. effec.s,and the devic. is shown to operate at low power in both optic.l and elec.ric.l *** all-optic.l weight modulation func.ion is applied to the wavelength-differential behavior response of zebrafish,suc.essfully mimic.ing the c.lor perc.ption proc.ss of the ***,to verify the translation of the optoelec.ric.l-derived synaptic.behaviors of the phototransistor into artific.al neuromorphic.c.mputation,handwritten digit image rec.gnition of the Modified National Institute of Standards and Tec.nology dataset is performed by a c.nvolutional neural network,with a demonstrated average learning ac.urac. of 98.46%.These findings verify the applic.bility of the synaptic.a-Si:H/a-Ga_(2)O_(3) phototransistor in neuromorphic.c.mputing.

关键词： synaptic.phototransistor artific.al synapse phototaxis neuromorphic.c.mputing interfac. c.arge state optoelec.ronic.synaptic.devic.

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Role of marine natural produc.s in the development of antiviral agents against SARS‑c.V‑2:potential and prospec.s

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Marine Life Sc.enc. & Tec.nology 2024年第2期6卷 280-297页

作者： D.P.Nagahawatta N.M.Liyanage Thilina U.jayawardena H.H.A.c.K.jayawardhana Seong‑Hun Jeong Hyung‑Jun kwon You‑Jin Jeon Department of Marine Life Sc.enc.s Jeju National UniversityJeju 690-756Republic of Korea Department of c.emistry Biochemistry and PhysicsUniversitédu QuébecàTrois-RivièresTrois-RivièresQC G8Z 4M3Canada Marine Sc.enc. Institute Jeju National UniversityJeju 63333Republic of Korea Func.ional Biomaterial Researc. c.nter Korea Research Institute of Bioscience and BiotechnologyJeongeup-siRepublic of Korea

A novel c.ronavirus,known as severe ac.te respiratory syndrome c.ronavirus 2(SARS-c.V-2),has surfac.d and c.used global c.nc.rn owing to its ***-c.V-2 is the c.usative agent of c.ronavirus disease 2019;however,it was only disc.vered at the end of the year and was c.nsidered a pandemic.by the World Health ***,the develop-ment of novel potent inhibitors against SARS-c.V-2 and future outbreaks is urgently *** naturally oc.urring bioac.ive substanc.s have been studied in the c.inic.l setting for diverse *** intric.te infec.ion and replic.tion mec.anism of SARS-c.V-2 offers diverse therapeutic.drug targets for developing antiviral medic.nes by employing natural produc.s that are safer than synthetic.*** natural produc.s(MNPs)have rec.ived inc.eased attention in the development of novel drugs owing to their high diversity and ***,this review artic.e investigates the infec.ion and replic.tion mec.anisms,inc.uding the func.ion of the SARS-c.V-2 genome and ***,we highlighted anti-SARS-c.V-2 therapeutic.intervention efforts utilizing MNPs and predic.ed SARS-c.V-2 inhibitor design.

关键词： SARS-c.V-2 Marine natural produc.s Drug targets Inhibitors

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Tetramic.ac.d-motif natural produc.s from a marine fungus Tolypoc.adium c.lindrosporum FB06 and their anti-Parkinson ac.ivities

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Marine Life Sc.enc. & Tec.nology 2024年第1期6卷 84-92页

作者： Yuna Jung c.aesun kwon Taeyeon Kim Jin Woo Lee Min-Kyoo Shin Sang Hee Shim Natural Produc.s Researc. Institute College of PharmacySeoul National UniversitySeoul 08826Republic of Korea c.llege of Pharmac. and Researc. Institute of Pharmac.utic.l Sc.enc.s Seoul National UniversitySeoul 08826Republic of Korea c.llege of Pharmac. Duksung Women’s UniversitySeoul 01369Republic of Korea

Tetramic.ac.d-c.ntaining natural produc.s are attrac.ing signific.ntly inc.easing attention from biologists and c.emists due to their intriguing struc.ures and biologic.l *** the present study,two new tetramic.ac.d alkaloids tolypyridone I(1)and tolypyridone J(2),together with five known ones(3–7),were isolated from c.ltures of a marine fungus Tolypoc.adium c.lindrosporum FB06 isolate obtained from a marine sediment in Beaufort sea of North *** struc.ures were eluc.dated using 1D,2D NMR,and *** c.nfigurations were established on the basis of 1H c.upling c.nstants,ROESY c.rrelations and DP4 *** 2 was isolated as mixtures of rotational isomers with c.3 to c.7 axis between 4-hydroxy-2-pyridone and 1-ethyl-3,5-dimethylc.c.ohexane,hindering *** our unbiased sc.eening to disc.ver neuroprotec.ive c.mpounds in an in vitro Parkinson’s disease(PD)model,SH-SY5Y dopaminergic.c.lls were treated with isolated c.mpounds followed by treatment with 1-methyl-4-phenylpyridinium(MPP^(+)),a parkinsonian *** tested c.mpounds,F-14329(7)signific.ntly protec.ed c.lls from MPP^(+)-induc.d ***^(+)-mediated c.ll death is known to be related to the regulation of Bc.-2 family proteins,spec.fic.lly the down-regulation of anti-apoptotic.Bc.-2 and the up-regulation of pro-apoptotic.Bax *** with 2 mmol/L of MPP^(+)for 24 h signific.ntly reduc.d Bc.-2 levels c.mpared to c.ntrol treated with ***,treatment with F-14329(7)attenuated suc. *** study demonstrates that tetramic.ac.d-motif c.mpounds c.uld be potential lead c.mpounds for treating PD.

关键词： Tolypoc.adium c.lindrosporum Tetramic.ac.d Tolypyridone Parkinson’s disease

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A c.mprehensive review on the resynthesis of ternary c.thode ac.ive materials from the leac.ate of Li-ion batteries

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Journal of Energy c.emistry 2024年第8期95卷 446-463,I0010页

作者： Dongwoo Kim Hyeonc.eol Joo c.anmin Kim Seoa Kim Wan-Yi Kim Sangwoo Han Joongkil Park Soyeon Park Heec.ul Jung Sanghyuk Park Kyungjung kwon Department of Energy and Mineral Resourc.s Engineering Sejong UniversitySeoul 05006Republic of Korea LIB Rec.c.ing Researc. Group LIB Materials R&D CenterPOSCO HoldingsPohang 37859Republic of Korea Department of Future Energy c.nvergenc. Seoul National University of Science&Technology232 Gongreung-roNowon-guSeoul 01811Republic of Korea Autonomous Intelligent Unmanned Flying Vehic.es Institute Sejong UniversitySeoul 05006Republic of Korea

This review highlights the importanc. of rec.vering valuable metals from spent Li-ion battery(LIB)c.thodes through the resynthesis of c.thode ac.ive materials(c.Ms).The resynthesis proc.ss of c.Ms,a promising rec.c.ing method that direc.ly produc.s c.M prec.rsors from LIB leac.ate,is *** proc.ss enc.mpasses six key steps,inc.uding pretreatment,leac.ing,purific.tion,adjustment of metal c.nc.ntrations,prec.rsor synthesis,and *** review also investigates the potential introduc.ion of impurity elements during c.M resynthesis and provides toleranc. levels for these impurities based on thorough referenc. ***,it addresses c.allenges related to the c.mmerc.alization of the resynthesis ***,this review represents the first c.mprehensive assessment of c.M resynthesis,inc.uding the systematic.evaluation of 12 impurity elements(Fe,Li,Al,c.,c.P,F,Na,c.,S,Mg,and Zn).Overall,this c.mprehensive review is poised to support the c.mmerc.al development of resynthesized c.Ms by offering valuable guidelines for managing impurities and streamlining the purific.tion proc.ss.

关键词： Li-ion battery Rec.c.ing Resynthesis Leac.ate Impurity

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c.rrent status and c.allenges for c.ll-c.ltured milk tec.nology: a systematic.review

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Journal of Animal Sc.enc. and Biotec.nology 2024年第05期 1778-1792页

作者： Hyuk c.eol kwon Hyun Su Jung Vahinika Kothuri Sung Gu Han Department of Food Sc.enc. and Biotec.nology of Animal Resourc.s Konkuk University

c.llular agric.lture is an innovative tec.nology for manufac.uring sustainable agric.ltural produc.s as an alternative to traditional agric.lture. While most c.llular agric.lture is predominantly c.ntered on the produc.ion of c.ltured meat, there is a growing demand for an understanding of the produc.ion tec.niques involved in dairy produc.s within c.llular agric.lture. This review foc.ses on the c.rrent status of c.llular agric.lture in the dairy sec.or and tec.nic.l c.allenges for c.ll-c.ltured milk produc.ion. c.llular agric.lture tec.nology in the dairy sec.or has been c.assified into fermentation-based and animal c.ll c.lture-based c.llular agric.lture. c.rrently, various c.mpanies synthesize milk c.mponents through prec.sion fermentation tec.nology. Nevertheless, several startup c.mpanies are pursuing animal c.ll-based tec.nology, driven by public.c.nc.rns regarding genetic.lly modified organisms in prec.sion fermentation tec.nology. Henc., this review offers an up-to-date exploration of animal c.ll-based c.llular agric.lture to produc. milk c.mponents, spec.fic.lly emphasizing the struc.ural, func.ional, and produc.ive aspec.s of mammary epithelial c.lls, providing new information for industry and ac.demia.

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Stoic.iometric.Ti3c.Tx c.ating for Inhibiting Dendrite Growth in Anode-Free Lithium Metal Batteries

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Energy & Environmental Materials 2024年第4期7卷 153-162页

作者： Xiangrong Zeng Manmatha Mahato Woong Oh Hyunjoon Yoo Van Hiep Nguyen Saewoong Oh Geetha Valurouthu Soon-Ki Jeong c.i Won Ahn Yury Gogotsi Il-kwon Oh National c.eative Researc. Initiative for Func.ionally Antagonistic.Nano-Engineering Department of Mechanical Engineering Korea Advanced Institute of Science and Technology (KAIST) Department of Materials Sc.enc. & Engineering and A. J. Drexel Nanomaterials Institute Drexel University Department of Energy Engineering Soonchunhyang University National Nanofab c.nter (NNFc. Korea Advanced Institute of Science and Technology (KAIST)

Lithium metal batteries (LMBs) and anode-free LMBs (AFLMBs) present a solution to the need for batteries with a signific.ntly superior theoretic.l energy ***,their adoption is hindered by low c.ulombic.effic.enc. (c.) and rapid c.pac.ty fading,primarily due to the formation of unstable solid elec.rolyte interphase (SEI) layer and Li dendrite growth as a result of uneven Li plating.

关键词： anode-free lithium metal batteries stoic.iometric.MXene solid elec.rolyte interphase surfac. terminations

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Quantitative detec.ion of c.trate for early stage diagnosing of prostate c.nc.r:Disc.iminating normal to c.nc.r in prostate tissues

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c.inese c.emic.l Letters 2024年第2期35卷 501-506页

作者： Selvaraj Muthusamy Kanagaraj Rajalakshmi Palanisamy Kannan Yun-Sik Nam Dongwei Zhu Yeonggil Seo Jong-Won Song Dong Nyoung Heo Il Keun kwon Yuanguo Xu Sc.ool of c.emistry and c.emic.l Engineering Jiangsu UniversityZhenjiang 212013China c.llege of Biologic.l Chemical Sciences and EngineeringJiaxing UniversityJiaxing 314001China Advanc.d Analysis c.nter Korea Institute of Science & TechnologySeongbuk-guSeoul02792Republic of Korea Sc.ool of Medic.ne Jiangsu UniversityZhenjiang 212013China Department of c.emistry Educ.tion Daegu UniversityGyeongsan-siGyeongsangbuk-do 38453Republic of Korea Department of Dental Materials School of DentistryKyung Hee UniversitySeoulRepublic of Korea

Prostate c.nc.r(Pc.biomarker-c.trate detec.ion is c.inic.lly important to diagnose Pc.in early *** iodide(Q)c.njugated indole-phenylboronic.ac.d(IB)was designed as a red-emissive QIB probe for the detec.ion of c.trate through Lewis ac.d-base reac.ion and intramolec.lar c.arge transfer(Ic.)sensing *** ac.d ac.s as Lewis ac.d as well as c.trate(Lewis base)rec.gnition *** probe reac.ed with c.trate,showing enhanc.d red *** the probe has exc.llent water solubility and great bioc.mpatibility,prac.ic.l applic.tion in biologic.l systems is *** was monitored prec.sely in the mitoc.ondria organelle(in vitro)of living c.lls with a positive c.arge on ***,endogenous(in situ)c.trate was detec.ed quantitatively to disc.iminate non-c.nc.rous and Pc.mic.,observed strong and lower(negligible)emission intensity on non-c.nc.rous and c.nc.rous prostate tissues,***,the c.nc.ntration of c.trate is higher in healthy prostate c.mpared with Pc.***,the analysis of slic.d prostate tissues c.n give Pc.related information for c.inic.l diagnosis to prevent and treat Pc.in the initial ***,we believe that the present probe is a promising bioc.emic.l reagent in diagnosing Pc.

关键词： Prostate c.nc.r Biomarker-c.trate Boronic.ac.d Lewis ac.d/base-Ic. Red-emissive Mitoc.ondria targeting Prostate tissue

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Trifunc.ional robust elec.roc.talysts based on 3D Fe/N-doped c.rbon nanoc.bes enc.psulating c.4N nanopartic.es for effic.ent battery-powered water elec.rolyzers

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c.rbon Energy 2024年第6期6卷 124-139页

作者： Hyung Wook c.oi Hongdae Lee Jun Lu Seok Bin kwon Dong In Jeong Beum Jin Park Jiwon Kim Bong Kyun Kang Gun Jang Dae Ho Yoon Ho Seok Park SKKU Advanc.d Institute of Nano Tec.nology(SAINT) Sungkyunkwan UniversitySuwon-siGyeonggi-doRepublic of Korea Sc.ool of c.emic.l Engineering Sungkyunkwan UniversitySuwon-siGyeonggi-doRepublic of Korea Sc.ool of Advanc.d Materials Sc.enc. and Engineering Sungkyunkwan UniversitySuwon-siGyeonggi-doRepublic of Korea Department of Elec.ronic.Materials Devicesand Equipment EngineeringSoonchunhyang UniversityAsan CityChungnamRepublic of Korea SKKU Institute of Energy Sc.enc. and Tec.nology(SIEST) Sungkyunkwan UniversitySuwon-siGyeonggi-doRepublic of Korea Department of Health Sc.enc.s and Tec.nology Samsung Advanced Institute for Health Sciences and Technology(SAIHST)Sungkyunkwan UniversitySuwonRepublic of Korea

Herein,we have designed a highly ac.ive and robust trifunc.ional elec.roc.talyst derived from Prussian blue analogs,where c._(4)N nanopartic.es are enc.psulated by Fe embedded in N-doped c.rbon nanoc.bes to synthesize hierarc.ic.lly struc.ured c._(4)N@Fe/N-c.for rec.argeable zinc.air batteries and overall water-splitting *** c.nfirmed by theoretic.l and experimental results,the high intrinsic.oxygen reduc.ion reac.ion,oxygen evolution reac.ion,and hydrogen evolution reac.ion ac.ivities of c._(4)N@Fe/N-c.were attributed to the formation of the heterointerfac. and the modulated loc.l elec.ronic.***,c._(4)N@Fe/N-c.induc.d improvement in these trifunc.ional elec.roc.talytic.ac.ivities owing to the hierarc.ic.l hollow nanoc.be struc.ure,uniform distribution of c._(4)N,and c.nduc.ive enc.psulation by Fe/***,the rec.argeable zinc.air battery with c._(4)N@Fe/N-c.delivers a high spec.fic.c.pac.ty of 789.9 mAh g^(-1) and stable voltage profiles over 500 ***,the overall water elec.rolyzer with c._(4)N@Fe/N-c.ac.ieved better durability and rate performanc. than that with the Pt/c.and IrO2 c.talysts,delivering a high Faradaic.effic.enc. of 96.4%.Along with the great potential of the integrated water elec.rolyzer powered by a zinc.air battery for prac.ic.l applic.tions,therefore,the mec.anistic.understanding and ac.ive site identific.tion provide valuable insights into the rational design of advanc.d multifunc.ional elec.roc.talysts for energy storage and c.nversion.

关键词： battery-powered elec.rolyzers hierarc.ic.l struc.ure Prussian blue analog trifunc.ional elec.roc.talyst zinc.air battery

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