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Microsurgical management of radicular cyst using guided tissue regeneration technique:A case report

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World Journal of Clinical Cases 2024年第7期12卷 1346-1355页

作者： Juan Carlos Gómez Mireles Eugenia Karina Martínez Carrillo Katia Alcalá Barbosa Evangelina Gutiérrez Cortés javier González ramos Luis Antonio González Gómez Rubén Alberto Bayardo González Sarah Monserrat Lomelí Martínez periodontics Specialty Department of Integral Dentistry ClinicsCentro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340Mexico Endodontics Specialty Department of Integral Dentistry ClinicsCentro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340Mexico Endodontics Specialty Department of ClinicsCentro Universitario de Los AltosUniversidad de GuadalajaraTepatitlán de Morelos 47620Mexico Specialty in Oral pathology Surgical-Stomatological DepartmentAutonomous University of GuadalajaraZapopan 45129Mexico Independent Researcher Guadalajara 44340Mexico Department of Integral Dentistry Clinics Centro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340Mexico Department of Medical and Life Sciences Centro Universitario de la CiénegaUniversidad de GuadalajaraOcotlán 47810Mexico Master of public Health Department of Well-being and Sustainable DevelopmentCentro Universitario del NorteUniversidad de GuadalajaraColotlán 46200Mexico

BACKGROUND Radicular cyst is a lesion of odontogenic origin that arises from epithelial remains due to periapical periodontitis caused by inflammatory reactions generated at the apex of affected teeth with infected or necrotic *** therapeutic mana gement of radicular cysts is *** is only one case report of enucleation of a radicular cyst managed with microsurgery and apicoectomy,but without the use of the guided tissue regeneration(GTR)technique in the same surgical *** present clinical case describes the management of a radicular cyst with microsurgical approach,performance of an apicoectomy of the tooth associated with the entity,application of GTR technique,use of a resorbable membrane of type I bovine collagen,and bovine *** SUMMARY A 68-year-old patient presented with a radicular cyst from an upper lateral *** microsurgical management used was aimed at enucleating the chemical membrane,performing apicoectomy of the tooth along with careful and precise retrograde filling,and implementing GTR technique using a resorbable collagen membrane and bovine *** diagnosis of radicular cyst was confirmed using histopathological *** patient underwent follow-up evaluations at 10 and 30 d *** 4 months postoperative evaluation,she remained asymptomatic,and radiographs showed significant periapical healing with adequate bone *** These results suggest that microsurgical management using the GTR technique with collagen membrane and xenograft,contributes to bone regeneration.

关键词： Odontogenic cysts Apical periodontal cyst Dental root end cyst Case report

The Quaternary Structure of NADpH Thioredoxin Reductase C Is Redox-Sensitive

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Molecular plant 2009年第3期2卷 457-467页

作者： Juan Manuel pérez-Ruiz Maricruz Gonzalez Maria Cristina Spinola Luisa Maria Sandalio Francisco javier Cejudo Instituto de Bioqulmica Vegetal y Fotoslntesis Universidad de Sevilla y CSIC Avda Américo Vespucio 49 41092-Sevilla Spain present address: plant Biology Laboratory The Salk Institute 10010 N. Torrey Pines Rd La Jolla CA 92037 USA Estacion Experimental del Zaidin CSIC C/Prof Albareda 1 18008-Granada Spain

NADpH thioredoxin reductase C （NTRC） is a chloroplast enzyme able to conjugate NADpH thioredoxin reductase （NTR） and thioredoxin （TRX） activities for the efficient reduction of 2-Cys peroxiredoxin （2-Cys pRX）. Because NADpH can be produced in chloroplasts during darkness, NTRC plays a key role for plant peroxide detoxification during the night. Here, it is shown that the quaternary structure of NTRC is highly dependent on its redox status. In vitro, most of the enzyme adopted an oligomeric state that disaggregated in dimers upon addition of NADpH, NADH, or DTT. Gel filtration and Western blot analysis of protein extracts from Arabidopsis chloroplast stroma showed that native NTRC forms aggregates, which are sensitive to NADpH and DTT, suggesting that the aggregation state might be a significant aspect of NTRC activity in vivo. Moreover, the enzyme is localized in clusters in Arabidopsis chloroplasts. NTRC triple and double mutants, A164G- V182E-R183F and A164G-R183F, replacing key residues of NADpH binding site, showed reduced activity but were still able to dimerize though with an increase in intermediary forms. Based on these results, we propose that the catalytically active form of NTRC is the dimer, which formation is induced by NADpH.

关键词： Abiotic/environmental stress oxidative and photo-oxidative stress photosynthesis Arabidopsis rice.

Benchmarking Approach to Compare Web Applications Static Analysis Tools Detecting OWASp Top Ten Security Vulnerabilities

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Computers, Materials & Continua 2020年第9期64卷 1555-1577页

作者： Juan R.Bermejo Higuera javier Bermejo Higuera Juan A.Sicilia Montalvo javier Cubo Villalba Juan JoséNombela pérez Escuela Superior de Ingeniería y Tecnología Universidad Internacional de La RiojaLa Rioja26006Spain

To detect security vulnerabilities in a web application,the security analyst must choose the best performance Security Analysis Static Tool(SAST)in terms of discovering the greatest number of security vulnerabilities as *** compare static analysis tools for web applications,an adapted benchmark to the vulnerability categories included in the known standard Open Web Application Security project(OWASp)Top Ten project is *** information of the security effectiveness of a commercial static analysis tool is not usually a publicly accessible research and the state of the art on static security tool analyzers shows that the different design and implementation of those tools has different effectiveness rates in terms of security *** the significant cost of commercial tools,this paper studies the performance of seven static tools using a new methodology proposal and a new benchmark designed for vulnerability categories included in the known standard OWASp Top Ten ***,the practitioners will have more precise information to select the best tool using a benchmark adapted to the last versions of OWASp Top Ten *** results of this work have been obtaining using widely acceptable metrics to classify them according to three different degree of web application criticality.

关键词： Web application benchmark security vulnerability Security Analysis Static Tools assessment methodology false positive false negative precision f-measure

The challenging management of malignant ureteral obstruction:Analysis of a series of 188 cases

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Current Urology 2024年第1期18卷 34-42页

作者： Alberto Artiles Medina Inés Laso García Fernando González Tello Sara Álvarez Rodríguez Manuel Hevia palacios Marina Mata Alcaraz César Mínguez Ojeda Fernando Arias Funez Victoria Gómez Dos Santos Francisco javier Burgos Revilla Department of Urology Hospital Universitario Ramón y CajalMadridSpain Department of Radiology Hospital Universitario Ramón y CajalMadridSpain

Background:Malignant ureteral obstruction(MUO)is a common condition that complicates the course of advanced *** aims of this study are to analyze the causes,management,and survival of patients with obstructive nephropathy due to malignant ureteric obstruction and to determine prognostic ***,we studied the complications and outcomes in patients who underwent urinary *** and methods:A retrospective study was conducted on patients with computed tomography-confirmed MUO between January 2016 and November ***,clinical,radiological,laboratory,and management data were *** curves were estimated using the Kaplan-Meier method,and univariate and multivariate Cox proportional hazards models were used to test the association between parameters and ***:A total of 188 patients were *** mean age was 69.01 years(SD,14.95 years),and the majority(54.8%)were *** most common mechanism leading to MUO was compression by a pelvic mass(36.9%),and the 3 most frequent tumors causing MUO were prostate(17.6%),bladder(16.5%),and rectal cancer(11.7%).Forty-seven patients(25%)underwent urinary diversion:23(48.9%)underwent double-J stenting and 21(44.7%)underwent percutaneous *** most common reason for urinary diversion was acute kidney injury(53.3%).Recovery of renal function was observed in 55.8%of the patients after urinary *** most frequently identified complications after urinary diversion were urinary tract infection(24.4%),hematuria(17.0%),and urinary sepsis(14.9%).The median survival after hydronephrosis diagnosis was 6.43 months(interquartile range,1.91-14.81 months).In patients who underwent urinary decompression,the median survival after urinary diversion was 8.67 months(interquartile range,2.99-17.28 months).In the multivariate analysis,a lower grade of hydronephrosis and cancer cachexia negatively impacted ***:Cancer patients with MUO have a poor pro

关键词： Hydronephrosis Ureteral obstruction Neoplasms Urinary diversion Survival prognosis

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Insights into the role of major bioactive dietary nutrients in lamb meat quality:a review

城市环境设计 2024年第1期147卷 16-23页

作者： javier Villar Ruiz 寺崎豊涌田纯树胡实秋天 Rita Topa 埃里塔·阿塔利加纳永一

我们维护并修复了一个建于1972年的砖砌造船厂，该船厂位于上海黄浦江边，翻修后成为一个新的综合设施，包含剧院和零售空间。一个高20米、长150米的“洞穴”穿透建筑的中心，让你感受到一艘巨轮的体量感，在空间中产生强烈的印象。支...

我们维护并修复了一个建于1972年的砖砌造船厂，该船厂位于上海黄浦江边，翻修后成为一个新的综合设施，包含剧院和零售空间。一个高20米、长150米的“洞穴”穿透建筑的中心，让你感受到一艘巨轮的体量感，在空间中产生强烈的印象。支撑原建筑的混凝土柱子进一步强化了这种效果。西侧的外墙是一道半透明的“屏风”，由多孔砖制成，用直径8毫米的不锈钢丝固定。砖排列的密度会发生变化，就像渐变色一样。

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Journal of Animal Science and Biotechnology 2022年第4期13卷 951-966页

作者： javierÁlvarez-Rodríguez Olaia Urrutia Sandra Lobón Guillermo Ripoll Juan ramón Bertolín Margalida Joy Departament de Ciència Animal Universitat de Lleida25198 LleidaSpain Departamento de Agronomía Biotecnología y AlimentaciónIS-FOOD InstituteEscuela Técnica Superior de Ingeniería Agronómica y BiocienciasUniversidad Pública de NavarraPamplonaSpain Centro de Investigación y Tecnología Agroalimentaria de Aragón(CITA) Avda.Montañana 93050059 ZaragozaSpain Instituto Agroalimentario de Aragón–IA2(CITA-Universidad de Zaragoza) Avda.Miguel Servet17750013 ZaragozaSpain.

Feed supplementation withα-linolenic acid(ALA)and linoleic acid(LA)increases their content in muscle,ALA increases n-3 polyunsaturated fatty acids and decrease n-6/n-3 ratio in muscle,and LA increases rumenic ***,high LA supplementation may have negative effects on lambs’lipid oxidative stability of *** the sources of ALA and LA are fed as fresh forage,the negative effects are counterbalanced by the presence of other bioactive compounds,as vitamin E(mainlyα-tocopherol)and polyphenols,which delay the lipid oxidation in *** is a wide consensus on the capability of vitamin E delaying lipid oxidation on lamb meat,and its feed content should be adjusted to the length of supplementation.A high dietary inclusion of proanthocyanidins,phenolic compounds and terpenes reduce the lipid oxidation in muscle and may improve the shelf life of meat,probably as a result of a combined effect with dietary vitamin ***,the recommended dietary inclusion levels depend on the polyphenol type and concentration and antioxidant capacity of the feedstuffs,which cannot be compared easily because no routine analytical grading methods are yet *** phenolic compounds content in dietary ingredients/supplements for lambs are reported,no specific association with animal physiology responses may be established.

关键词： Fatty acid Forage Oilseed polyphenol Vitamin E

NADpH Thioredoxin Reductase C Is Involved in Redox Regulation of the Mg-Chelatase I Subunit in Arabidopsis thaliana Chloroplasts

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Molecular plant 2014年第7期7卷 1252-1255页

作者： Juan Manuel pérez-Ruiz Manuel Guinea Leonor puerto-Galán Francisco javier Cejudo Instituto de Bioquímica Vegetal y Fotosíntesis Universidad de Sevilla-Consejo Superior de Investigaciones Científicas 41092-Sevilla Spain Umea plant Science Centre Department of Plant Physiology Umea University S-901 87 Umea Sweden

Dear Editor, The synthesis of tetrapyrroles, including chlorophylls, is central for chloroplast function. The metabolic pathway of tetrapyrrole biosynthesis in Arabidopsis is initiated with the formation of amino levulinic acid （ALA）, which is con- verted by a series of common reactions to protoporphy- tin IX （proto IX）（Tanaka et al., 2011）. Then the pathway diverges into two branches： the synthesis of heme/bilin and chlorophylls. The insertion of Mg2＋ into proto IX, cata- lyzed by Mg-chelatase, is the first committed reaction of the chlorophyll branch and is considered a key step for the regulation of the whole pathway. Mg-chelatase is a het- erotrimeric enzyme composed of subunits CHLI, CHLD, and CHLH, the reaction mechanism of which has been estab- lished. It is a two-step process consisting in the Mg-ATp- dependent activation of the enzyme, which implies the formation of a ternary complex of subunits CHLI and CHLD with ATp-Mg2＋, and Mg2＋ chelation, which is catalyzed by CHLH driven by ATp hydrolysis, CHLI providing ATpase activity to the complex （Tanaka et al., 2011）. In Arabidopsis, CHLH and CHLD are encoded by single genes, whereas two genes, CHLI-I and CHLI-2, encode the two isoforms of CHLI.

关键词： synthesis of tetrapyrroles chlorophylls Arabidopsis

The versatility of Fe(Ⅱ) in the synthesis of uniform citrate-stabilized plasmonic nanoparticles with tunable size at room temperature

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Nano Research 2020年第9期13卷 2351-2355页

作者： Carlos Fernández-Lodeiro javier Fernández-Lodeiro Enrique Carbó-Argibay Carlos Lodeiro Jorge pérez-Juste Isabel pastoriza-Santos CINBIO Universidade de VigoCampus universitario LagoasMarcosende36310 VigoSpain Galicia Sur Health Research Institute(IIS Galicia Sur) SERGAS-UVIGO36312 VigoSpain BIOSCOpE Group LAQV@REQUIMTEChemistry DepartmentNOVA School of Science and TechnologyNOVA University LisbonCaparica Campus2829-516 CaparicaPortugal pROTEOMASS Scientific Society Rua dos InventoresMadam ParqueCaparica Campus2829-516 CaparicaPortugal International Iberian Nanotechnology Laboratory(INL) Av.Mestre Jose Veiga s/n4715-330 BragaPortugal

A highly versatile seed-mediated approach for the synthesis of citrate-stabilized gold,silver and palladium nanoparticles(Nps)with size control is *** use of iron(Ⅱ)as a reducing agent enables the fabrication of monodisperse Nps in a wide range of sizes(from 15 nm to at least 120 nm(90 nm for pd))at room *** citrate as capping ligand on the Nps surface facilitates its further surface modification with proteins and thiolated molecules.

关键词： plasmonic nanoparticles gold silver palladium citrate-stabilized Fe(Ⅱ)

DLST mutations in pheochromocytoma and paraganglioma cause proteome hyposuccinylation andmetabolic remodeling

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Cancer Communications 2023年第7期43卷 838-843页

作者： Sara Mellid Fernando García Luis javier Leandro-García Alberto Díaz-Talavera Ángel Mario Martínez-Montes Eduardo Gil Bruna Calsina María Monteagudo Rocío Letón Juan María Roldán-Romero María Santos javier Lanillos Carlos Valdivia Natalia Martínez-puente javier de Nicolás-Hernández Scherezade Jiménez Manuel pérez-Martínez Emiliano Honrado javier Coloma Ana Cerezo Clara María Santiveri Manel Esteller ramón Campos-Olivas Eduardo Caleiras Cristina Montero-Conde Cristina Rodríguez-Antona javier Muñoz Mercedes Robledo Alberto Cascón Hereditary Endocrine Cancer Group Spanish National Cancer Research Centre(CNIO)MadridSpain proteomics Unit Spanish National Cancer Research Centre(CNIO)MadridSpain Centro de Investigación Biomédica en Red de Enfermedades Raras(CIBERER) MadridSpain Monoclonal Antibodies Core Unit Spanish National Cancer Research Centre(CNIO)MadridSpain Confocal Microscopy Core Unit Spanish National Cancer Research Centre(CNIO)MadridSpain Anatomical pathology Service Hospital of LeónLeónCastilla y LeónSpain Structural Biology programme Spanish National Cancer Research Centre(CNIO)MadridSpain CNIO-Lilly Cell Signalling and Immunometabolism Section Spanish National Cancer Research Centre(CNIO)MadridSpain Spectroscopy and Nuclear Magnetic Resonance Unit Spanish National Cancer Research Centre(CNIO)MadridSpain Josep Carreras Leukaemia Research Institute(IJC) BadalonaBarcelonaSpain Centro de Investigacion Biomedica en Red Cancer(CIBERONC) MadridSpain Institucio Catalana de Recerca i Estudis Avançats(ICREA) BarcelonaSpain physiological Sciences Department School of Medicine and Health SciencesUniversity of Barcelona(UB)L’HospitaletBarcelonaSpain Histopathology Core Unit Spanish National Cancer Research Centre(CNIO)MadridSpain Cell Signaling and Clinical proteomics Group Biocruces Bizkaia Health Research InstituteBarakaldoSpain Ikerbasque Basque Foundation for ScienceBilbaoSpain

Dear Editor,Of all human tumors,pheochromocytomas and paragangliomas(ppGLs)have the highest heritability *** 15%of ppGLs harbor mutations in genes encoding tricarboxylic acid(TCA)cycle-related enzymes that cause oncometabolite accumulation and drive tumorigenesis via metabolic adaptation to hypoxia and global hypermethylation[1].The dihydrolipoamide S-succinyltransferase(DLST)gene was recently described as a new ppGL susceptibility gene[2].

关键词： glioma remodeling cytoma