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World Journal of Pediatrics 2020年第6期16卷 629-632页

作者： Pan Roses-Gibert javier gimeno castillo Amaia Saenz Aguirre Francisco javier De la Torre Gomar Lucia Carnero Gonzalez Zurine Martinez de Lagran Alvarez de Arcaya Ricardo Gonzalez-Perez Araba University Hospital Francisco Leandro de Viana Street01009 VitoriaSpain

Background To describe the cutaneous acral findings in a pediatric population noticed during this *** A retrospective descriptive study was performed collecting data on 36 patients under 14 years old,presenting suspicious acral skin manifestations for coronavirus disease 2019(COVID-19).Results Patients were mostly male(63.8%).The mean age was 11.11 years.66.67%of patients showed erythematous papules,and 44.44%purpuric *** were aifected in 97.22%of patients and hands in 5.55%.Lesions were asymptomatic in 50%of patients.30.55%of patients showed extracutaneous findings,preceding skin lesions in 12.62 *** patients underwent specific severe acute coronavirus 2(SARS-CoV-2)testing;all of these patients tested *** The association between these symptoms and SARS-CoV-2 remains *** recommend using these manifestations as a sign of SARS-CoV-2 infection in *** could lead to the examination of asymptomatic and mildly symptomatic children so that contagions may be avoided.

关键词： Acral lesions Acute acro-ischemia Chilblain-like COVID-19

Intense pulsed light‑based treatment for the improvement of symptoms in glaucoma patients treated with hypotensive eye drops

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Eye and Vision 2024年第2期10卷 12-21页

作者： Jose Maria Martinez‑de‑la‑Casa Carlos Oribio‑Quinto Almudena Milans‑del‑Bosch Pilar Perez‑Garcia Laura Morales‑Fernandez javier Garcia‑Bella Jose Manuel Benitez‑del‑castillo Julian Garcia‑Feijoo David P.Pinero Ophthalmology Unit Department of Ophthalmology and ORLFaculty of MedicineHospital Clinico San-CarlosUniversidad Complutense de MadridInstituto de Investigacion Sanitaria del Hospital Clinico San-Carlos(IdISSC)28040 MadridSpain Department of Immunology Ophthalmology and ORLSchool of MedicineInstituto de Investigaciones Oftalmologicas Ramon CastroviejoUniversidad Complutense de MadridMadridSpain Department of Optics Pharmacology and AnatomyUniversity of AlicanteAlicanteSpain

Background:Ocular surface disease in glaucoma patients is a significant ocular co-morbidity that can affect 40%to 59%of these patients *** current study was aimed at evaluating the potential clinical benefit of an intense pulsed light(IPL)-based treatment in glaucomatous patients with ocular surface disease due to prolonged hypotensive eyedrop *** our knowledge,this is the first series analyzing the therapeutic effect of this treatment option in this type of ***:This non-comparative prospective case series study enrolled a total of 30 glaucoma patients ranging in age from 57 to 94 years old and treated with hypotensive eyedrops for years with dry eye *** patients received four sessions of IPL treatment using the Optima IPL system(Lumenis,Yokneam,Israel)adjusted to the official optimized Lumenis *** in symptomatology,corneal staining,conjunctival hyperemia,non-invasive break-up time(NIBUT),tear osmolarity,tear meniscus height(TMH),meiboscore and meibomian gland expressibility was analyzed after ***:Statistically significant reductions were observed after IPL treatment in the symptomatology scores measured with different questionnaires[ocular surface disease index(OSDI),standard patient evaluation of eye dryness(SPEED)and symptom assessment questionnaire in dry eye(SANDE)]as well as with the visual analogue scale(P<0.001).Mean change in OSDI was−15.0±11.3.A significant reduction was found after treatment in the corneal staining score(P<0.001).A significant reduction was found in tear film meniscus height(P=0.012),as well as in tear film osmolarity(P=0.001).A significant reduction was also found in meibomian gland expressibility(P=0.003),changing the percentage of grade 3 eyes from 44.4%before IPL to 17.2%after ***:IPL therapy combined with meibomian gland expression(MGX)seems to be an effective option to improve symptomatology in glaucomatous patients with ocular surface diseas

关键词： Glaucoma Intense pulsed light Dry eye Meibomian glands

From Deterministic to Random Models: An Analysis of the New Spanish Overtaking Traffic Law

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Open Journal of Statistics 2023年第1期13卷 74-111页

作者： Enrique castillo José Duato javier Girón Spanish Royal Academy of Engineering Don Pedro Madrid Spain Spanish Royal Academy of Sciences Valverde Madrid Spain

The purpose of the research is to analyze the new Spanish law of Traffic, which no longer permits exceeding by up to 20 km/hour the generic speed limits when overtaking on conventional roads. In this research, deterministic and random models are developed to analyze the associated safety risks. The deterministic model highlights the importance of dimensional analysis and provides dimensionless abacuses to analyze the problem. Next, Bayesian networks and Bayesian models are used to build a random model from the previous one, providing a general method to convert deterministic into random models. In addition, the problems of ignoring the dimensions of the variables and parameters are discussed, a common mistake to be corrected. Some examples and multidimensional graphics illustrate the huge reduction in safety and the need to review the existing end of prohibition signs, most of which must be removed. Shortly, the research results show that the distance required for overtaking with safety increases drastically.

关键词： Bayesian Network Modelling OpenBUGS Weibull Distribution

Effects of Hedera helix L. removal on the understory early regeneration in an oak temperate forest in Mexico City

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Ecological Processes 2023年第3期12卷 3-14页

作者： Héctor Adrián Jiménez-Hernández Leticia Bonilla-Valencia Yuriana Martínez-Orea Mara Jessica Zamora-Almazan Francisco javier Espinosa-García Silvia castillo-Argüero Facultad de Ciencias Universidad Nacional Autónoma de México Instituto de Investigaciones en Ecosistemas y Sustentabilidad Universidad Nacional Autónoma de México

Background Hedera helix L. is an invasive weed species introduced in several regions of the world, so it is relevant to study its effects on the plant community and the changes occurring after its eradication. We established invaded(with/without removal of H. helix) and non-invaded(with/without removal of the understory) plots to compare some community attributes in an oak forest in Mexico City and monitored them every 2 months for 1 year, taking soil samples to compare some edaphic variables between the plots. If invasive species negatively affect natural regeneration, seedlings of native species would be less abundant in plots invaded by H. helix than in the non-invaded ones. As invasive species modify the soil microbiota through exudates and often allelochemicals, soil chemical variables would differ between invaded and non-invaded *** The abundance of native species was lower in the invaded plots, but the richness and diversity of species were not statistically different. The composition of the two invaded plots was similar to each other and more alike to that of the non-invaded plots. The species composition of the invaded plots was associated with soil potassium and phosphorus concentrations, whereas that of the non-invaded plots was more associated with soil nitrogen *** Following the removal of H. helix, several native species were registered, leading to a similar species composition as in the non-invaded plots, suggesting that some vegetation recovery can be expected following H. helix removal in 1 year.

关键词： Ivy Invasive plant Mechanical control Diversity Species composition

New perspectives in occult hepatitis C virus infection

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World Journal of Gastroenterology 2012年第23期18卷 2887-2894页

作者： Vicente Carreño javier Bartolomé Inmaculada castillo Juan Antonio Quiroga Foundation for the Study of Viral Hepatitis C/Guzmán el Bueno 7228015 MadridSpain

Occult hepatitis C virus (HCV) infection, defined as the presence of HCV RNA in liver and in peripheral blood mononuclear cells (PBMCs) in the absence of detectable viral RNA in serum by standard assays, can be found in anti-HCV positive patients with normal serum levels of liver enzymes and in anti-HCV negative patients with persistently elevated liver enzymes of unknown etiology. Occult HCV infection is distributed worldwide and all HCV genotypes seem to be involved in this infection. Occult hepatitis C has been found not only in anti-HCV positive subjects with normal values of liver enzymes or in chronic hepatitis of unknown origin but also in several groups at risk for HCV infection such as hemodialysis patients or family members of patients with occult HCV. This occult infection has been reported also in healthy populations without evidence of liver disease. Occult HCV infection seems to be less aggressive than chronic hepatitis C although patients affected by occult HCV may develop liver cirrhosis and even hepatocellular carcinoma. Thus, anti-HCV negative patients with occult HCV may benefit from antiviral therapy with pegylated-interferon plus ribavirin. The persistence of very low levels of HCV RNA in serum and in PBMCs, along with the maintenance of specific T-cell responses against HCV-antigens observed during a long-term follow-up of patients with occult hepatitis C, indicate that occult HCV is a persistent infection that is not spontaneously eradicated. This is an updated report on diagnosis, epidemiology and clinical implications of occult HCV with special emphasis on anti-HCV negative cases.

关键词：丙型肝炎病毒病毒感染隐匿性外周血单个核细胞肝脏疾病抗病毒治疗 T细胞反应抗原特异性

Effects of Hedera helix L. removal on the understory early regeneration in an oak temperate forest in Mexico City

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Ecological Processes 2023年 438-449页

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Evaluation of redox-sensitive metals in marine surface sediments influenced by the oxygen minimum zone of the Humboldt Current System, Northern Chile

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International Journal of Sediment Research 2019年第2期34卷 178-190页

作者： Alexis castillo Jorge Valdés Abdel Sifeddine Sue-Ellen Vega javier Díaz-Ochoa Yery Marambio PhD Program in Applied Sciences Mention Marine Coastal Systems Faculty of Marine Sciences and Biological Resources University of Antofagasta Laboratory of Sedimentology and Palaeoenvironments Alexander von Humboldt InstituteFaculty of Marine Sciences and Biological Resources University of Antofagasta International Joint Laboratory PALEOTRACES (Research Institute for Development Federal Fluminense University University of Antofagasta Peruvian University Cayetano Heredia) Network for Extreme Environments Research (University of Antofagasta University of the Frontera University of Magallanes) Department of Geochemistry Federal Fluminense University IRD-Sorbonne University (UPMC CNRS-MNHN) Department of Sciences and Natural Resources Faculty of SciencesUniversity of Magallanes

Upwelling coastal systems can be used to understand how dissolved oxygen and biological productivity control the accumulation of redox-sensitive metals in marine *** aluminium(Al),cadmium(Cd),iron(Fe),nickel(Ni),molybdenum(Mo),vanadium(V),total organic carbon(TOC),total nitrogen(TN)and total sulfur(TS)contents in surficial sediment collected from different water depths(30,70,and 120 m)in three northern Chilean bays influenced by coastal upwelling and oxygen minimum zones(OMZs)were *** component analysis(PCA),cluster analysis,and Spearman’s rank correlation were used to identify the mechanisms responsible for the redox-sensitive metal *** content of redox-sensitive metals and organic components in sediment increased with increasing water column depth,whereas lithogenic metals *** the Mejillones del Sur and Caldera bays,the enrichment factors of the redox-sensitive metals showed enrichment for all metals with *** Cd and V enrichments are mainly the product of biogenic flow to the seabed,and the Mo and Ni enrichments are due to preservation under low subsurface oxygen *** reduction is not an important mechanism in the accumulation of redox-sensitive metals in the sediment of the three *** PCA showed that the behaviors of the redox-sensitive metals and organic components reflect differences in the effects of the OMZ in sediment along the coast of northern Chile,with a more intense OMZ in Mejillones del Sur bay and weaker OMZs in Caldera and Inglesa ***,the high degree of enrichment in redox-sensitive metals in Caldera Bay can be attributed to the intense activity of the mining industry near the bay,a situation that produces geochemical behavior similar to that observed in Mejillones del Sur Bay.

关键词： Redox sensitive-metals Atacama Desert Enrichment factor Mejillones del Sur Bay Caldera Bay system PCA

Recent advances in bird sperm morphometric analysis and its role in male gamete characterization and reproduction technologies

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Asian Journal of Andrology 2016年第6期18卷 882-888页

作者： Julian Santiago-Moreno Milagros Cristina Esteso Silvia Villaverde-Morcillo Adolfo Toledano-Diaz Cristina Castafio Rosario Velazquez Antonio Lopez-Sebastian Agustin Lopez Goya javier gimeno Martinez Department of Animal Reproduction INIA 28040 Madrid Spain Veterinary Clinical and Research Services Fieb Foundation 28760 Tres Cantos Madrid Spain FAUNIA 28032 Madrid Spain

Postcopulatory sexual selection through sperm competition may be an important evolutionary force affecting many reproductive traits, including sperm morphometrics. Environmental factors such as pollutants, pesticides, and climate change may affect different sperm traits, and thus reproduction, in sensitive bird species. Many sperm-handling processes used in assisted reproductive techniques may also affect the size of sperm cells. The accurately measured dimensions of sperm cell structures （especially the head） can thus be used as indicators of environmental influences, in improving our understanding of reproductive and evolutionary strategies, and for optimizing assisted reproductive techniques （e.g., sperm cryopreservation） for use with birds. Computer-assisted sperm morphometry analysis （CASA-Morph） provides an accurate and reliable method for assessing sperm morphometry, reducing the problem of subjectivity associated with human visual assessment. Computerized systems have been standardized for use with semen from different mammalian species. Avian spermatozoa, however, are filiform, limiting their analysis with such systems, which were developed to examine the approximately spherical heads of mammalian sperm cells. To help overcome this, the standardization of staining techniques to be used in compute^-assessed light microscopical methods is a priority. The present review discusses these points and describes the sperm morphometric characteristics of several wild and domestic bird species.

关键词： avian computer-assisted assay morphometry spermatozoa

Narrow band imaging and white light endoscopy in the characterization of a polypectomy scar:A single-blind observational study

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World Journal of Gastroenterology 2018年第45期24卷 5179-5188页

作者： Fausto Riu Pons Montserrat Andreu javier gimeno Beltran Marco Antonioálvarez-Gonzalez Agustín Seoane Urgorri Josep Maria Dedeu Luis Barranco Priego Xavier Bessa Gastroenterology Department Hospital del MarBarcelona 08003Spain IMIM(Hospital del Mar Medical Research Institute) Barcelona 08003Spain Department of Medicine Autonomous University of BarcelonaBarcelona 08003Spain Pompeu Fabra University Barcelona 08003Spain Pathology Department Hospital del MarBarcelona 08003Spain.

AIM To assess the incremental benefit of narrow band imaging(NBI) and white light endoscopy(WLE), randomizing the initial technique for the detection of residual neoplasia at the polypectomy scar after an endoscopic piecemeal mucosal resection(EPMR).METHODS We conducted an observational study in an academic center to assess the incremental benefit of NBI and WLE randomly applied 1:1(NBI-WLE or WLE-NBI) in the follow-up of a post-EPMR scar by the same *** A total of 112 EPMR scars were included. The median baseline polyp size was 20 mm(interquartile range: 14-30). At first review, NBI and WLE showed good sensitivity(85.0% vs 78.9%), specificity(77.1% vs 84.2%) and overall accuracy(80.0% vs 82.5%). NBI after WLE(WLE-NBI group) improved accuracy, but this difference was not statistically significant [area under the curve(AUC): 86.8% vs 81.6%, P = 0.15]. WLE after NBI(NBI-WLE group) did not improve accuracy(AUC: 81.4% vs 81.1%, P = 0.9). Overall, recurrence was found in 39/112(34.8%) *** Although no statistically significant differences were found between the two techniques at the first postEPMR assessment, the use of NBI after WLE may improve residual neoplasia detection. Nevertheless, biopsy is still required in the first scar review.

关键词： Colonoscopy Narrow band imaging Endoscopic mucosal resection

Interaction of Acaena elongata *** Arbuscular Mycorrhizal Fungi under Phosphorus Limitation Conditions in a Temperate Forest

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Phyton-International Journal of Experimental Botany 2021年第2期90卷 605-619页

作者： Yasmin Vázquez-Santos Yuriana Martínez-Orea javierÁlvarez-Sánchez NoéManuel Montaño Sara Lucía Camargo-Ricalde Silvia castillo-Argüero Departamento de Ecología y Recursos Naturales Facultad de CienciasUniversidad Nacional Autónoma de MéxicoFacultad de CienciasCiudad de México04510México Departamento de Biología División de Ciencias Biológicas y de la SaludUniversidad Autónoma Metropolitana-IztapalapaCiudad de México09340México

The aim of this study was to analyze the performance of Acaena elongata colonized by arbuscular mycorrhizal fungi(AMF)to different phosphorus(P)concentrations,as a measure of AMF ***,is a species from soils where P availability is limited,such as temperate *** research questions were:1)How do different P concentrations affect the AMF association in Acaena elongata,and 2)How does the AMF association influence ***’s growth under different P concentrations?***’s growth,P content in plant tissue,AMF colonization and dependency were measured under four P concentrations:control(0 g P kg^(-1)),low(0.05 g P kg^(-1)),intermediate(0.2 g P kg^(-1))and high(2 g P kg^(-1))in different harvests.A complete randomized block design was ***’s growth was higher under-AMF in intermediate and high P concentrations,and the lowest growth corresponded to+AMF in the low and intermediate P *** observed a negative effect on the root biomass under+AMF in intermediate P concentration,while the P concentration had a positive effect on the leaf area *** AMF colonization in *** decreased in the highest P concentration and it was favored under intermediate P concentration;while the low and the high concentrations generated a cost-benefit *** results suggest that the performance of some plant species in soils with low P availability may not be favored by their association with AMF,but a synergy between AMF and intermediate P concentrations might drive ***’s growth.

关键词： Abies religiosa forest arbuscular mycorrhizae plant growth soil fertilization