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Two titans fin ally meet each other under nitrogen deficiencies:FERONIA-TORC1 activation promotes plant growth

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Molecular Plant 2022年第7期15卷 1095-1097页

作者： javier martinez Pacheco Jose M.Estevez Fundación Instituto Leloir and IIBBA-CONICET.Av.Patricias Argentinas 435 Buenos Aires C1405BWEArgentina Centro de Biotecnología Vegetal Facultad de Ciencias de la VidaUniversidad Andres BelloSantiagoChile ANID-Millennium Science Initiative Program-Millennium Nucleus for the Development of Super Adaptable Plants(MN-SAP) SantiagoChile

Plant growth is determined by well-defined developmental processes that integrate cell-intrinsic factors and external environmental cues,and it is largely dependent on the assimilation of macro-and micro-nutrients from the *** the macro-nutrients,the inorganic nitrogen(e.g.,nitrate and ammonium)and amino acids are essential for plant survival and *** acting as macro-nutrients and structural components of macro-molecules,these nitrogen-containing molecules could also act as signaling molecules to orchestrate diverse genetic programs(Wang et al.,2018).

关键词： activation inorganic nitrate

Contributions to data transmission at critical moments on unmanned aerial vehicles

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Chinese Journal of Aeronautics 2023年第8期36卷 247-257页

作者： Jose Enrique RODRIGUEZ David SEGURADO Manuel SANCHEZ Jose javier martinez Rafael GONZALEZ National Institute of Aerospace Technology Madrid 28850Spain Department of Computer Science University of AlcalaAlcala de HenaresMadrid 28054Spain

As for unmanned aircraft, the knowledge of the aircraft performance is directly related with the navigation, guidance, and control system programming. Therefore, the measured data in each phase of the flight must be sufficiently precise to obtain a good characterization of *** article proposes new methods of sending information to ground, which make it possible to know the aircraft behavior accurately, and for this purpose, four contributions have been made for ALO(Avión Ligero de Observación, Spanish acronym for Light Observation Aircraft). Currently, the characterization is based on data obtained at ten samples per second, insufficient to acquire detailed knowledge of what happened during the whole flight of an aircraft. As a result of these contributions, many more samples per second of accelerations and angular velocities are obtained at the most critical moments of the flight, such as takeoff or landing. Among the improvements included are data compression techniques, providing references to locate the measured data in time and identifying labels of each parameter.

关键词： Critical moments Data transmission Datacompression tech-niques Radio-modem Recommended Standard 232(RS-232) Unmannedaerial vehicle

Phase Ⅱ trial of CDK4/6 inhibitor palbociclib in advanced sarcoma based on mRNA expression of CDK4/CDKN2A

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Signal Transduction and Targeted Therapy 2023年第11期8卷 5518-5527页

作者： javier Martin-Broto Jeronimo martinez-Garcia David SMoura Andres Redondo Antonio Gutierrez Antonio Lopez-Pousa javier martinez-Trufero Isabel Sevilla Roberto Diaz-Beveridge Maria Pilar Solis-Hernandez Amancio Carnero Marco Perez David Marcilla Jesus Garcia-Foncillas Pablo Romero javier Fernandez-Jara Daniel Lopez-Lopez Ivan Arribas Nadia Hindi Health Research Institute-Fundación Jiménez Díaz University Hospital Universidad Autónoma de Madrid(IIS-FJDUAM)28040MadridSpain Medical Oncology Department Fundación Jimenez Diaz University Hospital28040MadridSpain General de Villalba University Hospital 28400MadridSpain Medical Oncology Department University Hospital Virgen de la Arrixaca30120MurciaSpain Department of Medical Oncology Hospital Universitario La Paz-IdiPAZP.Castellana26128046MadridSpain Hematology Department University Hospital Son Espases07120MallorcaSpain Medical Oncology Department Sant Pau Hospital08025BarcelonaSpain Medical Oncology Department University Hospital Miguel Servet50009ZaragozaSpain Investigación Clínica y Traslacional en Cáncer/Instituto de Investigaciones Biomédicas de Malaga(IBIMA)/Hospitales Universitarios Regional y Virgen de la Victoria de Malaga MalagaSpain Medical Oncology Department Hospital Universitari i Politècnic La Fe46026ValenciaSpain Medical Oncology Department Central University Hospital of Asturias33011OviedoSpain Instituto de Biomedicina de Sevilla(IBiS HUVRCSICUS)41013SevillaSpain Pathology Department Virgen del Rocio University Hospital41013SevillaSpain Radiology Department Fundación Jimenez Diaz University Hospital28040MadridSpain Computational Medicine Platform Fundación progreso y salud(FPS)Hospital Virgen del Rocío41013SevilleSpain Bioinformatics in Rare Diseases(BiER).Centro de Investigación Biomédica en Red de Enfermedades Raras(CIBERER) FPSHospital Virgen del RocioSevillaSpain Universitat de València-ERI-CES 46010ValenciaSpain

Cyclin-dependent kinases 4 and 6(CDK4/6)inhibitors demonstrated activity in terms of progression-free survival(PFS)in advanced dedifferentiated liposarcoma(DD-LPS),a sarcoma with CDK4 ***4 overexpression is by far more common than amplification in sarcomas and it might be a rational target for CDK *** investigators of this study found that CDK4 overexpression,while not of CDKN2A,was the most consistent predictive factor for palbociclib efficacy in *** adult-type soft-tissue sarcoma,excluding DD-LPS,or bone sarcoma patients,progressing after at least one systemic line,whose tumors overexpressed CDK4,but not CDKN2A at baseline biopsy,were accrued in this single-arm phase II trial(EudraCT number:2016-004039-19).With the main endpoint of a 6-month PFS rate,40%was considered promising in this *** was administered orally at 125 mg/day for 21 days in 28-day cycles.A total of 214 patients with 236 CDK4/CDKN2A determinations were assessed for prescreening,archival material(141),and screening,baseline biopsy(95).There were 28(29%)with favorable mRNA profiles from 95 screened patients at *** 23 enrolled patients,21 evaluable,the 6-month PFS rate was 29%(95%CI 9–48),and there were 6 patients out of 21 with a PFS longer than 6 *** median PFS and overall survival were 4.2(95%CI 3.6–4.8)and 12(95%CI 8.7–15.4)months,*** research showed a significant correlation between CDK4 mRNA and protein *** was active in a variety of sarcoma subtypes,selected by CDK4/CDKN2A,and deserves further investigation in the sarcoma context.

关键词： CDKN2A sarcoma CDK4

Manipulation of parasite load induces significant changes in the structural-based throat color of male iberian green lizards

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Current Zoology 2018年第3期64卷 293-302页

作者： Rodrigo MEGiA-PALMA javier martinez Santiago MERINO Dept Ecologia Evolutiva Museo Nacional de Ciencias Naturales-CSIC J. Gutierrez Abascal 2 E-28006 Madrid Spain Area Parasitologia Dept Biomedicina y Biotecnologia Area de Parasitologia. Facultad de Farmacia Universidad de Alcala de Henares Alcala de Henares E-28871 Madrid Spain

The honesty of structural-based ornaments is controversial. Sexual selection theory predicts that the honesty of a sexual signal relies on its cost of production or maintenance. Therefore, environmental factors with negative impact on individuals could generate high costs and affect the expres- sion of these sexual signals. In this sense, parasites are a main cost for their hosts. To probe the effect of parasites on the structural-based coloration of a lacertid species Lacerta schreiberi, we have experimentally removed ticks from a group of male Iberian green lizards using an acaricide treatment （i.e., the broad-use insecticide fipronil）. All individuals were radio-tracked and recaptured after 15 days to study changes in coloration in both the ultraviolet （UV）-blue （structural-based） and UV-yellow （structural and pigment-based） ornamentations after manipulation, as well as changes in endoand ectoparasitic load and body condition. Additionally, after the experiment, we measured the skin inflammatory response to a mitogen. The fipronil treatment was effective in reducing ticks and it was associated with a significant reduction of hemoparasite load. Throughout the season, individuals treated with fipronil tended to maintain the brightness of the UV-blue throat coloration while control lizards tended to increase it. However, individuals treated with fipronil that were not infected with hemoparasites significantly reduced the brightness of the UV-blue throat color ation. Individuals with a higher initial tick load exhibited a lower UV saturation increment （UV-blue） and a higher brightness increment （UV-yellow） during the experiment. Overall these results experimentally support the idea that parasites adversely influence the expression of the structural-based coloration of male Iberian green lizards. This adds evidence to the hypothesis that sexual ornaments in lizards function as honest signals.

关键词： animal communication ectoparasites Hamilton & Zuk structural-coloration.

Letter to the Editor concerning:Gallbladder perforation:A single-center experience in north India and a step-up approach for management

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Hepatobiliary & Pancreatic Diseases International 2022年第6期21卷 617-618页

作者： Hermilo Jeptef Angeles-Mar Mariano Garcia-Camp RodrigoEnrique Elizondo-Omaña Santos Guzmán-López javier Humberto martinez-Garza Alejandro Quiroga-Garza Universidad Autonoma de Nuevo Leon School of MedicineHuman Anatomy DepartmentMonterreyNuevo León CP 64460México Universidad Autonoma de Nuevo Leon School of MedicinePlataforma INVEST-KER Unito Mayo Clinic(KER Unit Mexico)MonterreyNuevo LeónMéxico General Surgery Division Instituto Mexicano del Seguro SocialMonterreyNuevo LeónMéxico

To the Editor:We sincerely applaud the work done by Gupta et al.,in which they analyzed a single-center experience regarding gallbladder per-foration(GBP)management[1].Currently,there is a lack of cohort studies to adequately describe the approach strategies and man-agement for this pathology,with international guidelines making ambiguous recommendations[2,3].Their study stratified GBP types and provided details regarding clinical presentation,comorbidities,preoperative diagnosis,etiology,imaging techniques,and surgical *** study reported a high conversion rate when a la-paroscopic approach was attempted for cholecystectomy.

关键词： diagnosis concerning approach

Lesser kestrels of the same colony do not overwinter together

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Current Zoology 2024年第4期70卷 505-512页

作者： Jorge Garcia-Macia Munir Chaouni Sara Morollon javier Bustamante Lina Lopez-Ricaurte Juan martinez-Dalmau Beatriz Rodriguez-Moreno and Vicente Urios Grupo de Investigacion Zoologia de Vertebrados Universidad de AlicanteApdo.99E-03080 AlicanteSpain Department of Wetland Ecology Estacion Biologica de Donana(CSIC)C/Americo Vespucio 2641092SevillaSpain GREFA C/MontedelPilarS/NE-28220MajadahondaMadridSpain

Migratory connectivity describes the linkage between breeding and nonbreeding sites,having major ecological implications in birds:1 season influence the success of an individual or a population in the following *** studies on migratory connectivity have used large-scale approaches,often considering regional populations,but fine-scale studies are also necessary to understand colony *** lesser kestrel Falco naumanni,an insectivorous migratory raptor which form colonies during the breeding period,was considered to have strong connectivity based on regional ***,no small-scale studies on migratory connectivity have been ***,we GPS(Global Positioning System)-tracked 40 adult lesser kestrels from 15 different Spanish breeding colonies,estimating the overlap index between home ranges and the distance between their *** was found that lesser kestrels from the same breeding colony placed their nonbreeding areas at 347±281 km(mean±standard deviation)away from each other(range=23-990),and their home ranges over-lapped by 38.4±23.6%.No differences between intra-colony and inter-colony metrics were found,which suggests that lesser kestrels from the same breeding cluster do not overwinter together,but they spread out and mixed independently of the colony belonging throughout the nonbreeding range of the ***,this study highlights the importance of performing connectivity studies using fine-scale approaches.

关键词： Falco naumanni GPS telemetry migratory connectivity nonbreeding raptor spatial ecology wintering.

Origin of nucleation and growth of extension twins in grains unsuitably oriented for twinning during deformation of Mg-1%Al

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Journal of Magnesium and Alloys 2024年第3期12卷 1186-1203页

作者： Biaobiao Yang javier LLorca IMDEA Materials Institute C/Eric Kandel 2GetafeMadrid 28906Spain Department of Materials Science Polytechnic University of Madrid/Universidad Politécnica de MadridE.T.S.de Ingenieros de CaminosMadrid 28040Spain

A large number of anomalous extension twins,with low or even negative twinning Schmid factors,were found to nucleate and grow in a strongly textured Mg-1Al alloy during tensile deformation along the extruded *** deformation mechanisms responsible for this behaviour were investigated through in-situ electron back-scattered diffraction,grain reference orientation deviation,and slip trace-modified lattice *** was found that anomalous extension twins nucleated mainly at the onset of plastic deformation at or near grain boundary triple *** were associated with the severe strain incompatibility between neighbour grains as a result from the differentbasal slip-induced lattice ***,the anomalous twins were able to grow with the applied strain due to the continuous activation ofbasal slip in different neighbour grains,which enhanced the strain *** results reveal the complexity of the deformation mechanisms in Mg alloys at the local level when deformed along hard orientations.

关键词： Magnesium Extension twinning In-situ electron back-scattered diffraction basal slip Deformation mechanisms.

Contributions to the knowledge of Antarctodon sobrali(Mammalia:Astrapotheria)from the Eocene of Antarctica

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Advances in Polar Science 2024年第1期35卷 48-62页

作者： javier N.GELFO Consejo Nacional de Investigaciones Científicasy Técnicas(CONICET) Buenos Aires C1425FQBArgentina División Paleontología Vertebrados Museo de La PlataFacultad de Ciencias Naturales y Museo de La PlataUniversidad Nacional de La PlataLa Plata B1900FWAArgentina

The Astrapotheria constitutes one of the five orders of extinct South American native ungulates,with a fossil record that also extends to the Eocene of the Antarctic *** contrast to the abundant specimens known for litoptern Sparnotheriodontidae and metatherians,astrapotheres are represented by scant remains assigned to the endemic Antarctodon sobrali and indeterminate astrapotheres,restricted to levels 35C_(u0)and 35n of the Cucullaea I Allomember of the La Meseta *** discovery of alower molar assignable to this species in the Eocene levels of Seymour(Marambio)Island,enables a revision of the diagnosis and the homologies of the dental characters used to describe this taxon.A reanalysis of its phylogenetic relationships reveals the nearly simultaneous presence of basal astrapotheres in the early Eocene of Itaboraí(Brazil),Patagonia,and West *** taxa are characterized by lacking dental specializations usually associated with more abrasive diets like terminal forms of Uruguaytheriinae and *** appears to have thrived on the Antarctic continent during the Early Eocene Climatic Optimum within the paleoclimatic context of a hot-house *** present conditions in Antarctica where no terrestrial mammals inhabit,the early Eocene climate was characterized by warmer temperatures and a biologically diverse environment rich in primary producers,dominated by Nothofagus forests,encompassing both deciduous and evergreen forests,which supported a diverse assemblage of continental vertebrates.

关键词： Astrapotheria Antarctodon Eocene Seymour Island La Meseta Formation

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Multiple color patches and parasites in Sceloporus occidentalis:differential relationships by sex and infection

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Current Zoology 2018年第6期64卷 703-711页

作者： Rodrigo MEGIA-PALMA Dhanashree PARANJPE Senda REGUERA javier martinez Robert D COOPER Pauline BLAIMONT Santiago MERINO Barry SINERVO Department of Ecologia Evolutiva Museo Nacional de Ciencias Naturales-CSICJose Gutierrez Abascal 2.Madrid E-28006Spain Departrnent of Ecology and Evolutionary Biology University of CaliforniaSanta Cruz1156High StSanta CruzCA 95064USA Department of Zoologia Facultad de CienciasUniversidad de GranadaGranada E-18071Spain Area Parasitologia Department of Biomedicina y BiotecnologiaArea de ParasitologiaFacultad de FarmaciaUniversidad de Alcala de HenaresAlcala de HenaresMadrid E-28871Spain

Parasites generally have a negative influence on the color expression of their *** selection theory predicts resistant high-quality individuals should show intense coloration,whereas susceptible low-quality individuals would show poor ***,intensely colored males of different species of Oid and New World lizards were more often infected by *** results suggest that high-quality males,with intense coloration,would suffer higher susceptibility to *** hypothesis remains poorly understood and contradicts general theories on sexual *** surveyed a population of Sceloporus occidentalis for parasites and found infections by the parasite genera Lankesterella and *** this population,both males and females express ventral blue and yellow color *** was almost exclusively infecting *** body size of the males significantly predicted the coloration of both blue and yellow *** males showed darker (lower lightness)blue ventral patches and more saturated yellow patches that were also ***,these males were more often infected by Lankesterella than smaller *** intestinal parasite Acroeimeria infected both males and *** infection by intestinal parasites of the genus Acroeimeria was the best predictor for the chroma in the blue patch of the males and for hue in the yellow patch of the *** males infected by Acroeimeria expressed blue patches with significantly lower chroma than the uninfected ***,the hue of the yellow patch was not significantly different between infected and uninfected *** results suggest a different effect of Lankesterella and Acroeimeria on the *** the one hand,the intense coloration of male lizards infected by Lankesterella suggested high-quality male lizards may tolerate *** the other hand,the low chroma of the blue coloration of the infected males suggested that this coloration could honest

关键词： animal communication coloration Hamilton and Zuk parasites sexual selection