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Meteorological indicators of dengue epidemics in non-endemic Northwest Argentina

Infectious Disease Modelling 2022年第4期7卷 823-834页

作者： javier Armando Gutierrez Karina Laneri Juan Pablo Aparicio Gustavo javier Sibona Departamento de Física-FCE-Universidad Nacional de Salta SaltaArgentina Grupo de Física Estadística e Interdisciplinaria CONICETCentro Atòmico Bariloche-CNEASan Carlos de BarilocheRío NegroArgentina Instituto de Investigaciones en Energía no Convencional(INENCO)Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET)-Universidad Nacional de Salta Av.Bolivia 51004400SaltaArgentina Simon A.Levin Mathematical Computational and Modeling Sciences Center Arizona State UniversityPO Box 871904TempeAZ85287-1904USA IFEG-CONICET and Fa.M.A.F.-Universidad Nacional de Cordoba CordobaArgentina

In the last two decades dengue cases increased significantly throughout the world,giving place to more frequent outbreaks in Latin America.In the non-endemic city of San Ramòn de la Nueva Orán,located in Northwest Argentina,large dengue outbreaks alternate with several years of smaller ones.This pattern,as well as the understanding of the underlying mechanisms,could be essential to design proper strategies to reduce epidemic size.We develop a stochastic model that includes climate variables,social structure,and mobility between a non-endemic city and an endemic area.Climatic variables were input of a mosquito population ecological model,which in turn was coupled to a meta-population,spatially explicit,epidemiological model.Human mobility was included into the model given the high border crossing to the northern country of Bolivia,where dengue transmission is sustained during the whole year.We tested different hypotheses regarding people mobility as well as climate variability by fitting numerical simulations to weekly clinical data reported from 2009 to 2016.After assessing the number of imported cases that triggered the observed outbreaks,our model allows to explain the observed epidemic pattern.We found that the number of vectors per host and the effective reproductive number are proxies for large epidemics.Both proxies are related with climate variability such as rainfall and temperature,opening the possibility to test these meteorological variables for forecast purposes.

关键词： Mathematical modelling Dengue Outbreak Mosquitoes population

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Auricular embryonal rhabdomyosarcoma

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World Journal of Pediatrics 2022年第5期18卷 358-360页

作者： javier Arredondo Montero Monica Bronte Anaut Sara Hernandez-Martin Juan Carlos Lopez-gutierrez Pediatric Surgery Department Complejo Hospitalario de NavarraCalle Irunlarrea 331008 PamplonaNavarraSpain Pathology Department Complejo Hospitalario de NavarraPamplonaSpain Pediatric Surgery Department Hospital Universitario La PazMadridSpain

A 13-month-old girl presented with a red-violaceous tumor of 13 mm in diameter on the inner side of the root of the right helix,with increased temperature and cystic consistency(Fig.1).No pulse was palpable in the lesion.An ultrasonography was performed,showing a 1.6 cm rounded lesion with well-defined margins,hypoechogenic and homogeneous,compatible with hemangioma.Empirical treatment with oral propranolol was started without improve-ment.

关键词： sarcoma ultrasonography showing

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降低控制系统成本的有效途径

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中国电子商情 2011年第6期 53-55页

作者： javier gutierrez NI高级产品经理

在设计和升级装置的过程中经常会遇到的挑战就是如何降低成本,包括开发、部署以及维护的成本。尽管可能会有很多方法,但是考虑到当前计算机的性能和新的控制策略,运用先进控制技术（APC）更易于实现成本的降低。如果我们减少需要控制的... 详细信息

在设计和升级装置的过程中经常会遇到的挑战就是如何降低成本,包括开发、部署以及维护的成本。尽管可能会有很多方法,但是考虑到当前计算机的性能和新的控制策略,运用先进控制技术（APC）更易于实现成本的降低。如果我们减少需要控制的变量数目,会怎么样呢？用更少的变量,将会使所需的硬件更少、过程更简单,并且更容易学习掌握。那么,用户如何才能减少控制循环的个数呢？

关键词：系统成本控制策略控制技术计算机硬件

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Vertical Displacement Measurement in a Slow-Moving Sinkhole Using BOTDA

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Photonic Sensors 2024年第1期14卷 23-39页

作者： Pascual SEVILLANO javier PRECIADO-GARBAYO Jorge SEVIL Francisco gutierrez Juan JMARTiNEZ Sonia MARTiN-LOPEZ Miguel GONZALEZ-HERRAEZ Aragon Institute of Engineering Research(I3A) Universidad de ZaragozaZaragoza 50018Spain Electronic Enginering and Communicaton Dpartment EINAUniversidad de ZaragzaZaragza 50018Spain Aragon Photonics Labs. Zaragoza 50009Spain Department of Earth Sciences Universidad de ZaragozaZaragoza 50009Spain Department of Electronics Escuela Politecnica SuperiorUniversidad de AlcalaMadrid 28805Spain

The effectiveness of monitoring and early-warning systems for ground deformation phenomena,such as sinkholes,depends on their ability to accurately resolve the ongoing ground displacement and detect the subtle deformation preceding catastrophic failures.Sagging sinkholes with a slow subsidence rate and diffuse edges pose a significant challenge for subsidence monitoring due to the low deformation rates and limited lateral strain gradients.In this work,we satisfactorily illustrate the practicality of the Brillouin optical time domain analysis(BOTDA)to measure the spatial-temporal patterns of the vertical displacement in such challenging slow-moving sagging sinkholes.To assess the performance of the approach,we compare the strain recorded by the distributed optical fiber sensor with the vertical displacement measured by high-precision leveling.The results show a good spatial correlation with the ability to identify the maximum subsidence point.There is also a good temporal correlation with the detection of an acceleration phase in the subsidence associated with a flood event.

关键词： Distributed fiber optic sensing(DFOS) vertical displacement measurement slow subsidence rate sinkhole hazard early-warning system

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Implementation outcomes of a sensory integration therapy program with computerized dynamic posturography in patients with balance and sensory dysfunction

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Journal of Otology 2023年第1期18卷 26-32页

作者： Francisco javier Gonzalez Eslait Paola Andrea Escudero Trivino Yaidy Viviana Giraldo Vergara Monica Andrea Morales Garcia Vanessa Fernanda Lucero gutierrez Universidad del Valle Audiological and Otological Balance CenterImbanaco Clinic-Grupo Quiron SaludCaliColombia Research Institute.Imbanaco Clinic-Grupo Quiron Salud CaliColombia

Objective:We describe the first-year implementation experience of an Instrumented Sensory Integration Therapy Program in Audiological&Balance Center patients.Design:This is a retrospective descriptive study.Participants included Seventy-three adults with diagnoses of acute,episodic,or chronic vestibular syndromes.They were classified into the following two groups:group 1 included 46 individuals treated with ISIT plus VRT,and group 2 included 27 individuals treated only with ISIT.Results:The Sensory Organization Test(SOT)for both groups showed a statistical significance for all three sensory inputs;visual systems(G1:p=0.0003;G2:p=0.0337),vestibular system(G1:p<0.0001;G2:p=0.0003),and balance as demonstrated by compound balance score(G1:p<0.0001;G2:p=0.0035),and balance percentage deficit(G1:p<0.0001;G2:p=0.0078).Conclusions:The severity and complexity of functional neurological disorders in the context of vestibular syndromes seem to require between 10 and 20 therapy sessions,and combined ISIT plus VRT appears to be more effective than ISIT as a monotherapy.

关键词： Posturography Vestibular rehabilitation therapy Dizziness handicap inventory

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Evaluation of an Examination in Biochemistry and Molecular Biology

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Journal of Pharmacy and Pharmacology 2017年第6期5卷 359-365页

作者： Delgadillo-gutierrez Hector javier Mendez-Ramirez Ignacio Saldafia-Balmori Yolanda Departamento de Sistemas Biologicos Universidad Autonoma Metropolitana-Xochimileo Calzada del Hueso 1100 Col. Villa Quietud Coyoacan Ciudad de Mexico 04960 Mexico Instituto de Investigaciones y Matematicas Aplicadasy Sistemas Universidad National Autonoma de Mexico Av. Universidad 3000 Col. Universidad National Aut6noma de Mexico Coyoacan Ciudad de Mexico 04510 Mexico Departamento de Bioquimica Facultad de Medicina Universidad Nacional Autonoma de Mexico Av. Universidad 3000 Col. Universidad National Autonoma de Mexico Coyoacan Ciudad de Mexico 04510 Mexico

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Effects of dielectric stoichiometry on the photoluminescence properties of encapsulated WSe2 monolayers

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Nano Research 2018年第3期11卷 1399-1414页

作者： javier Martfn-Sanchez Antonio Mariscal Marta De Luca Aitana Tarazaga Martin-Luengo Georg Gramse Alma Halilovic Rosalia Serna Alberta Bonanni Ilaria Zardo Rinaldo Trotta armando Rastelli Institute of Semiconductor and Solid State Physics Johannes Kepler University Linz Altenbergerstrasse 69 A-4040 Linz Austria Laser Processing Group Instituto de Optica CSIC C/Serrano 121 28006 Madrid Spain Department of Physics University of Basel Klingelbergstrasse 82 4056 Basel Switzerland Institute for Biophysics Johannes Kepler University Linz Gruberstrasse 40 A-4020 Linz Austria

Two-dimensional transition metal dichalcogenide semiconductors have emerged as promising candidates for optoelectronic devices with unprecedented properties and ultra-compact footprints. However, the high sensitivity of atomically thin materials to the surrounding dielectric media imposes severe limitations on their practical applicability. Hence, to enable the effective integration of these materials in devices, the development of reliable encapsulation procedures that preserve their physical properties is required. Here, the excitonic photoluminescence （at room temperature and 10 K） is assessed on mechanically exfoliated WSe2 monolayer flakes encapsulated with SiOx and AlxOy layers by means of chemical and physical deposition techniques. Conformal coating on untreated and non- functionalized flakes is successfully achieved by all the techniques examined, with the exception of atomic layer deposition, for which a cluster-like oxide coating is formed. No significant compositional or strain state changes in the flakes are detected upon encapsulation, independently of the technique adopted. Remarkably, our results show that the optical emission of the flakes is strongly influenced by the stoichiometry quality of the encapsulating oxide. When the encapsulation is carried out with slightly sub-stoichiometric oxides, two remarkable phenomena are observed. First, dominant trion （charged exciton） photoluminescence is detected at room temperature, revealing a clear electrical doping of the monolayers. Second, a strong decrease in the optical emission of the monolayers is observed, and attributed to non-radiative recombination processes and/or carrier transfer from the flake to the oxide. Power- and temperature-dependent photoluminescence measurements further confirm that stoichiometric oxides obtained by physical deposition lead to a successful encapsulation, opening a promising route for the development of integrated two-dimensional devices.

关键词： two dimensional （2D）materials,dielectric encapsulation,transition metaldichalcogenides,semiconductors,photoluminescence,WSe2

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虚拟原型技术与机电一体化设计结合

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中国电子商情 2010年第11期 44-45页

作者： javier gutierrez Christian Fritz Stephen Endersby 美国国家仪器公司 Dassault Systemes SolidWorks公司

用户总是要求我们提高所设计的机械的性能，同时减少资金成本。为了达到这两个矛盾的目标，我们将注意力放到在机械设计方面有巨大潜力的机电一体化上。本文着重展示了使用嵌入式分析工具的现代计算机辅助设计（CAD）系统如何实现机电... 详细信息

用户总是要求我们提高所设计的机械的性能，同时减少资金成本。为了达到这两个矛盾的目标，我们将注意力放到在机械设计方面有巨大潜力的机电一体化上。本文着重展示了使用嵌入式分析工具的现代计算机辅助设计（CAD）系统如何实现机电一体化设计。

关键词：一体化设计机电一体化虚拟原型计算机辅助设计技术机械设计资金成本分析工具

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Multi-omic study to unmask genes involved in prostate cancer development in amulti-case family

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Cancer Communications 2024年第3期44卷 443-447页

作者： Lucia Chica-Redecillas Sergio Cuenca-Lopez Eduardo Andres-Leon Laura Carmen Terron-Camero Blanca Cano-gutierrez Jose Manuel Cozar Jose Antonio Lorente Fernando Vazquez-Alonso Luis javier Martinez-Gonzalez Maria Jesus Alvarez-Cubero GENYO Centre for Genomics and Oncological ResearchPfizerUniversity of GranadaAndalusian Regional GovernmentPTS GranadaGranadaGranadaSpain Department of Biochemistry Molecular Biology III and ImmunologyFaculty of MedicineUniversity of GranadaPTS GranadaGranadaGranadaSpain Bioinformatics Unit Institute of Parasitology and Biomedicine“López-Neyra”Spanish National Research CouncilGranadaGranadaSpain Nursery Service.University Hospital Clínico San Cecilio GranadaGranadaSpain Urology Department University Hospital Virgen de las NievesGranadaGranadaSpain Legal Medicine and Toxicology Department Faculty of MedicineUniversity of GranadaPTS GranadaGranadaGranadaSpain Ibs Biosanitary Research InstituteGranadaGranadaSpain

Dear Editor,Hereditary prostate cancer(PC)comprises 5%-10%of all PC cases.The increased risk of PC in menwith a family his-tory of the disease is well known and is commonly caused by germline mutations,leading to clinical guidelines men-tioning various genes for identifying high-risk individuals.However,the complex inheritance patterns involvingmul-tiple single nucleotide polymorphisms(SNPs)make it a genetically heterogeneous disease,with genetic testing still in its early stages.

关键词： cancer clinical cases

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Automated Deep Learning Empowered Breast Cancer Diagnosis UsingBiomedical Mammogram Images

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Computers, Materials & Continua 2022年第6期71卷 4221-4235页

作者： JoséEscorcia-gutierrez Romany F.Mansour Kelvin Belen javier Jiménez-Cabas Meglys Pérez Natasha Madera Kevin Velasquez Electronics and Telecommunications Engineering Program Universidad Autónoma del CaribeBarranquilla08001Colombia Department of Mathematics Faculty of ScienceNew Valley UniversityEl-Kharga72511Egypt Mechatronics Engineering Program Universidad Autónoma del CaribeBarranquilla08001Colombia Department of Computational Science and Electronic Universidad de la CostaCUCBarranquilla08001Colombia

Biomedical image processing is a hot research topic which helps to majorly assist the disease diagnostic process.At the same time,breast cancer becomes the deadliest disease among women and can be detected by the use of different imaging techniques.Digital mammograms can be used for the earlier identification and diagnostic of breast cancer to minimize the death rate.But the proper identification of breast cancer has mainly relied on the mammography findings and results to increased false positives.For resolving the issues of false positives of breast cancer diagnosis,this paper presents an automated deep learning based breast cancer diagnosis(ADL-BCD)model using digital mammograms.The goal of the ADL-BCD technique is to properly detect the existence of breast lesions using digital mammograms.The proposed model involves Gaussian filter based pre-processing and Tsallis entropy based image segmentation.In addition,Deep Convolutional Neural Network based Residual Network(ResNet 34)is applied for feature extraction purposes.Specifically,a hyper parameter tuning process using chimp optimization algorithm(COA)is applied to tune the parameters involved in ResNet 34 model.The wavelet neural network(WNN)is used for the classification of digital mammograms for the detection of breast cancer.The ADL-BCD method is evaluated using a benchmark dataset and the results are analyzed under several performance measures.The simulation outcome indicated that the ADL-BCD model outperforms the state of art methods in terms of different measures.

关键词： Breast cancer digital mammograms deep learning wavelet neural network Resnet 34 disease diagnosis

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