Multi-omic study to unmask genes involved in prostate cancer development in amulti-case family

作     者：Lucia Chica-Redecillas Sergio Cuenca-Lopez Eduardo Andres-Leon Laura Carmen Terron-Camero Blanca Cano-Gutierrez Jose Manuel Cozar Jose Antonio Lorente Fernando Vazquez-Alonso Luis Javier Martinez-Gonzalez Maria Jesus Alvarez-Cubero 

作者机构：GENYOCentre for Genomics and Oncological ResearchPfizerUniversity of GranadaAndalusian Regional GovernmentPTS GranadaGranadaGranadaSpain Department of BiochemistryMolecular Biology III and ImmunologyFaculty of MedicineUniversity of GranadaPTS GranadaGranadaGranadaSpain Bioinformatics UnitInstitute of Parasitology and Biomedicine“López-Neyra”Spanish National Research CouncilGranadaGranadaSpain Nursery Service.University Hospital Clínico San CecilioGranadaGranadaSpain Urology DepartmentUniversity Hospital Virgen de las NievesGranadaGranadaSpain Legal Medicine and Toxicology DepartmentFaculty of MedicineUniversity of GranadaPTS GranadaGranadaGranadaSpain IbsBiosanitary Research InstituteGranadaGranadaSpain 

出 版 物：《Cancer Communications》 (癌症通讯（英文）)

年 卷 期：2024年第44卷第3期

页      面：443-447页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：The study was funded by the Ministerio de Ciencia e Innovación,Spain(No.PID2019-110512RA-I00/MCIN/AEI/10.13039/501100011033) Fundación para la Investigación en Urología(FIU)(No.G80445661). 

主　　题：cancer clinical cases 

摘      要：Dear Editor,Hereditary prostate cancer(PC)comprises 5%-10%of all PC cases.The increased risk of PC in menwith a family his-tory of the disease is well known and is commonly caused by germline mutations,leading to clinical guidelines men-tioning various genes for identifying high-risk individuals.However,the complex inheritance patterns involvingmul-tiple single nucleotide polymorphisms(SNPs)make it a genetically heterogeneous disease,with genetic testing still in its early stages.