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Mitigating osteonecrosis of the jaw(ONJ) through preventive dent.l.care and understanding of risk factors

Bone Research 2020年第1期8卷 14-25页

作者： jason tWan Douglas MSheeley Martha JSomerman Janice Slee National Institute of Dent.l.and Craniofacial Research National Institutes of HealthBethesdaMDUSA laboratory for Oral Connective tissue Biology National Institute of Arthritis and Musculoskeletal and Skin DiseasesNational Institutes of HealthBethesdaMDUSA

It is well established that alterations in phosphate metabolism have a profound effect on hard and soft tissues of the oral cavity. the present-day clinical form of osteonecrosis of the jaw(ONJ) was preceded by phosphorus necrosis of the jaw, ca. 1860. the subsequent removal of yellow phosphorus from matches in the early 20 th century saw a parallel decline in "phossy jaw" unt.l.the early 2000 s, when similar reports of unusual jaw bone necrosis began to appear in the literature describing jaw necrosis in patients undergoing chemotherapy and concomitant steroid and bisphosphonate treatment. today, the potential side effect of ONJ associated with medications that block osteoclast activity(antiresorptive) is well known, though the mechanism remains unclear and the management and outcomes are often unsatisfactory. Much of the existing literature has focused on the continuing concerns of appropriate use of bisphosphonates and other antiresorptive medications, the incomplete or underdeveloped research on ONJ, and the use of drugs with anabolic potential for treatment of osteoporosis. While recognizing that ONJ is a rare occurrence and ONJ-associated medications play an important role in fracture risk reduction in osteoporotic patients, evidence to date suggests that health care providers can lower the risk further by dent.l.evaluations and care prior to initiating antiresorptive therapies and by monitoring dent.l.health during and after treatment. this review describes the current clinical management guidelines for ONJ, the critical role of dent.l.medical management in mitigating risks, and the current understanding of the effects of predominantly osteoclast-modulating drugs on bone homeostasis.

关键词： drugs metabolism alterations

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How do quantum numbers generally vary in the adiabatic transformation of an ideal gas?

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Chinese Physics B 2011年第10期20卷 305-311页

作者： t. Yarman A. l. Kholmetskii Department of Engineering Okan UniversityAkfirat Istanbul Turkey & Savronik Eskisehir Turkey Department of Physics Belarus State University4 Nezavisimosti Avenue 220030 Minsk Belarus

We continue to analyse the known law of adiabatic transformation for an ideal gas PV5/3=Constant, where P isthe pressure and V is the volume, and following the approach of non-relativistic quantum mechanics which we suggested in a previous work （Yarman et al. 2010 Int. J. Phys. Sci. 5 1524）. We explicitly determine the constant for the general parallelepiped geometry of a container. We also disclose how the quantum numbers associated with molecules of an ideal gas vary through an arbitrary adiabatic transformation. Physical implications of the results obtained are discussed.

关键词： ideal gas adiabatic transformation non-relativistic quantum mechanics

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tuning the particle size,physical properties,and photocat.l.tic activity of Ag_(3)PO_(4)materials by changing the Ag^(+)/PO_(4)^(3-)ratio

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Chinese Physics B 2023年第3期32卷 561-568页

作者： Hung N M Oanh l t M Chung D P thang D V Mai V t Hang l t Minh N V Center for Nano Science and technology Hanoi National University of Education136 Xuan Thuy RoadCau Giay DistrictHanoi 100000Vietnam Department of Physics Hanoi National University of Education136 Xuan Thuy RoadCau Giay DistrictHanoi 100000Vietnam Hanoi University of Mining and Geology Duc Thang WardNorth Tu Liem DistrictHanoi 100000Vietnam Institute of Materials Science Vietnam Academy of Science and Technology18 Hoang Quoc VietHanoi 100000Vietnam Faculty of Basic Sciences Hanoi University of Natural Resources and Environment41 A Phu Dien RoadNorth Tu LiemHanoi 100000Vietnam

this study demonstrates the influence of the Ag^(+)/PO_(4)^(3-)ratio in precursor solution on the cryst.l.structural formation,morphology,physical properties,and photocat.l.tic performance of a Ag_(3)PO_(4)photocat.l.st that is fabricated,using a facile precipitation method,from AgNO_(3)and Na2HPO_(4)·12H_(2)*** material characterizations were carried out using x-ray diffraction(XRD),scanning electron microscopy(SEM),energy-dispersive x-ray spectroscopy(EDX),Brunauer–Emmett–t.l.er(BEt)surface area,Fourier transform infrared(FtIR)absorption,Raman scattering,x-ray photoelectron spectroscopy(XPS),UV-vis absorption,and phot.l.minescence(Pl).the results show that Ag_(3)PO_(4)cryst.l.izes better when the excess PO_(4)^(3-)content increases,and the lattice parameters decrease slightly,while the cryst.l.diameter and the particle size *** change is also observed in the Raman scattering and FtIR spectra with the increase in the vibration frequency of the[PO_(4)]*** compression of the[PO_(4)]unit was also confirmed in the XPS spectra with the shift of P 2p peaks toward higher binding *** photocat.l.tic results showed that the samples synthesized from excess PO_(4)^(3-)solution exhibited higher photocat.l.tic performance compared to the sample with a Ag^(+)/PO_(4)^(3-)ratio of 3:1.A sample prepared from the precursor solution with a Ag^(+)/PO_(4)^(3-)ratio of 3:1.5 was optimal for RhB decomposition under both visible light and natural sunlight,complet.l. decomposing 10 ppm RhB after 15 minutes of xenon lamp irradiation and after 60 minutes under solar light *** is attributed to the high cryst.l.inity,small particle size and low electron–hole recombination rate of the sample.

关键词： morphology photocat.l.tic Ag^(+)/PO_(4)^(3-)ratio visible light

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美国医药费调查委员会

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中华医学杂志 1933年第4期19卷 543-550页

作者： t.l.

美国的医务分配和医药费用,经美国的医药费调查委员会(the Committee on the Costs of Medical Care)第一次反复详细研究曾发生许多争议,现已完成。此会的会长为Ray lyman Wilbur,会员计共四十八个,乃医师,经济家,社会学家,商人和普通...

美国的医务分配和医药费用,经美国的医药费调查委员会(the Committee on the Costs of Medical Care)第一次反复详细研究曾发生许多争议,现已完成。此会的会长为Ray lyman Wilbur,会员计共四十八个,乃医师,经济家,社会学家,商人和普通人的代

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StUDY OF tCP PHASE PRECIPItAtING IN GH4199 SUPERAllOY

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Acta Met.l.urgica Sinica(English letters) 2004年第5期17卷 645-650页

作者： t.Cui Y.S.Zhang S.W.Guo l.wang H.C.Yang SchoolofMaterialsandMet.l.urgy NortheasternUniversityShenyang110004ChinaManuscriptreceived15July2003 inrevisedform19January2004

the precipitating regulation and mechanism of tCP phase (μ phase and σ phase) are studied, using electron hole number (EHN) theory, phase analysis technology and tEM observation. the results indicate that the EHN in studied alloy is 2.311-2.348 which is higher than that of critical EHN of μ phase precipitate (2.30), so μ phase could precipitate if there is enough thermo-exposition. In contrast, the calculated EHN is less than that of critical EHN of σ phase precipitate (2.52). However the σ phase is also observed by tEM. Enrich of Cr and Mo around γ phase after γ′phase precipitated leads to σ phase precipitated.

关键词： superalloy tCP phase electron hole number

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Ultrasonic excitation induced nanocryst.l.ization and toughening of Zr46.75Cu46.75Al6.5 bulk met.l.ic glass

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Journal of Materials Science & technology 2020年第10期42卷 157-161页

作者： W.Zhai l.H.Nie X.D.Hui Y.Xiao t.wang B.Wei School of Physical Science and technology Northwestern Polytechnical UniversityXi'an 710072China State Key laboratory for Advanced Met.l. and Materials University of Science&Technology BeijingBeijing 100083China

Intensive power ultrasound is introduced to Zr46.75Cu46.75Al6.5bulk met.l.ic glass(BMG)as an easy-procurable,non-destructive physical method to modulate its atomic rearrangement and shear deformation *** microstructure after ultrasonic excitation with amplitude about 15μm in 20 k Hz for 2 h is characterized by large amount of Cu10Zr7 nanocryst.l. with size of 20–50 nm embedded in the glass *** leads to a sharp increase in the critical stress for the first pop-in event of shear banding,and thus simultaneously improves both compressive plasticity and yield *** findings provide a novel approach for overcoming the strength-duct.l.ty trade-off dilemma.

关键词： Bulk met.l.ic glass Nanocryst.l.ization Plasticity toughness Ultrasound

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Effect of surface layer softening from previous electrochemical corrosion on electrochemical cold drawing of Q235 steel bar

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Journal of Iron and Steel Research International 2022年第5期29卷 819-835页

作者： J.l.Guo t.J.Chen State Key laboratory of Advanced Processing and Recycling of Nonferrous Met.l. Lanzhou University of TechnologyLanzhou730050GansuChina

the effects of H_(2)SO_(4)concentration and current in electrochemical corrosion on surface layer softening or plasticizing of Q235 steel bar and their effects on subsequent electrochemical cold drawing(ECD)were *** results indicate that the electrochemical corrosion can soften or plasticize the surface layer of Q235 steel bar and then make the subsequent ECD be conducted more *** softening degree and thickness of the surface layer are continuously enhanced with increasing corrosion rate,i.e.,increasing H_(2)SO_(4)concentration or current,due to the generation of more vacancy clusters in deeper regions of surface *** vacancy clusters then relax dislocations through being absorbed during ECD,and the formation and movement of additional dislocation flux are thereby enhanced,resulting in the further obvious decrease in the drawing *** is also due to the enhanced formation and movement of additional dislocation flux that the dislocation density and thus the hardness of the surface layer are decreased,as well as that the texture structure is *** behaviors are enhanced as the corrosion rate increases.

关键词： Electrochemical corrosion Electrochemical cold drawing Surface layer softening Vacancy Additional dislocation flux

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Resveratrol engages selective apoptotic signals in gastric adenocarcinoma cells

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World Journal of Gastroenterology 2006年第35期12卷 5628-5634页

作者： William l Riles jason Erickson Sanjay Nayyar Mary Jo Atten Bashar M Attar Oksana Holian Department of Medicine Division of Gastroenterology John H. Stroger Hospital of Cook County Chicago IL 60612 United States

AIM： to investigate the intracellular apoptotic signals engaged by resveratrol in three gastric adenocarcinoma cancer cell lines, two of which （AGS and SNU-1） express p53 and one （KAtO-M） with deleted p53. MEtHODS： Nuclear fragmentation was used to quantitate apoptotic cells; caspase activity was determined by photometric detection of cleaved substrates; formation of oxidized cytochrome C was used to measure cytochrome C activity, and Western blot analysis was used to determine protein expression, RESUltS： Gastric cancer cells, irrespective of their p53 status, responded to resveratrol with fragmentation of DNA and cleavage of nuclear lamins A and B and PARP. Resveratrol, however, has no effect on mitochondria-associated apoptotic proteins Bcl-2, Bcl- xl, Bax, Bid or Smac/Diablo, and did not promote sub-cellular redistribution of cytochrome C, indicating that resveratrol-induced apoptosis of gastric carcinoma cells does not require breakdown of mitochondrial membrane integrity. Resveratrol up-regulated p53 protein in SNU-1 and AGS cells but there was a difference in response of intracellular apoptotic signals between these cell lines. SNU-1 cells responded to resveratrol treatment with down-regulation of survivin, whereas in AGS and KAtO- 111 cells resveratrol stimulated caspase 3 and cytochrome C oxidase activities. CONClUSION： these findings indicate that even within a specific cancer the intracellular apoptotic signals engaged by resveratrol are cell type dependent and suggest that such differences may be related to differentiation or lack of differentiation of these cells.

关键词： Resveratrol Chemoprevention Apoptosis p53 Survivin Cytochrome C oxidase

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Nonlinear-Optical Analogies in Nuclear-like Soliton Reactions:Selection Rules,Nonlinear tunneling and Sub-Barrier Fusion–Fission

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Chinese Physics letters 2024年第8期41卷 1-7页

作者： t.l.Belyaeva V.N.Serkin Universidad Autonoma del Estado de Mexico Av.Instituto Literario 100C.P.50000TolucaMexico Benemerita Universidad Autonoma de Puebla Av.4 Sur 104C.P.72001PueblaMexico

the main goal of our study is to reveal unexpected but intriguing analogies arising between optical solitons and nuclear physics,which st.l. remain hidden from *** consider the main cornerstones of the concept of nonlinear optics of nuclear reactions and the well-dressed repulsive-core *** the base of this model,we reveal the most intriguing properties of the nonlinear tunneling of nucleus-like solitons and the soliton selfinduced sub-barrier transparency *** describe novel interesting and stimulating analogies between the interaction of nucleus-like solitons on the repulsive barrier and nuclear sub-barrier *** main finding of this study concerns the conservation of tot.l.number of nucleons(or the baryon number)in nuclear-like soliton *** show that inelastic interactions among well-dressed repulsive-core solitons arise only when a“cloud”of“dressing”spectral side-bands appears in the frequency spectra of the *** property of nucleus-like solitons is directly related to the nuclear density distribution described by the dimensionless small shape-squareness *** the Fourier spectra of nucleus-like solitons are similar to the nuclear form *** show that the nuclear-like reactions between well-dressed solitons are realized by“exchange”between“particle-like”side bands in their spectra.

关键词： solitons soliton Nonlinear

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Changes in clinical indicators among human immunodeficiency virus patients who failed in antiretroviral therapy during 2004–2016 in Yunnan, China: an observational cohort study

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Global Health Journal 2020年第2期4卷 57-63页

作者： Peicheng wang Junfang Xu Bingbing Guo jason K wang liangmin Gao Qianyun wang Jun Jing Feng Cheng Research Center for Public Health School of MedicineTsinghua University30 Shuangqing RoadBeijing 100084China Research Institute of Health Policy School of Public HealthZhejiang University866 Yuhangtang RoadHangzhou 310058China College of life Science and Bioengineering Beijing University of Technology100 Ping Le YuanBeijing 100124China Schwarzman College Tsinghua University30 Shuangqing RoadBeijing 100084China Department of Sociology Tsinghua University30 Shuangqing RoadBeijing 100084China

Background:this study aimed to investigate the changes in the clinical indicators and influencing factors of treatment duration among human immunodeficiency virus(HIV)patients in whom antiretroviral therapy(ARt)was ***:In this retrospective study,a tot.l.of 9,418 HIV patients who failed in ARt during 2004–2016 were included and divided into two treatment groups—Group 1(treatment time≤3 years,n1=5,218)and Group 2(treatment time>3 years,n2=4,200).Patient follow-up data,including age,cluster of differentiation 4(CD4)count,and viral load,glucose,creatinine,and triglyceride levels,were extracted from electronic health record *** analysis for repeated measures was used to analyze the biochemical indicators,and multiple logistic regression modeling was used to compare relevant data extracted from the Group 1 and Group 2 HIV patient cohorts with different treatment ***:the median initial CD4 count was 175.0 cells/μl(interquart.l. range,77.0–282.0),while the initial CD4 counts for Group 1 were lower than those for Group 2(Pt interaction between group and time effects was observed(Ptot.l.cholesterol(tC).Changes in hemoglobin level among HIV patients were also significantly associated with treatment time(P=0.001).the initial CD4 count(odds ratio[OR]=0.756),female sex(OR=0.713),Zerit(d4t)(OR=1.443),tC(OR=1.285),and aspartate aminotransferase level(OR=1.002)were significantly associated with the survival time of dead patients with HIV(Ptionally,the initial CD4 count(OR=1.456),age(OR=1.022),time interval(OR=0.903),patient’s living status(OR=0.597),d4t(OR=2.256),and triglyceride(OR=0.930)and hemoglobin levels(OR=0.997)were significantly associated with the treatment time of HIV patients with drug withdrawal(Plusion:the initial biochemical parameters can affect the survival and treatment time of HIV *** a comprehensive understanding of the physiological and biochemical indicators

关键词： treatment time Biochemical indicators HIV/AIDS Failure of antiretroviral therapy

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